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1.

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

2.

Review   Open Access Highly Accessed

From staff-mix to skill-mix and beyond: towards a systemic approach to health workforce management

Carl-Ardy Dubois, Debbie Singh Human Resources for Health 2009, 7:87 (19 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

Research   Open Access Highly Accessed

Early childhood television viewing predicts explosive leg strength and waist circumference by middle childhood

Caroline Fitzpatrick, Linda S Pagani, Tracie A Barnett International Journal of Behavioral Nutrition and Physical Activity 2012, 9:87 (16 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Increased television viewing between 29 and 53 months is associated with increased waist circumference and reduced explosive leg strength at 8 - 10 years old, independent of physical activity levels, according to this study of 1314 children.

4.

Review   Open Access Highly Accessed

The role of NGOs in global health research for development

Hélène Delisle, Janet Roberts, Michelle Munro, Lori Jones, Theresa W Gyorkos Health Research Policy and Systems 2005, 3:3 (21 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

Research   Open Access

Global health and national borders: the ethics of foreign aid in a time of financial crisis

Mira Johri, Ryoa Chung, Angus Dawson, Ted Schrecker Globalization and Health 2012, 8:19 (28 June 2012)

Abstract | Full text | PDF | PubMed

6.

Research   Open Access

Poor nutritional status of schoolchildren in urban and peri-urban areas of Ouagadougou (Burkina Faso)

Charles Daboné, Hélène F Delisle, Olivier Receveur Nutrition Journal 2011, 10:34 (19 April 2011)

Abstract | Full text | PDF | PubMed

7.

Research article   Open Access Highly Accessed

Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Joanne Kotsopoulos, Jan Lubinski, Leonardo Salmena, Henry T Lynch, Charmaine Kim-Sing, William D Foulkes, Parviz Ghadirian, Susan L Neuhausen, Rochelle Demsky, Nadine Tung, Peter Ainsworth, Leigha Senter, Andrea Eisen, Charis Eng, Christian Singer, Ophira Ginsburg, Joanne Blum, Tomasz Huzarski, Aletta Poll, Ping Sun, Steven A Narod, Breast Cancer Research 2012, 14:R42 (9 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Breastfeeding is protective against BRCA1- but not BRCA2-associated breast cancer, suggesting they have different biological pathways for carcinogenesis, and mutation carriers should be advised of the potential benefit of breastfeeding.

8.

Review   Open Access Highly Accessed

Origin and evolution of spliceosomal introns

Igor B Rogozin, Liran Carmel, Miklos Csuros, Eugene V Koonin Biology Direct 2012, 7:11 (16 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

9.

Commentary   Open Access Highly Accessed

Defining the critical hurdles in cancer immunotherapy

Bernard A Fox, Dolores J Schendel, Lisa H Butterfield, Steinar Aamdal, James P Allison, Paolo Ascierto, Michael B Atkins, Jirina Bartunkova, Lothar Bergmann, Neil Berinstein, Cristina C Bonorino, Ernest Borden, Jonathan L Bramson, Cedrik M Britten, Xuetao Cao, William E Carson, Alfred E Chang, Dainius Characiejus, A Raja Choudhury, George Coukos, Tanja de Gruijl, Robert O Dillman, Harry Dolstra, Glenn Dranoff, Lindy G Durrant, James H Finke, Jerome Galon, Jared A Gollob, Cécile Gouttefangeas, Fabio Grizzi et al. Journal of Translational Medicine 2011, 9:214 (14 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

Research   Open Access Highly Accessed

The case of Montréal's missing food deserts: Evaluation of accessibility to food supermarkets

Philippe Apparicio, Marie-Soleil Cloutier, Richard Shearmur International Journal of Health Geographics 2007, 6:4 (12 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

Research article   Open Access Highly Accessed

Cnidarian phylogenetic relationships as revealed by mitogenomics

Ehsan Kayal, Béatrice Roure, Hervé Philippe, Allen G Collins, Dennis V Lavrov BMC Evolutionary Biology 2013, 13:5 (9 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Re-evaluation of the phylogeny of the Cnidaria, using an expanded dataset of mitochondrial protein genes, differs from existing phylogeny and groups the Octocorallia and Medusozoa, resulting in a paraphyletic Anthozoa.

12.

Review   Open Access Highly Accessed

Cancer classification using the Immunoscore: a worldwide task force

Jérôme Galon, Franck Pagès, Francesco M Marincola, Helen K Angell, Magdalena Thurin, Alessandro Lugli, Inti Zlobec, Anne Berger, Carlo Bifulco, Gerardo Botti, Fabiana Tatangelo, Cedrik M Britten, Sebastian Kreiter, Lotfi Chouchane, Paolo Delrio, Hartmann Arndt, Martin Asslaber, Michele Maio, Giuseppe V Masucci, Martin Mihm, Fernando Vidal-Vanaclocha, James P Allison, Sacha Gnjatic, Leif Hakansson, Christoph Huber, Harpreet Singh-Jasuja, Christian Ottensmeier, Heinz Zwierzina, Luigi Laghi, Fabio Grizzi et al. Journal of Translational Medicine 2012, 10:205 (3 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

Research article   Open Access Highly Accessed

Common stressful life events and difficulties are associated with mental health symptoms and substance use in young adolescents

Nancy CP Low, Erika Dugas, Erin O’Loughlin, Daniel Rodriguez, Gisele Contreras, Michael Chaiton, Jennifer O’Loughlin BMC Psychiatry 2012, 12:116 (17 August 2012)

Abstract | Full text | PDF | PubMed

14.

