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1.

Focus   Open Access

Programmed cell death in trypanosomatids: is it an altruistic mechanism for survival of the fittest?

Alain Debrabant, Hira Nakhasi Kinetoplastid Biology and Disease 2003, 2:7 (25 June 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

2.

Review   Open Access Highly Accessed

The "impact factor" revisited

Peng Dong, Marie Loh, Adrian Mondry Biomedical Digital Libraries 2005, 2:7 (5 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

Research   Open Access Highly Accessed

Effect of peppermint water on prevention of nipple cracks in lactating primiparous women: a randomized controlled trial

Manizheh Sayyah Melli, Mohammad Reza Rashidi, Abbas Delazar, Elaheh Madarek, Mohammad Hassan Kargar Maher, Alieh Ghasemzadeh, Kamran Sadaghat, Zohreh Tahmasebi International Breastfeeding Journal 2007, 2:7 (19 April 2007)

Abstract | Full text | PDF | PubMed

4.

Method   Open Access Highly Accessed

ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions

Naim U Rashid, Paul G Giresi, Joseph G Ibrahim, Wei Sun, Jason D Lieb Genome Biology 2011, 12:R67 (25 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

ZINBA is a method for analyzing peaks in next generation sequencing datasets such as ChIP-seq or DNase-seq

5.

Research article   Open Access

Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study

Jiří Masopust, Radovan Malý, Ctirad Andrýs, Martin Vališ, Jan Bažant, Ladislav Hosák BMC Psychiatry 2011, 11:2 (3 January 2011)

Abstract | Full text | PDF | PubMed | 1 comment

6.

Review   Open Access Highly Accessed

Osteopetrosis

Zornitza Stark, Ravi Savarirayan Orphanet Journal of Rare Diseases 2009, 4:5 (20 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research   Open Access Highly Accessed

Management of bleeding and coagulopathy following major trauma: an updated European guideline

Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernandez-Mondejar, Daniela Filipescu, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2013, 17:R76 (19 April 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Task Force for Advanced Bleeding Care in Trauma have updated their guidelines on the management of bleeding following traumatic injury, with new recommendations addressing changes made in clinical care.

8.

Review   Open Access Highly Accessed

Weight Science: Evaluating the Evidence for a Paradigm Shift

Linda Bacon, Lucy Aphramor Nutrition Journal 2011, 10:9 (24 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

Research   Open Access

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

Marguerite Prior, Richard Dargusch, Jennifer L Ehren, Chandramouli Chiruta, Dave Schubert Alzheimer's Research & Therapy 2013, 5:25 (14 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Novel drug candidate J147 is able to arrest and reverse memory deficits and improve several aspects of brain function in aged mice with advanced symptoms of Alzheimer's disease (AD).

10.

Research article   Open Access

Depression, antidepressant medications, and risk of Clostridium difficile infection

Mary A M Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff BMC Medicine 2013, 11:121 (7 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The risk of Clostridium difficile infection is increased in adults with depression and in those taking antidepressants during hospitalization, indicating that physicians should be aware of the elevated infection risk in these patients.

11.

Technical advance   Open Access Highly Accessed

A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants

Tanis R Fenton, Jae H Kim BMC Pediatrics 2013, 13:59 (20 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The Fenton growth chart for preterm infants has been revised to accommodate the World Health Organization Growth Standard and reflect actual age instead of completed weeks, in order to improve preterm infant growth monitoring.

12.

Research   Open Access Highly Accessed

Long-term effects of low-fat diets either low or high in protein on cardiovascular and metabolic risk factors: a systematic review and meta-analysis

Lukas Schwingshackl, Georg Hoffmann Nutrition Journal 2013, 12:48 (15 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

13.

Research   Open Access

Long-term effects of sulfur mustard on civilians’ mental health 20 years after exposure (The Sardasht-Iran Cohort Study)

Rasoul Roshan, Parvin Rahnama, Zeinab Ghazanfari, Ali Montazeri, Mohammad Reza Soroush, Mohammad Mehdi Naghizadeh, Mahdiyeh Melyani, Azadeh Tavoli, Tooba Ghazanfari Health and Quality of Life Outcomes 2013, 11:69 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

14.

