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1.

Research   Open Access Highly Accessed

Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice?

Philippe Robert, Steven Ferris, Serge Gauthier, Ralf Ihl, Bengt Winblad, Frank Tennigkeit Alzheimer's Research & Therapy 2010, 2:24 (26 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

2.

Debate   Open Access Highly Accessed

Sicily statement on evidence-based practice

Martin Dawes, William Summerskill, Paul Glasziou, Antonino Cartabellotta, Janet Martin, Kevork Hopayian, Franz Porzsolt, Amanda Burls, James Osborne BMC Medical Education 2005, 5:1 (5 January 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A consensus statement from the 2003 Conference of Evidence-Based Health Care Teachers and Developers should provide direction to Evidence Based Practice research and implementation.

3.

Review   Open Access Highly Accessed

Canadian clinical practice guidelines for acute and chronic rhinosinusitis

Martin Desrosiers, Gerald A Evans, Paul K Keith, Erin D Wright, Alan Kaplan, Jacques Bouchard, Anthony Ciavarella, Patrick W Doyle, Amin R Javer, Eric S Leith, Atreyi Mukherji, R Robert Schellenberg, Peter Small, Ian J Witterick Allergy, Asthma & Clinical Immunology 2011, 7:2 (10 February 2011)

Abstract | Full text | PDF | PubMed

4.

Research article   Open Access Highly Accessed

Human papillomavirus (HPV) types 16, 18, 31, 45 DNA loads and HPV-16 integration in persistent and transient infections in young women

Agnihotram V Ramanakumar, Otelinda Goncalves, Harriet Richardson, Pierre Tellier, Alex Ferenczy, François Coutlée, Eduardo L Franco BMC Infectious Diseases 2010, 10:326 (11 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

Review   Open Access Highly Accessed

The six most essential questions in psychiatric diagnosis: a pluralogue part 1: conceptual and definitional issues in psychiatric diagnosis

James Phillips, Allen Frances, Michael A Cerullo, John Chardavoyne, Hannah S Decker, Michael B First, Nassir Ghaemi, Gary Greenberg, Andrew C Hinderliter, Warren A Kinghorn, Steven G LoBello, Elliott B Martin, Aaron L Mishara, Joel Paris, Joseph M Pierre, Ronald W Pies, Harold A Pincus, Douglas Porter, Claire Pouncey, Michael A Schwartz, Thomas Szasz, Jerome C Wakefield, G Scott Waterman, Owen Whooley, Peter Zachar Philosophy, Ethics, and Humanities in Medicine 2012, 7:3 (13 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

Review   Open Access Highly Accessed

The role of NGOs in global health research for development

Hélène Delisle, Janet Roberts, Michelle Munro, Lori Jones, Theresa W Gyorkos Health Research Policy and Systems 2005, 3:3 (21 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research   Open Access Highly Accessed

Whole-genome reconstruction and mutational signatures in gastric cancer

Niranjan Nagarajan, Denis Bertrand, Axel M Hillmer, Zhi Zang, Fei Yao, Pierre-Étienne Jacques, Audrey SM Teo, Ioana Cutcutache, Zhenshui Zhang, Wah Lee, Yee Sia, Song Gao, Pramila N Ariyaratne, Andrea Ho, Xing Woo, Lavanya Veeravali, Choon Ong, Niantao Deng, Kartiki V Desai, Chiea Khor, Martin L Hibberd, Atif Shahab, Jaideepraj Rao, Mengchu Wu, Ming Teh, Feng Zhu, Sze Chin, Brendan Pang, Jimmy BY So, Guillaume Bourque et al. Genome Biology 2012, 13:R115 (13 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In this study the whole genome sequencing is used to reveal mutational signatures in gastric cancer.

8.

Short Report   Open Access Highly Accessed

MRI assessment of cortical thickness and functional activity changes in adolescent girls following three months of practice on a visual-spatial task

Richard J Haier, Sherif Karama, Leonard Leyba, Rex E Jung BMC Research Notes 2009, 2:174 (1 September 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Brain imaging reveals a thickened brain cortex after regular playing of the videogame Tetris, while cortical activation observed during play decreases slightly with practice, in areas distinct from those showing maximum structural change.