Research article   Open Access Highly Accessed

Advanced practice physiotherapy in patients with musculoskeletal disorders: a systematic review

François Desmeules, Jean-Sébastien Roy, Joy C MacDermid, François Champagne, Odette Hinse, Linda June Woodhouse BMC Musculoskeletal Disorders 2012, 13:107 (21 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

Review   Open Access Highly Accessed

Prokaryotic evolution and the tree of life are two different things

Eric Bapteste, Maureen A O'Malley, Robert G Beiko, Marc Ereshefsky, J Peter Gogarten, Laura Franklin-Hall, François-Joseph Lapointe, John Dupré, Tal Dagan, Yan Boucher, William Martin Biology Direct 2009, 4:34 (29 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

From philosophical, scientific and epistemological perspectives, we argue that the tree of life can not successfully account for prokaryotic evolution, and we briefly set out alternative models to study their evolution.

16.

Research article   Open Access Highly Accessed

Kangaroo mother care diminishes pain from heel lance in very preterm neonates: A crossover trial

C Celeste Johnston, Francoise Filion, Marsha Campbell-Yeo, Celine Goulet, Linda Bell, Kathryn McNaughton, Jasmine Byron, Marilyn Aita, G Allen Finley, Claire-Dominique Walker BMC Pediatrics 2008, 8:13 (24 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Maternal skin-to-skin contact before and during routine blood draws significantly reduces pain responses in very preterm infants, promoting a swifter return to baseline than when the procedure is performed in an incubator.

17.

Research   Open Access

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

Stephen R Fairclough, Zehua Chen, Eric Kramer, Qiandong Zeng, Sarah Young, Hugh M Robertson, Emina Begovic, Daniel J Richter, Carsten Russ, M Jody Westbrook, Gerard Manning, B Franz Lang, Brian Haas, Chad Nusbaum, Nicole King Genome Biology 2013, 14:R15 (18 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Genome sequencing of Salpingoeca rosetta reveals insights into the genome composition of the metazoan ancestor and the evolution of multicellularity

18.

Research article   Open Access Highly Accessed

Rehabilitation needs for older adults with stroke living at home: perceptions of four populations

Claude Vincent, Isabelle Deaudelin, Line Robichaud, Jacqueline Rousseau, Chantal Viscogliosi, Lise R Talbot, Johanne Desrosiers, BMC Geriatrics 2007, 7:20 (13 August 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

Research article   Open Access

Does accreditation stimulate change? A study of the impact of the accreditation process on Canadian healthcare organizations

Marie-Pascale Pomey, Louise Lemieux-Charles, François Champagne, Doug Angus, Abdo Shabah, André-Pierre Contandriopoulos Implementation Science 2010, 5:31 (26 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

Research   Open Access Highly Accessed

Antimicrobial breakpoint estimation accounting for variability in pharmacokinetics

Goue Bi, Jun Li, Fahima Nekka Theoretical Biology and Medical Modelling 2009, 6:10 (26 June 2009)

Abstract | Full text | PDF | PubMed

21.

Research   Open Access

The effects of midwives’ job satisfaction on burnout, intention to quit and turnover: a longitudinal study in Senegal

Dominique Rouleau, Pierre Fournier, Aline Philibert, Betty Mbengue, Alexandre Dumont Human Resources for Health 2012, 10:9 (30 April 2012)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access Highly Accessed

Origin of land plants: Do conjugating green algae hold the key?

Sabina Wodniok, Henner Brinkmann, Gernot Glöckner, Andrew J Heidel, Hervé Philippe, Michael Melkonian, Burkhard Becker BMC Evolutionary Biology 2011, 11:104 (18 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The closest living algal relative of the land plants appears to be the conjugating green algae rather than the stonewort-like algae, as revealed by phylogenetic analysis of 129 nuclear genes across a broad range of land plants and algal groups.

23.

Review   Open Access Highly Accessed

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

Christophe Frémin, Sylvain Meloche Journal of Hematology & Oncology 2010, 3:8 (11 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Review   Open Access Highly Accessed

A generalizable pre-clinical research approach for orphan disease therapy

Chandree L Beaulieu, Mark E Samuels, Sean Ekins, Christopher R McMaster, Aled M Edwards, Adrian R Krainer, Geoffrey G Hicks, Brendan J Frey, Kym M Boycott, Alex E MacKenzie Orphanet Journal of Rare Diseases 2012, 7:39 (15 June 2012)

Abstract | Full text | PDF | PubMed

25.

Research article   Open Access Highly Accessed

A taxonomy of nursing care organization models in hospitals

Carl-Ardy Dubois, Danielle D’Amour, Eric Tchouaket, Michèle Rivard, Sean Clarke, Régis Blais BMC Health Services Research 2012, 12:286 (28 August 2012)

Abstract | Full text | PDF | PubMed

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