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A problem in the provided numbers (Ozgun Babur, 29 August 2015)

Dear authors of... read full comment

Comment on: Leiserson et al. Genome Biology, 16:160

Comments to 'Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans.' (Andrea Hartwig, 27 August 2015)

Threshold value for Granular biopersistent particles... read full comment

Comment on: Morfeld et al. Particle and Fibre Toxicology, 12:3

Erratum to: Etman A, Kamphuis CBM, Prins R, Burdorf A, Pierik FH and Van Lenthe FJ. Characteristics of residential areas and transportational walking amongfrail and non-frail Dutch elderly: does the size of the area matter? Int J Health Geogr. 2014 Mar 4;13:7. doi: 10.1186/1476-072X-13-7. (Astrid Etman, 27 August 2015)

After publication of this paper, the authors have determined that the estimates for functional features were incorrect and that the log-transformed beta-coefficients were somewhat misinterpreted. For the corrected tables, please contact Astrid Etman ( The information provided in the text of the article is correct except for some sentences in the Abstract, Results section, and Discussion
section. In the Abstract, the first two sentences of the results paragraph should read like this: An increase in aesthetics (e.g. absence of litter and graffiti) within 800 and 1200 meter buffers, and an increase of one destination per buffer of 400 and 800 meters were associated with more transportational walking, up to a 2.83-fold... read full comment

Comment on: Etman et al. International Journal of Health Geographics, 13:7

Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone - Major issues with analysis (Vasilios Berdoukas, 26 August 2015)

We read with interest the article by Porter et al, as the authors address the important clinical question of whether or not deferoxamine (DFO) combined with deferiprone (DFP) promotes greater improvement  in left ventricular ejection fraction (LVEF) than DFO monotherapy in patients with impaired cardiac function. The authors’ conclusion is that both treatments significantly improved LVEF. This was a well designed study; however the strength and the validity of the conclusions are limited due to several methodological issues. The main drawback is the final numbers of participants, which are very low to allow the type of methodology applied by the authors. Linear mixed models with repeated measurements require the assumption of normality, which is very difficult... read full comment

Comment on: Porter et al. Journal of Cardiovascular Magnetic Resonance, 15:38

Wrong ORCID link (Andreas Leimbach, 24 August 2015)

Please note, that the ORCID link for author Andreas Leimbach has a typo. It should be: instead of read full comment

Comment on: Ullrich et al. Standards in Genomic Sciences, 10:56

Corresponding author (Alireza Rezaee khorasany, 24 August 2015)

The corresponding author is Massoud Houshmand Email: read full comment

Comment on: MA Mohammed et al. Diagnostic Pathology, 10:115

Funding sources (Javier Mar, 24 August 2015)

In relationship with the funding sources of this work I want to declare that there was a mistake and the correct declaration is: All authors were funded by their institutions. This work was also supported by grant 2010111096 from the Department of Health, Basque Government, grant DFG11/003 from “Diputación de Gipuzkoa” and grant PI11/02599 from the “Carlos III” Health Institute, Madrid included in Plan Nacional de I+D+I 2008-2011 and FEDER funds. read full comment

Comment on: Mar et al. Alzheimer's Research & Therapy, 7:2

Authors response to comments (Thomas Kosloff, 24 August 2015)

We thank Drs. Thaler and Paulus for their thoughtful comments regarding our study ‘Chiropractic care and the risk of vertebrobasilar stroke: results of a case–control study in U.S. commercial and Medicare Advantage populations’ [1]. We agree, as acknowledged in the paper, the potential for misclassification bias represents a study limitation. Although we concur the reporting of cervical artery dissection (CAD) diagnostic codes is more common in the United States, our study was focused on the clinical diagnosis – vertebrobasilar artery system (VBA) stroke – viewed as a ‘major’ adverse event in association with chiropractic care... read full comment

