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  • Image attributed to: Figure from DawnRank by Ma

    Finding personalized cancer drivers

    It is a challenge to assess whether rare and patient-specific mutations are cancer drivers. The algorithm DawnRank prioritizes altered genes on a single patient level.

    Genome Medicine 2014, 6:56
  • Physical activity and cellular aging in breast cancer survivors

    A self-reported lack of physical activity was associated with shortened telomere length in early stage breast cancer survivors, suggesting a mechanism by which exercise can reduce cellular aging.

    Breast Cancer Research 2014, 16:413
  • Image attributed to: Abramsky et al. (2014)

    Community intervention reduces IPV

    In a randomized trial, a community-based intervention aiming to prevent intimate partner violence (IPV) and HIV-risk behaviors in Uganda successfully reduced acceptance and incidence of IPV, and is now being delivered in other communities.

    BMC Medicine 2014, 12:122
  • Systematic cancer drug target identification

    An integrated approach to predict and validate novel anti-cancer drug targets, with demonstration of strong anti-proliferative effects of predicted targets.

    Genome Medicine 2014, 6:57
  • Image attributed to: iStock photos

    Peer review: aims, training and recognition

    Jigisha Patel suggests current flaws within peer review systems in medical journals can be tackled by defining aims of peer review, offering training and recognition for reviewers, and providing readers with a way of identifying individual published articles that have been assessed by ‘trained’ reviewers.

    BMC Medicine 2014, 12:128
  • Therapeutic hypothermia and immune response

    Induced hypothermia after cardiac arrest does not alter immune response when compared with patients with a body temperature regulated at 36°C, contradicting fears that induced hypothermia may increase the risk of infection.

    Critical Care 2014, 18:R162
  • Next-generation sequencing in microbial forensics

    High throughput sequencing (HTS) for microbial forensics has the potential to solve crimes and enhance public safety, however, interpretation of the results relies on understanding the performance and limitations of HTS methods. Bruce Budowle and colleagues present new criteria to be considered for HTS validation for microbial forensics.

    Investigative Genetics 2014, 5:9
  • ChIP-seq zinger motifs

    An analysis of the novel common TF binding site motif – zinger motif – reveals the need for careful analysis of ChIP-seq data

    Genome Biology 2014, 15:412
  • Image attributed to: iStock

    HIV patients at greater risk of hypertension 

    HIV-infected adults who have been using antiretroviral therapy for over two years have a higher incidence of hypertension compared with adults without HIV, indicating that screening measures should be targeted towards these patients.

    BMC Medicine 2014, 12:125
  • Syringomyelia: risk factors associated with head shape in the Cavalier King Charles Spaniel

    The authors identified two significant risk factors associated with Chiari-like malformation/syringomyelia in the skull shape of the Cavalier King Charles Spaniel: extent of brachycephaly and distribution of doming of the cranium.

    Canine Genetics and Epidemiology 2014, 1:9
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