9.

Review   Open Access

The six most essential questions in psychiatric diagnosis: a pluralogue part 3: issues of utility and alternative approaches in psychiatric diagnosis

James Phillips, Allen Frances, Michael A Cerullo, John Chardavoyne, Hannah S Decker, Michael B First, Nassir Ghaemi, Gary Greenberg, Andrew C Hinderliter, Warren A Kinghorn, Steven G LoBello, Elliott B Martin, Aaron L Mishara, Joel Paris, Joseph M Pierre, Ronald W Pies, Harold A Pincus, Douglas Porter, Claire Pouncey, Michael A Schwartz, Thomas Szasz, Jerome C Wakefield, G Waterman, Owen Whooley, Peter Zachar Philosophy, Ethics, and Humanities in Medicine 2012, 7:9 (23 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

Research   Open Access Highly Accessed

Common genetic variants, acting additively, are a major source of risk for autism

Lambertus Klei, Stephan J Sanders, Michael T Murtha, Vanessa Hus, Jennifer K Lowe, A Willsey, Daniel Moreno-De-Luca, Timothy W Yu, Eric Fombonne, Daniel Geschwind, Dorothy E Grice, David H Ledbetter, Catherine Lord, Shrikant M Mane, Christa Martin, Donna M Martin, Eric M Morrow, Christopher A Walsh, Nadine M Melhem, Pauline Chaste, James S Sutcliffe, Matthew W State, Edwin H Cook, Kathryn Roeder, Bernie Devlin Molecular Autism 2012, 3:9 (15 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Common genetic variants have a substantial additive genetic effect on autism spectrum disorder liability and this effect differs between simplex and multiplex families.

11.

Correspondence   Open Access Highly Accessed

Reducing bias through directed acyclic graphs

Ian Shrier, Robert W Platt BMC Medical Research Methodology 2008, 8:70 (30 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A simple 6-step approach to applying direct acyclic graphs in biomedical research may aid researchers to more accurately identify and adjust for multiple confounding effects and reduce the degree of bias better than traditional methods.

12.

Review   Open Access Highly Accessed

Phosphoprotein analysis: from proteins to proteomes

Frédéric Delom, Eric Chevet Proteome Science 2006, 4:15 (19 July 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

Research   Open Access Highly Accessed

Cutaneous tactile allodynia associated with microvascular dysfunction in muscle

Andre Laferrière, Magali Millecamps, Dimitris N Xanthos, Wen Xiao, Chiang Siau, Marissa de Mos, Christelle Sachot, J Vaigunda Ragavendran, Frank JPM Huygen, Gary J Bennett, Terence J Coderre Molecular Pain 2008, 4:49 (28 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Medicine | F1000 Biology

14.

Research article   Open Access Highly Accessed

Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Joanne Kotsopoulos, Jan Lubinski, Leonardo Salmena, Henry T Lynch, Charmaine Kim-Sing, William D Foulkes, Parviz Ghadirian, Susan L Neuhausen, Rochelle Demsky, Nadine Tung, Peter Ainsworth, Leigha Senter, Andrea Eisen, Charis Eng, Christian Singer, Ophira Ginsburg, Joanne Blum, Tomasz Huzarski, Aletta Poll, Ping Sun, Steven A Narod, Breast Cancer Research 2012, 14:R42 (9 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Breastfeeding is protective against BRCA1- but not BRCA2-associated breast cancer, suggesting they have different biological pathways for carcinogenesis, and mutation carriers should be advised of the potential benefit of breastfeeding.

15.

Research article   Open Access Highly Accessed

Socioeconomic inequality in the prevalence of noncommunicable diseases in low- and middle-income countries: Results from the World Health Survey

Ahmad Hosseinpoor, Nicole Bergen, Shanthi Mendis, Sam Harper, Emese Verdes, Anton Kunst, Somnath Chatterji BMC Public Health 2012, 12:474 (22 June 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Noncommunicable diseases (NCDs) and their comorbidity among people in low- and middle-income countries are unequally distributed to the detriment of those with lower wealth or education levels, suggesting further investigation into socioeconomic inequality is important for NCD management efforts.

