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Change of Affiliation for Author (Astha Ramaiya, 22 May 2015)

Zoe Hildon's affiliation is : Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, #09-01R, Singapore 117549 read full comment

Comment on: Ramaiya et al. BMC Research Notes, 7:750

Details of funding for this study (Louisa Flintoft, 21 May 2015)

Added on behalf of the authors: "This work was supported by Grant-in-Aid for Scientific Research (B) 22310117, Grant-in-Aid for Exploratory Research 23659050, from the Japan Society for the Promotion of Science, and Grant-in-Aid for Scientific Research on Innovative Areas 23125503 from the Ministry of Education, Culture, Sports, Science and Technology, Japan.  This research was also supported by CREST, JST, and by the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program),” initiated by the Council for Science and Technology Policy (CSTP)."

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Comment on: Inoue et al. Genome Biology, 15:R63

Differences between Mental Health First Aid (MHFA) Programs in Australia and United States (Betty Kitchener, 20 May 2015)

Congratulations to Dr Subedi and colleagues for evaluating the MHFA USA course with a cultural community in the US. Unfortunately, the results were not as strong as those found in evaluations of the MHFA Australia course delivered to Vietnamese and Chinese immigrants. There are a number of differences that may acount for this. The MHFA Australia program: 1. is longer - 12 hours (2 days) compared to 8 hours in the US. 2. is tailored culturally, and 3. is delivered in the traditional language of the cultural group. read full comment

Comment on: Subedi et al. International Journal of Mental Health Systems, 9:20

TLR4 and amyotrophic lateral sclerosis: new aPEAling role for palmitoylethanolamide? (jan keppel hesselink, 19 May 2015)

In the thought-provoking article of Lee and colleagues, the pathogenetic role of the toll-like receptor 4 is elegantly shown in a mouse model for... read full comment

Comment on: Lee et al. Journal of Neuroinflammation, 12:90

Quote attribution (David Riley, 14 May 2015)

I have searched for years for the source of this quote and greatly appreciate the author's clarfication of the evidence trail related to this.   David Riley MD read full comment

Comment on: Spellberg et al. Infectious Diseases of Poverty, 2:3

Does Irisin Really Exist in Human Circulation ? JiaQi Chen, Shen Qu*Corresponding author: Shen Qu (Jiaqi Chen, 13 May 2015)

Recently, Elke Albrecht et al. [1] questioned about the existence of circulating irisin in human by testing the accuracy of four polyclonal antibodies used in commercial ELISA kits, using Western Blot. The researchers used recombinant non-glycosylated and glycosylated irisin (molecular weights are ~13kDa and ~20kDa, respectively) as positive standards. They found that the antibodies could only detect the recombinant irisin added in PBS, but no band was found at the same position in murine or in human samples. Furthermore, the antibodies were found to have prominent cross-reaction with unspecific proteins, and the bands of similar molecular weight of recombinant irisin at ~16kDa and ~25kDa were further examined by mass spectrometric analysis and proved not to be... read full comment

Comment on: Chen et al. Lipids in Health and Disease, 14:2

RE: On NFAT regulation (Michele Ceccarelli, 12 May 2015)

Hi Sebastien, thanks for your comment. It is much appreciated that an expert of NFAT signalling finds the paper interesting. I agree 100% with your clarification. The discussion was intended to describe in general what it is known about the NFAT family and not just NFAT5. As you reported in the paper (Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol. 2002;4(7):540–4) NFAT5 lacks  most of the regulatory domain present in NFAT1 to NFAT4 and its  mechanisms are still largely unknown.       read full comment

Comment on: Remo et al. Journal of Translational Medicine, 13:138

CMR reference values: Are we ready for normals? (Murilo Foppa, 08 May 2015)

We read with great interest the extensive review from Kawel-Boehm et al.[1] with proposed normal values for cardiovascular magnetic resonance (CMR) imaging. This is an important and essential step towards standardization of CMR acquisition and measurement... read full comment

Comment on: Kawel-Boehm et al. Journal of Cardiovascular Magnetic Resonance, 17:29

Author correction to a citation (Matthew Shane Loop, 08 May 2015)