Comment on: Kosloff et al. Chiropractic & Manual Therapies, 23:19

Incorrect spelling in the title (HARINDRAN NAMASIVAYAM, 21 August 2015)

The title should read " Linagliptin: pharmacology.. " not " Linagliptin: farmacology,..." read full comment

Comment on: Guedes et al. Diabetology & Metabolic Syndrome, 5:25

Error in Table 1 (Robert Terry, 20 August 2015)

Please note: The first sub-total for Research Expenditure ($USD) for HIV/AIDs, TB, Malaria and Neglected Tropical Diseases should read 16,250,000 and not 63,350,000.
The staffing sub-total is correct. The error was introduced when we moved the figures for TDR to lower down in the table but did not alter the sub-total. No changes are required in the text. read full comment

Comment on: Terry et al. Health Research Policy and Systems, 8:25

Correction to the sample size description (posted by the authors) (Katie Dainty, 20 August 2015)

Dear... read full comment

Comment on: Dainty et al. Implementation Science, 6:4

Vitamin D does reduce the risk of pre-eclampsia (William B. Grant, 20 August 2015)

Can you please enter the following text for the... read full comment

Comment on: Schoenaker et al. BMC Medicine, 12:157


We have been pleasantly surprised to read the paper of Christiane Muth et al (1). There is an interesting coincidence because we have been working on this topic using metaphors, and we have created, for educational purposes, a patient named “Mr. Minotaur”! – “Which is the best treatment for a patient of 46 years, with angina, hypertension wrong controlled, left ventricular hypertrophy, heart failure, diastolic dysfunction, diabetes mellitus type 2, diabetic nephropathy, dyslipidemia, obesity, anxiety-depressive syndrome, alcoholic liver disease, alcohol abuse, smoking, bronchial asthma and chronic urticaria, legal and economic problems, and which is religious, with poor therapeutic compliance, frequent attendance with an occasionally hostile behavior, and living in a... read full comment

Comment on: Muth et al. BMC Medicine, 12:223

Translational bioinformatics in the cloud (sara sota, 20 August 2015)

 There has been a little talk about cloud computing on Bioinformatics at the BackupMag. We highlight some fundamental issues of translational bioinformatics and the potential use of cloud computing in NGS data processing for the Translational bioinformatics.       read full comment

Comment on: Dudley et al. Genome Medicine, 2:51

Best practices for prevention of BPD along with SAIL intervention or not (Sandesh Shivananda, 19 August 2015)

Based on previous literature on sustained inflation and other interventions during resuscitation, the effect seems to be sustained till 72 hours and not later. I am concerned about study centers focussing on initial resuscitation but loose an opportunity on concurrently implementing best practices for reduction of BPD. I would like to... read full comment

Comment on: Foglia et al. Trials, 16:95

Download PDF file of the paper (Rallis Karamichalis, 19 August 2015)

The webpage version (including the beta version) of this paper is garbled and poorly formatted. Please download the pdf file of the paper instead.   The Authors   read full comment

Comment on: Karamichalis et al. BMC Bioinformatics, 16:246

Catalog No. correction for anti-Haptoglobin antibody (Patricia Talamás-Rohana, 18 August 2015)

This is just to notify the readers that in the description of “Western blot and lectin binding assays” in the Methods section, we incorrectly indicated the catalog number of the anti-Haptoglobin antibody as being Abcam, Cat. No. ab90924. The correct catalog number of the antibody we used in this work is [HG-36] (ab13429). This error occurred while writing the manuscript. We apologize for any inconvenience. read full comment

Comment on: Garibay-Cerdenares et al. Journal of Ovarian Research, 7:27

Founder mutation in EYS (Akio Oishi, 18 August 2015)

I read with interest the article by Yoon et al. They are to be congratulated for demonstrating the genetic overview of Korean RP... read full comment

Comment on: Yoon et al. BMC Genomics, 16:515

CoryneCenter no longer available? (Charles Chu, 17 August 2015)

