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26.

3599
Accesses

Research article   Open Access Highly Accessed

Human milk metagenome: a functional capacity analysis

Tonya L Ward, Sergey Hosid, Ilya Ioshikhes, Illimar Altosaar BMC Microbiology 2013, 13:116 (25 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

27.

3560
Accesses

Research   Open Access Highly Accessed

Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.)

Ray Ming, Robert VanBuren, Yanling Liu, Mei Yang, Yuepeng Han, Lei-Ting Li, Qiong Zhang, Min-Jeong Kim, Michael C Schatz, Michael Campbell, Jingping Li, John E Bowers, Haibao Tang, Eric Lyons, Ann A Ferguson, Giuseppe Narzisi, David R Nelson, Crysten E Blaby-Haas, Andrea R Gschwend, Yuannian Jiao, Joshua P Der, Fanchang Zeng, Jennifer Han, Xiang Jia Min, Karen A Hudson, Ratnesh Singh, Aleel K Grennan, Steven J Karpowicz, Jennifer R Watling, Kikukatsu Ito et al. Genome Biology 2013, 14:R41 (10 May 2013)

Abstract | Provisional PDF | PubMed | F1000 Biology |  Editor’s summary

The genome of the long-living, slowly evolving sacred lotus reveals the genetic mechanisms underlying its adaptation to limited nutrient availability

28.

3555
Accesses

Study protocol   Open Access Highly Accessed

ACHESS – The Australian study of child health in same-sex families: background research, design and methodology

Simon Crouch, Elizabeth Waters, Ruth McNair, Jennifer Power, Elise Davis BMC Public Health 2012, 12:646 (13 August 2012)

Abstract | Full text | PDF | PubMed

29.

3498
Accesses

Research   Open Access Highly Accessed

The importance of human resources management in health care: a global context

Stefane M Kabene, Carole Orchard, John M Howard, Mark A Soriano, Raymond Leduc Human Resources for Health 2006, 4:20 (27 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

3482
Accesses

Review   Open Access Highly Accessed

The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes

Damien P Belobrajdic, Anthony R Bird Nutrition Journal 2013, 12:62 (16 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

31.

3439
Accesses

Debate   Open Access Highly Accessed

Wikis, blogs and podcasts: a new generation of Web-based tools for virtual collaborative clinical practice and education

Maged Boulos, Inocencio Maramba, Steve Wheeler BMC Medical Education 2006, 6:41 (15 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

32.

3437
Accesses

Journal club critique   Free Highly Accessed

Crystalloids vs. colloids: KO at the twelfth round?

Dennis P Phillips, A Kaynar, John A Kellum, Hernando Gomez Critical Care 2013, 17:319 (29 May 2013)

Abstract | Full text | PDF | PubMed

33.

3252
Accesses

Study protocol   Open Access Highly Accessed

Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol

Anouk GW van Norden, Karlijn F de Laat, Rob AR Gons, Inge WM van Uden, Ewoud J van Dijk, Lucas JB van Oudheusden, Rianne AJ Esselink, Bastiaan R Bloem, Baziel GM van Engelen, Machiel J Zwarts, Indira Tendolkar, Marcel G Olde-Rikkert, Maureen J van der Vlugt, Marcel P Zwiers, David G Norris, Frank-Erik de Leeuw BMC Neurology 2011, 11:29 (28 February 2011)

Abstract | Full text | PDF | PubMed

34.

3225
Accesses

Review   Open Access Highly Accessed

Weight Science: Evaluating the Evidence for a Paradigm Shift

Linda Bacon, Lucy Aphramor Nutrition Journal 2011, 10:9 (24 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

3172
Accesses

Methodology   Open Access Highly Accessed

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Elaine O Petrof, Gregory B Gloor, Stephen J Vanner, Scott J Weese, David Carter, Michelle C Daigneault, Eric M Brown, Kathleen Schroeter, Emma Allen-Vercoe Microbiome 2013, 1:3 (9 January 2013)

Abstract | Full text | PDF |  Editor’s summary

A super-probiotic synthetic stool, composed of 33 different bacterial strains, was developed and used to treat two patients with severe C. difficile infection. The probiotic bacteria could still be detected up to six months after inoculation.

36.

3158
Accesses

Technical advance   Open Access Highly Accessed

A new growth chart for preterm babies: Babson and Benda's chart updated with recent data and a new format

Tanis R Fenton BMC Pediatrics 2003, 3:13 (16 December 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

3132
Accesses

Question and Answer   Open Access Highly Accessed

Q&A: Antibiotic resistance: what more do we know and what more can we do?

Gerard D Wright BMC Biology 2013, 11:51 (17 May 2013)

Full text | PDF | PubMed |  Editor’s summary

Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.

