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1.

13226
Accesses

Research article   Open Access Highly Accessed

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

Gregory R Leong, Karen R Goulding, Nancy Amin, Helena E Richardson, Anthony M Brumby BMC Biology 2009, 7:62 (24 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Scribble, a cell polarity regulator in Drosophila, represses tumorigenesis by inhibiting atypical protein kinase C and Jun N-terminal kinase-dependent pathways, and this might be relevant for how human Scrib restrains oncogene-mediated transformation.

2.

13205
Accesses

Research article   Open Access Highly Accessed

Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

Mari Palgi, Dario Greco, Riitta Lindström, Petri Auvinen, Tapio I Heino BMC Genomics 2012, 13:134 (11 April 2012)

Abstract | Full text | PDF | PubMed

3.

9441
Accesses

Method   Open Access Highly Accessed

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg Genome Biology 2013, 14:R36 (25 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A major update to TopHat, the popular Bowtie-based spliced aligner

4.

9065
Accesses

Review   Open Access Highly Accessed

Nutrient timing revisited: is there a post-exercise anabolic window?

Alan Albert Aragon, Brad Jon Schoenfeld Journal of the International Society of Sports Nutrition 2013, 10:5 (29 January 2013)

Abstract | Full text | PDF | PubMed

5.

8930
Accesses

Research article   Open Access Highly Accessed

Love thy neighbour: facilitation through an alternative signalling modality in plants

Monica Gagliano, Michael Renton BMC Ecology 2013, 13:19 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Chilli seedlings germinate better when grown in the presence of ‘good neighbour’ plants like basil even when all forms of chemical and visual signals are blocked, suggesting that an as-yet unidentified system of communication exists between plants.

6.

7848
Accesses

Research article   Open Access Highly Accessed

A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes

Robert Alexander Pyron, Frank T Burbrink, John J Wiens BMC Evolutionary Biology 2013, 13:93 (29 April 2013)

Abstract | Provisional PDF | PubMed

7.

7429
Accesses

Research article   Open Access Highly Accessed

Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Sabine Rohrmann, Kim Overvad, H Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie et al. BMC Medicine 2013, 11:63 (7 March 2013)

Abstract | Full text | PDF | PubMed | 2 comments |  Editor’s summary

A large study finds a positive association between processed meat consumption and mortality due to cardiovascular disease and cancer, indicating that reducing the amount of processed meat in the diet could reduce mortality risk.

8.

7164
Accesses

Editorial   Free Highly Accessed

Raymond Gosling: the man who crystallized genes

Naomi Attar Genome Biology 2013, 14:402 (25 April 2013)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

"The most wonderful thing!" - Genome Biology meets Raymond Gosling, a key player in the discovery of the double helix

9.

6961
Accesses

Comment   Subscription Highly Accessed

After the gold rush

Neil Hall Genome Biology 2013, 14:115 (7 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Neil Hall wonders whether genomics is ready for a plateau in sequencing costs

10.

6720
Accesses

Research   Open Access Highly Accessed

Management of bleeding and coagulopathy following major trauma: an updated European guideline

Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2013, 17:R76 (19 April 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Task Force for Advanced Bleeding Care in Trauma have updated their guidelines on the management of bleeding following traumatic injury, with new recommendations addressing changes made in clinical care.

11.

6343
Accesses

Research Article   Open Access Highly Accessed

Inferring the potential risks of H7N9 infection by spatiotemporally characterizing bird migration and poultry distribution in eastern China

Benyun Shi, Shang Xia, Guo-Jing Yang, Xiao-Nong Zhou, Jiming Liu Infectious Diseases of Poverty 2013, 2:8 (3 May 2013)

Abstract | Full text | PDF |  Editor’s summary

In view of the rapid geographic spread and increased number of confirmed cases of novel influenza A(H7N9) virus infections in eastern China, this study develops a model to characterize the impacts of bird migration and poultry distribution on the geographic spread of the infection.

12.

6268
Accesses

Research article   Open Access Highly Accessed

Depression, antidepressant medications, and risk of Clostridium difficile infection

Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.

13.

6154
Accesses

Review   Open Access Highly Accessed

Childhood obesity, prevalence and prevention

Mahshid Dehghan, Noori Akhtar-Danesh, Anwar T Merchant Nutrition Journal 2005, 4:24 (2 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

14.

