Campylobacter infection in a cohort of rural children in Moramanga, Madagascar
BMC Infectious Diseases 2014, 14:372 (5 July 2014)
Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study
Malaria Journal 2014, 13:110 (21 March 2014)
A new flow-cytometry-based method, with the unique application to studying the schizont/merozoite to ring transition, which can be used to evaluate in vitro anti-malarial drug susceptibility on isolates of P. falciparum.
Antimicrobial resistance of bacterial enteropathogens isolated from stools in Madagascar
BMC Infectious Diseases 2014, 14:104 (25 February 2014)
Entomological and parasitological impacts of indoor residual spraying with DDT, alphacypermethrin and deltamethrin in the western foothill area of Madagascar
Malaria Journal 2014, 13:21 (14 January 2014)
Entomological and parasitological impact of IRS in a specific area in Madagascar.
This kind of information is relevant to the field of vector control efficacy evaluation.
Efficacy and safety of artemether + lumefantrine, artesunate + sulphamethoxypyrazine-pyrimethamine and artesunate + amodiaquine and sulphadoxine-pyrimethamine + amodiaquine in the treatment of uncomplicated falciparum malaria in Bangui, Central African Republic: a randomized trial
Malaria Journal 2014, 13:9 (7 January 2014)
A four-arm clinical trial comparing the efficacies of leading combination therapies for uncomplicated falciparum malaria in Central African Republic a country for which very limited data are available on anti-malarial treatment efficacy.
In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene
Malaria Journal 2013, 12:431 (25 November 2013)
The paper addresses the correlation between the in vitro activity of the anti-malarial drugs chloroquine and piperaquine in Plasmodium falciparum isolates collected from malaria patients. Although chloroquine has been removed from clinical use more than a decade ago, the results are of more than academic interest, because chloroquine resistance continues to be the benchmark for such studies.
Epidemiology of malaria in an area of seasonal transmission in Niger and implications for the design of a seasonal malaria chemoprevention strategy
Malaria Journal 2013, 12:379 (30 October 2013)
The authors describe the malaria epidemiology in a village in Niger - an area of seasonal transmission - and argue that more targeted strategies for malaria control in Niger are needed, because existing strategies have only had modest success so far. One way forward would be to implement seasonal malaria chemoprevention (SMC) ¿ for which the baseline (seasonal) epidemiology of malaria needs to be described better.
Towards a better understanding of Rift Valley fever epidemiology in the south-west of the Indian Ocean
Jean Jose Nipomichene,
Veterinary Research 2013, 44:78 (9 September 2013)
Thomas Balenghien and colleagues describe that a single infected animal can trigger a major outbreak of Rift Valley Fever when entering a country with no history of infection.
Surveillance and control of rabies in La Reunion, Mayotte, and Madagascar
Veterinary Research 2013, 44:77 (9 September 2013)
Inland valley rice production systems and malaria infection and disease in the forest region of western Côte d’Ivoire
Malaria Journal 2013, 12:233 (10 July 2013)
A study to determine the epidemiological impact of rice cultivation in inland valleys on malaria in the forest region of western Cote d'Ivoire, based on a rich unpublished dataset, which puts the entomological data into a historical perspective.
Population genetics analysis during the elimination process of Plasmodium falciparum in Djibouti
Malaria Journal 2013, 12:201 (13 June 2013)
Djibouti is a small country on the edge of the endemic distribution of malaria in the horn of Africa, which has been considered as having potential for future local malaria elimination. This study analyses the genetic diversity of P. falciparum sampled at four different time points and discusses results in the context of the possibility for future elimination.
In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na +/H + exchanger transporter ( Pfnhe-1) gene in 393 isolates from Dakar, Senegal
Malaria Journal 2013, 12:189 (7 June 2013)
Evaluation of the association between the Pfnhe polymorphism and quinine susceptibility in isolates from Senegal, aiming to assess the validity of Pfnhe as a molecular marker of QN susceptibility.
