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1.

14505
Accesses

Correspondence   Open Access Highly Accessed

Mistaken Identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics

Barry R Zeeberg, Joseph Riss, David W Kane, Kimberly J Bussey, Edward Uchio, W Marston Linehan, J Carl Barrett, John N Weinstein BMC Bioinformatics 2004, 5:80 (23 June 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 7 comments

2.

13202
Accesses

Research article   Open Access Highly Accessed

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.

3.

10150
Accesses

Research   Open Access Highly Accessed

Management of bleeding and coagulopathy following major trauma: an updated European guideline

Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernandez-Mondejar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2013, 17:R76 (19 April 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Task Force for Advanced Bleeding Care in Trauma have updated their guidelines on the management of bleeding following traumatic injury, with new recommendations addressing changes made in clinical care.

4.

9047
Accesses

Research article   Open Access Highly Accessed

Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

Mari Palgi, Dario Greco, Riitta Lindström, Petri Auvinen, Tapio I Heino BMC Genomics 2012, 13:134 (11 April 2012)

Abstract | Full text | PDF | PubMed

5.

8508
Accesses

Review   Open Access Highly Accessed

Nutrient timing revisited: is there a post-exercise anabolic window?

Alan Albert Aragon, Brad Jon Schoenfeld Journal of the International Society of Sports Nutrition 2013, 10:5 (29 January 2013)

Abstract | Full text | PDF | PubMed

6.

8354
Accesses

Method   Open Access Highly Accessed

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg Genome Biology 2013, 14:R36 (25 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A major update to TopHat, the popular Bowtie-based spliced aligner

7.

8019
Accesses

Method   Open Access Highly Accessed

Quartz-Seq: a highly reproducible and sensitive single-cell RNA-Seq reveals non-genetic gene expression heterogeneity

Yohei Sasagawa, Itoshi Nikaido, Tetsutaro Hayashi, Hiroki Danno, Kenichiro D Uno, Takeshi Imai, Hiroki R Ueda Genome Biology 2013, 14:R31 (17 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Quartz-Seq is a method for performing single cell RNA-seq which displays high reproducibility

8.

7994
Accesses

Research article   Open Access

Love thy neighbour: facilitation through an alternative signalling modality in plants

Monica Gagliano, Michael Renton BMC Ecology 2013, 13:19 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Chilli seedlings germinate better when grown in the presence of ‘good neighbour’ plants like basil even when all forms of chemical and visual signals are blocked, suggesting that an as-yet unidentified system of communication exists between plants.

9.

7158
Accesses

Research article   Open Access Highly Accessed

A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes

Robert Alexander Pyron, Frank T Burbrink, John J Wiens BMC Evolutionary Biology 2013, 13:93 (29 April 2013)

Abstract | Provisional PDF | PubMed

10.

7067
Accesses

Review   Open Access Highly Accessed

Childhood obesity, prevalence and prevention

Mahshid Dehghan, Noori Akhtar-Danesh, Anwar T Merchant Nutrition Journal 2005, 4:24 (2 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

11.

6939
Accesses

Editorial   Free Highly Accessed

Raymond Gosling: the man who crystallized genes

Naomi Attar Genome Biology 2013, 14:402 (25 April 2013)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

"The most wonderful thing!" - Genome Biology meets Raymond Gosling, a key player in the discovery of the double helix

12.

6433
Accesses

Research article   Open Access Highly Accessed

Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women

Hector L Lopez, Tim N Ziegenfuss, Jennifer E Hofheins, Scott M Habowski, Shawn M Arent, Joseph P Weir, Arny A Ferrando Journal of the International Society of Sports Nutrition 2013, 10:22 (19 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

13.

6217
Accesses

Comment   Subscription

After the gold rush

Neil Hall Genome Biology 2013, 14:115 (7 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Neil Hall wonders whether genomics is ready for a plateau in sequencing costs

14.

