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1.

Research article   Open Access

Computational modelling of the regulation of Insulin signalling by oxidative stress

Graham R Smith, Daryl P Shanley BMC Systems Biology 2013, 7:41 (24 May 2013)

Abstract | Provisional PDF

2.

Debate   Open Access Highly Accessed

Knowledge translation of research findings

Jeremy M Grimshaw, Martin P Eccles, John N Lavis, Sophie J Hill, Janet E Squires Implementation Science 2012, 7:50 (31 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

3.

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

4.

Research   Open Access Highly Accessed

Health care priority setting: principles, practice and challenges

Craig Mitton, Cam Donaldson Cost Effectiveness and Resource Allocation 2004, 2:3 (22 April 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

Systematic review   Open Access Highly Accessed

The effectiveness of strategies to change organisational culture to improve healthcare performance: a systematic review

Elena Parmelli, Gerd Flodgren, Fiona Beyer, Nick Baillie, Mary Schaafsma, Martin P Eccles Implementation Science 2011, 6:33 (3 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

Research article   Open Access Highly Accessed

Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches The GRADE Working Group

David Atkins, Martin Eccles, Signe Flottorp, Gordon H Guyatt, David Henry, Suzanne Hill, Alessandro Liberati, Dianne O'Connell, Andrew D Oxman, Bob Phillips, Holger Schünemann, Tessa Edejer, Gunn E Vist, John W Williams, BMC Health Services Research 2004, 4:38 (22 December 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research article   Open Access Highly Accessed

Centile charts for birthweight for gestational age for Scottish singleton births

Sandra Bonellie, James Chalmers, Ron Gray, Ian Greer, Stephen Jarvis, Claire Williams BMC Pregnancy and Childbirth 2008, 8:5 (25 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

Commentary   Open Access Highly Accessed

Tackling Africa's chronic disease burden: from the local to the global

Ama de-Graft Aikins, Nigel Unwin, Charles Agyemang, Pascale Allotey, Catherine Campbell, Daniel Arhinful Globalization and Health 2010, 6:5 (19 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

Research article   Open Access Highly Accessed

Removing Noise From Pyrosequenced Amplicons

Christopher Quince, Anders Lanzen, Russell J Davenport, Peter J Turnbaugh BMC Bioinformatics 2011, 12:38 (28 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

AmpliconNoise and Perseus are novel algorithms for the removal of noise and chimeras from pyrosequenced amplicons, reducing per-base error rates and allowing more accurate estimates of operational taxonomic units than alternative methods.

10.

Research article   Open Access Highly Accessed

Development of a theory of implementation and integration: Normalization Process Theory

Carl R May, Frances Mair, Tracy Finch, Anne MacFarlane, Christopher Dowrick, Shaun Treweek, Tim Rapley, Luciana Ballini, Bie Ong, Anne Rogers, Elizabeth Murray, Glyn Elwyn, France Légaré, Jane Gunn, Victor M Montori Implementation Science 2009, 4:29 (21 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

11.

Research article   Open Access Highly Accessed

Using quantitative and qualitative data in health services research – what happens when mixed method findings conflict? [ISRCTN61522618]

Suzanne Moffatt, Martin White, Joan Mackintosh, Denise Howel BMC Health Services Research 2006, 6:28 (8 March 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

Research article   Open Access Highly Accessed

Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial

Neil C Thomson, Adalberto S Rubin, Robert M Niven, Paul A Corris, Hans Siersted, Ronald Olivenstein, Ian D Pavord, David McCormack, Michel Laviolette, Narinder S Shargill, Gerard Cox, BMC Pulmonary Medicine 2011, 11:8 (11 February 2011)

Abstract | Full text | PDF | PubMed | 1 comment

13.

Research article   Open Access Highly Accessed

Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans

Mait Metspalu, Toomas Kivisild, Ene Metspalu, Jüri Parik, Georgi Hudjashov, Katrin Kaldma, Piia Serk, Monika Karmin, Doron M Behar, M Thomas P Gilbert, Phillip Endicott, Sarabjit Mastana, Surinder S Papiha, Karl Skorecki, Antonio Torroni, Richard Villems BMC Genetics 2004, 5:26 (31 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Research   Open Access Highly Accessed

Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire

C André Lévesque, Henk Brouwer, Liliana Cano, John P Hamilton, Carson Holt, Edgar Huitema, Sylvain Raffaele, Gregg P Robideau, Marco Thines, Joe Win, Marcelo M Zerillo, Gordon W Beakes, Jeffrey L Boore, Dana Busam, Bernard Dumas, Steve Ferriera, Susan I Fuerstenberg, Claire MM Gachon, Elodie Gaulin, Francine Govers, Laura Grenville-Briggs, Neil Horner, Jessica Hostetler, Rays HY Jiang, Justin Johnson, Theerapong Krajaejun, Haining Lin, Harold JG Meijer, Barry Moore, Paul Morris et al. Genome Biology 2010, 11:R73 (13 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The genome sequence of the plant pathogenic oomycete, Pythium ultimum and a comparison with the related potato blight pathogen genome reveals differences in pathogenicity.

