Learning contextual gene set interaction networks of cancer with condition specificity
BMC Genomics 2013, 14:110 (19 February 2013)
A practical method to target individuals for outbreak detection and control
BMC Medicine 2013, 11:36 (12 February 2013)
Gerardo Chowell and Cécile Viboud comment on a novel method that identifies risk of influenza transmission and allows early detection of infection in schools, but caution that this promising method needs testing on outbreaks in different settings.
Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes
BMC Genomics 2013, 14:49 (23 January 2013)
Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax?
Malaria Journal 2013, 12:15 (11 January 2013)
In this article, the authors use a model to examine difference in the life-histories of P. falciparum and P. vivax and its consequences for the evolution of drug resistance. The paper highlights the paucity of research focusing on the effect of gametocyta emia dynamics in the evolution of mutations associated with resistance.
GR-FET application for high-frequency detection device
Nanoscale Research Letters 2013, 8:22 (10 January 2013)
Microbe observation and cultivation array (MOCA) for cultivating and analyzing environmental microbiota
Microbiome 2013, 1:4 (9 January 2013)
A new system to cultivate bacteria is described, which consists of a Petri dish that contains an array of droplets as cultivation chambers and provides a cost-efficient platform for isolation of bacteria from natural environments.
Systems integrity in health and aging - an animal model approach
Longevity & Healthspan 2013, 2:2 (7 January 2013)
Revisiting the evolution of mouse LINE-1 in the genomic era
Mobile DNA 2013, 4:3 (3 January 2013)
Functional α7 β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides
BMC Neuroscience 2012, 13:155 (29 December 2012)
High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems
Retrovirology 2012, 9:108 (17 December 2012)
Deep sequencing defines HIV-1 population complexity and structure, reveals the ebb and flow of dominant and rare viral variants in the host ecosystem, and identifies an evolutionary record of low-frequency cell-associated viral V3 variants that persist for years.
Extinction learning deficit in a rodent model of attention-deficit hyperactivity disorder
Behavioral and Brain Functions 2012, 8:59 (13 December 2012)
Multiple virtual screening approaches for finding new Hepatitis c virus RNA-dependent RNA polymerase inhibitors: Structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors
BMC Bioinformatics 2012, 13(Suppl 17):S5 (13 December 2012)
The age distribution of mortality due to influenza: pandemic and peri-pandemic
BMC Medicine 2012, 10:162 (12 December 2012)
Mathematical modeling of influenza mortality rates shows that emerging virus strains are similar to those that were present previously, suggesting that mortality levels are affected by virulence and moderated by acquired immunity in older people.
Local population structure of Plasmodium: impact on malaria control and elimination
Malaria Journal 2012, 11:412 (11 December 2012)
This investigation explores the problem of identifying genetic markers, in this case microsatellites, to unveil Plasmodium genetic structures that could affect decisions in the context of elimination. This may have a huge impact for designing malaria control programmes.
Modeling rapidly disseminating infectious disease during mass gatherings
BMC Medicine 2012, 10:159 (7 December 2012)
Gerardo Chowell and colleagues review models of infectious disease transmission at mass gatherings, and discuss factors influencing model formulation, proposing strategies for better integration with outbreak management.
Paternal kin recognition in the high frequency / ultrasonic range in a solitary foraging mammal
BMC Ecology 2012, 12:26 (30 November 2012)
Analysis of the ultrasonic advertisement calls of grey mouse lemurs reveals distinct signatures among paternally related individuals, which may have evolved as a method of inbreeding avoidance by allowing females to recognize the calls of their fathers.
Differential proteomics and physiology of Pseudomonas putida KT2440 under filament-inducing conditions
BMC Microbiology 2012, 12:282 (27 November 2012)
Alcohol beverage control, privatization and the geographic distribution of alcohol outlets
BMC Public Health 2012, 12:1015 (21 November 2012)
Effects of Carpal Tunnel Syndrome on adaptation of multi-digit forces to object mass distribution for whole-hand manipulation
Journal of NeuroEngineering and Rehabilitation 2012, 9:83 (21 November 2012)
The influence of climatic conditions on the transmission dynamics of the 2009 A/H1N1 influenza pandemic in Chile
BMC Infectious Diseases 2012, 12:298 (13 November 2012)
Commenting on the effects of surface treated- and non-surface treated TiO 2 in the Caco-2 cell model
Particle and Fibre Toxicology 2012, 9:42 (12 November 2012)
Ethnicity and elevated liver transaminases among newly diagnosed children with type 2 diabetes
BMC Pediatrics 2012, 12:174 (7 November 2012)
Hispanics adolescents with type 2 diabetes mellitus (T2DM) are more likely than their African-American counterparts to have elevated alanine transaminases, suggesting that they may be at higher risk of developing non-alcoholic fatty liver disease (NAFLD).
Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury
Journal of Neuroinflammation 2012, 9:247 (30 October 2012)
Sharing and re-use of phylogenetic trees (and associated data) to facilitate synthesis
BMC Research Notes 2012, 5:574 (22 October 2012)
As part of our series on data sharing Arlin Stoltzfus and colleagues call for a standardized system for handling information from phylogenetic trees, including centralized data deposition, and user friendly means of data retrieval and integration.
Resistance to malaria in humans: the impact of strong, recent selection
Malaria Journal 2012, 11:349 (22 October 2012)
Malaria resistance genes comprise some of the most widely accepted examples of strong positive selection in humans. Overall, the original ¿malaria hypothesis¿ of Haldane that diseases like thalassaemia are polymorphisms because of resistance to malaria, has been proven correct. However, much is still to be learned about actual mechanisms of protection, other genes that confer resistance, and the population genetics of this variation.