38.

3110
Accesses

Review   Open Access Highly Accessed

Critical care management of severe traumatic brain injury in adults

Samir H Haddad, Yaseen M Arabi Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012, 20:12 (3 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

3103
Accesses

Research   Open Access Highly Accessed

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation

Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci, Martin Marsala Stem Cell Research & Therapy 2013, 4:57 (28 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Human foetal stem cell grafts improve both motor and sensory functions in rats suffering from a spinal cord injury, demonstrating potential for cell replacement therapy in human spinal cord injuries.

40.

3053
Accesses

Research   Open Access Highly Accessed

An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study

John Griffiths, Robert A Hatch, Judith Bishop, Kayleigh Morgan, Crispin Jenkinson, Brian H Cuthbertson, Stephen J Brett Critical Care 2013, 17:R100 (28 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Survivors of critical illness in the UK face a negative impact on employment and commonly have a care requirement after discharge from hospital.

41.

3037
Accesses

Editorial   Open Access Highly Accessed

Evolutionary medicine – the quest for a better understanding of health, disease and prevention

Martin Brüne, Ze’ev Hochberg BMC Medicine 2013, 11:116 (29 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In an editorial to launch our article collection on Evolutionary Medicine, Martin Brüne and Ze’ev Hochberg discuss the relevance of evolutionary medicine in clinical research as a means of ultimately gaining deeper understanding about human diseases.

42.

3015
Accesses

Research   Open Access Highly Accessed

A novel virus genome discovered in an extreme environment suggests recombination between unrelated groups of RNA and DNA viruses

Geoffrey S Diemer, Kenneth M Stedman Biology Direct 2012, 7:13 (19 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The discovery of a previously unknown viral genome, the apparent result of a recombination event between unrelated RNA and DNA viruses, has implications for theories of viral evolution.

43.

2994
Accesses

Research article   Open Access Highly Accessed

Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study

Riccardo Polosa, Pasquale Caponnetto, Jaymin B Morjaria, Gabriella Papale, Davide Campagna, Cristina Russo BMC Public Health 2011, 11:786 (11 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

2946
Accesses

Commentary   Open Access Highly Accessed

International Society of Sports Nutrition position stand: protein and exercise

Bill Campbell, Richard B Kreider, Tim Ziegenfuss, Paul La Bounty, Mike Roberts, Darren Burke, Jamie Landis, Hector Lopez, Jose Antonio Journal of the International Society of Sports Nutrition 2007, 4:8 (26 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

45.

2935
Accesses

Research highlight   Subscription

New gene expression pipelines gush lncRNAs

Jiashi Wang, Bronwyn A Lucas, Lynne E Maquat Genome Biology 2013, 14:117 (24 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The characterization of lncRNA expression during neuronal development is a useful resource for elucidating the functions of non-coding transcripts

46.

2891
Accesses

Review   Open Access Highly Accessed

A novel coronavirus capable of lethal human infections: an emerging picture

Gulfaraz Khan Virology Journal 2013, 10:66 (28 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This timely review summarises the ongoing outbreak of a novel coronavirus (HCoV-EMC), which has caused a number of fatal cases in the UK and Middle East.

47.

2886
Accesses

Research   Open Access Highly Accessed

Decreased tryptophan metabolism in patients with autism spectrum disorders

Luigi Boccuto, Chin-Fu Chen, Ayla R Pittman, Cindy D Skinner, Heather J McCartney, Kelly Jones, Barry R Bochner, Roger E Stevenson, Charles E Schwartz Molecular Autism 2013, 4:16 (3 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

48.

2883
Accesses

Comment   Open Access Highly Accessed

Open questions: A logic (or lack thereof) of genome organization

Laurence D Hurst BMC Biology 2013, 11:58 (28 May 2013)

Full text | PDF | PubMed |  Editor’s summary

Laurence Hurst reflects on the range of genome biological factors determining whether mutations have a selective effect, and how knowing more might help us to predict which will cause disease.

49.

2858
Accesses

Review   Open Access Highly Accessed

A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef

Cynthia A Daley, Amber Abbott, Patrick S Doyle, Glenn A Nader, Stephanie Larson Nutrition Journal 2010, 9:10 (10 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

2841
Accesses

Research   Open Access

The plasticity of the grapevine berry transcriptome

Silvia Santo, Giovanni Tornielli, Sara Zenoni, Marianna Fasoli, Lorenzo Farina, Andrea Anesi, Flavia Guzzo, Massimo Delledonne, Mario Pezzotti Genome Biology 2013, 14:r54 (10 June 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A transcriptomic and metabolomic analysis of the plasticity of grapevine berry gene expression in response to development and the environment

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