Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar
Malaria Journal 2003, 2:25 (24 July 2003)
This is a useful contribution to the study of Madagascan medicinal plants, which shows
care and sensitivity in collecting the ethnobotanical data.
Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
BMC Microbiology 2006, 6:23 (6 March 2006)
Gametocytogenesis : the puberty of Plasmodium falciparum
Malaria Journal 2004, 3:24 (14 July 2004)
A review which addresses several aspects of gametocyte biology, focusing on sex differentiation and determination, transmission strategies and evolution; it highlight areas where the gametocyte might be targetted for control interventions.
Implication of haematophagous arthropod salivary proteins in host-vector interactions
Parasites & Vectors 2011, 4:187 (28 September 2011)
This review summarises the pharmacological activity and immunogenic properties of salivary proteins characterised in various haematophagous arthropod species and the usefulness of immunogenic salivary molecules to treat allergic reactions to arthropod bites, to improve host protection against vector-borne diseases or to assess host/vector contacts. Image : The role of haematophagous arthropod saliva in counteracting host haemostatic and immune defences.
In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria
Malaria Journal 2011, 10:346 (25 November 2011)
Surprisingly, while Plasmodium falciparum has been grown in vitro for many years, other malaria parasites have always proven much more difficult to adapt. Optimization of the in vitro culture conditions for P. berghei parasites is likely open up the field.
Sentinel surveillance system for early outbreak detection in Madagascar
BMC Public Health 2010, 10:31 (21 January 2010)
Dissemination of multidrug resistant Acinetobacter baumannii in various hospitals of Antananarivo Madagascar
Annals of Clinical Microbiology and Antimicrobials 2010, 9:17 (30 June 2010)
Distribution of the species of the Anopheles gambiae complex and first evidence of Anopheles merus as a malaria vector in Madagascar
Malaria Journal 2003, 2:33 (8 October 2003)
It is a Herculean task to survey the distribution of Anopheles over a large country like Madagascar and this study, using state-of-the-art molecular typing techniques, provides important information in a rapidly changing environment.
Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective
cohort with intensive malaria screening and prompt treatment
Malaria Journal 2013, 12:139 (24 April 2013)
Malaria in pregnancy is a major public health problem in endemic areas of sub-Saharan Africa and has important consequences on birth outcome. In this study, the timing, parasitaemia level and number of peripherally-detected malaria infections, but not the presence of fever, were associated with adverse birth outcomes. Hence, prompt malaria detection and treatment should be offered to pregnant women, with increased focus on mothers living in remote areas.
Environmental determinant of malaria cases among travellers
Malaria Journal 2013, 12:87 (4 March 2013)
A vey detailed study of environmental influences that may be important in long-term exposure of non-immune visitors to the Ivory Coast. The authors correctly point out that the threat of malaria can be controlled by the compliant use of preventative measures and that this is often done badly.
Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?
Malaria Journal 2011, 10(Suppl 1):S7 (15 March 2011)
A possible alternative method for collecting mosquito larvae in rice fields
Malaria Journal 2002, 1:4 (8 April 2002)
Plasmodium vivax and Plasmodium falciparum infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants
Malaria Journal 2012, 11:395 (28 November 2012)
The paper adds to the increasing scientific literature addressing the monitoring of naturally acquired humoral immune responses to malaria antigens as a measure of transmission and malaria risk in regions targeted for elimination.
Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis
van den Broek,
Malaria Journal 2009, 8:203 (23 August 2009)
This multi-center analysis study addresses efficacy of artesunate-amodiaquine, a very important candidate for the treatment of uncomplicated malaria globally. The analysis of patient-level data examining the efficacy of AS&AQ compared to local standard therapy, makes a strong case for the use of AS&AQ in all transmission settings.