15.

Research article   Open Access Highly Accessed

Physical activity in pregnancy: a qualitative study of the beliefs of overweight and obese pregnant women

Zoe Weir, Judith Bush, Stephen C Robson, Catherine McParlin, Judith Rankin, Ruth Bell BMC Pregnancy and Childbirth 2010, 10:18 (28 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Short Report   Open Access Highly Accessed

Analysing time course microarray data using Bioconductor: a case study using yeast2 Affymetrix arrays

Colin S Gillespie, Guiyuan Lei, Richard J Boys, Amanda Greenall, Darren J Wilkinson BMC Research Notes 2010, 3:81 (19 March 2010)

Abstract | Full text | PDF | PubMed

17.

Editorial   Open Access Highly Accessed

An implementation research agenda

Martin P Eccles, David Armstrong, Richard Baker, Kevin Cleary, Huw Davies, Stephen Davies, Paul Glasziou, Irene Ilott, Ann-Louise Kinmonth, Gillian Leng, Stuart Logan, Theresa Marteau, Susan Michie, Hugh Rogers, Jo Rycroft-Malone, Bonnie Sibbald Implementation Science 2009, 4:18 (7 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

Methodology   Open Access Highly Accessed

Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations

Steven Woolf, Holger J Schünemann, Martin P Eccles, Jeremy M Grimshaw, Paul Shekelle Implementation Science 2012, 7:61 (4 July 2012)

Abstract | Full text | PDF | PubMed

19.

Editorial   Open Access Highly Accessed

Specifying and reporting complex behaviour change interventions: the need for a scientific method

Susan Michie, Dean Fixsen, Jeremy M Grimshaw, Martin P Eccles Implementation Science 2009, 4:40 (16 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

20.

Research article   Open Access Highly Accessed

Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence

Catherine R Stevenson, Nita G Forouhi, Gojka Roglic, Brian G Williams, Jeremy A Lauer, Chirstopher Dye, Nigel Unwin BMC Public Health 2007, 7:234 (6 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Focused, coordinated action is needed to prevent a diabetes-driven resurgence of tuberculosis in regions where diabetes is epidemic and TB endemic.

21.

Methodology   Open Access Highly Accessed

Developing clinical practice guidelines: reviewing, reporting, and publishing guidelines; updating guidelines; and the emerging issues of enhancing guideline implementability and accounting for comorbid conditions in guideline development

Paul Shekelle, Steven Woolf, Jeremy M Grimshaw, Holger J Schünemann, Martin P Eccles Implementation Science 2012, 7:62 (4 July 2012)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access Highly Accessed

More in hope than expectation: a systematic review of women's expectations and experience of pain relief in labour

Joanne E Lally, Madeleine J Murtagh, Sheila Macphail, Richard Thomson BMC Medicine 2008, 6:7 (14 March 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Medicine | F1000 Biology |  Editor’s summary

Women's expectations of pain and pain relief during childbirth differ significantly from their actual experiences, highlighting the need for improved antenatal education that enables women to express their preferences but still have realistic expectations of labor.

23.

Research   Open Access Highly Accessed

Explaining clinical behaviors using multiple theoretical models

Martin P Eccles, Jeremy M Grimshaw, Graeme MacLennan, Debbie Bonetti, Liz Glidewell, Nigel B Pitts, Nick Steen, Ruth Thomas, Anne Walker, Marie Johnston Implementation Science 2012, 7:99 (17 October 2012)

Abstract | Full text | PDF | PubMed

24.

Research article   Open Access Highly Accessed

The influence of childhood IQ and education on social mobility in the Newcastle Thousand Families birth cohort

Lynne F Forrest, Susan Hodgson, Louise Parker, Mark S Pearce BMC Public Health 2011, 11:895 (25 November 2011)

Abstract | Full text | PDF | PubMed

25.

Review   Open Access

A review of co-morbidity between infectious and chronic disease in Sub Saharan Africa: TB and Diabetes Mellitus, HIV and Metabolic Syndrome, and the impact of globalization

Fiona Young, Julia A Critchley, Lucy K Johnstone, Nigel C Unwin Globalization and Health 2009, 5:9 (14 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

26.

Study protocol   Open Access Highly Accessed

Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) Protocol

A David Mendelow, Barbara A Gregson, Patrick M Mitchell, Gordon D Murray, Elise N Rowan, Anil R Gholkar, Trials 2011, 12:124 (17 May 2011)

Abstract | Full text | PDF | PubMed

27.

