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1.

Research   Open Access Highly Accessed

The dual effect of mesenchymal stem cells on tumour growth and tumour angiogenesis

Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard, Jean-Luc Coll, Claire Rome Stem Cell Research & Therapy 2013, 4:41 (29 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Injection of human mesenchymal stem cells into established tumors in mice slowed tumor growth, and this effect appeared to be due to changes in tumor angiogenesis.

2.

Research article   Open Access Highly Accessed

Limit of detection and limit of quantification development procedures for organochlorine pesticides analysis in water and sediment matrices

Naghmeh Saadati, Md Pauzi Abdullah, Zuriati Zakaria, Seyedeh Belin Tavakoli Sany, Majid Rezayi, Houshang Hassonizadeh Chemistry Central Journal 2013, 7:63 (5 April 2013)

Abstract | Full text | PDF | PubMed | Graphical abstract

3.

Research article   Open Access Highly Accessed

Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves

Nidyaletchmy Reddy, Suerialoasan Navanesan, Saravana Sinniah, Norhanom Wahab, Kae Sim BMC Complementary and Alternative Medicine 2012, 12:128 (17 August 2012)

Abstract | Full text | PDF | PubMed

4.

Study protocol   Open Access

Study protocol: the effect of vitamin D supplements on cardiometabolic risk factors among urban premenopausal women in a tropical country - a randomized controlled trial

Mazliza Ramly, Foong Moy, Rokiah Pendek, Suhaili Suboh, Alexander Tan Tong Boon BMC Public Health 2013, 13:416 (1 May 2013)

Abstract | Full text | PDF | PubMed

5.

Research article   Open Access Highly Accessed

Specific detection of fungal pathogens by 18S rRNA gene PCR in microbial keratitis

Zunaina Embong, Wan Hazabbah Wan Hitam, Chan Yean, Nur Rashid, Balqis Kamarudin, Siti Abidin, Sabariah Osman, Zainul F Zainuddin, Manickam Ravichandran BMC Ophthalmology 2008, 8:7 (29 April 2008)

Abstract | Full text | PDF | PubMed

6.

Research article   Open Access

Optimization of reaction parameters in hydrothermal synthesis: a strategy towards the formation of CuS hexagonal plates

Yow Loo Auyoong, Pei Lay Yap, Xing Huang, Sharifah Bee Abd Hamid Chemistry Central Journal 2013, 7:67 (10 April 2013)

Abstract | Full text | PDF | PubMed | Graphical abstract

7.

Research article   Open Access

Extract of Scutellaria baicalensis inhibits dengue virus replication

Keivan Zandi, Tong-Hye Lim, Nor-Aziyah Rahim, Meng-Hooi Shu, Boon-Teong Teoh, Sing-Sin Sam, Mohammed-Bashar Danlami, Kim-Kee Tan, Sazaly Abubakar BMC Complementary and Alternative Medicine 2013, 13:91 (29 April 2013)

Abstract | Full text | PDF | PubMed

8.

Review   Open Access

The difficult coughing child: prolonged acute cough in children

Michael D Shields, Surendran Thavagnanam Cough 2013, 9:11 (10 April 2013)

Abstract | Full text | PDF | PubMed

9.

Research article   Open Access

Enhanced recovery of alkaline protease from fish viscera by phase partitioning and its application

Sunantha Ketnawa, Soottawat Benjakul, Tau Chuan Ling, Oscar Martínez-Alvarez, Saroat Rawdkuen Chemistry Central Journal 2013, 7:79 (30 April 2013)

Abstract | Full text | PDF | PubMed | Graphical abstract

10.

Research article   Open Access Highly Accessed

Horizontal transfer of expressed genes in a parasitic flowering plant

Zhenxiang Xi, Robert K Bradley, Kenneth J Wurdack, KM Wong, M Sugumaran, Kirsten Bomblies, Joshua S Rest, Charles C Davis BMC Genomics 2012, 13:227 (8 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Charles Davis and colleagues provide first evidence of horizontal gene transfer from host to the parasitic flowering plant, Rafflesia cantleyi, on an unprecedented scale raising the possibility that there is a 'fitness' benefit to the parasite.

11.

Research article   Open Access

In-silico design of computational nucleic acids for molecular information processing

Effirul Ikhwan Ramlan, Klaus-Peter Zauner Journal of Cheminformatics 2013, 5:22 (7 May 2013)

Abstract | Provisional PDF | PubMed

12.

