Submit a manuscript Sign up for article alerts Contact us


Latest comments

Some corrections (Liang He, 31 March 2015)

In the last line of the expressions (2), αβ2 should have been σβ2. The second equation in the expression (5) should have been deleted. In the expression (6), 'y' is better replaced by 'Data'. In the footnotes of Table 1, '(2)' should have been '(5)', and '(3)' should have been '(6)'.  read full comment

Comment on: He et al. BMC Proceedings, 8:S37

Nwe location for the source code (Pedro Mendes, 31 March 2015)

The source code of this project is now hosted on GitHub as a subproject of COPASI: read full comment

Comment on: Kent et al. BMC Systems Biology, 6:91

erratum in affiliation  (Annemiek Van Dijke, 31 March 2015)

Please note that my affiliation is also with Yulius: Yulius Academy and COLK centre for complex somatoform disorders, Rotterdam, the Netherlands. read full comment

Comment on: van Dijke et al. Borderline Personality Disorder and Emotion Dysregulation, 2:6

Plant Part (Ben Haskell, 31 March 2015)

What part of the plant was used?  read full comment

Comment on: Yang et al. BMC Complementary and Alternative Medicine, 12:250

Figure 3 labels switched (A. Rossi, 30 March 2015)

The article states that "Figure 3 shows the percentage of hysterectomized women based on all women with uterine fibroids is highest in the USA with 29.1%..." but Figure 3 does not actually show this because the labels of "Women with a diagnosis of uterine fibroids" and "Women without a diagnosis of uterine fibroids" appear to have been switched. read full comment

Comment on: Zimmermann et al. BMC Women's Health, 12:6

Foundation: (Christoph Schimmer, 30 March 2015)

This publication was funded by the German Research Foundation (DFG) and the University of Wuerzburg in the funding programme Open Access Publishing. read full comment

Comment on: Hamouda et al. Journal of Cardiothoracic Surgery, 10:25

Addition to acknowledgements (Lenka Maletinska, 27 March 2015)

This project was supported also by a grant No. 7AMB12FR011 of MInistry of education of the Czech Republic. read full comment

Comment on: Špolcová et al. BMC Neuroscience, 15:111

Dynamic Evolution of Leukemia Stem Cells both at the Carcinogenesis and Relapse (Go Yoshida, 27 March 2015)

As mentioned in this review article, leukemia stem cells undergo drastic change orchestrated with somatic genetic mutations and epigenetic alteration. Leukemia stem cells are derived from HSCs localized in the niche under the conditions of hypoxia, chronic inflammation, accumulated ROS, all of which are responsible for the carcinogenesis. Niche factors are also affected to induce the aberrant proliferation of pre-malignant cells. For instance, PNH-anaplastic anemia syndrome as well as MDS is considered to be pre-malignant disorders to induce leukemia. Furthermore, the molecular-targeting drugs characterized by imatinib cause the activation of alternative signaling pathways, which results in the acquisition of adaptive resistance to conventional anti-cancer therapy. We have to keep in mind... read full comment

Comment on: Schulenburg et al. Journal of Hematology & Oncology, 8:16

Regarding the table named Moyamoya syndrome in NF1 paediatric patients since 1976 in your article (Mayur Kaku, 27 March 2015)

Sir, this article gives wholesome information about moya moya syndrome in NF1. While reading this article, I came across this table named Moyamoya syndrome in NF1 paediatric patients since 1976. In this table, I was surprised to see inclusion of adult patients despite being headed as pediatric NF1 patients. It would be great if this is corrected. read full comment

Comment on: Vargiami et al. Italian Journal of Pediatrics, 40:59

A failure to respond to legitimate concerns (Brian Carter, 27 March 2015)

With all due respect, Dr. Popova, you have not responded to any of the substantive comments detailed below.  Legitimate questions have been raised concerning your methodology that have a direct bearing on how “valuable” your data is and if your conclusions are justified to the extent of informing policy... read full comment

Comment on: Popova et al. BMC Public Health, 14:997

Correction of reported mutation in Patient 5 (Lucia Abela, 25 March 2015)

Following the publication of our article “Early co-occurrence of a neurologic-psychiatric disease pattern in Niemann-Pick Type C disease: a retrospective Swiss cohort study” by Abela et al. we have become aware that the mutation of Patient 5 is not reported correctly in Table 1. Reported mutation: p.Ile1067Thr/p.Asp948Asn Correct mutation: p.Ile1061Thr/p.Asp948Asn  read full comment

Comment on: Abela et al. Orphanet Journal of Rare Diseases, 9:176

Supplementary Figure 2 (Johanna Lotsari, 24 March 2015)

Arrows denoting transcriptional direction for miR-663, miR-132, and miR-34a should be in the left to right orientation (i.e. opposite to that shown). read full comment

Comment on: Kaur et al. Clinical Epigenetics, 7:20

THE HIGH-PRIORITY ISSUE OF FRAILTY IN CARDIAC SURGERY (Daniel Hernandez-Vaquero Panizo, 24 March 2015)

We read with great interest the article by Scandroglio AM [1] analyzing the outcomes of a cohort of octogenarian patients undergoing cardiac surgery in a single center.... read full comment

Comment on: Scandroglio et al. BMC Anesthesiology, 15:15

Correct Affiliation for Matthew F Chersich (matthew chersich, 24 March 2015)

