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1.

Original article   Open Access

Tip induced fluorescence quenching for nanometer optical and topographical resolution

Olaf Schulz, Zhao Zhao, Alex Ward, Marcelle Koenig, Felix Koberling, Yan Liu, Jörg Enderlein, Hao Yan, Robert Ros Optical Nanoscopy 2013, 2:1 (21 February 2013)

Abstract | Provisional PDF

2.

Commentary   Open Access

A practical method to target individuals for outbreak detection and control

Gerardo Chowell, Cecile Viboud BMC Medicine 2013, 11:36 (12 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Gerardo Chowell and Cécile Viboud comment on a novel method that identifies risk of influenza transmission and allows early detection of infection in schools, but caution that this promising method needs testing on outbreaks in different settings.

3.

Research article   Open Access Highly Accessed

Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes

Walter L Eckalbar, Elizabeth D Hutchins, Glenn J Markov, April N Allen, Jason J Corneveaux, Kerstin Lindblad-Toh, Federica Di Palma, Jessica Alföldi, Matthew J Huentelman, Kenro Kusumi BMC Genomics 2013, 14:49 (23 January 2013)

Abstract | Full text | PDF | PubMed

4.

Research   Open Access Highly Accessed

Fitness components and natural selection: why are there different patterns on the emergence of drug resistance in Plasmodium falciparum and Plasmodium vivax?

Kristan A Schneider, Ananias A Escalante Malaria Journal 2013, 12:15 (11 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In this article, the authors use a model to examine difference in the life-histories of P. falciparum and P. vivax and its consequences for the evolution of drug resistance. The paper highlights the paucity of research focusing on the effect of gametocyta emia dynamics in the evolution of mutations associated with resistance.

5.

Nano Express   Open Access

GR-FET application for high-frequency detection device

Akram M Mahjoub, Alec Nicol, Takuto Abe, Takahiro Ouchi, Yuhei Iso, Michio Kida, Noboyuki Aoki, Katsuhiko Miyamoto, Takashige Omatsu, Jonathan P Bird, David K Ferry, Koji Ishibashi, Yuichi Ochiai Nanoscale Research Letters 2013, 8:22 (10 January 2013)

Abstract | Full text | PDF | PubMed

6.

Methodology   Open Access

Microbe observation and cultivation array (MOCA) for cultivating and analyzing environmental microbiota

Weimin Gao, Dena Navarroli, Jared Naimark, Weiwen Zhang, Shih-hui Chao, Deirdre R Meldrum Microbiome 2013, 1:4 (9 January 2013)

Abstract | Full text | PDF |  Editor’s summary

A new system to cultivate bacteria is described, which consists of a Petri dish that contains an array of droplets as cultivation chambers and provides a cost-efficient platform for isolation of bacteria from natural environments.

7.

Review   Open Access

Systems integrity in health and aging - an animal model approach

Marije Oostindjer, Gro V Amdam Longevity & Healthspan 2013, 2:2 (7 January 2013)

Abstract | Full text | PDF

8.

Research article   Open Access Highly Accessed

Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides

Qiang Liu, Yao Huang, Jianxin Shen, Scott Steffensen, Jie Wu BMC Neuroscience 2012, 13:155 (29 December 2012)

Abstract | Full text | PDF | PubMed

9.

Research   Open Access Highly Accessed

High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems

Li Yin, Li Liu, Yijun Sun, Wei Hou, Amanda C Lowe, Brent P Gardner, Marco Salemi, Wilton B Williams, William G Farmerie, John W Sleasman, Maureen M Goodenow Retrovirology 2012, 9:108 (17 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Deep sequencing defines HIV-1 population complexity and structure, reveals the ebb and flow of dominant and rare viral variants in the host ecosystem, and identifies an evolutionary record of low-frequency cell-associated viral V3 variants that persist for years.

10.

Research   Open Access

Extinction learning deficit in a rodent model of attention-deficit hyperactivity disorder

Ryan J Brackney, Timothy HC Cheung, Katrina Herbst, Jade C Hill, Federico Sanabria Behavioral and Brain Functions 2012, 8:59 (13 December 2012)

Abstract | Full text | PDF | PubMed

11.

Proceedings   Open Access

Multiple virtual screening approaches for finding new Hepatitis c virus RNA-dependent RNA polymerase inhibitors: Structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors

Mahmoud ElHefnawi, Mohammad ElGamacy, Mohamed Fares BMC Bioinformatics 2012, 13(Suppl 17):S5 (13 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

Research article   Open Access

The age distribution of mortality due to influenza: pandemic and peri-pandemic

Tom Reichert, Gerardo Chowell, Jonathan A McCullers BMC Medicine 2012, 10:162 (12 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Mathematical modeling of influenza mortality rates shows that emerging virus strains are similar to those that were present previously, suggesting that mortality levels are affected by virulence and moderated by acquired immunity in older people.

13.

Research   Open Access Highly Accessed

Local population structure of Plasmodium: impact on malaria control and elimination

Stella M Chenet, Kristan A Schneider, Leopoldo Villegas, Ananias A Escalante Malaria Journal 2012, 11:412 (11 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This investigation explores the problem of identifying genetic markers, in this case microsatellites, to unveil Plasmodium genetic structures that could affect decisions in the context of elimination. This may have a huge impact for designing malaria control programmes.

