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1.

Focus   Open Access

Programmed cell death in trypanosomatids: is it an altruistic mechanism for survival of the fittest?

Alain Debrabant, Hira Nakhasi Kinetoplastid Biology and Disease 2003, 2:7 (25 June 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

2.

Review   Open Access Highly Accessed

The "impact factor" revisited

Peng Dong, Marie Loh, Adrian Mondry Biomedical Digital Libraries 2005, 2:7 (5 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

Research   Open Access Highly Accessed

Effect of peppermint water on prevention of nipple cracks in lactating primiparous women: a randomized controlled trial

Manizheh Sayyah Melli, Mohammad Reza Rashidi, Abbas Delazar, Elaheh Madarek, Mohammad Hassan Kargar Maher, Alieh Ghasemzadeh, Kamran Sadaghat, Zohreh Tahmasebi International Breastfeeding Journal 2007, 2:7 (19 April 2007)

Abstract | Full text | PDF | PubMed

4.

Method   Open Access Highly Accessed

ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions

Naim U Rashid, Paul G Giresi, Joseph G Ibrahim, Wei Sun, Jason D Lieb Genome Biology 2011, 12:R67 (25 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

ZINBA is a method for analyzing peaks in next generation sequencing datasets such as ChIP-seq or DNase-seq

5.

Research article   Open Access

Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study

Jiří Masopust, Radovan Malý, Ctirad Andrýs, Martin Vališ, Jan Bažant, Ladislav Hosák BMC Psychiatry 2011, 11:2 (3 January 2011)

Abstract | Full text | PDF | PubMed | 1 comment

6.

Review   Open Access Highly Accessed

Osteopetrosis

Zornitza Stark, Ravi Savarirayan Orphanet Journal of Rare Diseases 2009, 4:5 (20 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research   Open Access

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

Marguerite Prior, Richard Dargusch, Jennifer L Ehren, Chandramouli Chiruta, David Schubert Alzheimer's Research & Therapy 2013, 5:25 (14 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Novel drug candidate J147 is able to arrest and reverse memory deficits and improve several aspects of brain function in aged mice with advanced symptoms of Alzheimer's disease (AD).

8.

Research   Open Access Highly Accessed

Management of bleeding and coagulopathy following major trauma: an updated European guideline

Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2013, 17:R76 (19 April 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Task Force for Advanced Bleeding Care in Trauma have updated their guidelines on the management of bleeding following traumatic injury, with new recommendations addressing changes made in clinical care.

9.

Review   Open Access Highly Accessed

Weight Science: Evaluating the Evidence for a Paradigm Shift

Linda Bacon, Lucy Aphramor Nutrition Journal 2011, 10:9 (24 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

Research article   Open Access Highly Accessed

Depression, antidepressant medications, and risk of Clostridium difficile infection

Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.

11.

Technical advance   Open Access Highly Accessed

A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants

Tanis R Fenton, Jae H Kim BMC Pediatrics 2013, 13:59 (20 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The Fenton growth chart for preterm infants has been revised to accommodate the World Health Organization Growth Standard and reflect actual age instead of completed weeks, in order to improve preterm infant growth monitoring.

12.

Research   Open Access

Long-term effects of sulfur mustard on civilians’ mental health 20 years after exposure (The Sardasht-Iran Cohort Study)

Rasoul Roshan, Parvin Rahnama, Zeinab Ghazanfari, Ali Montazeri, Mohammad Reza Soroush, Mohammad Mehdi Naghizadeh, Mahdiyeh Melyani, Azadeh Tavoli, Tooba Ghazanfari Health and Quality of Life Outcomes 2013, 11:69 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

13.

Review   Open Access Highly Accessed

Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease

Donald P Tashkin, Gary T Ferguson Respiratory Research 2013, 14:49 (8 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

14.

Research article   Open Access Highly Accessed

A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes

Robert Alexander Pyron, Frank T Burbrink, John J Wiens BMC Evolutionary Biology 2013, 13:93 (29 April 2013)

Abstract | Provisional PDF | PubMed

15.