In the manuscript, we cited Auchincloss et al. (2012). We actually intended to cite Fritz C, Schuurman N, Robertson C, and Lear S. (2013). "A scoping review of spatial cluster analysis techniques for point-event data." Geospatial Health 7(2): 183-198. read full comment

Comment on: Loop et al. International Journal of Health Geographics, 14:4

Erratum to: Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study (Coen Stehouwer, 07 May 2015)

After publication of [1], it has come to our attention that the samples used for the MMPs and TIMP-1 measurements were serum samples instead of plasma samples.... read full comment

Comment on: Peeters et al. Cardiovascular Diabetology, 14:31

A new bridge between experimental cytogenetic analyses of mammary precancers and cancers of rats and their relevance to clinical distinctions between preneoplastic dysplasias and neoplastic carcinomas of humans from Alfred Boecking (Duesseldorf/Dueren, Germany). (Peter Duesberg, 06 May 2015)

A new Letter-to-the editor by Alfred Boecking (Duesseldorf/Dueren, Germany), "Comparability of tumor-cytogenetics and DNA cytometry" (Mol Cyogenet (2015) 8:28) builds a most eye-opnening brigde between human and animal cancers:  It explains the amazing similarities between our cytogenetic and phenotypic data on the non-clonal karyotypes of preneoplastic mammary hyperplasias and the clonal individual karyotypes of mammary carinomas of experimental rats (Bloomfield et al. (2014), "Karyotypic evolutions of cancer species in rats .. after nitrosourea", Mol Cytogenet, 7: 2014) and the clincal distinctions between human preneoplastic dysplasias and cancers - based on clinical DNA content and cell morpholgy... read full comment

Comment on: Bloomfield et al. Molecular Cytogenetics, 7:71

Simplified diagnostic tests in the ICU (Nicola Latronico, 05 May 2015)

Simplified diagnostic tests in the... read full comment

Comment on: Parry et al. Critical Care, 19:52

Limitations of observational studies in the prevention of cardiac-surgery AKI by sodium bicarbonate (Helmut Schiffl, 05 May 2015)

The secondary data reported by Dr Wetz and her colleagues suggest that perioperative sodium bicarbonate (SBIC) infusion may reduce the incidence of post-cardiac surgery (CS) - AKI in low risk patients [1]. This observational study is in contradiction with two recent meta-analyses demonstrating uniformly that SBIC does not reduce the incidence of CS-AKI but – on the contrary - harms these patients [2... read full comment

Comment on: Wetz et al. Critical Care, 19:183

On NFAT regulation (sebastien jauliac, 01 May 2015)

This paper is another critical step on the wide role of NFAT factor in breast cancer as we showed for the fist time in 2002 (Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol.... read full comment

Comment on: Remo et al. Journal of Translational Medicine, 13:138

Recognition (Christopher Cammiss, 01 May 2015)

My name is Chris Cammiss and I have just read your... read full comment

Comment on: Kinnear et al. BMC Research Notes, 7:854

Mammalian dive response may explain water exposure relief (John Hayman, 01 May 2015)

The mammalian dive response is a complex reflex reaction to water exposure and is present in humans to a variable extent. Its effect is to reduce aerobic (mitochondrial) metabolism and to conserve body oxygen. Activation of this response may explain the relief obtained from water exposure in these patients. read full comment

Comment on: Fleisher et al. BMC Medicine, 3:20

Neem (GreeNeem Agri, 01 May 2015)

  • Neem has anti microbial properties too. It can be used effectively in skin ailments like acne, pimple and back acne. Pick up handful of fresh juicy neem leaves. Wash them in clean water. Crush them to extract juice. (This can be done in a mixer also). Apply this juice on acne, pimple and back acne. Wash this off in cold water after 20 minutes.
  • Neem flowers and neem leaves can be collected during blossoming season and dried powder of this mixture can be used when the season ends. Take care to dry this mixture in hot sun and store in cool dry place. 
  • Neem can be used effectively to treat gum diseases. Chewing tender branches of neem helps to prevent bleeding from gum.
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Comment on: Franco et al. Radiation Oncology, 9:297

New web address (Jizu Zhi, 29 April 2015)

