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1.

13143
Accesses

Research article   Open Access Highly Accessed

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.

2.

10113
Accesses

Research article   Open Access Highly Accessed

Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

Mari Palgi, Dario Greco, Riitta Lindström, Petri Auvinen, Tapio I Heino BMC Genomics 2012, 13:134 (11 April 2012)

Abstract | Full text | PDF | PubMed

3.

8616
Accesses

Review   Open Access Highly Accessed

Nutrient timing revisited: is there a post-exercise anabolic window?

Alan Albert Aragon, Brad Jon Schoenfeld Journal of the International Society of Sports Nutrition 2013, 10:5 (29 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A different look at the science of nutrient timing.

4.

7132
Accesses

Research   Open Access Highly Accessed

Characterizing and measuring bias in sequence data

Michael G Ross, Carsten Russ, Maura Costello, Andrew Hollinger, Niall J Lennon, Ryan Hegarty, Chad Nusbaum, David B Jaffe Genome Biology 2013, 14:R51 (29 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A comparison of the bias in sequencing data from four different platforms reveals that some human promoters are completelymissed

5.

6771
Accesses

Research article   Open Access Highly Accessed

Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?

Rebeca Lugaresi, Marco Leme, Vítor de Salles Painelli, Igor Murai, Hamilton Roschel, Marcelo Sapienza, Antonio Lancha Junior, Bruno Gualano Journal of the International Society of Sports Nutrition 2013, 10:26 (16 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

More evidence to show that creatine is safe.

6.

6662
Accesses

Research article   Open Access Highly Accessed

Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.

7.

5872
Accesses

Review   Open Access Highly Accessed

Ketogenic diets and physical performance

Stephen D Phinney Nutrition & Metabolism 2004, 1:2 (17 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

5810
Accesses

Review   Open Access Highly Accessed

Gene regulation by the act of long non-coding RNA transcription

Aleksandra E Kornienko, Philipp M Guenzl, Denise P Barlow, Florian M Pauler BMC Biology 2013, 11:59 (30 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Florian Pauler, Denise Barlow and colleagues review the evidence on long non-protein-coding RNAs for which the process of transcription itself functions in the regulation of nearby genes, but the RNA product may be irrelevant.

9.

5656
Accesses

Research article   Open Access Highly Accessed

A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

Michael A Quail, Miriam Smith, Paul Coupland, Thomas D Otto, Simon R Harris, Thomas R Connor, Anna Bertoni, Harold P Swerdlow, Yong Gu BMC Genomics 2012, 13:341 (24 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Sequencing of four microbial genomes with widely differing GC content is compared on performance using three major new platforms: Ion Torrent PGM, Pacific Biosciences RS, and illumina MiSeq versus Illumina HiSeq system.

10.

5535
Accesses

Research article   Open Access Highly Accessed

The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild

Javier Prado-Martinez, Irene Hernando-Herraez, Belen Lorente-Galdos, Marc Dabad, Oscar Ramirez, Carlos Baeza-Delgado, Carlos Morcillo-Suarez, Can Alkan, Fereydoun Hormozdiari, Emanuele Raineri, Jordi Estellé, Marcos Fernandez-Callejo, Mònica Valles, Lars Ritscher, Torsten Schöneberg, Elisa de la Calle-Mustienes, Sònia Casillas, Raquel Rubio-Acero, Marta Melé, Johannes Engelken, Mario Caceres, Jose Gomez-Skarmeta, Marta Gut, Jaume Bertranpetit, Ivo G Gut, Teresa Abello, Evan E Eichler, Ismael Mingarro, Carles Lalueza-Fox, Arcadi Navarro, Tomas Marques-Bonet et al. BMC Genomics 2013, 14:363 (31 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A phenotypically unique gorilla carries a private non-synonymous substitution in a transmembrane domain in SLC45A2, one of the candidate genes associated with the OCA4 class of albinism

11.

5258
Accesses

Research   Open Access Highly Accessed

Management of bleeding and coagulopathy following major trauma: an updated European guideline

Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2013, 17:R76 (19 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Task Force for Advanced Bleeding Care in Trauma have updated their guidelines on the management of bleeding following traumatic injury, with new recommendations addressing changes made in clinical care.

12.