Review   Open Access

The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes

Jaclyn A Smith, Lesley A Houghton Cough 2013, 9:12 (16 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

16.

Position statement   Open Access Highly Accessed

Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing

Jeanette Schulz-Menger, David A Bluemke, Jens Bremerich, Scott D Flamm, Mark A Fogel, Matthias G Friedrich, Raymond J Kim, Florian von Knobelsdorff-Brenkenhoff, Christopher M Kramer, Dudley J Pennell, Sven Plein, Eike Nagel Journal of Cardiovascular Magnetic Resonance 2013, 15:35 (1 May 2013)

Abstract | Provisional PDF | PubMed

17.

Review   Subscription Highly Accessed

Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients

Peter B Hjortrup, Nicolai Haase, Mik Wetterslev, Anders Perner Critical Care 2013, 17:211 (24 April 2013)

Abstract | Full text | PDF | PubMed

18.

Review   Subscription Highly Accessed

Clinical review: Does it matter which hemodynamic monitoring system is used?

Davinder Ramsingh, Brenton Alexander, Maxime Cannesson Critical Care 2012, 17:208 (5 March 2013)

Abstract | Full text | PDF

19.

Research article   Open Access

Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15

Jacqueline Lehmann-Che, Anne Sophie Hamy, Raphael Porcher, Marc Barritault, Fatiha Bouhidel, Hanadi Habuellelah, Solenne Leman-Detours, Anne de Roquancourt, Laurence Cahen-Doidy, Edwige Bourstyn, Patricia de Cremoux, Cedric de Bazelaire, Marcela Albiter, Sylvie Giacchetti, Caroline Cuvier, Anne Janin, Marc Espie, Hugues de The, Philippe Bertheau Breast Cancer Research 2013, 15:R37 (11 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A novel and simplified molecular and immunohistochemical signature has been described for molecular apocrine breast tumours which could help with easy identification in clinical practice.

20.

Research article   Open Access Highly Accessed

Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium

Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen, Mohamed Bentires-Alj Breast Cancer Research 2013, 15:R36 (29 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Early parity in mice alters the genomic signature of a distinct subset of mammary epithelial cells by inducing differentiation and reducing proliferation, ultimately protecting against breast cancer.

21.

Method   Open Access Highly Accessed

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg Genome Biology 2013, 14:R36 (25 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A major update to TopHat, the popular Bowtie-based spliced aligner

22.

Comment   Subscription Highly Accessed

How to evaluate a graduate studentship, or choosing the right doctoral advisor

Duncan T Odom Genome Biology 2013, 14:114 (29 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Duncan Odom has some sage advice for those considering PhD options

23.

Review   Open Access Highly Accessed

Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future

Philipp Schuetz, Werner Albrich, Beat Mueller BMC Medicine 2011, 9:107 (22 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Mueller and colleagues kick off our new thematic series on Clinical Biomarkers with a review on the utility of procalcitonin in the diagnosis of bacterial infection and decisions about antibiotic treatment in different clinical settings.

24.

Research article   Open Access Highly Accessed

Unique immunologic patterns in fibromyalgia

Frederick G Behm, Igor M Gavin, Oleksiy Karpenko, Valerie Lindgren, Sujata Gaitonde, Peter A Gashkoff, Bruce S Gillis BMC Clinical Pathology 2012, 12:25 (17 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cytokine levels in stimulated blood cells taken from patients suffering from the chronic pain and fatigue syndrome fibromyalgia were significantly lower than in cells taken from healthy controls, offering a potential diagnostic test for this disease

25.

Research article   Open Access Highly Accessed

Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension

Hisham Aljadhey, Wanzhu Tu, Richard A Hansen, Susan J Blalock, D Brater, Michael D Murray BMC Cardiovascular Disorders 2012, 12:93 (24 October 2012)

Abstract | Full text | PDF | PubMed

26.