Research   Open Access Highly Accessed

Effect of fruit restriction on glycemic control in patients with type 2 diabetes – a randomized trial

Allan S Christensen, Lone Viggers, Kjeld Hasselström, Søren Gregersen Nutrition Journal 2013, 12:29 (5 March 2013)

Abstract | Full text | PDF | PubMed

15.

Correspondence   Open Access Highly Accessed

Mistaken Identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics

Barry R Zeeberg, Joseph Riss, David W Kane, Kimberly J Bussey, Edward Uchio, W Marston Linehan, J Carl Barrett, John N Weinstein BMC Bioinformatics 2004, 5:80 (23 June 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 7 comments

16.

Research   Open Access

Development of quality of care indicators from systematic reviews: the case of hospital delivery

Xavier Bonfill, Marta Roqué, Marta Beatriz Aller, Dimelza Osorio, Carles Foradada, Àngels Vives, David Rigau Implementation Science 2013, 8:42 (10 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

17.

Review   Subscription

Clinical review: Predictive value of neutrophil gelatinase-associated lipocalin for acute kidney injury in intensive care patients

Peter B Hjortrup, Nicolai Haase, Mik Wetterslev, Anders Perner Critical Care 2013, 17:211 (24 April 2013)

Abstract | Full text | PDF

18.

Review   Subscription Highly Accessed

Clinical review: Does it matter which hemodynamic monitoring system is used?

Davinder Ramsingh, Brenton Alexander, Maxime Cannesson Critical Care 2012, 17:208 (5 March 2013)

Abstract | Full text | PDF

19.

Research article   Open Access

Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15

Jacqueline Lehmann-Che, Anne Sophie Hamy, Raphael Porcher, Marc Barritault, Fatiha Bouhidel, Hanadi Habuellelah, Solenne Leman-Detours, Anne de Roquancourt, Laurence Cahen-Doidy, Edwige Bourstyn, Patricia de Cremoux, Cedric de Bazelaire, Marcela Albiter, Sylvie Giacchetti, Caroline Cuvier, Anne Janin, Marc Espie, Hugues de The, Philippe Bertheau Breast Cancer Research 2013, 15:R37 (11 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A novel and simplified molecular and immunohistochemical signature has been described for molecular apocrine breast tumours which could help with easy identification in clinical practice.

20.

Research article   Open Access Highly Accessed

Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium

Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen, Mohamed Bentires-Alj Breast Cancer Research 2013, 15:R36 (29 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Early parity in mice alters the genomic signature of a distinct subset of mammary epithelial cells by inducing differentiation and reducing proliferation, ultimately protecting against breast cancer.

21.

Method   Open Access Highly Accessed

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg Genome Biology 2013, 14:R36 (25 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A major update to TopHat, the popular Bowtie-based spliced aligner

22.

Method   Open Access Highly Accessed

Quartz-Seq: a highly reproducible and sensitive single-cell RNA-Seq reveals non-genetic gene expression heterogeneity

Yohei Sasagawa, Itoshi Nikaido, Tetsutaro Hayashi, Hiroki Danno, Kenichiro D Uno, Takeshi Imai, Hiroki R Ueda Genome Biology 2013, 14:R31 (17 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Quartz-Seq is a method for performing single cell RNA-seq which displays high reproducibility

23.

Comment   Subscription Highly Accessed

How to evaluate a graduate studentship, or choosing the right doctoral advisor

Duncan T Odom Genome Biology 2013, 14:114 (29 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Duncan Odom has some sage advice for those considering PhD options

24.

Research article   Open Access Highly Accessed

Apps for asthma self-management: a systematic assessment of content and tools

Kit Huckvale, Mate Car, Cecily Morrison, Josip Car BMC Medicine 2012, 10:144 (22 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A systematic assessment of apps for asthma self-management finds that none combine reliable information with appropriate supportive tools, thus physicians considering recommending these should apply caution as some apps may be unsafe.

25.

Position statement   Open Access Highly Accessed

Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing

Jeanette Schulz-Menger, David A Bluemke, Jens Bremerich, Scott D Flamm, Mark A Fogel, Matthias G Friedrich, Raymond J Kim, Florian von Knobelsdorff-Brenkenhoff, Christopher M Kramer, Dudley J Pennell, Sven Plein, Eike Nagel Journal of Cardiovascular Magnetic Resonance 2013, 15:35 (1 May 2013)

Abstract | Provisional PDF | PubMed

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