4856
Accesses

Review   Open Access Highly Accessed

Food Advertising and Marketing Directed at Children and Adolescents in the US

Mary Story, Simone French International Journal of Behavioral Nutrition and Physical Activity 2004, 1:3 (10 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

4742
Accesses

Research   Open Access Highly Accessed

The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color

Juan C Motamayor, Keithanne Mockaitis, Jeremy Schmutz, Niina Haiminen, Donald Livingstone, Omar Cornejo, Seth D Findley, Ping Zheng, Filippo Utro, Stefan Royaert, Christopher Saski, Jerry Jenkins, Ram Podicheti, Meixia Zhao, Brian E Scheffler, Joseph C Stack, Frank A Feltus, Guiliana M Mustiga, Freddy Amores, Wilbert Phillips, Jean Philippe Marelli, Gregory D May, Howard Shapiro, Jianxin Ma, Carlos D Bustamante, Raymond J Schnell, Dorrie Main, Don Gilbert, Laxmi Parida, David N Kuhn et al. Genome Biology 2013, 14:R53 (3 June 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

The genome sequence of Theobroma cacao Matina 1-6 allows the identification of a gene associated with pod color

14.

4475
Accesses

Review   Subscription Highly Accessed

Machine learning and genome annotation: a match meant to be?

Kevin Y Yip, Chao Cheng, Mark Gerstein Genome Biology 2013, 14:205 (29 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Mark Gerstein, Kevin Yip and Chao Cheng present a beginner's guide to machine learning for genome annotation

15.

4264
Accesses

Review   Open Access Highly Accessed

Dietary protein intake and renal function

William F Martin, Lawrence E Armstrong, Nancy R Rodriguez Nutrition & Metabolism 2005, 2:25 (20 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

4259
Accesses

Review   Open Access Highly Accessed

Physical education, school physical activity, school sports and academic performance

François Trudeau, Roy J Shephard International Journal of Behavioral Nutrition and Physical Activity 2008, 5:10 (25 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

4078
Accesses

Software   Open Access Highly Accessed

REAPR: a universal tool for genome assembly evaluation

Martin Hunt, Taisei Kikuchi, Mandy Sanders, Chris Newbold, Matthew Berriman, Thomas D Otto Genome Biology 2013, 14:R47 (27 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A new user-friendly software tool for genome assembly evaluation

18.

4007
Accesses

Review   Open Access Highly Accessed

Childhood obesity, prevalence and prevention

Mahshid Dehghan, Noori Akhtar-Danesh, Anwar T Merchant Nutrition Journal 2005, 4:24 (2 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

19.

4006
Accesses

Opinion   Open Access Highly Accessed

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.

20.

3949
Accesses

Research   Open Access Highly Accessed

Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance

David Martino, Yuk Jin Loke, Lavinia Gordon, Miina Ollikainen, Mark N Cruickshank, Richard Saffery, Jeffrey M Craig Genome Biology 2013, 14:R42 (22 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A longitudinal study of DNA methylation in twins at birth and 18 months finds that some loci drift in methylation status

21.

3857
Accesses

Method   Open Access Highly Accessed

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg Genome Biology 2013, 14:R36 (25 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A major update to TopHat, the popular Bowtie-based spliced aligner

22.

3851
Accesses

Debate   Open Access Highly Accessed

A theory of organizational readiness for change

Bryan J Weiner Implementation Science 2009, 4:67 (19 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

3789
Accesses

Review   Open Access Highly Accessed

ISSN exercise & sport nutrition review: research & recommendations

Richard B Kreider, Colin D Wilborn, Lem Taylor, Bill Campbell, Anthony L Almada, Rick Collins, Mathew Cooke, Conrad P Earnest, Mike Greenwood, Douglas S Kalman, Chad M Kerksick, Susan M Kleiner, Brian Leutholtz, Hector Lopez, Lonnie M Lowery, Ron Mendel, Abbie Smith, Marie Spano, Robert Wildman, Darryn S Willoughby, Tim N Ziegenfuss, Jose Antonio Journal of the International Society of Sports Nutrition 2010, 7:7 (2 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

3776
Accesses

Review   Open Access Highly Accessed

Cancer as a metabolic disease

Thomas N Seyfried, Laura M Shelton Nutrition & Metabolism 2010, 7:7 (27 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

3729
Accesses

Research   Open Access Highly Accessed

The effects of pre- and post-exercise consumption of multi-ingredient performance supplements on cardiovascular health and body fat in trained men after six weeks of resistance training: a stratified, randomized, double-blind study

Michael J Ormsbee, Dennison Thomas, William Mandler, Emery G Ward, Amber W Kinsey, Lynn B Panton, Timothy P Scheett, Shirin Hooshmand, Emily Simonavice, Jeong-Su Kim Nutrition & Metabolism 2013, 10:39 (16 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

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