In silico identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex
BMC Structural Biology 2012, 12:25 (3 October 2012)
Does the central dogma still stand?
Biology Direct 2012, 7:27 (23 August 2012)
Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes
Virology Journal 2012, 9:161 (14 August 2012)
Research confirming that the Nucleo-Cytoplasmic Large DNA viruses, from smallpox to mimivirus, evolved from a single common ancestor. Interestingly a number of core genes, carrying out the same function in these diverse viruses, were unrelated to each other but were instead independently acquired from their eukaryotic hosts. This remarkable example of convergent evolution reveals a complex genetic history for an important group of viruses.
Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics
Biology Direct 2012, 7:18 (25 June 2012)
Comprehensive dissection of polymorphic and related secreted toxin systems uncovers nearly 240 toxin and immunity domains with implications for intra-organismal conflict, kin discrimination, pathogenesis and emergence of eukaryotic sub-cellular systems.
Automated hierarchical classification of protein domain subfamilies based on functionally-divergent residue signatures
BMC Bioinformatics 2012, 13:144 (22 June 2012)
Epigenetic functions enriched in transcription factors binding to mouse recombination hotspots
Proteome Science 2012, 10(Suppl 1):S11 (21 June 2012)
Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction
BMC Bioinformatics 2012, 13:134 (18 June 2012)
New finite-size correction for local alignment score distributions
BMC Research Notes 2012, 5:286 (12 June 2012)
A unified phylogeny-based nomenclature for histone variants
Epigenetics & Chromatin 2012, 5:7 (31 May 2012)
In response to an urgent need to rationalize the current schemes for naming histone variants, researchers from over 30 institutions worldwide have developed consistent but flexible naming rules that are informative and database-searchable.
CytoITMprobe: a network information flow plugin for Cytoscape
BMC Research Notes 2012, 5:237 (15 May 2012)
The Physalis peruviana leaf transcriptome: assembly, annotation and gene model prediction
BMC Genomics 2012, 13:151 (25 April 2012)
Mediation of Drosophila autosomal dosage effects and compensation by network interactions
Genome Biology 2012, 13:R28 (24 April 2012)
A comprehensive RNA-seq analysis of autosomal dosage effects and compensation in 21 autosomal deficiency Drosophila lines
Domain enhanced lookup time accelerated BLAST
Biology Direct 2012, 7:12 (17 April 2012)
DELTA-BLAST is a new BLAST alignment tool for sensitive protein searches that uses conserved domain models to construct a position specific scoring matrix.
Origin and evolution of spliceosomal introns
Biology Direct 2012, 7:11 (16 April 2012)
Archaeal origin of tubulin
Biology Direct 2012, 7:10 (29 March 2012)
Probable ancestors of eukaryotic tubulins, denoted artubulins, were discovered in two genomes of thaumarchaeota of the genus Nitrosoarchaeum.
Post-radiation increase in VEGF enhances glioma cell motility in vitro
Radiation Oncology 2012, 7:25 (22 February 2012)
Automatic identification and normalization of dosage forms in drug monographs
BMC Medical Informatics and Decision Making 2012, 12:9 (15 February 2012)
The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotes
Biology Direct 2012, 7:7 (13 February 2012)
Comparative genomic analysis reveals diverged orthologs of eukaryotic CDC45 protein and bacterial RecJ nuclease in nearly all archaeal genomes; the CMG complex is conserved in both archaea and eukaryotes, and appears to be an essential component of the ancestral DNA replication machinery.
Increasing peptide identifications and decreasing search times for ETD spectra by pre-processing and calculation of parent precursor charge
Proteome Science 2012, 10:8 (9 February 2012)
Predicting tissue specific cis-regulatory modules in the human genome using pairs of co-occurring motifs
BMC Bioinformatics 2012, 13:25 (7 February 2012)
Female Anopheles gambiae antennae: increased transcript accumulation of the mosquito-specific odorant-binding-protein OBP2
Parasites & Vectors 2012, 5:27 (6 February 2012)
The odorant binding protein, OBP2, had increased transcript accumulation in the antennae of female vs. male Anopheles gambiae. suggesting it may play a role in female feeding and breeding behavior. Image: Heads, mouthparts and antennae of female (left) and male (right) Anopheles gambiae
Constructing a semantic predication gold standard from the biomedical literature
BMC Bioinformatics 2011, 12:486 (20 December 2011)
A unified framework for managing provenance information in translational research
BMC Bioinformatics 2011, 12:461 (29 November 2011)
Automated annotation of chemical names in the literature with tunable accuracy
Journal of Cheminformatics 2011, 3:52 (22 November 2011)
An automated chemical name annotation system has been developed to annotate small molecule names in scientific abstracts with the aim of reproducing MeSH term annotations on biomedical and chemical literature
Francisella RNA polymerase contains a heterodimer of non-identical α subunits
BMC Molecular Biology 2011, 12:50 (22 November 2011)
Unlike all other known bacterial genera, Francisella possesses two rpoA genes, encoding two non-identical alpha subunits of the RNA polymerase, and both subunits must be present in the same enzyme to ensure robust transcription activity.