University of Oxford, United Kingdom
Cell Communication and Signaling is an open access, peer-reviewed, online journal that encompasses all basic and translational aspects of cellular communications and signaling pathways in normal and pathological conditions.
“These are exciting times as we might be getting a first glimpse into the molecular basis of higher order signal processing events in cells.”
Stephan Feller is a Research Scientist at the Weatherall Instuitute of Molecular Medicine (WIMM) in Oxford and teaches at the University of Oxford. He holds a professorship in Tumor Biology.
Stephan graduated in 1989 with a Diploma in Biology after studying at Kaiserlautern and Heidelberg. In 1994 he obtained a PhD in biochemistry and cell biology from Rockefeller University, New York. He then stayed on for another year as a postdoctoral fellow in the laboratory of renowned cancer virologist Hidesaburo Hanafusa, before moving to Wuerzburg University, where he established an independent junior research group. Starting with his doctoral research, Stephan has been interested in the molecular signaling mechanisms that allow cancer cells to develop and persist. In 2001 he moved to Oxford to continue and extend his cancer cell research into structural biology and other biophysical studies.
His most recent work aims to understand the molecular architecture of signaling protein complexes and networks. He has put forward the N-terminal folding nucleation (NFN) hypothesis, which might explain how complex signals are molecularly computed in multi-protein complexes assembled on intrinsically disordered proteins.