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1.

27405
Accesses

Research article   Open Access Highly Accessed

Breast cancer incidence and overdiagnosis in Catalonia (Spain)

Montserrat Martinez-Alonso, Ester Vilaprinyo, Rafael Marcos-Gragera, Montserrat Rue Breast Cancer Research 2010, 12:R58 (3 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Mammography screening contributed to overdiagnosis of breast cancer in Catalonia by detecting cases of tumours with limited malignant potential which would otherwise have gone undetected during a lifetime.

2.

27176
Accesses

Case Report   Open Access

Trichobezoar presenting with the 'comma sign' in Rapunzel Syndrome: a case report and literature review

S Dindyal, NJ Bhuva, S Dindyal, MJ Ramdass, V Narayansingh Cases Journal 2008, 1:286 (30 October 2008)

Abstract | Full text | PDF | PubMed

3.

26123
Accesses

Research article   Open Access Highly Accessed

Risk of placenta previa in second birth after first birth cesarean section: a population-based study and meta-analysis

Ipek Gurol-Urganci, David A Cromwell, Leroy C Edozien, Gordon CS Smith, Chidimma Onwere, Tahir A Mahmood, Allan Templeton, Jan H van der Meulen BMC Pregnancy and Childbirth 2011, 11:95 (21 November 2011)

Abstract | Full text | PDF | PubMed

4.

20009
Accesses

Research article   Open Access Highly Accessed

Transcriptome changes during fruit development and ripening of sweet orange (Citrus sinensis)

Keqin Yu, Qiang Xu, Xinlei Da, Fei Guo, Yuduan Ding, Xiuxin Deng BMC Genomics 2012, 13:10 (10 January 2012)

Abstract | Full text | PDF | PubMed

5.

19966
Accesses

Research article   Open Access Highly Accessed

Identifying patients with diabetes and the earliest date of diagnosis in real time: an electronic health record case-finding algorithm

Anil N Makam, Oanh K Nguyen, Billy Moore, Ying Ma, Ruben Amarasingham BMC Medical Informatics and Decision Making 2013, 13:81 (1 August 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

An automated, case-finding algorithm identifies patients with diabetes at the earliest possible date within a healthcare system, enabling improved risk stratification and proactive disease management.

6.

17000
Accesses

Original research article   Open Access Highly Accessed

Expectantly waiting: a survey of thyroid surgery wait times among Canadian Otolaryngologists

Maria Brake, Paige Moore, S Taylor, Jonathan Trites, Scott Murray, Rob Hart Journal of Otolaryngology - Head & Neck Surgery 2013, 42:47 (11 September 2013)

Abstract | Full text | PDF | PubMed

7.

16150
Accesses

Study protocol   Open Access Highly Accessed

Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial

Federico Marchetti, Alessandra Maestro, Francesca Rovere, Davide Zanon, Alberto Arrighini, Paolo Bertolani, Paolo Biban, Liviana Da Dalt, Pasquale Di Pietro, Salvatore Renna, Andrea Guala, Francesco Mannelli, Anna Pazzaglia, Gianni Messi, Francesco Perri, Antonino Reale, Antonio Urbino, Enrico Valletta, Antonio Vitale, Tiziana Zangardi, Maria Tondelli, Antonio Clavenna, Maurizio Bonati, Luca Ronfani BMC Pediatrics 2011, 11:15 (10 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

15730
Accesses

Viewpoint   Free Highly Accessed

Tracking the genomic evolution of breast cancer metastasis

Davide Zecchin, Alberto Bardelli Breast Cancer Research 2010, 12:302 (2 February 2010)

Abstract | Full text | PDF | PubMed

9.

13767
Accesses

Research article   Open Access Highly Accessed

Alcohol intake, wine consumption and the development of depression: the PREDIMED study

Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González, for the PREDIMED GROUP BMC Medicine 2013, 11:192 (30 August 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Moderate consumption of alcohol, specifically wine, is associated with lower incidence of depression in a Mediterranean population, suggesting that those who drink two to seven drinks per week may be less likely to be depressed in comparison to abstainers.

10.

14000
Accesses

Open debate   Open Access Highly Accessed

Constructing narratives of heroism and villainy: case study of Myriad's BRACAnalysis® compared to Genentech's Herceptin®

A Baldwin, Robert Cook-Deegan Genome Medicine 2013, 5:8 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A comparison of the development of Myriad's BRCAnalysis and Genetech's Herceptin shows that business practices have an impact on the public perception of both companies.

11.

12494
Accesses

Research   Open Access Highly Accessed

Quorum sensing in the probiotic bacterium Escherichia coli Nissle 1917 (Mutaflor) – evidence that furanosyl borate diester (AI-2) is influencing the cytokine expression in the DSS colitis mouse model

Christoph A Jacobi, Stefanie Grundler, Chih-Jen Hsieh, Julia Stefanie Frick, Patrick Adam, Georg Lamprecht, Ingo B Autenrieth, Michael Gregor, Peter Malfertheiner Gut Pathogens 2012, 4:8 (3 August 2012)

Abstract | Full text | PDF | PubMed

12.

12428
Accesses

Research article   Open Access Highly Accessed

Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells

Masateru Uchiyama, Xiangyuan Jin, Qi Zhang, Toshihito Hirai, Atsushi Amano, Hisashi Bashuda, Masanori Niimi Journal of Cardiothoracic Surgery 2012, 7:26 (23 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Mice exposed to opera and classical music after a heart transplant have an improved immune response, resulting in prolonged allograft survival. Future studies could consider whether music also affects organ rejection after transplantation.