Review   Open Access Highly Accessed

The DBCLS BioHackathon: standardization and interoperability for bioinformatics web services and workflows.

Toshiaki Katayama, Kazuharu Arakawa, Mitsuteru Nakao, Keiichiro Ono, Kiyoko F Aoki-Kinoshita, Yasunori Yamamoto, Atsuko Yamaguchi, Shuichi Kawashima, Hong-Woo Chun, Jan Aerts, Bruno Aranda, Lord Barboza, Raoul JP Bonnal, Richard Bruskiewich, Jan C Bryne, José M Fernández, Akira Funahashi, Paul MK Gordon, Naohisa Goto, Andreas Groscurth, Alex Gutteridge, Richard Holland, Yoshinobu Kano, Edward A Kawas, Arnaud Kerhornou, Eri Kibukawa, Akira R Kinjo, Michael Kuhn, Hilmar Lapp, Heikki Lehvaslaiho et al. Journal of Biomedical Semantics 2010, 1:8 (21 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

Review   Subscription

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Jane WY Ng, Laura M Barrett, Andrew Wong, Diana Kuh, George Smith, Caroline L Relton Genome Biology 2012, 13:246 (29 June 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Longitudinal cohort studies provide an opportunity to study how changes in epigenetic patterns occur in response to diverse factors

29.

Editorial   Open Access Highly Accessed

Implementation Science six years on—our evolving scope and common reasons for rejection without review

Martin P Eccles, Robbie Foy, Anne Sales, Michel Wensing, Brian Mittman Implementation Science 2012, 7:71 (27 July 2012)

Abstract | Full text | PDF | PubMed

30.

Research   Open Access

Implementing nutrition guidelines for older people in residential care homes: a qualitative study using Normalization Process Theory

Claire Bamford, Ben Heaven, Carl May, Paula Moynihan Implementation Science 2012, 7:106 (30 October 2012)

Abstract | Full text | PDF | PubMed

31.

Research   Open Access Highly Accessed

Ethical issues posed by cluster randomized trials in health research

Charles Weijer, Jeremy M Grimshaw, Monica Taljaard, Ariella Binik, Robert Boruch, Jamie C Brehaut, Allan Donner, Martin P Eccles, Antonio Gallo, Andrew D McRae, Raphael Saginur, Merrick Zwarenstein Trials 2011, 12:100 (20 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

32.

Methodology   Open Access Highly Accessed

Developing clinical practice guidelines: target audiences, identifying topics for guidelines, guideline group composition and functioning and conflicts of interest

Martin P Eccles, Jeremy M Grimshaw, Paul Shekelle, Holger J Schünemann, Steven Woolf Implementation Science 2012, 7:60 (4 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

Research article   Open Access Highly Accessed

Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? A systematic review and meta-analysis

Nicola Hobbs, Alan Godfrey, Jose Lara, Linda Errington, Thomas D Meyer, Lynn Rochester, Martin White, John C Mathers, Falko F Sniehotta BMC Medicine 2013, 11:75 (19 March 2013)

Abstract | Provisional PDF | PubMed | 1 comment |  Editor’s summary

It is important to remain active in retirement to reduce the risk of age-related diseases; evidence from a systematic review and meta-analysis shows interventions improve physical activity in older adults, so could have significant health benefits.

34.

Research   Open Access

Production and validation of a good manufacturing practice grade human fibroblast line for supporting human embryonic stem cell derivation and culture

Nilendran Prathalingam, Linda Ferguson, Lesley Young, Georg Lietz, Rachel Oldershaw, Lyn Healy, Albert Craig, Helen Lister, Rakesh Binaykia, Radhika Sheth, Alison Murdoch, Mary Herbert Stem Cell Research & Therapy 2012, 3:12 (28 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The human fibroblast line Ncl1Fed1A, produced in compliance with good manufacturing practice (GMP) standards, has been qualified for derivation and maintenance of human embryonic stem cells (hESCs).

35.

