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1.

Methodology   Open Access Highly Accessed

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut

Elaine O Petrof, Gregory B Gloor, Stephen J Vanner, Scott J Weese, David Carter, Michelle C Daigneault, Eric M Brown, Kathleen Schroeter, Emma Allen-Vercoe Microbiome 2013, 1:3 (9 January 2013)

Abstract | Full text | PDF |  Editor’s summary

A super-probiotic synthetic stool, composed of 33 different bacterial strains, was developed and used to treat two patients with severe C. difficile infection. The probiotic bacteria could still be detected up to six months after inoculation.

2.

Study protocol   Open Access Highly Accessed

Collaborative Care for Older Adults with low back pain by family medicine physicians and doctors of chiropractic (COCOA): study protocol for a randomized controlled trial

Christine M Goertz, Stacie A Salsbury, Robert D Vining, Cynthia R Long, Andrew A Andresen, Mark E Jones, Kevin J Lyons, Maria A Hondras, Lisa Z Killinger, Fredric D Wolinsky, Robert B Wallace Trials 2013, 14:18 (16 January 2013)

Abstract | Full text | PDF | PubMed

3.

Methodology article   Open Access Highly Accessed

In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish

Kohei Watanabe, Yuhei Nishimura, Tsuyoshi Nomoto, Noriko Umemoto, Zi Zhang, Beibei Zhang, Junya Kuroyanagi, Yasuhito Shimada, Taichi Shintou, Mie Okano, Takeshi Miyazaki, Takeshi Imamura, Toshio Tanaka BMC Neuroscience 2012, 13:101 (16 August 2012)

Abstract | Full text | PDF | PubMed

4.

Research   Open Access Highly Accessed

Cyclist route choice, traffic-related air pollution, and lung function: a scripted exposure study

Sarah Jarjour, Michael Jerrett, Dane Westerdahl, Audrey Nazelle, Cooper Hanning, Laura Daly, Jonah Lipsitt, John Balmes Environmental Health 2013, 12:14 (7 February 2013)

Abstract | Provisional PDF | PubMed

5.

Review   Open Access Highly Accessed

Physical education, school physical activity, school sports and academic performance

François Trudeau, Roy J Shephard International Journal of Behavioral Nutrition and Physical Activity 2008, 5:10 (25 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

Research article   Open Access Highly Accessed

Unique immunologic patterns in fibromyalgia

Frederick G Behm, Igor M Gavin, Oleksiy Karpenko, Valerie Lindgren, Sujata Gaitonde, Peter A Gashkoff, Bruce S Gillis BMC Clinical Pathology 2012, 12:25 (17 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Cytokine levels in stimulated blood cells taken from patients suffering from the chronic pain and fatigue syndrome fibromyalgia were significantly lower than in cells taken from healthy controls, offering a potential diagnostic test for this disease

7.

Review   Open Access Highly Accessed

Childhood obesity, prevalence and prevention

Mahshid Dehghan, Noori Akhtar-Danesh, Anwar T Merchant Nutrition Journal 2005, 4:24 (2 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

8.

Debate   Open Access Highly Accessed

A theory of organizational readiness for change

Bryan J Weiner Implementation Science 2009, 4:67 (19 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

Research article   Open Access Highly Accessed

The phylogenetic distribution of ultraviolet sensitivity in birds

Anders Ödeen, Olle Håstad BMC Evolutionary Biology 2013, 13:36 (11 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Phylogenetic analysis of a single opsin gene in birds shows that their vision has shifted between the visible spectrum and UV-sensitive vision at least 14 times, each of which can be explained by a single nucleotide change.

10.

Research   Open Access Highly Accessed

Effect of cholesterol depletion on the pore dilation of TRPV1

Erik T Jansson, Carolina L Trkulja, Aikeremu Ahemaiti, Maria Millingen, Gavin DM Jeffries, Kent Jardemark, Owe Orwar Molecular Pain 2013, 9:1 (2 January 2013)

Abstract | Full text | PDF | PubMed

11.

Research   Open Access

Characterization of physicochemical properties of ivy nanoparticles for cosmetic application

Yujian Huang, Scott C Lenaghan, Lijin Xia, Jason N Burris, C Neal Jr Stewart, Mingjun Zhang Journal of Nanobiotechnology 2013, 11:3 (1 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Naturally occurring nanoparticles found in English Ivy, Hedera helix, could confer UV protection with greater transparency and lower cytotoxicity than the metal oxides that are commonly used as sunscreen. 

12.

Debate   Open Access

Use of the evidence base in substance abuse treatment programs for American Indians and Alaska natives: pursuing quality in the crucible of practice and policy

Douglas K Novins, Gregory A Aarons, Sarah G Conti, Dennis Dahlke, Raymond Daw, Alexandra Fickenscher, Candace Fleming, Craig Love, Kathleen Masis, Paul Spicer, the Centers for American Indian and Alaska Native Health's Substance Abuse Treatment Advisory Board Implementation Science 2011, 6:63 (16 June 2011)

Abstract | Full text | PDF | PubMed

13.