13.

11698
Accesses

Method   Open Access Highly Accessed

Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data

Franck Rapaport, Raya Khanin, Yupu Liang, Mono Pirun, Azra Krek, Paul Zumbo, Christopher E Mason, Nicholas D Socci, Doron Betel Genome Biology 2013, 14:R95 (10 September 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

An evaluation of differential gene expression analysis methods for RNA-seq data using the SEQC gold standard dataset

14.

11229
Accesses

Research   Open Access

Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children

Daniel Dodoo, Anastasia Aikins, Kwadwo Kusi, Helena Lamptey, Ed Remarque, Paul Milligan, Samuel Bosomprah, Roma Chilengi, Yaa Difie Osei, Bartholomew Akanmori, Michael Theisen Malaria Journal 2008, 7:142 (29 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Using standardized procedures, the study has confirmed the importance of antibodies to MSP1-19 (compared to four other antigens, AMA-1, MSP3 and GLURP)in reducing the risk of clinical malaria in Ghanaian children, thus substantiating its potential as a malaria vaccine candidate.

15.

10981
Accesses

Research   Open Access Highly Accessed

Antibacterial activity of Aquilaria crassna leaf extract against Staphylococcus epidermidis by disruption of cell wall

Sirilak Kamonwannasit, Nawarat Nantapong, Pakarang Kumkrai, Prathan Luecha, Sajeera Kupittayanant, Nuannoi Chudapongse Annals of Clinical Microbiology and Antimicrobials 2013, 12:20 (20 August 2013)

Abstract | Full text | PDF | ePUB | PubMed

16.

10353
Accesses

Review   Open Access Highly Accessed

Second primary cancers after radiation for prostate cancer: a review of data from planning studies

Louise Murray, Ann Henry, Peter Hoskin, Frank-Andre Siebert, Jack Venselaar, on behalf of the BRAPHYQS/PROBATE group of the GEC ESTRO Radiation Oncology 2013, 8:172 (8 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

17.

10000
Accesses

Research article   Open Access Highly Accessed

Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents

Hiu-Ying Lau, Chit-Ming Leung, Yap-Hang Chan, Anne Wing-Mui Lee, Dora Lai-Wan Kwong, Maria Lung, Tai-Hing Lam BMC Cancer 2013, 13:298 (19 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

18.

9186
Accesses

Research   Open Access Highly Accessed

Advanced health biotechnologies in Thailand: redefining policy directions

Román Pérez Velasco, Usa Chaikledkaew, Chaw Yin Myint, Roongnapa Khampang, Sripen Tantivess, Yot Teerawattananon Journal of Translational Medicine 2013, 11:1 (2 January 2013)

Abstract | Full text | PDF | PubMed

19.

9126
Accesses

Review   Open Access Highly Accessed

Nutrient timing revisited: is there a post-exercise anabolic window?

Alan Albert Aragon, Brad Jon Schoenfeld Journal of the International Society of Sports Nutrition 2013, 10:5 (29 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A different look at the science of nutrient timing.

20.

9130
Accesses

Review   Open Access Highly Accessed

Normal and cancer stem cells of the human female reproductive system

Jacqueline López, Francisco J Valdez-Morales, Luis Benítez-Bribiesca, Marco Cerbón, Alejandro Carrancá Reproductive Biology and Endocrinology 2013, 11:53 (19 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

21.

9102
Accesses

Research   Open Access Highly Accessed

Spatial and temporal variations relevant to tsetse control in the Bipindi focus of southern Cameroon

Judith Tchouomene-Labou, Hugues Nana-Djeunga, Gustave Simo, Guy Njitchouang, Gerard Cuny, Tazoacha Asonganyi, Flobert Njiokou Parasites & Vectors 2013, 6:193 (1 July 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

This study shows that suitable tsetse trap sites as well as the temporal climatic variations highly influence the assessment of sleeping sickness transmission in a forest environment where the hydrographic network is important. Image: Pyramidal trap for tsetse flies set near a laundry and bathing spot.

22.

9115
Accesses

Research article   Open Access Highly Accessed

Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions

Nicolaas C Gey van Pittius, Samantha L Sampson, Hyeyoung Lee, Yeun Kim, Paul D van Helden, Robin M Warren BMC Evolutionary Biology 2006, 6:95 (15 November 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

8898
Accesses

Research article   Open Access Highly Accessed

Pharmacoeconomics and its implication on priority-setting for essential medicines in Tanzania: a systematic review

Amani Mori, Bjarne Robberstad BMC Medical Informatics and Decision Making 2012, 12:110 (27 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

8519
Accesses

Research   Open Access Highly Accessed

Consumption habits of pregnant women and implications for developmental biology: a survey of predominantly Hispanic women in California

Sarah E Santiago, Grace H Park, Kelly J Huffman Nutrition Journal 2013, 12:91 (1 July 2013)

Abstract | Full text | PDF | PubMed

25.

8433
Accesses

Research article   Open Access Highly Accessed

Molecular diversity of rumen bacterial communities from tannin-rich and fiber-rich forage fed domestic Sika deer (Cervus nippon) in China

Zhi Li, Han Liu, Guang Li, Kun Bao, Kai Wang, Chao Xu, Yi Yang, Fu Yang, André-Denis G Wright BMC Microbiology 2013, 13:151 (8 July 2013)

Abstract | Full text | PDF | ePUB | PubMed

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