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The NHRI consists of 10 research divisions and 4 departments. These divisions range from the common problems such as aging, cancer, infectious diseases, mental disorders, occupational diseases, to health policy.

http://www.nhri.org.tw

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Work published with BioMed Central, Chemistry Central and SpringerOpen by researchers at National Health Research Institutes

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	1.	Research *Improvement of n-butanol tolerance in Escherichia coli* by membrane-targeted tilapia metallothionein** Wei-Chih Chin, Kuo-Hsing Lin, Jui-Jen Chang, Chieh-Chen Huang Biotechnology for Biofuels 2013, 6:130 (11 September 2013) Abstract \| Full text \| PDF \| PubMed
	2.	Review Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors Cynthia Wei-Sheng Lee, Ing-Kang Ho Molecular Pain 2013, 9:45 (8 September 2013) Abstract \| Full text \| PDF \| PubMed
	3.	Software Pathway-PDT: a flexible pathway analysis tool for nuclear families Yo Park, Michael Schmidt, Eden R Martin, Margaret A Pericak-Vance, Ren-Hua Chung BMC Bioinformatics 2013, 14:267 (4 September 2013) Abstract \| Full text \| PDF \| PubMed
	4.	Research Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization Fong-Lee Huang, Young-Ji Shiao, Sheue-Jane Hou, Cheng-Ning Yang, Yi-Jen Chen, Chao-Hsiung Lin, Feng-Shiun Shie, Huey-Jen Tsay Journal of Biomedical Science 2013, 20:54 (2 August 2013) Abstract \| Full text \| PDF \| PubMed
	5.	Research *Deep exon resequencing of DLGAP2* as a candidate gene of autism spectrum disorders** Wei-Hsien Chien, Susan Shur-Fen Gau, Hsiao-Mei Liao, Yen-Nan Chiu, Yu-Yu Wu, Yu-Shu Huang, Wen-Che Tsai, Ho-Min Tsai, Chia-Hsiang Chen Molecular Autism 2013, 4:26 (1 August 2013) Abstract \| Full text \| PDF \| PubMed
	6.	Research article Incidence and outcome of newly-diagnosed tuberculosis in schizophrenics: a 12-year, nationwide, retrospective longitudinal study Shu-Chen Kuo, Yung-Tai Chen, Szu-Yuan Li, Yi-Tzu Lee, Albert C Yang, Te-Li Chen, Chia-Jen Liu, Tzeng-Ji Chen, Ih-Jen Su, Chang-Phone Fung BMC Infectious Diseases 2013, 13:351 (29 July 2013) Abstract \| Full text \| PDF \| PubMed
	7.	Research article Investigating the utilization of radiological services by physician patients: a population-based cohort study in Taiwan Chen-Yi Wu, Hsiao-Yun Hu, Likwang Chen, Nicole Huang, Yiing-Jeng Chou, Chung-Pin Li BMC Health Services Research 2013, 13:284 (23 July 2013) Abstract \| Full text \| PDF \| PubMed
	8.	Research article *Dissemination of imipenem-resistant Acinetobacter baumannii* with new plasmid-borne bla_OXA-72 in Taiwan** Shu-Chen Kuo, Su-Pen Yang, Yi-Tzu Lee, Han-Chuan Chuang, Chien-Pei Chen, Chi-Ling Chang, Te-Li Chen, Po-Liang Lu, Po-Ren Hsueh, Chang-Phone Fung BMC Infectious Diseases 2013, 13:319 (13 July 2013) Abstract \| Full text \| PDF \| PubMed
	9.	Research *Increased gene expression of FOXP1* in patients with autism spectrum disorders** Wei-Hsien Chien, Susan Shur-Fen Gau, Chun-Houh Chen, Wen-Che Tsai, Yu-Yu Wu, Po-Hsu Chen, Chi-Yung Shang, Chia-Hsiang Chen Molecular Autism 2013, 4:23 (1 July 2013) Abstract \| Full text \| PDF \| PubMed
	10.	Research Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance Kwang-Yu Chang, Shan-Yin Tsai, Shang-Hung Chen, Hsiao-Hui Tsou, Chia-Jui Yen, Ko-Jiunn Liu, Hsun-Lang Fang, Hung-Chang Wu, Bin-Fay Chuang, Shao-Wen Chou, Careen K Tang, Shyun-Yeu Liu, Pei-Jung Lu, Ching-Yu Yen, Jang-Yang Chang Journal of Biomedical Science 2013, 20:43 (27 June 2013) Abstract \| Full text \| PDF \| PubMed
	11.	Research Role of SIRT3 in the regulation of redox balance during oral carcinogenesis I-Chieh Chen, Wei-Fan Chiang, Shyun-Yeu Liu, Pei-Fen Chen, Hung-Che Chiang Molecular Cancer 2013, 12:68 (23 June 2013) Abstract \| Full text \| PDF \| PubMed
	12.	Software SeqSIMLA: a sequence and phenotype simulation tool for complex disease studies Ren-Hua Chung, Chung-Chin Shih BMC Bioinformatics 2013, 14:199 (20 June 2013) Abstract \| Full text \| PDF \| PubMed
	13.	Technical Note Monitoring the antigenic evolution of human influenza A viruses to understand how and when viruses escape from existing immunity Yu-Chieh Liao, Hsin-Hung Lin, Chieh-Hua Lin BMC Research Notes 2013, 6:227 (11 June 2013) Abstract \| Full text \| PDF \| PubMed