14.

Review   Open Access

Modeling rapidly disseminating infectious disease during mass gatherings

Gerardo Chowell, Hiroshi Nishiura, Cécile Viboud BMC Medicine 2012, 10:159 (7 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Gerardo Chowell and colleagues review models of infectious disease transmission at mass gatherings, and discuss factors influencing model formulation, proposing strategies for better integration with outbreak management.

15.

Research article   Open Access Highly Accessed

Paternal kin recognition in the high frequency / ultrasonic range in a solitary foraging mammal

Sharon E Kessler, Marina Scheumann, Leanne T Nash, Elke Zimmermann BMC Ecology 2012, 12:26 (30 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Analysis of the ultrasonic advertisement calls of grey mouse lemurs reveals distinct signatures among paternally related individuals, which may have evolved as a method of inbreeding avoidance by allowing females to recognize the calls of their fathers.

16.

Research article   Open Access

Differential proteomics and physiology of Pseudomonas putida KT2440 under filament-inducing conditions

Aurélie Crabbé, Baptiste Leroy, Ruddy Wattiez, Abram Aertsen, Natalie Leys, Pierre Cornelis, Rob Van Houdt BMC Microbiology 2012, 12:282 (27 November 2012)

Abstract | Full text | PDF | PubMed

17.

Research article   Open Access

Alcohol beverage control, privatization and the geographic distribution of alcohol outlets

Tony H Grubesic, Alan T Murray, William Pridemore, Loni Tabb, Yin Liu, Ran Wei BMC Public Health 2012, 12:1015 (21 November 2012)

Abstract | Full text | PDF | PubMed

18.

Research   Open Access

Effects of Carpal Tunnel Syndrome on adaptation of multi-digit forces to object mass distribution for whole-hand manipulation

Wei Zhang, Jamie A Johnston, Mark A Ross, Brandon J Coakley, Elizabeth A Gleason, Amylou C Dueck, Marco Santello Journal of NeuroEngineering and Rehabilitation 2012, 9:83 (21 November 2012)

Abstract | Full text | PDF | PubMed

19.

Research article   Open Access

The influence of climatic conditions on the transmission dynamics of the 2009 A/H1N1 influenza pandemic in Chile

Gerardo Chowell, Sherry Towers, Cécile Viboud, Rodrigo Fuentes, Viviana Sotomayor, Lone Simonsen, Mark A Miller, Mauricio Lima, Claudia Villarroel, Monica Chiu, Jose E Villarroel, Andrea Olea BMC Infectious Diseases 2012, 12:298 (13 November 2012)

Abstract | Full text | PDF | PubMed

20.

Letter to the Editor   Open Access

Commenting on the effects of surface treated- and non-surface treated TiO2 in the Caco-2 cell model

James J Faust, Wen Zhang, Brian A Koeneman, Yongsheng Chen, David G Capco Particle and Fibre Toxicology 2012, 9:42 (12 November 2012)

Abstract | Full text | PDF | PubMed

21.

Research article   Open Access

Ethnicity and elevated liver transaminases among newly diagnosed children with type 2 diabetes

Omar D Hudson, Martha Nunez, Gabriel Q Shaibi BMC Pediatrics 2012, 12:174 (7 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Hispanics adolescents with type 2 diabetes mellitus (T2DM) are more likely than their African-American counterparts to have elevated alanine transaminases, suggesting that they may be at higher risk of developing non-alcoholic fatty liver disease (NAFLD).

22.

Research   Open Access Highly Accessed

Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury

Jenna M Ziebell, Samuel E Taylor, Tuoxin Cao, Jordan L Harrison, Jonathan Lifshitz Journal of Neuroinflammation 2012, 9:247 (30 October 2012)

Abstract | Full text | PDF | PubMed

23.

Data Note   Open Access Highly Accessed

Sharing and re-use of phylogenetic trees (and associated data) to facilitate synthesis

Arlin Stoltzfus, Brian O'Meara, Jamie Whitacre, Ross Mounce, Emily L Gillespie, Sudhir Kumar, Dan F Rosauer, Rutger A Vos BMC Research Notes 2012, 5:574 (22 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

As part of our series on data sharing Arlin Stoltzfus and colleagues call for a standardized system for handling information from phylogenetic trees, including centralized data deposition, and user friendly means of data retrieval and integration.

24.

Review   Open Access Highly Accessed

Resistance to malaria in humans: the impact of strong, recent selection

Philip W Hedrick Malaria Journal 2012, 11:349 (22 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Malaria resistance genes comprise some of the most widely accepted examples of strong positive selection in humans. Overall, the original ¿malaria hypothesis¿ of Haldane that diseases like thalassaemia are polymorphisms because of resistance to malaria, has been proven correct. However, much is still to be learned about actual mechanisms of protection, other genes that confer resistance, and the population genetics of this variation.

25.

Meeting abstract   Open Access

Brain imaging biomarkers for the Alzheimer’s Prevention Initiative

Kewei Chen, Adam S Fleisher, Napatkamon Ayutyanont, Jessica B Langbaum, Richard Caselli, Yakeel T Quiroz, Francisco Lopera, Pierre N Tariot, Eric M Reiman Journal of Translational Medicine 2012, 10(Suppl 2):A28 (17 October 2012)

Full text | PDF

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