Research article   Open Access

Structural and optical characterization of metal tungstates (MWO4; M=Ni, Ba, Bi) synthesized by a sucrose-templated method

Siti Murni M Zawawi, Rosiyah Yahya, Aziz Hassan, H N M Ekramul Mahmud, Mohammad Noh Daud Chemistry Central Journal 2013, 7:80 (1 May 2013)

Abstract | Full text | PDF | PubMed | Graphical abstract

13.

Review   Open Access Highly Accessed

Molecular signatures of T-cell inhibition in HIV-1 infection

Marie Larsson, Esaki M Shankar, Karlhans F Che, Alireza Saeidi, Rada Ellegård, Muttiah Barathan, Vijayakumar Velu, Adeeba Kamarulzaman Retrovirology 2013, 10:31 (20 March 2013)

Abstract | Full text | PDF | PubMed

14.

Research article   Open Access

Low prevalence of ‘classical’ microscopic colitis but evidence of microscopic inflammation in Asian Irritable Bowel Syndrome patients with diarrhoea

Ida Hilmi, Juanda Hartono, Jayalakshmi Pailoor, Sanjiv Mahadeva, Khean-Lee Goh BMC Gastroenterology 2013, 13:80 (8 May 2013)

Abstract | Full text | PDF | PubMed

15.

Research   Open Access Highly Accessed

Mimiviridae: clusters of orthologous genes, reconstruction of gene repertoire evolution and proposed expansion of the giant virus family

Natalya Yutin, Philippe Colson, Didier Raoult, Eugene V Koonin Virology Journal 2013, 10:106 (4 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Clusters of orthologous genes for mimiviruses (mimiCOGs) were constructed and used for comprehensive phylogenetic analysis of large dsDNA viruses, finding that two Phycodnaviruses actually belong in the Mimiviridae.

16.

Research   Open Access

Genome sequencing and analysis of Salmonella enterica serovar Typhi strain CR0063 representing a carrier individual during an outbreak of typhoid fever in Kelantan, Malaysia

Ramani Baddam, Narender Kumar, Sabiha Shaik, Tiruvayipati Suma, Soo Tein Ngoi, Kwai-Lin Thong, Niyaz Ahmed Gut Pathogens 2012, 4:20 (13 December 2012)

Abstract | Full text | PDF | PubMed

17.

Research   Open Access

Anthropometric, biochemical and clinical assessment of malnutrition in Malaysian patients with advanced cirrhosis

Mei-Ling S Tai, Khean-Lee Goh, Siti Mohd-Taib, Sanjay Rampal, Sanjiv Mahadeva Nutrition Journal 2010, 9:27 (24 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

Research article   Open Access Highly Accessed

Triple-negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early-onset and familial breast cancer, but not in women with isolated late-onset breast cancer

Sze-Yee Phuah, Lai-Meng Looi, Norhashimah Hassan, Anthony Rhodes, Sarah Dean, Nur Taib, Cheng-Har Yip, Soo-Hwang Teo Breast Cancer Research 2012, 14:R142 (2 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Women up to 35 years old with triple negative breast cancer (TNBC) may benefit from genetic testing, however, prevalence of BRCA mutations was similar in TNBC and non-TNBC patients aged 36 to 50.

19.

Research   Open Access Highly Accessed

Differentiating Entamoeba histolytica, Entamoeba dispar and Entamoeba moshkovskii using nested polymerase chain reaction (PCR) in rural communities in Malaysia

Romano Ngui, Lorainne Angal, Siti Fakhrurrazi, Yvonne Lim Lian, Lau Ling, Jamaiah Ibrahim, Rohela Mahmud Parasites & Vectors 2012, 5:187 (4 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This study was conducted to determine the prevalence of Entamoeba histolytica, Entamoeba dispar and Entamoeba moshkovskii infection via a combination of microscopic examination and nested polymerase chain reaction (PCR) targeting 16S ribosomal RNA gene of Entamoeba species in Peninsular Malaysia. Image: An iodine-stained cyst of Entamoeba species under 400x magnification.

20.

