University of Pittsburgh, United States of America
Herpesviridae is an open access journal created by scientists in the field, publishing high quality articles that contribute to the overall knowledge of the role of herpes viruses in health and disease.
Dr. Hendricks received his PhD degree in Microbiology and Immunology at the University of Illinois at Chicago in 1978. His thesis work focused on regulation of T lymphocyte function. During his postdoctoral research, he became interested in the immune response to herpes simplex virus type 1 (HSV-1) and studied the mechanisms of HSV-1 induced immunopathology in the cornea of the eye. His laboratory later discovered that CD8+ T lymphocytes infiltrate the trigeminal ganglia of mice following HSV-1 corneal infection and remain in close apposition to latently infected neurons. This observation led to studies defining a role for CD8+ T cells in maintaining HSV-1 in a latent or quiescent state within neurons. Since reactivation of latent virus in sensory neurons is considered the main source of the HSV that causes recurrent disease, these findings suggested an important role for the immune system in preventing recurrent herpetic disease. In 1998, Dr. Hendricks was recruited to the University of Pittsburgh where he is currently the Joseph F. Novak Professor of Ophthalmology, Immunology, and Microbiology and Molecular Genetics. He is the Director of the Ophthalmology and Visual Sciences Research Center, Vice-Chair for Research in the Department of Ophthalmology, and Interim Scientific Director of the Louis J. Fox Center for Vision Restoration.