Link to online resource CoryneCenter comes back with an error message: #404 Page not found. Search for CoryneCenter online resource on the CeBiTec website or on the internet does not find the resource. read full comment

Comment on: Neuweger et al. BMC Systems Biology, 1:55

Species richness is not an indicator for the success of habitat restoration (Roy van Grunsven, 14 August 2015)

In this paper the authors show that rewetting of a drained peatland results in an increase in both the number of individuals and species of dragonflies. Three years after the restoration they find ten species of dragonflies in the restored peatlands, comparable to pristine peatlands and much more than the 2 or 3 species in drained bogs. They claim that the restoration was thus successful. However, looking at species numbers as a measure for the success of habitat restoration can be... read full comment

Comment on: Elo et al. BMC Ecology, 15:11

Similar, second case of lymphoma concerned with human dirofilariosis. (Piotr Borkowski, 14 August 2015)

In the presentation "Human Dirofilaria repens infection in Hungary" by István Kucsera, shown 27 May 2010, in Novi Sad, available for download on the sides of the center of the Hungarian National Epidemiology:
is described 69- year old woman, shepard, who has removed 5 worms Dirofilaria repens. One year later she also developed lymphoma. This is the second similar case in which there was a similar relationship between Dirofilaria repens and lymphoma. P.K.Borkowski read full comment

Comment on: Borkowski et al. Infectious Agents and Cancer, 10:1

Unstated library requirements for software (B Ochoa Montano, 14 August 2015)

Running the provided Linux binary seems to require a shared library (, which is not stated on the article or the website. A little googling suggests it's probably part of MATLAB. The runtime which should contain it can be downloaded free of charge from, however, it is unclear which version of it is required. Additionally, the Windows version seems to get flagged as malicious by both Firefox and Chrome, and refuses to download; IE has no qualms about it. It's presumably related to the executable being hosted on Dropbox, which the modern browsers justifiably treat with caution. read full comment

Comment on: Park et al. BMC Bioinformatics, 15:307

Correction (Roberto Rosa', 14 August 2015)

There are two errors along the article: - The 1st error is at Page 6 at the beginning of the paragraph "Mosquito collection and feeding preference indices in the field". The error concerns the numbers of mosquito specimens belonging to different mosquito species identified from the 259 blood-fed females. Specifically, the correct numbers are: Cx. pipiens (188), Anopheles maculipennis complex (39), Aedes albopictus (11) and Ochlerotatus caspius (21). - The 2nd error is at Page 9 within Table 1 and concerns N values (2nd and 3rd columns) for House sparrow (last row). Specifically, N are not 54 (odour) and 35 (control) as reported but the correct values are 35 (for the odour column) and 19 (for the control column). Percentages and statistics are instead correct. read full comment

Comment on: Rizzoli et al. Parasites & Vectors, 8:213

Potential cancer stem-like cells of this atypical hepatic cancer in the Li-Fraumeni syndrome  (Go Yoshida, 13 August 2015)

It has recently been identified the presence of liver stem cells located near to the central vein with the method of lineage tracing focusing on Wnt-responsive gene Axin2 in mice.1,2 Central vein endothelial cells, which secrete Wnt9b ligand, correspond to niche to maintain the homeostasis and the zonation of liver lobules,2 whereas Lgr5-positive oval hepatic stem-like cells rapidly respond to the injury and exhibit robust self-renewal proliferation.3 It is also notable that the former diploid stem cells retain unlimited replicative potential,2,4 which can partially explain the reasons why hepatic tumor cells often lack tumor suppressor genes such as APC or Axin,1 and also they arise exclusively... read full comment

Comment on: Yoshida et al. BMC Cancer, 12:444

Editor's comment (Catherine Potenski, 13 August 2015)

Daniel Winkler should be attributed as the winner of the "Landscape Ecology" section.  read full comment

Comment on: Potenski et al. BMC Ecology, 15:22