Research article   Open Access Highly Accessed

Understanding the implementation of complex interventions in health care: the normalization process model

Carl May, Tracy Finch, Frances Mair, Luciana Ballini, Christopher Dowrick, Martin Eccles, Linda Gask, Anne MacFarlane, Elizabeth Murray, Tim Rapley, Anne Rogers, Shaun Treweek, Paul Wallace, George Anderson, Jo Burns, Ben Heaven BMC Health Services Research 2007, 7:148 (19 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

Debate   Open Access Highly Accessed

Designing theoretically-informed implementation interventions

Implementation Science 2006, 1:4 (23 February 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

Study protocol   Open Access Highly Accessed

Strengthening evaluation and implementation by specifying components of behaviour change interventions: a study protocol

Susan Michie, Charles Abraham, Martin P Eccles, Jill J Francis, Wendy Hardeman, Marie Johnston Implementation Science 2011, 6:10 (7 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

Research   Open Access Highly Accessed

Using shared goal setting to improve access and equity: a mixed methods study of the Good Goals intervention in children’s occupational therapy

Niina Kolehmainen, Graeme MacLennan, Laura Ternent, Edward AS Duncan, Eilidh M Duncan, Stephen B Ryan, Lorna McKee, Jill J Francis Implementation Science 2012, 7:76 (16 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

Correspondence   Open Access

Improving recognition of delirium in clinical practice: a call for action

Andrew Teodorczuk, Emma Reynish, Koen Milisen BMC Geriatrics 2012, 12:55 (14 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Delirium is under-recognized by health professionals due to its low strategic and financial priorities, suggesting more targeted education at individual and organizational levels is needed.

40.

Research article   Open Access Highly Accessed

GSK3 and p53 - is there a link in Alzheimer's disease?

Carole J Proctor, Douglas A Gray Molecular Neurodegeneration 2010, 5:7 (26 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

Research article   Open Access Highly Accessed

The improving outcomes in intermittent exotropia study: outcomes at 2 years after diagnosis in an observational cohort

Deborah Buck, Christine J Powell, Jugnoo Rahi, Phillippa Cumberland, Peter Tiffin, Robert Taylor, John Sloper, Helen Davis, Emma Dawson, Michael P Clarke BMC Ophthalmology 2012, 12:1 (18 January 2012)

Abstract | Full text | PDF | PubMed

42.

Review   Subscription Highly Accessed

Pharmacogenomics of adverse drug reactions

Ann K Daly Genome Medicine 2013, 5:5 (29 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Ann Daly reviews progress in identification of pharmacogenomic risk factors for serious adverse drug reactions, including different approaches used, and prospects for further progress.

43.

Research article   Open Access Highly Accessed

Integrating telecare for chronic disease management in the community: What needs to be done?

Carl R May, Tracy L Finch, James Cornford, Catherine Exley, Claire Gately, Sue Kirk, K Jenkings, Janice Osbourne, A Robinson, Anne Rogers, Robert Wilson, Frances S Mair BMC Health Services Research 2011, 11:131 (27 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

Research   Open Access

What helps and hinders midwives in engaging with pregnant women about stopping smoking? A cross-sectional survey of perceived implementation difficulties among midwives in the North East of England

Jane Beenstock, Falko F Sniehotta, Martin White, Ruth Bell, Eugene MG Milne, Vera Araujo-Soares Implementation Science 2012, 7:36 (24 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

45.

Review   Open Access Highly Accessed

How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor

Suzanne Madgwick, Keith T Jones Cell Division 2007, 2:4 (26 January 2007)

Abstract | Full text | PDF | PubMed

46.

Editorial   Open Access

Requirements for ethics committee review for studies submitted to Implementation Science

Martin P Eccles, Charles Weijer, Brian Mittman Implementation Science 2011, 6:32 (31 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

47.

Research   Open Access Highly Accessed

Isolation and characterisation of human pulmonary microvascular endothelial cells from patients with severe emphysema

Laura S Mackay, Sara Dodd, Iain G Dougall, Wendy Tomlinson, James Lordan, Andrew J Fisher, Paul A Corris Respiratory Research 2013, 14:23 (20 February 2013)

Abstract | Full text | PDF | PubMed

48.

Research   Open Access

Altering gait by way of stimulation of the plantar surface of the foot: the immediate effect of wearing textured insoles in older fallers

Anna L Hatton, John Dixon, Keith Rome, Julia L Newton, Denis J Martin Journal of Foot and Ankle Research 2012, 5:11 (30 April 2012)

Abstract | Full text | PDF | PubMed

49.

Commentary   Open Access Highly Accessed

Biological functions of natural antisense transcripts

Andreas Werner BMC Biology 2013, 11:31 (12 April 2013)

Abstract | Full text | PDF | PubMed

50.

Research article   Open Access Highly Accessed

Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system

David Atkins, Peter A Briss, Martin Eccles, Signe Flottorp, Gordon H Guyatt, Robin T Harbour, Suzanne Hill, Roman Jaeschke, Alessandro Liberati, Nicola Magrini, James Mason, Dianne O'Connell, Andrew D Oxman, Bob Phillips, Holger Schünemann, Tessa Edejer, Gunn E Vist, John W Williams, BMC Health Services Research 2005, 5:25 (23 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A pilot study of the GRADE approach to grading evidence and recommendations showed that it balanced the need for simplicity with the need for full and transparent consideration of all important issues.

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