Activation of minority-variant Plasmodium vivax hypnozoites following artesunate + amodiaquine treatment in a 23-year old man with relapsing malaria in Antananarivo, Madagascar
Malaria Journal 2013, 12:177 (31 May 2013)
In endemic areas, Plasmodium vivax relapses are difficult to distinguish from new infections. Parasite DNA extracted from blood samples was analysed to compare the genotypic profile of the P. vivax isolates collected from the patient during each of the three malaria episodes.
Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective
cohort with intensive malaria screening and prompt treatment
Malaria Journal 2013, 12:139 (24 April 2013)
Malaria in pregnancy is a major public health problem in endemic areas of sub-Saharan Africa and has important consequences on birth outcome. In this study, the timing, parasitaemia level and number of peripherally-detected malaria infections, but not the presence of fever, were associated with adverse birth outcomes. Hence, prompt malaria detection and treatment should be offered to pregnant women, with increased focus on mothers living in remote areas.
Molecular characterization of multidrug-resistant extended-spectrum β-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar
BMC Microbiology 2013, 13:85 (17 April 2013)
Diversity of culturable bacteria including Pantoea in wild mosquito Aedes albopictus
BMC Microbiology 2013, 13:70 (27 March 2013)
Environmental determinant of malaria cases among travellers
Malaria Journal 2013, 12:87 (4 March 2013)
A vey detailed study of environmental influences that may be important in long-term exposure of non-immune visitors to the Ivory Coast. The authors correctly point out that the threat of malaria can be controlled by the compliant use of preventative measures and that this is often done badly.
Assessment of Anopheles salivary antigens as individual exposure biomarkers to species-specific malaria vector bites
Malaria Journal 2012, 11:439 (31 December 2012)
The authors confirm an approach for detecting IgG responses to Anopheles salivary antigens as individual exposure biomarkers to the bites of different anopheline species (An. funestus, An. gambiae s.l.) in three localities of Senegal where vector densities and species compositions vary.
Plasmodium vivax and Plasmodium falciparum infections in the Republic of Djibouti: evaluation of their prevalence and potential determinants
Malaria Journal 2012, 11:395 (28 November 2012)
The paper adds to the increasing scientific literature addressing the monitoring of naturally acquired humoral immune responses to malaria antigens as a measure of transmission and malaria risk in regions targeted for elimination.
Anopheles salivary gland proteomes from major malaria vectors
BMC Genomics 2012, 13:614 (13 November 2012)
Management of uncomplicated malaria in febrile under five-year-old children by community health workers in Madagascar: reliability of malaria rapid diagnostic tests
Malaria Journal 2012, 11:85 (25 March 2012)
A study of test performance characteristics of rapid malaria diagnostics when used by community health workers. Consistent with past studies, RDTs appear to be accurate in the hands of minimally-trained CHWs and add value for management of fever in among children in remote settings without access to quality-controlled laboratory facilities.
The implementation of malaria intermittent preventive trialtreatment with sulphadoxine-pyrimethamine in infants reduced all-cause mortality in the district of Kolokani, Mali: results from a cluster randomized control
Malaria Journal 2012, 11:73 (16 March 2012)
The implementation of the IPTi-SP in Mali resulted in a substantial reduction in all-cause mortality in children. The results of this study support the adoption and the implementation of IPTi-SP as malaria control strategy.
IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal
Malaria Journal 2012, 11:72 (16 March 2012)
Paper on an alternative way to measure entomological exposure in malaria studies, by the detection of human immunoglobulins to a specific Anopheles saliva antigen.
Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum
Malaria Journal 2012, 11:45 (14 February 2012)
The susceptibility of the 181 P. falciparum isolates to the nine anti-malarial drugs was assessed using the standard 42-hours 3H-hypoxanthine uptake inhibition method.
In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria
Malaria Journal 2011, 10:346 (25 November 2011)
Surprisingly, while Plasmodium falciparum has been grown in vitro for many years, other malaria parasites have always proven much more difficult to adapt. Optimization of the in vitro culture conditions for P. berghei parasites is likely open up the field.