Research article   Open Access Highly Accessed

Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology

Karine Brudey, Jeffrey R Driscoll, Leen Rigouts, Wolfgang M Prodinger, Andrea Gori, Sahal A Al-Hajoj, Caroline Allix, Liselotte Aristimuño, Jyoti Arora, Viesturs Baumanis, Lothar Binder, Patricia Cafrune, Angel Cataldi, Soonfatt Cheong, Roland Diel, Christopher Ellermeier, Jason T Evans, Maryse Fauville-Dufaux, Séverine Ferdinand, Dario de Viedma, Carlo Garzelli, Lidia Gazzola, Harrison M Gomes, M Cristina Guttierez, Peter M Hawkey, Paul D van Helden, Gurujaj V Kadival, Barry N Kreiswirth, Kristin Kremer, Milan Kubin et al. BMC Microbiology 2006, 6:23 (6 March 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

Research article   Open Access

Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats

Suzy M Salama, Mahmood Ameen Abdulla, Ahmed S AlRashdi, Salmah Ismail, Salim S Alkiyumi, Shahram Golbabapour BMC Complementary and Alternative Medicine 2013, 13:56 (5 March 2013)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access

Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases

Xiu Koh, Chien Chiou, Noni Ajam, Haruo Watanabe, Norazah Ahmad, Kwai Thong BMC Infectious Diseases 2012, 12:122 (20 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

Research   Open Access

Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains

Pooi Chung, Parasakthi Navaratnam, Lip Chung Annals of Clinical Microbiology and Antimicrobials 2011, 10:25 (9 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Research   Open Access

Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model

Jérome Dormoi, Sébastien Briolant, Camille Desgrouas, Bruno Pradines Malaria Journal 2013, 12:127 (15 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Evaluation of methylene blue (MB) alone, atorvastatin (AVA) alone, and MB plus AVA in mice infected with the Plasmodium berghei ANKA strain.The in vitro synergism observed between MB and AVA suggests a potential for combination therapy.

25.

Research article   Open Access Highly Accessed

Allele-specific polymerase chain reaction for the detection of Alzheimer’s disease-related single nucleotide polymorphisms

Mohd Nazif Darawi, Chin Ai-Vyrn, Kalavathy Ramasamy, Philip Poi Jun Hua, Tan Maw Pin, Shahrul Bahyah Kamaruzzaman, Abu Bakar Abdul Majeed BMC Medical Genetics 2013, 14:27 (19 February 2013)

Abstract | Full text | PDF | PubMed

26.

Case report   Open Access Highly Accessed

Hyperparasitaemic human Plasmodium knowlesi infection with atypical morphology in peninsular Malaysia

Wenn-Chyau Lee, Pek-Woon Chin, Yee-Ling Lau, Lit-Chein Chin, Mun-Yik Fong, Chee-Jiek Yap, Raymond Supramaniam, Rohela Mahmud Malaria Journal 2013, 12:88 (6 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A case report which adds supportive information to current descriptions of severe knowlesi malaria, in this case with hyperparasitaemia.

27.

Research article   Open Access

Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study

Hasniza Zaman Huri, Hoo Fun Wee BMC Endocrine Disorders 2013, 13:2 (7 January 2013)

Abstract | Full text | PDF | PubMed

28.

Research   Open Access

Numerical investigation of the effect of cannula placement on thrombosis

ChiWei Ong, Socrates Dokos, BeeTing Chan, Einly Lim, Amr Al Abed, Noor Azuan Osman, Suhaini Kadiman, Nigel H Lovell Theoretical Biology and Medical Modelling 2013, 10:35 (16 May 2013)

Abstract | Provisional PDF | PubMed

29.

Research   Open Access Highly Accessed

Domestic violence management in Malaysia: A survey on the primary health care providers

Sajaratulnisah Othman, Noor Azmi Mat Adenan Asia Pacific Family Medicine 2008, 7:2 (29 September 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

Research   Open Access

Plasmodium vivax and Plasmodium falciparum infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants

Bouh Abdi Khaireh, Sébastien Briolant, Aurélie Pascual, Madjid Mokrane, Vanessa Machault, Christelle Travaillé, Mohamed Abdi Khaireh, Ismail Hassan Farah, Habib Moussa Ali, Abdul-Ilah Ahmed Abdi, Souleiman Ayeh, Houssein Youssouf Darar, Lénaïck Ollivier, Mohamed Killeh Waiss, Hervé Bogreau, Christophe Rogier, Bruno Pradines Malaria Journal 2012, 11:395 (28 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The paper adds to the increasing scientific literature addressing the monitoring of naturally acquired humoral immune responses to malaria antigens as a measure of transmission and malaria risk in regions targeted for elimination.