Commentary   Subscription Highly Accessed

The STOP the Bleeding Campaign

Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Marc Maegele, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Donat R Spahn, the STOP the Bleeding Campaign Critical Care 2013, 17:136 (26 April 2013)

Abstract | Full text | PDF | PubMed

27.

Research   Open Access Highly Accessed

Guideline adaptation and implementation planning: a prospective observational study

Margaret B Harrison, Ian D Graham, Joan van den Hoek, Elizabeth J Dogherty, Meg E Carley, Valerie Angus Implementation Science 2013, 8:49 (8 May 2013)

Abstract | Provisional PDF | PubMed

28.

Debate   Open Access Highly Accessed

A theory of organizational readiness for change

Bryan J Weiner Implementation Science 2009, 4:67 (19 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

29.

Research   Open Access Highly Accessed

Effect of fruit restriction on glycemic control in patients with type 2 diabetes – a randomized trial

Allan S Christensen, Lone Viggers, Kjeld Hasselström, Søren Gregersen Nutrition Journal 2013, 12:29 (5 March 2013)

Abstract | Full text | PDF | PubMed

30.

Research   Open Access Highly Accessed

A survey of energy drink consumption patterns among college students

Brenda M Malinauskas, Victor G Aeby, Reginald F Overton, Tracy Carpenter-Aeby, Kimberly Barber-Heidal Nutrition Journal 2007, 6:35 (31 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

Review   Open Access Highly Accessed

Heparin-induced thrombocytopenia: an update

Massimo Franchini Thrombosis Journal 2005, 3:14 (4 October 2005)

Abstract | Full text | PDF | PubMed

32.

Research   Open Access Highly Accessed

Motivational interviewing and problem solving treatment to reduce type 2 diabetes and cardiovascular disease risk in real life: a randomized controlled trial

Jeroen Lakerveld, Sandra D Bot, Mai J Chinapaw, Maurits W van Tulder, Piet J Kostense, Jacqueline M Dekker, Giel Nijpels International Journal of Behavioral Nutrition and Physical Activity 2013, 10:47 (19 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

33.

Research   Open Access

Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration

Cai Song, Ye Zhang, Yilong Dong Journal of Neuroinflammation 2013, 10:59 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

34.

Research   Open Access

The sexual quality of life-female (SQOL-F) questionnaire: translation and psychometric properties of the Iranian version

Raziyeh Maasoumi, Minoor Lamyian, Ali Montazeri, Seyed Azin, Maria E Aguilar-Vafaie, Ebrahim Hajizadeh Reproductive Health 2013, 10:25 (5 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

35.

Methodology   Open Access Highly Accessed

Implementing evidence-based interventions in health care: application of the replicating effective programs framework

Amy M Kilbourne, Mary S Neumann, Harold A Pincus, Mark S Bauer, Ronald Stall Implementation Science 2007, 2:42 (9 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

Research   Open Access

Stereotactic body radiotherapy for localized prostate cancer: disease control and quality of life at 6 years

Alan J Katz, Michael Santoro, Fred Diblasio, Richard Ashley Radiation Oncology 2013, 8:118 (13 May 2013)

Abstract | Provisional PDF | PubMed

37.

Study protocol   Open Access

The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder - study protocol of the randomised, multi-centre controlled SOSTA - net trial

Christine M Freitag, Hannah Cholemkery, Leyla Elsuni, Anne K Kroeger, Stephan Bender, Cornelia Ursula Kunz, Meinhard Kieser Trials 2013, 14:6 (7 January 2013)

Abstract | Full text | PDF | PubMed

38.

Study protocol   Open Access Highly Accessed

Clinical effect of catgut implantation at acupoints for allergic rhinitis: study protocol for a randomized controlled trial

Xinrong Li, Qinxiu Zhang, Luyun Jiang, Tao Li, Min Liu, Huanxing Liu, Xiaopei Wang, Fubing Zhang Trials 2013, 14:12 (10 January 2013)

Abstract | Full text | PDF | PubMed

39.