Wits Reproductive Health & HIV Institute, Faculty of Health Sciences,    
University of the Witwatersrand, South Africa read full comment

Comment on: Footman et al. Globalization and Health, 10:72

Ignoring a term in the "Authors’ contribution." (Mahdi Tondar, 24 March 2015)

In the "Authors’ contribution," the following term did not exist in our manuscript when we submitted it to the journal: "S72-91." It does not not have any meaning and should have been deleted in our manuscript.  read full comment

Comment on: Hadjighassem et al. Nutrition Journal, 14:20

Correction of author's affiliation (Guoliang Jiang, 23 March 2015)

Evaluation of the value of ENI in radiotherapy for cervical and upper thoracic esophageal cancer: a retrospective analysis
Radiation Oncology 2014, 9:232 
We correct the Dr. Mina Liu's affiliation as the following:
1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China;
2.Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;
Current address: Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China read full comment

Comment on: Liu et al. Radiation Oncology, 9:232

Correction to the Funding Agency and project under the Acknowledgements section  (Cecilia Jimenez-Mallebrera, 23 March 2015)

This work is funded by the " Plan Nacional de I+D+I and Instituto de Salud Carlos III– Subdirección General de Evaluación y Fomento de la Investigación Sanitaria", project PI10/00177,  and the European Regional Development Fund (FEDER).  read full comment

Comment on: Kalko et al. BMC Genomics, 15:91

Apparent Statistical and Reporting Errors in “Effect of transcutaneous auricular vagus nerve stimulation on impaired glucose tolerance: a pilot randomized study” (Lisa Antoine, 23 March 2015)

1.  Huang et al. compared the efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) and sham taVNS on patients with impaired glucose tolerance (IGT) in a pilot randomized clinical trial. The authors state in the Abstract, specifically in the Results section, that “100 participants completed the study and were included in data analysis. “ Thereafter, Huang et al. state in the Methods section of the article that “After screening, 72 IGT participants were randomly assigned to either the transcutaneous auricular vagus nerve stimulation group (taVNS) or sham taVNS group (randomization sequence created using SAS System 7.0)”. In the Results section, Huang et al. state that “A total of 102 participants completed the study (72 females, 54.4 ±... read full comment

Comment on: Huang et al. BMC Complementary and Alternative Medicine, 14:203

In HGT how have foreign sequences entered the human genome? (Kevin Smith, 23 March 2015)

I suggest that the most likely route by which exogenous sequences have entered the human genome is via sperm-mediated gene transfer. I hypothesised about this possibility previously, if interested please see Smith K. The Role of Sperm-Mediated Gene Transfer in Genome Mutation and Evolution. Medical Hypotheses, 2002; 59(4): 433-437.     read full comment

Comment on: Crisp et al. Genome Biology, 16:50

Author affilations (Nathan Hutting, 20 March 2015)

The correct author affilations are: 1 Radboud University Medical Center, Radboud Institute for Health Sciences, IQ Healthcare, Nijmegen, The Netherlands 2 HAN University of Applied Sciences, Research Group Occupation and Health, Nijmegen 6503 GL, The Netherlands read full comment

Comment on: Hutting et al. Journal of Occupational Medicine and Toxicology, 10:9

Response letter (Maria Esteve-Gassent, 20 March 2015)

A response letter to this Letter to the Editor has been published and it is available at: read full comment

Comment on: Norris et al. Parasites & Vectors, 7:467

Acknowledgement Amendment (Adam Healey, 19 March 2015)

The authors would like amend the acknowledgements of this manuscript to include that the sequence data was produced by the US Department of Energy Joint Genome Institute ( in collaboration with the user community and the Joint BioEnergy Institute (   read full comment

Comment on: Healey et al. Plant Methods, 10:21

New repository for source code (Stinus Lindgreen, 17 March 2015)

I am the author of the paper "AdapterRemoval: easy cleaning of next-generation sequencing reads". When the paper was published, I made the source code available using Google Code. However, Google is shutting down this service in August 2015, so I have migrated the code to GitHub instead:
You might also be interested in the updated version 2 of the program available here: Thanks, Stinus Lindgreen read full comment

Comment on: Lindgreen BMC Research Notes, 5:337

The frequency of musculoskeletal problems and related pain medication (Thomas Frese, 17 March 2015)

Ndlovu et al. provide interesting data regarding the prescription of analgesic medications for consultations due to a new musculoskeletal problem in a routine general practice setting [1].
The frequency of musculoskeletal problems as reason for encounter was reported with 38.6 per 1,000 patients [1]. This seems to be extremely low and maybe attributed to the strong exclusion criteria applied in the current work. This impression is supported by the comparison to cross-sectional European studies and our own data that found frequencies of musculoskeletal problems from 14.3 to 22.0% of all reasons for encounter in general practice [2, 3, 4, unpublished data from the SESAM 2... read full comment

Comment on: Ndlovu et al. BMC Musculoskeletal Disorders, 15:418

Author affililiation revisions (Adrienne Gilligan, 16 March 2015)

Darrell L Lange2 Jaime E Dickerson Jr2,4 2Smith & Nephew Inc, 3909 Hulen Street, Fort Worth, TX 76107, USA 4Department of Cell Biology and Immunology, University of North Texas Health Sciences Center, Fort Worth, TX, USA   read full comment

Comment on: Motley et al. Journal of Foot and Ankle Research, 8:7