Multiple host-switching of Haemosporidia parasites in bats
Malaria Journal 2007, 6:157 (29 November 2007)
Understanding parasites of bats has a broad significance to the study of a potential emergence of infectious disease in humans; in addition, studies of haemosporida in bats are rare and these are the first molecular data available. The geographical location of the study in Madagascar and Cambodia, two areas of considerable animal biodiversity, is also noteworthy.
Management of uncomplicated malaria in febrile under five-year-old children by community health workers in Madagascar: reliability of malaria rapid diagnostic tests
Malaria Journal 2012, 11:85 (25 March 2012)
A study of test performance characteristics of rapid malaria diagnostics when used by community health workers. Consistent with past studies, RDTs appear to be accurate in the hands of minimally-trained CHWs and add value for management of fever in among children in remote settings without access to quality-controlled laboratory facilities.
Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests
Malaria Journal 2010, 9:129 (17 May 2010)
This paper describes the extensive sequencing and comparison of histidine-rich proteins II and III deduced protein sequences in a significant collection of samples from malaria transmission areas around the globe. The authors report the characterization of a number of features of this exceedingly variable protein, but fail to find a correlation between the variability of the protein and the sensitivity of rapid diagnostic tests.
Assessment of Anopheles salivary antigens as individual exposure biomarkers to species-specific malaria vector bites
Malaria Journal 2012, 11:439 (31 December 2012)
The authors confirm an approach for detecting IgG responses to Anopheles salivary antigens as individual exposure biomarkers to the bites of different anopheline species (An. funestus, An. gambiae s.l.) in three localities of Senegal where vector densities and species compositions vary.
World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology
Malaria Journal 2007, 6:122 (6 September 2007)
The determinants of treatment response are multi-factorial, but reaching adequate blood concentrations is pivotal to cure. Pharmacokinetic data can inform on optimal dosing, but only small number of patients have been studied, with even less conducted in the most vulnerable populations. A better understanding of the pharmacokinetic properties of antimalarials and a more clear definition of what constitutes “therapeutic drug levels” would allow more precise use of the term “antimalarial resistance”, as it would indicate when treatment failure is not caused by intrinsic parasite resistance but is the result of inadequate drug levels.
Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum
Malaria Journal 2012, 11:45 (14 February 2012)
The susceptibility of the 181 P. falciparum isolates to the nine anti-malarial drugs was assessed using the standard 42-hours 3H-hypoxanthine uptake inhibition method.
IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal
Malaria Journal 2012, 11:72 (16 March 2012)
Paper on an alternative way to measure entomological exposure in malaria studies, by the detection of human immunoglobulins to a specific Anopheles saliva antigen.
Anopheles salivary gland proteomes from major malaria vectors
BMC Genomics 2012, 13:614 (13 November 2012)
Vivax malaria in Mauritania includes infection of a Duffy-negative individual
Ould Mohamed Salem Boukhary,
Ould Ahmedou Salem,
Malaria Journal 2011, 10:336 (3 November 2011)
The paper further documents the susceptibility of individuals previously considered to be resistant to P. vivax infection and disease. Moreover, with previous reports, their findings in Mauritania now illustrate that the capacity of P. vivax to infect Duffy-negatives spans from coastal western Africa to eastern African study locations in Kenya and in Madagascar.
Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria
Malaria Journal 2009, 8:125 (8 June 2009)
A carefully-conducted clinical trial presenting a three-armed randomized, non-inferiority, multicentre study of a fixed-dose artesunate-amodiaquine combination either administered once or twice daily compared with standard artemether-lumefantrine treatment during a follow-up duration of 28 days with PCR-corrected cure rates.
Assessment of the efficacy of antimalarial drugs recommended by the National Malaria Control Programme in Madagascar: Up-dated baseline data from randomized and multi-site clinical trials
Malaria Journal 2008, 7:55 (4 April 2008)
A study that provides important updated antimalarial drug efficacy surveillance data in an area of Africa where such data was previously limited. After setting up a high quality sentinel site surveillance system, the study was conducted using widely accepted standardized guidelines