Research   Open Access Highly Accessed

Effects of Transcendental Meditation on mental health: a before-after study

Masud Yunesian, Afshin Aslani, Javad Vash, Abbas Yazdi Clinical Practice and Epidemiology in Mental Health 2008, 4:25 (1 November 2008)

Abstract | Full text | PDF | PubMed

40.

Research   Open Access

Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration

Wan-Seob Cho, Byeong-Cheol Kang, Jong Kwon Lee, Jayoung Jeong, Jeong-Hwan Che, Seung Hyeok Seok Particle and Fibre Toxicology 2013, 10:9 (26 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

41.

Research   Open Access

Slower immune system ageing in women versus men in the Japanese population

Katsuiku Hirokawa, Masanori Utsuyama, Yoshio Hayashi, Masanobu Kitagawa, Takashi Makinodan, Tamas Fulop Immunity & Ageing 2013, 10:19 (15 May 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The female's immune system declines at a slower rate than the male's during ageing, contributing (in part) to the significantly longer life expectancy found in women, compared to men.

42.

Research article   Open Access

Patterns of genetic variation across inversions: geographic variation in the In(2L)t inversion in populations of Drosophila melanogaster from eastern Australia

W Jason Kennington, Ary A Hoffmann BMC Evolutionary Biology 2013, 13:100 (20 May 2013)

Abstract | Provisional PDF | PubMed

43.

Analytic Perspective   Open Access Highly Accessed

The missed lessons of Sir Austin Bradford Hill

Carl V Phillips, Karen J Goodman Epidemiologic Perspectives & Innovations 2004, 1:3 (4 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

Review   Open Access Highly Accessed

Post-streptococcal reactive arthritis in children: a distinct entity from acute rheumatic fever

Yosef Uziel, Liat Perl, Judith Barash, Philip J Hashkes Pediatric Rheumatology 2011, 9:32 (20 October 2011)

Abstract | Full text | PDF | PubMed

45.

Review   Open Access Highly Accessed

Growing pains in children

Yosef Uziel, Philip J Hashkes Pediatric Rheumatology 2007, 5:5 (19 April 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

46.

Case report   Open Access

Spontaneus bilateral pedicle fracture 30 years after Harrington Instrumentation for idiopathic scoliosis: a case report

Peter Obid, Alexander Richter, Hüseyin Übeyli, Thomas Niemeyer Journal of Medical Case Reports 2012, 6:29 (23 January 2012)

Abstract | Full text | PDF | PubMed

47.

Research article   Open Access Highly Accessed

AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development

Jianing Zhang, Julie R Shemezis, Erin R McQuinn, Jing Wang, Maria Sverdlov, Anjen Chenn Neural Development 2013, 8:7 (25 April 2013)

Abstract | Full text | PDF | PubMed

48.

Review   Open Access Highly Accessed

Vascular clamping in liver surgery: physiology, indications and techniques

Elie K Chouillard, Andrew A Gumbs, Daniel Cherqui Annals of Surgical Innovation and Research 2010, 4:2 (26 March 2010)

Abstract | Full text | PDF | PubMed

49.

Review   Open Access

Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net

Michael Girschikofsky, Maurizio Arico, Diego Castillo, Anthony Chu, Claus Doberauer, Joachim Fichter, Julien Haroche, Gregory A Kaltsas, Polyzois Makras, Angelo V Marzano, Mathilde de Menthon, Oliver Micke, Emanuela Passoni, Heinrich M Seegenschmiedt, Abdellatif Tazi, Kenneth L McClain Orphanet Journal of Rare Diseases 2013, 8:72 (14 May 2013)

Abstract | Provisional PDF | PubMed

50.

Research   Open Access

Development of quality of care indicators from systematic reviews: the case of hospital delivery

Xavier Bonfill, Marta Roqué, Marta Beatriz Aller, Dimelza Osorio, Carles Foradada, Àngels Vives, David Rigau Implementation Science 2013, 8:42 (10 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

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