16.

Research article   Open Access Highly Accessed

Sample size requirements for case-control study designs

Michael D Edwardes BMC Medical Research Methodology 2001, 1:11 (19 November 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

Research article   Open Access Highly Accessed

Amniotic fluid embolism incidence, risk factors and outcomes: a review and recommendations

Marian Knight, Cynthia Berg, Peter Brocklehurst, Michael Kramer, Gwyneth Lewis, Jeremy Oats, Christine L Roberts, Catherine Spong, Elizabeth Sullivan, Jos van Roosmalen, Joost Zwart BMC Pregnancy and Childbirth 2012, 12:7 (10 February 2012)

Abstract | Full text | PDF | PubMed

18.

Research article   Open Access Highly Accessed

Institutionalizing evidence-based practice: an organizational case study using a model of strategic change

Cheryl B Stetler, Judith A Ritchie, Jo Rycroft-Malone, Alyce A Schultz, Martin P Charns Implementation Science 2009, 4:78 (30 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

Review   Open Access Highly Accessed

Melatonin, immune function and aging

V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal, SC Miller Immunity & Ageing 2005, 2:17 (29 November 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

20.

Research   Open Access Highly Accessed

Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose

Kumaran Sivagnanam, Vijaya GS Raghavan, Manesh Shah, Robert L Hettich, Nathan C Verberkmoes, Mark G Lefsrud Proteome Science 2011, 9:66 (18 October 2011)

Abstract | Full text | PDF | PubMed

21.

Research article   Open Access Highly Accessed

Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial

Neil C Thomson, Adalberto S Rubin, Robert M Niven, Paul A Corris, Hans Siersted, Ronald Olivenstein, Ian D Pavord, David McCormack, Michel Laviolette, Narinder S Shargill, Gerard Cox, BMC Pulmonary Medicine 2011, 11:8 (11 February 2011)

Abstract | Full text | PDF | PubMed | 1 comment

22.

Review   Open Access Highly Accessed

The six most essential questions in psychiatric diagnosis: A pluralogue part 2: Issues of conservatism and pragmatism in psychiatric diagnosis

James Phillips, Allen Frances, Michael A Cerullo, John Chardavoyne, Hannah S Decker, Michael B First, Nassir Ghaemi, Gary Greenberg, Andrew C Hinderliter, Warren A Kinghorn, Steven G LoBello, Elliott B Martin, Aaron L Mishara, Joel Paris, Joseph M Pierre, Ronald W Pies, Harold A Pincus, Douglas Porter, Claire Pouncey, Michael A Schwartz, Thomas Szasz, Jerome C Wakefield, G Waterman, Owen Whooley, Peter Zachar Philosophy, Ethics, and Humanities in Medicine 2012, 7:8 (18 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

Research article   Open Access Highly Accessed

A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)

Paul H Desan, Andrea J Weinstein, Erin E Michalak, Edwin M Tam, Ybe Meesters, Martine J Ruiter, Edward Horn, John Telner, Hani Iskandar, Diane B Boivin, Raymond W Lam BMC Psychiatry 2007, 7:38 (7 August 2007)

Abstract | Full text | PDF | PubMed

24.

Research article   Open Access Highly Accessed

A randomized controlled trial of CBT therapy for adults with ADHD with and without medication

Margaret Weiss, Candice Murray, Michael Wasdell, Brian Greenfield, Lauren Giles, Lily Hechtman BMC Psychiatry 2012, 12:30 (5 April 2012)

Abstract | Full text | PDF | PubMed

25.

Research article   Open Access Highly Accessed

Common stressful life events and difficulties are associated with mental health symptoms and substance use in young adolescents

Nancy CP Low, Erika Dugas, Erin O’Loughlin, Daniel Rodriguez, Gisele Contreras, Michael Chaiton, Jennifer O’Loughlin BMC Psychiatry 2012, 12:116 (17 August 2012)

Abstract | Full text | PDF | PubMed

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