5578
Accesses

Opinion   Subscription Highly Accessed

Sixty years of genome biology

W Doolittle, Peter Fraser, Mark B Gerstein, Brenton R Graveley, Steven Henikoff, Curtis Huttenhower, Alicia Oshlack, Chris P Ponting, John L Rinn, Michael C Schatz, Jernej Ule, Detlef Weigel, George M Weinstock Genome Biology 2013, 14:113 (25 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Members of Genome Biology's Editorial Board select their highlights from the 60 years of genome biology that followed the double helix

15.

5654
Accesses

Research   Open Access Highly Accessed

Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial

Lisa M Davis, Christopher Coleman, Jessica Kiel, Joni Rampolla, Tammy Hutchisen, Laura Ford, Wayne S Andersen, Andrea Hanlon-Mitola Nutrition Journal 2010, 9:11 (11 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

5616
Accesses

Research article   Open Access Highly Accessed

A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

Michael A Quail, Miriam Smith, Paul Coupland, Thomas D Otto, Simon R Harris, Thomas R Connor, Anna Bertoni, Harold P Swerdlow, Yong Gu BMC Genomics 2012, 13:341 (24 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Sequencing of four microbial genomes with widely differing GC content is compared on performance using three major new platforms: Ion Torrent PGM, Pacific Biosciences RS, and illumina MiSeq versus Illumina HiSeq system.

17.

5596
Accesses

Comment   Subscription Highly Accessed

How to evaluate a graduate studentship, or choosing the right doctoral advisor

Duncan T Odom Genome Biology 2013, 14:114 (29 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Duncan Odom has some sage advice for those considering PhD options

18.

5592
Accesses

Research   Open Access Highly Accessed

Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.)

Ray Ming, Robert VanBuren, Yanling Liu, Mei Yang, Yuepeng Han, Lei-Ting Li, Qiong Zhang, Min-Jeong Kim, Michael C Schatz, Michael Campbell, Jingping Li, John E Bowers, Haibao Tang, Eric Lyons, Ann A Ferguson, Giuseppe Narzisi, David R Nelson, Crysten E Blaby-Haas, Andrea R Gschwend, Yuannian Jiao, Joshua P Der, Fanchang Zeng, Jennifer Han, Xiang Jia Min, Karen A Hudson, Ratnesh Singh, Aleel K Grennan, Steven J Karpowicz, Jennifer R Watling, Kikukatsu Ito et al. Genome Biology 2013, 14:R41 (10 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

The genome of the long-living, slowly evolving sacred lotus reveals the genetic mechanisms underlying its adaptation to limited nutrient availability

19.

5392
Accesses

Review   Open Access Highly Accessed

Food Advertising and Marketing Directed at Children and Adolescents in the US

Mary Story, Simone French International Journal of Behavioral Nutrition and Physical Activity 2004, 1:3 (10 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

5339
Accesses

Review   Open Access Highly Accessed

Physical education, school physical activity, school sports and academic performance

François Trudeau, Roy J Shephard International Journal of Behavioral Nutrition and Physical Activity 2008, 5:10 (25 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

5273
Accesses

Research   Open Access Highly Accessed

The importance of human resources management in health care: a global context

Stefane M Kabene, Carole Orchard, John M Howard, Mark A Soriano, Raymond Leduc Human Resources for Health 2006, 4:20 (27 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

5196
Accesses

Research   Open Access Highly Accessed

A novel virus genome discovered in an extreme environment suggests recombination between unrelated groups of RNA and DNA viruses

Geoffrey S Diemer, Kenneth M Stedman Biology Direct 2012, 7:13 (19 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The discovery of a previously unknown viral genome, the apparent result of a recombination event between unrelated RNA and DNA viruses, has implications for theories of viral evolution.

23.

4797
Accesses

Review   Open Access Highly Accessed

Dietary protein intake and renal function

William F Martin, Lawrence E Armstrong, Nancy R Rodriguez Nutrition & Metabolism 2005, 2:25 (20 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

4613
Accesses

Opinion   Open Access Highly Accessed

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.

25.

4597
Accesses

Debate   Open Access Highly Accessed

A theory of organizational readiness for change

Bryan J Weiner Implementation Science 2009, 4:67 (19 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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