Correspondence   Open Access Highly Accessed

How to do a grounded theory study: a worked example of a study of dental practices

Alexandra Sbaraini, Stacy M Carter, R Evans, Anthony Blinkhorn BMC Medical Research Methodology 2011, 11:128 (9 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Commentary   Open Access

Predicting the evolution of antibiotic resistance

Martijn F Schenk, J Arjan GM de Visser BMC Biology 2013, 11:14 (22 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Commenting on research in BMC Evolutionary Biology, Arjan de Visser and Martijn Schenk discuss how two genetic properties, pleiotropy and epistasis, might help us to predict the evolution of antibiotic resistance.

15.

Research article   Open Access Highly Accessed

The songbird syrinx morphome: a three-dimensional, high-resolution, interactive morphological map of the zebra finch vocal organ

Daniel N Düring, Alexander Ziegler, Christopher K Thompson, Andreas Ziegler, Cornelius Faber, Johannes Müller, Constance Scharff, Coen PH Elemans BMC Biology 2013, 11:1 (8 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The three-dimensional anatomy of the zebra finch vocal organ is described in unprecedented detail, providing new insights into the biomechanics of song production in a species widely used as an experimental model for vocal learning.

16.

Research   Open Access

Persistence of peanut allergen on a table surface

Wade TA Watson, AnnMarie Woodrow, Andrew W Stadnyk Allergy, Asthma & Clinical Immunology 2013, 9:7 (18 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Peanut allergen remained present on a table top for 110 days, without degradation, and was removed on cleaning, reinforcing the importance of cleaning surfaces before and after eating for peanut allergen sufferers.

17.

Commentary   Open Access Highly Accessed

Sang Froid in a time of trouble: is a vaccine against HIV possible?

Stanley A Plotkin Journal of the International AIDS Society 2009, 12:2 (2 February 2009)

Abstract | Full text | PDF | PubMed

18.

Review   Open Access Highly Accessed

Protein timing and its effects on muscular hypertrophy and strength in individuals engaged in weight-training

Matthew Stark, Judith Lukaszuk, Aimee Prawitz, Amanda Salacinski Journal of the International Society of Sports Nutrition 2012, 9:54 (14 December 2012)

Abstract | Full text | PDF | PubMed

19.

Review   Open Access Highly Accessed

A focus on intra-abdominal infections

Massimo Sartelli World Journal of Emergency Surgery 2010, 5:9 (19 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

Research article   Open Access Highly Accessed

Relationships between post operative pain management and short term functional mobility in total knee arthroplasty patients with a femoral nerve catheter: A preliminary study

Catherine M Fetherston, Sarah Ward Journal of Orthopaedic Surgery and Research 2011, 6:7 (7 February 2011)

Abstract | Full text | PDF | PubMed

21.

Research   Open Access Highly Accessed

Public health program capacity for sustainability: a new framework

Sarah F Schell, Douglas A Luke, Michael W Schooley, Michael B Elliott, Stephanie H Herbers, Nancy B Mueller, Alicia C Bunger Implementation Science 2013, 8:15 (1 February 2013)

Abstract | Provisional PDF | PubMed

22.

Research   Open Access Highly Accessed

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

Kianoush Kashani, Ali Al-Khafaji, Thomas Ardiles, Antonio Artigas, Sean M Bagshaw, Max Bell, Azra Bihorac, Robert Birkhahn, Cynthia M Cely, Lakhmir S Chawla, Danielle L Davison, Thorsten Feldkamp, Lui G Forni, Michelle Gong, Kyle J Gunnerson, Michael Haase, James Hackett, Patrick M Honore, Eric AJ Hoste, Olivier Joannes-Boyau, Michael Joannidis, Patrick Kim, Jay L Koyner, Daniel T Laskowitz, Matthew E Lissauer, Gernot Marx, Peter A McCullough, Scott Mullaney, Marlies Ostermann, Thomas Rimmelé, Nathan I Shapiro, Andrew D Shaw, Jing Shi, Amy M Sprague, Jean-Louis Vincent, Christophe Vinsonneau et al. Critical Care 2013, 17:R25 (6 February 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Urine TIMP-2, and IGFBP7, two novel biomarkers for risk stratification of acute kidney injury, have been discovered and validated in more than 1000 critically ill patients. 

23.

Viewpoint   Subscription Highly Accessed

Does artificial nutrition improve outcome of critical illness?

Miet Schetz, Michael Casaer, Greet Van den Berghe Critical Care 2012, 17:302 (1 February 2013)

Abstract | Full text | PDF

24.

Research   Open Access

Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children

Christopher S Parshuram, Heather P Duncan, Ari R Joffe, Catherine A Farrell, Jacques R Lacroix, Kristen L Middaugh, James S Hutchison, David Wensley, Nadeene Blanchard, Joseph Beyene, Patricia C Parkin Critical Care 2011, 15:R184 (3 August 2011)

Abstract | Full text | PDF | PubMed

25.

Research article   Open Access

Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study

Verena Sengpiel, Elisabeth Elind, Jonas Bacelis, Staffan Nilsson, Jakob Grove, Ronny Myhre, Margaretha Haugen, Helle M Meltzer, Jan Alexander, Bo Jacobsson, Anne-Lise Brantsaeter BMC Medicine 2013, 11:42 (19 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Caffeine intake from various sources during pregnancy is associated with increased risk of the baby being small for gestational age and decreased birth weight, which may have implications for the recommended consumption of caffeine.

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