6072
Accesses

Research   Open Access Highly Accessed

The importance of human resources management in health care: a global context

Stefane M Kabene, Carole Orchard, John M Howard, Mark A Soriano, Raymond Leduc Human Resources for Health 2006, 4:20 (27 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

6047
Accesses

Research Article   Open Access Highly Accessed

Inferring the potential risks of H7N9 infection by spatiotemporally characterizing bird migration and poultry distribution in eastern China

Benyun Shi, Shang Xia, Guo-Jing Yang, Xiao-Nong Zhou, Jiming Liu Infectious Diseases of Poverty 2013, 2:8 (3 May 2013)

Abstract | Provisional PDF |  Editor’s summary

In view of the rapid geographic spread and increased number of confirmed cases of novel influenza A(H7N9) virus infections in eastern China, this study develops a model to characterize the impacts of bird migration and poultry distribution on the geographic spread of the infection.

16.

5881
Accesses

Review   Open Access Highly Accessed

Physical education, school physical activity, school sports and academic performance

François Trudeau, Roy J Shephard International Journal of Behavioral Nutrition and Physical Activity 2008, 5:10 (25 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

5784
Accesses

Opinion   Subscription Highly Accessed

Sixty years of genome biology

W Doolittle, Peter Fraser, Mark B Gerstein, Brenton R Graveley, Steven Henikoff, Curtis Huttenhower, Alicia Oshlack, Chris P Ponting, John L Rinn, Michael C Schatz, Jernej Ule, Detlef Weigel, George M Weinstock Genome Biology 2013, 14:113 (25 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Members of Genome Biology's Editorial Board select their highlights from the 60 years of genome biology that followed the double helix

18.

5733
Accesses

Review   Open Access Highly Accessed

Food Advertising and Marketing Directed at Children and Adolescents in the US

Mary Story, Simone French International Journal of Behavioral Nutrition and Physical Activity 2004, 1:3 (10 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

5594
Accesses

Research article   Open Access Highly Accessed

A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

Michael A Quail, Miriam Smith, Paul Coupland, Thomas D Otto, Simon R Harris, Thomas R Connor, Anna Bertoni, Harold P Swerdlow, Yong Gu BMC Genomics 2012, 13:341 (24 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Sequencing of four microbial genomes with widely differing GC content is compared on performance using three major new platforms: Ion Torrent PGM, Pacific Biosciences RS, and illumina MiSeq versus Illumina HiSeq system.

20.

5602
Accesses

Research   Open Access Highly Accessed

Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial

Lisa M Davis, Christopher Coleman, Jessica Kiel, Joni Rampolla, Tammy Hutchisen, Laura Ford, Wayne S Andersen, Andrea Hanlon-Mitola Nutrition Journal 2010, 9:11 (11 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

5592
Accesses

Research article   Open Access

Depression, antidepressant medications, and risk of Clostridium difficile infection

Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.

22.

5375
Accesses

Research article   Open Access Highly Accessed

Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013)

Abstract | Full text | PDF | PubMed | 2 comments |  Editor’s summary

A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.

23.

5165
Accesses

Comment   Subscription Highly Accessed

How to evaluate a graduate studentship, or choosing the right doctoral advisor

Duncan T Odom Genome Biology 2013, 14:114 (29 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Duncan Odom has some sage advice for those considering PhD options

24.

5079
Accesses

Research   Open Access Highly Accessed

The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage

John Abramyan, Daleen Badenhorst, Kyle K Biggar, Glen M Borchert, Christopher W Botka, Rachel M Bowden, Edward L Braun, Anne M Bronikowski, Benoit G Bruneau, Leslie T Buck, Blanche Capel, Todd A Castoe, Mike Czerwinski, Kim D Delehaunty, Scott V Edwards, Catrina C Fronick, Matthew K Fujita, Lucinda Fulton, Tina A Graves, Richard E Green, Wilfried Haerty, Ramkumar Hariharan, LaDeana H Hillier, Alisha K Holloway, Daniel Janes, Fredric J Janzen, Cyriac Kandoth, Lesheng Kong, Jason de Koning, Yang Li et al. Genome Biology 2013, 14:R28 (28 March 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

The genome of the western painted turtle, Chrysemys picta bellii, reveals insights into its extreme tolerance to anoxia and freezing

25.

4909
Accesses

Review   Open Access Highly Accessed

Dietary protein intake and renal function

William F Martin, Lawrence E Armstrong, Nancy R Rodriguez Nutrition & Metabolism 2005, 2:25 (20 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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