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1.

Original clinical investigation   Open Access

Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies

Martin H Prins, Anthonie WA Lensing, Rupert Bauersachs, Bonno van Bellen, Henri Bounameaux, Timothy A Brighton, Alexander T Cohen, Bruce L Davidson, Hervé Decousus, Gary E Raskob, Scott D Berkowitz, Philip S Wells Thrombosis Journal 2013, 11:21 (20 September 2013)

Abstract | Provisional PDF | PubMed

2.

Research article   Open Access

Genomic selection in sugar beet breeding populations

Tobias Würschum, Jochen C Reif, Thomas Kraft, Geert Janssen, Yusheng Zhao BMC Genetics 2013, 14:85 (18 September 2013)

Abstract | Full text | PDF | PubMed

3.

Research article   Open Access

Evaluation of an electronic diary for improvement of adherence to interferon beta-1b in patients with multiple sclerosis: design and baseline results of an observational cohort study

Uwe K Zettl, Ulrike Bauer-Steinhusen, Thomas Glaser, Klaus Hechenbichler, Volker Limmroth, BMC Neurology 2013, 13:117 (6 September 2013)

Abstract | Full text | PDF | PubMed

4.

Poster presentation   Open Access

Effects of age and gender on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat

Reiner Frey, John Lettieri, Andrea Nadel, Corina Becker, Wolfgang Mück BMC Pharmacology and Toxicology 2013, 14(Suppl 1):P23 (29 August 2013)

Full text | PDF

5.

Poster presentation   Open Access

Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment

Reiner Frey, Corina Becker, Sigrun Unger, Anja Schmidt, Georg Wensing, Wolfgang Mueck BMC Pharmacology and Toxicology 2013, 14(Suppl 1):P22 (29 August 2013)

Full text | PDF

6.

Poster presentation   Open Access

Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairment

Reiner Frey, Corina Becker, Sigrun Unger, Anja Schmidt, Georg Wensing, Wolfgang Mueck BMC Pharmacology and Toxicology 2013, 14(Suppl 1):P21 (29 August 2013)

Full text | PDF

7.

Poster presentation   Open Access

Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality

Corina Becker, Reiner Frey, Christiane Hesse, Sigrun Unger, Michael Reber, Wolfgang Mueck BMC Pharmacology and Toxicology 2013, 14(Suppl 1):P7 (29 August 2013)

Full text | PDF

8.

Poster presentation   Open Access

Effects of omeprazole and AlOH/MgOH on riociguat absorption

Corina Becker, Reiner Frey, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann, Wolfgang Mueck BMC Pharmacology and Toxicology 2013, 14(Suppl 1):P6 (29 August 2013)

Full text | PDF

9.

Poster presentation   Open Access

Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat

Corina Becker, Reiner Frey, Sigrun Unger, Dirk Thomas, Michael Reber, Gerrit Weimann, Hartmut Dietrich, Erich R Arens, Wolfgang Mueck BMC Pharmacology and Toxicology 2013, 14(Suppl 1):P5 (29 August 2013)

Full text | PDF

10.

Research   Open Access Highly Accessed

Efficacy of an imidacloprid/flumethrin collar against fleas, ticks and tick-borne pathogens in dogs

Filipe Dantas-Torres, Gioia Capelli, Alessio Giannelli, Rafael Antonio Ramos, Riccardo Lia, Cinzia Cantacessi, Donato de Caprariis, Anna De Tommasi, Maria Latrofa, Vita Lacasella, Viviana Tarallo, Giancarlo Di Paola, Barbara Qurollo, Edward Breitschwerdt, Dorothee Stanneck, Domenico Otranto Parasites & Vectors 2013, 6:245 (23 August 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This study evaluated the efficacy of an imidacloprid/flumethrin collar against flea and tick infestation as well as infection by Anaplasma platys, Babesia vogeli and Hepatozoon canis in dogs under field conditions. Image: Collared dogs protected from ticks and fleas and pathogens they transmit.

11.

Discussion   Open Access Highly Accessed

Five years REACH: lessons learned and first experiences - an industry’s view

Angelika Hanschmidt, Michael Lulei, Andrea Paetz Environmental Sciences Europe 2013, 25:19 (25 July 2013)

Abstract | Full text | PDF

12.

Study protocol   Open Access

A phase 3 tRial comparing capecitabinE in combination with SorafenIb or pLacebo for treatment of locally advanced or metastatIc HER2-Negative breast CancEr (the RESILIENCE study): study protocol for a randomized controlled trial

José Baselga, Frederico Costa, Henry Gomez, Clifford A Hudis, Bernardo Rapoport, Henri Roche, Lee S Schwartzberg, Oana Petrenciuc, Minghua Shan, William J Gradishar Trials 2013, 14:228 (22 July 2013)

Abstract | Full text | PDF | PubMed

13.

Original clinical investigation   Open Access

Derivation of the non-inferiority margin for the evaluation of direct oral anticoagulants in the treatment of venous thromboembolism

Martin H Prins, Anthonie WA Lensing Thrombosis Journal 2013, 11:13 (6 July 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Review   Open Access Highly Accessed

Laboratory assessment of rivaroxaban: a review

Meyer Samama, Geneviève Contant, Theodore E Spiro, Elisabeth Perzborn, Lena Le Flem, Céline Guinet, Yves Gourmelin, Gabriele Rohde, Jean-Luc Martinoli Thrombosis Journal 2013, 11:11 (3 July 2013)

Abstract | Full text | PDF | PubMed

15.