31.

Research article   Open Access

A cross-country comparison of tobacco consumption among youths from selected South-Asian countries

Mohammad Kabir, Kim-Leng Goh, Mobarak Khan BMC Public Health 2013, 13:379 (23 April 2013)

Abstract | Full text | PDF | PubMed

32.

Research   Open Access

Elucidation of the effect of ionic liquid pretreatment on rice husk via structural analyses

Teck Ang, Gek Ngoh, Adeline Seak Chua, Min Lee Biotechnology for Biofuels 2012, 5:67 (7 September 2012)

Abstract | Full text | PDF | PubMed

33.

Research article   Open Access

Piper betle shows antioxidant activities, inhibits MCF-7 cell proliferation and increases activities of catalase and superoxide dismutase

Noor Abrahim, M S Kanthimathi, Azlina Abdul-Aziz BMC Complementary and Alternative Medicine 2012, 12:220 (15 November 2012)

Abstract | Full text | PDF | PubMed

34.

Research article   Open Access Highly Accessed

Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer

E Thirthagiri, SY Lee, P Kang, DS Lee, GT Toh, S Selamat, S-Y Yoon, NA Mohd Taib, MK Thong, CH Yip, SH Teo Breast Cancer Research 2008, 10:R59 (16 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Evaluation of BRCA mutation testing in an Asian population highlights the need for validation of current breast cancer risk prediction models for non-Caucasian populations so they may benefit from genetic testing.

35.

Case report   Open Access Highly Accessed

Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report

Janet Cox-Singh, Jessie Hiu, Sebastian B Lucas, Paul C Divis, Mohammad Zulkarnaen, Patricia Chandran, Kum T Wong, Patricia Adem, Sherif R Zaki, Balbir Singh, Sanjeev Krishna Malaria Journal 2010, 9:10 (11 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A case report of a fatal case of malaria knowlesi in a formerly healthy 40-year old male, ten days after spending time in the jungle of North Borneo

36.

Research   Open Access Highly Accessed

Pyrosequencing, a method approved to detect the two major EGFR mutations for anti EGFR therapy in NSCLC

Sandrine Dufort, Marie-Jeanne Richard, Sylvie Lantuejoul, Florence de Fraipont Journal of Experimental & Clinical Cancer Research 2011, 30:57 (16 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

Nano Express   Open Access Highly Accessed

Antibacterial performance of Ag nanoparticles and AgGO nanocomposites prepared via rapid microwave-assisted synthesis method

Soon Chook, Chin Chia, Sarani Zakaria, Mohd Ayob, Kah Chee, Nay Huang, Hui Neoh, Hong Lim, Rahman Jamal, RahaMohdFadhilRajaAbdul Rahman Nanoscale Research Letters 2012, 7:541 (28 September 2012)

Abstract | Full text | PDF | PubMed

38.

Research   Open Access

Multipurpose contrast enhancement on epiphyseal plates and ossification centers for bone age assessment

Hum Yan Chai, Tan Tian Swee, Gan Hong Seng, Lai Khin Wee BioMedical Engineering OnLine 2013, 12:27 (8 April 2013)

Abstract | Full text | PDF | PubMed

39.

Research   Open Access

Towards an effective control programme of soil-transmitted helminth infections among Orang Asli in rural Malaysia. Part 1: Prevalence and associated key factors

Nabil A Nasr, Hesham M Al-Mekhlafi, Abdulhamid Ahmed, Muhammad Roslan, Awang Bulgiba Parasites & Vectors 2013, 6:27 (28 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This study reveals an alarmingly high prevalence of soil-transmitted helminth infections among Orang Asli children in rural Malaysia indicating an urgent need for a sustainable and effective control programme in these communities. Image: An Orang Asli village

40.

Research article   Open Access Highly Accessed

The modified NCEP ATP III criteria maybe better than the IDF criteria in diagnosing Metabolic Syndrome among Malays in Kuala Lumpur

Foong Ming Moy, Awang Bulgiba BMC Public Health 2010, 10:678 (6 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

Research article   Open Access

Enzymatic and molecular characterisation of leucine aminopeptidase of Burkholderia pseudomallei

Liew Siew Mun, Tay Sun Tee, Savithiri D Puthucheary BMC Microbiology 2013, 13:110 (17 May 2013)

Abstract | Provisional PDF | PubMed

42.

