Ana Marušić and colleagues present a five-step framework to establish authorship of industry-sponsored clinical trial publications early in the manuscript development process, with the aim of standardizing decisions and facilitating transparency.
Transparent documentation of clinical trial authorship is important; David Moher comments on Marušić and colleagues’ five-step authorship framework, highlighting the responsibilities of authors and ways in which the framework could be implemented.
Navdeep Chandel explains in an interview why it has been difficult to establish whether the anti-diabetic drug metformin affects tumor growth, and how the properties of individual tumors may be crucial.
Commenting on a recent paper in Cancer and Metabolism, Matthew vander Heiden and colleagues consider the mechanisms by which the anti-diabetic drug metformin can act via mitochondria to combat cancer.
In an analysis of patient records in the US, hospitalization and mortality rates for acute myocardial infarction (AMI) have declined overall in the past 18 years, but race and sex disparities remain, suggesting that further efforts to improve equity are required.
Neuromodulators disrupt the network synchrony characteristic of cortical neurons in culture - but not for ever. Even with a dose-calibrated application, synchrony reemerges after about 12 hours and a withdrawal period is needed to restore efficacy.
Mark Jobling addresses concerns over misinterpreting population genetics research, and it's potential to exacerbate racism.
Analysis of giraffe mitochondrial DNA supports the existence of an ancient rift valley that once separated populations in southern Africa and created the genetically distinct subspecies seen today; results with implications for both giraffe conservation and taxonomy.
Multimorbidity occurs in over 10% of survey respondents in southern China, and secondary care is used preferentially over primary care by those with multimorbidities, suggesting that a stronger primary care system needs to be developed for these patients.
New evidence that methylation beyond the CpG island could play a role in gene expression.
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