	14.	Research article Development of a non-invasive fibrosis test for chronic hepatitis B patients and comparison with other unpatented scores Chao-Wei Hsu, Kung-Hao Liang, Shiu-Feng Huang, Kuo-Chien Tsao, Chau-Ting Yeh BMC Research Notes 2013, 6:212 (27 May 2013) Abstract \| Full text \| PDF \| PubMed
	15.	Research article A small cohort of FRU^M and Engrailed-expressing neurons mediate successful copulation in Drosophila melanogaster Kristin L Latham, Ying-Show Liu, Barbara J Taylor BMC Neuroscience 2013, 14:57 (21 May 2013) Abstract \| Full text \| PDF \| PubMed
	16.	Research article Gene expression profiling of breast cancer survivability by pooled cDNA microarray analysis using logistic regression, artificial neural networks and decision trees Hsiu-Ling Chou, Chung-Tay Yao, Sui-Lun Su, Chia-Yi Lee, Kuang-Yu Hu, Harn-Jing Terng, Yun-Wen Shih, Yu-Tien Chang, Yu-Fen Lu, Chi-Wen Chang, Mark L Wahlqvist, Thomas Wetter, Chi-Ming Chu BMC Bioinformatics 2013, 14:100 (19 March 2013) Abstract \| Full text \| PDF \| PubMed
	17.	Case report Synchronous triple carcinoma of the colon and rectum Chien-Chih Yeh, Sheng-Chuan Hsi, Chih-Pin Chuu, Yung-Hsi Kao World Journal of Surgical Oncology 2013, 11:66 (13 March 2013) Abstract \| Full text \| PDF \| PubMed
	18.	Research article Joint predictability of health related quality of life and leisure time physical activity on mortality risk in people with diabetes Chia-Lin Li, Hsing-Yi Chang, Chih-Cheng Hsu, Jui-fen Rachel Lu, Hsin-Ling Fang BMC Public Health 2013, 13:67 (24 January 2013) Abstract \| Full text \| PDF \| PubMed
	19.	Research article HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma Peir-In Liang, Wei-Ming Li, Yu-Hui Wang, Ting-Feng Wu, Wen-Ren Wu, Alex C Liao, Kun-Hung Shen, Yu-Ching Wei, Chung-Hsi Hsing, Yow-Ling Shiue, Hsuan-Ying Huang, Han-Ping Hsu, Li-Tzon Chen, Ching-Yih Lin, Chein Tai, Chun-Mao Lin, Chien-Feng Li BMC Cancer 2012, 12:611 (21 December 2012) Abstract \| Full text \| PDF \| PubMed
	20.	Research Spending on vegetable and fruit consumption could reduce all-cause mortality among older adults Yuan-Ting Lo, Yu-Hung Chang, Mark L Wahlqvist, Han-Bin Huang, Meei-Shyuan Lee Nutrition Journal 2012, 11:113 (19 December 2012) Abstract \| Full text \| PDF \| PubMed
	21.	Proceedings Natural selection drives rapid evolution of mouse embryonic heart enhancers Ben-Yang Liao, Meng-Pin Weng BMC Systems Biology 2012, 6(Suppl 2):S1 (12 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	22.	Research article Molecular typing and characterization of nasal carriage and community-onset infection methicillin-susceptible Staphylococcus aureus isolates in two Taiwan medical centers Feng-Jui Chen, Leung-Kei Siu, Jung-Chung Lin, Chen-Her Wang, Po-Liang Lu BMC Infectious Diseases 2012, 12:343 (10 December 2012) Abstract \| Full text \| PDF \| PubMed
	23.	Research article *Multiple-omic data analysis of Klebsiella pneumoniae* MGH 78578 reveals its transcriptional architecture and regulatory features** Joo-Hyun Seo, Jay Sung-Joong Hong, Donghyuk Kim, Byung-Kwan Cho, Tzu-Wen Huang, Shih-Feng Tsai, Bernhard O Palsson, Pep Charusanti BMC Genomics 2012, 13:679 (29 November 2012) Abstract \| Full text \| PDF \| PubMed
	24.	Research article Increased risk of affective disorders in type 2 diabetes is minimized by sulfonylurea and metformin combination: a population-based cohort study Mark L Wahlqvist, Meei-Shyuan Lee, Shao-Yuan Chuang, Chih-Cheng Hsu, Hsin-Ni Tsai, Shu-Han Yu, Hsing-Yi Chang BMC Medicine 2012, 10:150 (29 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Type 2 diabetes patients treated with a combination of metformin and sulfonylurea have a lower risk of developing affective disorder than those not on these drugs, which may be relevant to reducing mental health problems in diabetes patients.
	25.	Research article Cell population-specific expression analysis of human cerebellum Alexandre Kuhn, Azad Kumar, Alexandra Beilina, Allissa Dillman, Mark R Cookson, Andrew B Singleton BMC Genomics 2012, 13:610 (12 November 2012) Abstract \| Full text \| PDF \| PubMed