Review   Open Access Highly Accessed

Rivaroxaban and other novel oral anticoagulants: pharmacokinetics in healthy subjects, specific patient populations and relevance of coagulation monitoring

Wolfgang Mueck, Stephan Schwers, Jan Stampfuss Thrombosis Journal 2013, 11:10 (28 June 2013)

Abstract | Full text | PDF | PubMed

16.

Research   Open Access

Use of mixed-treatment-comparison methods in estimating efficacy of treatments for heavy menstrual bleeding

David C Hoaglin, Anna Filonenko, Mark E Glickman, Radek Wasiak, Risha Gidwani European Journal of Medical Research 2013, 18:17 (21 June 2013)

Abstract | Full text | PDF | PubMed

17.

Research   Open Access Highly Accessed

Ticks and associated pathogens collected from dogs and cats in Belgium

Edwin Claerebout, Bertrand Losson, Christel Cochez, Stijn Casaert, Anne-Catherine Dalemans, Ann De Cat, Maxime Madder, Claude Saegerman, Paul Heyman, Laetitia Lempereur Parasites & Vectors 2013, 6:183 (19 June 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A survey was conducted to detect ticks and tick-associated pathogens in dogs and cats in Belgium. Next to Ixodes spp., Dermacentor reticulatus was confirmed to be an indigenous parasite. Borrelia lusitaniae and Rickettsia helvetica were detected in Belgium for the first time. Image: Dermacentor reticulatus ticks, collected in the environment of a dog that was repeatedly infested with this species.

18.

Original research   Open Access

High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats

Susanne Bäck, Mari Raki, Raimo K Tuominen, Atso Raasmaja, Kim Bergström, Pekka T Männistö EJNMMI Research 2013, 3:46 (10 June 2013)

Abstract | Full text | PDF | PubMed

19.

Original research   Open Access

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106

Akihiro Takano, Fredrik Piehl, Jan Hillert, Andrea Varrone, Sangram Nag, Balázs Gulyás, Per Stenkrona, Victor L Villemagne, Christopher C Rowe, Richard Macdonell, Nabil Al Tawil, Thomas Kucinski, Torsten Zimmermann, Marcus Schultze-Mosgau, Andrea Thiele, Anja Hoffmann, Christer Halldin EJNMMI Research 2013, 3:30 (24 April 2013)

Abstract | Full text | PDF | PubMed

20.

Original research   Open Access

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification

Markus Krauss, Rolf Burghaus, Jörg Lippert, Mikko Niemi, Pertti Neuvonen, Andreas Schuppert, Stefan Willmann, Lars Kuepfer, Linus Görlitz In Silico Pharmacology 2013, 1:6 (11 April 2013)

Abstract | Full text | PDF

21.

Oral presentation   Open Access

Dataset overlap density analysis

Andreas H Göller Journal of Cheminformatics 2013, 5(Suppl 1):O14 (22 March 2013)

Full text | PDF

22.

Research   Open Access

A flea and tick collar containing 10% imidacloprid and 4.5% flumethrin prevents flea transmission of Bartonella henselae in cats

Michael R Lappin, Wendell L Davis, Jennifer R Hawley, Melissa Brewer, Arianne Morris, Dorothee Stanneck Parasites & Vectors 2013, 6:26 (25 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Ctenocephalides felis is a vector for Bartonella henselae and the organism can live in flea frass for at least 9 days. Wearing a collar containing imidacloprid and moxidectin blocked B. henselae infection amongst cats for 8 months. Image: Adult Ctenocephalides felis and frass.

23.

Research article   Open Access Highly Accessed

Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis: a prospective, multicenter, observational study (AVANTI)

Alexander Chuchalin, Maryna Zakharova, Dejan Dokic, Mahir Tokić, Hans-Peter Marschall, Thomas Petri BMC Pulmonary Medicine 2013, 13:5 (23 January 2013)

Abstract | Full text | PDF | PubMed

24.

Research   Open Access Highly Accessed

18F-florbetaben Aβ imaging in mild cognitive impairment

Kevin Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Gaël Chételat, Parnesh Raniga, Rachel S Mulligan, Olivier Salvado, Barbara Putz, Katrin Roth, Colin L Masters, Cornelia B Reininger, Christopher C Rowe Alzheimer's Research & Therapy 2013, 5:4 (16 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Higher levels of amyloid-β deposition, measured using 18F-florbetaben imaging, was associated with more severe memory loss in mild cognitive impairment (MCI) patients, proving its utility in early MCI diagnosis.

25.

Research article   Open Access

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

Wulf Siggelkow, Daniel Boehm, Susanne Gebhard, Marco Battista, Isabel Sicking, Antje Lebrecht, Christine Solbach, Birte Hellwig, Jörg Rahnenführer, Heinz Koelbl, Mathias Gehrmann, Rosemarie Marchan, Cristina Cadenas, Jan G Hengstler, Marcus Schmidt BMC Cancer 2012, 12:562 (27 November 2012)

Abstract | Full text | PDF | PubMed

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