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Alexander Dobrovic
Peter MacCallum Cancer Centre

Alexander Dobrovic Molecular Pathology Research and Development Laboratory, Department of Pathology Alexander Dobrovic is an Editorial Board Member for BMC Cancer, BMC Blood Disorders and BMC Research Notes and is a Professor at the Peter MacCallum Cancer Centre. Molecular Pathology, which detects the multiple genetic and epigenetic changes that underlie tumour development, has become the key discipline in the development of personalised (also known as individualised) treatment of cancer. Dr Dobrovic's lab is involved both in basic research in this area and in working with clinicians to develop robust new tests relevant to patient management and to the choice of appropriate therapies. His team has a particular focus on DNA methylation which inactivates multiple genes that normally act to block carcinogenesis. Research article     High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies Do H, Krypuy M, Mitchell PL, Fox SB, Dobrovic A BMC Cancer 2008, 8:142 (21 May 2008) Short Report     Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting Hongdo Do, Benjamin Solomon, Paul L Mitchell, Stephen B Fox, Alexander Dobrovic BMC Research Notes 2008, 1:14 (16 May 2008) Technical advance     Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis Takano EA, Mitchell G, Fox SB, Dobrovic A BMC Cancer 2008, 8:59 (25 February 2008) Methodology article     Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail Essakali S, Carney D, Westerman D, Gambell P, Seymour JF, Dobrovic A BMC Biotechnology 2008, 8:6 (29 January 2008) Research article     High resolution melting for mutation scanning of TP53 exons 5–8 Krypuy M, Ahmed AA, Etemadmoghadam D, Hyland SJ, Australian Ovarian Cancer Study Group , deFazio A, Fox SB, Brenton JD, Bowtell DD, Dobrovic A BMC Cancer 2007, 7:168 (31 August 2007)