Buck Institute for Research on Aging, USA
Longevity & Healthspan is an open access, peer-reviewed, interdisciplinary journal that publishes articles on all aspects of aging biology in the context of healthy aging or age-related disease. More specifically, the journal emphasizes advancing understanding of how age-related changes in structure and function become risk factors for or accompany age-related diseases or conditions, and the biology underlying healthy aging and longevity.
Gordon Lithgow is Principal Investigator and Director of the Interdisciplinary Research Consortium on Geroscience at the Buck Institute for Research on Aging in Novato, California. He received his PhD in Genetics from the University of Glasgow, Scotland, before undertaking postdoctoral training at the Institute for Behavioral Genetics, University of Colorado, Boulder. Returning to the UK, he became Senior Lecturer in Molecular Gerontology at the University of Manchester, before moving to the Buck Institute in 2001.
His laboratory is involved in the identification of endogenous and exogenous agents that extend lifespan or prevent age-related disease by modifying natural stress defence mechanisms. Using C. elegans and human cell culture, his group found that elevated levels of the heat shock proteins promote longevity, most likely by maintaining protein homeostasis. In addition, the discovery that long-lived mutant strains are resistant to heavy metals has prompted his lab to investigate the relationship between longevity and cellular metalloregulation, work which is currently ongoing. His group has unveiled novel pharmacological compounds that intervene in the aging process, including the recent discovery of stress response mimetic compounds, which preserve protein stability and have shown promise in suppressing the pathology associated with Alzheimer’s disease.
Holding the paradigm that aging and disease stem from common mechanisms, his lab continues to screen and study compounds that slow aging and enhance healthspan.