This application has been moved to   read full comment

Comment on: Zhi BMC Research Notes, 3:137

Incorporation of the Shock Index (SI) into the Trauma-Induced Coagulopathy Clinical Score (TICCS): an interesting combination to be further investigated. (Martin TONGLET, 28 April 2015)

We would like to thank Pasquier and colleagues for their interest in our research on prehospital identification of trauma patients in need for Damage Control Resuscitation (DCR) and for their interesting suggestion. Whatever score or test is being used, we definitively and strongly believe that an early identification is pivotal for this dramatic situation. In this purpose, the Shock Index (SI) has, indeed, proven to be an interesting tool (1). Using an easy-to-calculate cut-off of SI >1, prehospital  SI calculation may facilitate the prehospital identification of normotensive patients at relatively high risk for Massive Transfusion (MT) and DCR. Mutschler and colleagues also demonstrated that SI calculation could help to identify patients in need for MT (2). In their application of... read full comment

Comment on: Pasquier et al. Critical Care, 19:152

Complexity of Fbxw7-mediated activation of Hippo pathway (Go Yoshida, 27 April 2015)

It has been demonstrated that the maintenance of Fbxw7 expression contributes to the inhibition of malignant phenotype of hepatic cancer cells. YAP-mediated apoptosis or cell cycle arrest might prevent the emergence and clonal expansion of hepatic cells with malignant potential (Molecular Cancer 2014, 13:110). 
Nakayama et al. have reported that loss of Fbxw7 increases the stabilization of transcriptional factors regulating lipid metabolism such as SREBP1 and SREBP2 as well as proteins related to proliferation such as CyclinE, c-Myc, and c-Jun (J Clin Invest. 2011;121:342–354). Metabolic reprogramming due to accumulation of SREBP family in the nucleus due to the lack of Fbxw7 non-alcoholic fatty liver disease (NAFLD), which has attracted clinical attention as precursor... read full comment

Comment on: Hergovich Breast Cancer Research, 14:326

Mechanism for thermal cycling in the RNA world (Rowena Ball, 24 April 2015)

Pleased to see that de Roos recognised in 2007 the necessity for thermal cycling to drive replication in the non- or proto-cellular RNA world. It is now accepted that primordial non-cellular RNA communities must have been subject to a periodic drive in order to replicate and prosper. We proposed and tested a natural mechanism for such a drive in three... read full comment

Comment on: de Roos Biology Direct, 2:12

Updated Rubber Genome Browser URL (Jennifer Saito, 23 April 2015)

The URL listed in reference #90 has been changed.  Please use the following link to access the Rubber Genome Browser: read full comment

Comment on: Rahman et al. BMC Genomics, 14:75

Incorrect capitalisation of the species name in the title (luciana christante, 22 April 2015)

The species name in the title of this article should be Pteroids volitans. We would like to apologise to authors and readers for the incorrect capitalisation. Luciana Christante, journal development editor, BioMed Central. read full comment

Comment on: Haddad et al. Journal of Venomous Animals and Toxins including Tropical Diseases, 21:8

Acknowledgment (Walter Wodchis, 22 April 2015)

This research was supported by a team grant from the Canadian Institutes of Health Research (FRN #128263). read full comment

Comment on: Rumball-Smith et al. BMC Family Practice, 15:149

Expected poor absorption of chewed raltegravir in HIV patients with severe intestinal impairment (Cristina Gervasoni, 22 April 2015)

Spinner and Coworkers have recently reported a case of an HIV-infected patient on raltegravir (RAL) maintenance therapy which required rifampicin for the treatment of disseminated Mycobacterium Avium infection [1]. By performing detailed RAL pharmacokinetic evaluations before and after adjusting RAL to the recommended dose of 800 mg BID the authors found comparable RAL AUC and Cmax values for 800 mg chewed vs. swallowed RAL, as well as for 400 mg chewed vs. swallowed RAL, thus providing conflicting results compared with our previous findings [2,3]. We believe, however, that these discrepancies are only apparent, being mainly biased by relevant confounding factors identified in this patient... read full comment

Comment on: Spinner et al. AIDS Research and Therapy, 12:1