Software   Open Access

OPPL-Galaxy, a Galaxy tool for enhancing ontology exploitation as part of bioinformatics workflows

Mikel Egaña Aranguren, Jesualdo Tomás Fernández-Breis, Chris Mungall, Erick Antezana, Alejandro Rodríguez González, Mark D Wilkinson Journal of Biomedical Semantics 2013, 4:2 (4 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The Ontology Pre Processor Language (OPPL) combined with the Galaxy framework allows automated ontology manipulations, leading to more advanced biological data analyses.

43.

Nano Express   Open Access

Structural and photoluminescence studies on catalytic growth of silicon/zinc oxide heterostructure nanowires

Su Kong Chong, Chang Fu Dee, Saadah Abdul Rahman Nanoscale Research Letters 2013, 8:174 (17 April 2013)

Abstract | Full text | PDF | PubMed

44.

Research article   Open Access

Isolation of Pediococcus acidilactici Kp10 with ability to secrete bacteriocin-like inhibitory substance from milk products for applications in food industry

Sahar Abbasiliasi, Joo Shun Tan, Tengku Azmi Tengku Ibrahim, Ramakrishnan Nagasundara Ramanan, Faezeh Vakhshiteh, Shuhaimi Mustafa, Tau Chuan Ling, Raha Abdul Rahim, Arbakariya B Ariff BMC Microbiology 2012, 12:260 (15 November 2012)

Abstract | Full text | PDF | PubMed

45.

Research article   Open Access Highly Accessed

Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: Co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia

Kok-Gan Chan, Steve Atkinson, Kalai Mathee, Choon-Kook Sam, Siri Chhabra, Miguel Cámara, Chong-Lek Koh, Paul Williams BMC Microbiology 2011, 11:51 (8 March 2011)

Abstract | Full text | PDF | PubMed

46.

Research   Open Access Highly Accessed

Mapping of mosquito breeding sites in malaria endemic areas in Pos Lenjang, Kuala Lipis, Pahang, Malaysia

Rohani Ahmad, Wan NWM Ali, Zurainee M Nor, Zamree Ismail, Azahari A Hadi, Mohd N Ibrahim, Lee H Lim Malaria Journal 2011, 10:361 (13 December 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A well-conducted study which shows an interesting way to map the malaria transmission risk area using spatial technologies, such as remote sensing, GPS and GIS. This is the way to go for improving information and knowledge on malaria vectors and for implementing more efficient and targeted vector control.

47.

Short report   Open Access Highly Accessed

Colonization of Anopheles cracens: a malaria vector of emerging importance

Amirah Amir, Jia Siang Sum, Yee Ling Lau, Indra Vythilingam, Mun Yik Fong Parasites & Vectors 2013, 6:81 (28 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Maintaining a laboratory colony of Anopheles cracens, a vector of Plasmodium knowlesi, using an artificial mating technique. Image: Male An. cracens clasping a female during artificial mating.

48.

Research   Open Access Highly Accessed

DNA vaccine constructs against enterovirus 71 elicit immune response in mice

Wong Tung, Sazaly Bakar, Zamberi Sekawi, Rozita Rosli Genetic Vaccines and Therapy 2007, 5:6 (19 April 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

49.

Research   Open Access Highly Accessed

Antiviral activity of four types of bioflavonoid against dengue virus type-2

Keivan Zandi, Boon-Teong Teoh, Sing-Sin Sam, Pooi-Fong Wong, Mohd Mustafa, Sazaly AbuBakar Virology Journal 2011, 8:560 (28 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

Research   Open Access Highly Accessed

Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal, in 2010: an ex vivo and drug resistance molecular markers study

Bécaye Fall, Aurélie Pascual, Fatoumata D Sarr, Nathalie Wurtz, Vincent Richard, Eric Baret, Yaya Diémé, Sébastien Briolant, Raymond Bercion, Boubacar Wade, Adama Tall, Bruno Pradines Malaria Journal 2013, 12:107 (20 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Results of the genetic analyses of several genetic markers of drug resistance in Plasmodium falciparum isolates from Senegal after the official introduction of ACT in the country in 2006. In parallel, the authors also evaluated the ex vivo response of the isolates to several anti-malarials.

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