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1.

Research article   Open Access

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Suzanne A Eccles, Eric O Aboagye, Simak Ali, Annie S Anderson, Jo Armes, Fedor Berditchevski, Jeremy P Blaydes, Keith Brennan, Nicola J Brown, Helen E Bryant, Nigel J Bundred, Joy M Burchell, Anna M Campbell, Jason S Carroll, Robert B Clarke, Charlotte E Coles, Gary JR Cook, Angela Cox, Nicola J Curtin, Lodewijk V Dekker, Isabel dos Santos Silva, Stephen W Duffy, Douglas F Easton, Diana M Eccles, Dylan R Edwards, Joanne Edwards, D Evans, Deborah F Fenlon, James M Flanagan, Claire Foster et al. Breast Cancer Research 2013, 15:R92 (1 October 2013)

Abstract | Full text | PDF |  Editor’s summary

Current knowledge 'gaps' in the understanding of breast cancer are examined, and research should focus on these to improve future clinical care.

2.

Research article   Open Access

Benchmarking of protein descriptor sets in proteochemometric modeling (part 2): modeling performance of 13 amino acid descriptor sets

Gerard JP van Westen, Remco F Swier, Isidro Cortes-Ciriano, Jörg K Wegner, John P Overington, Adriaan P IJzerman, Herman WT van Vlijmen, Andreas Bender Journal of Cheminformatics 2013, 5:42 (24 September 2013)

Abstract | Full text | PDF | PubMed

3.

Research article   Open Access

A powerful latent variable method for detecting and characterizing gene-based gene-gene interaction on multiple quantitative traits

Fangyu Li, Jinghua Zhao, Zhongshang Yuan, Xiaoshuai Zhang, Jiadong Ji, Fuzhong Xue BMC Genetics 2013, 14:89 (23 September 2013)

Abstract | Full text | PDF | PubMed

4.

Research article   Open Access

Benchmarking of protein descriptor sets in proteochemometric modeling (part 1): comparative study of 13 amino acid descriptor sets

Gerard JP van Westen, Remco F Swier, Jörg K Wegner, Adriaan P IJzerman, Herman WT van Vlijmen, Andreas Bender Journal of Cheminformatics 2013, 5:41 (23 September 2013)

Abstract | Full text | PDF | PubMed

5.

Methodology article   Open Access

A general linear model-based approach for inferring selection to climate

Srilakshmi M Raj, Luca Pagani, Irene Gallego Romero, Toomas Kivisild, William Amos BMC Genetics 2013, 14:87 (22 September 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A new method to identify regions of the human genome under selection combines population-specific and genome-wide patterns of background variation with environmental data to provide an improved picture of climate-related selection in human populations.

6.

Methodology   Open Access

Issues in the incorporation of economic perspectives and evidence into Cochrane reviews

Ian Shemilt, David McDaid, Kevin Marsh, Catherine Henderson, Evelina Bertranou, Jacqueline Mallander, Mike Drummond, Miranda Mugford, Luke Vale, Systematic Reviews 2013, 2:83 (20 September 2013)

Abstract | Full text | PDF | PubMed

7.

Poster presentation   Open Access

A novel method to examine individual RNA structures within a mixed population reveals insights into the HIV-1 RNA dimerization process

Julia Kenyon, Liam Prestwood, Stuart Le Grice, Andrew Lever Retrovirology 2013, 10(Suppl 1):P41 (19 September 2013)

Full text | PDF

8.

Poster presentation   Open Access

Mapping antigenic variation in HIV-1 envelope

Simon Frost Retrovirology 2013, 10(Suppl 1):P32 (19 September 2013)

Full text | PDF

9.

Study protocol   Open Access

Vitamin D supplementation in older people (VDOP): Study protocol for a randomised controlled intervention trial with monthly oral dosing with 12,000 IU, 24,000 IU or 48,000 IU of vitamin D3

Inez Schoenmakers, Roger M Francis, Elaine McColl, Thomas Chadwick, Gail R Goldberg, Christine Harle, Alison Yarnall, Jennifer Wilkinson, Jennie Parker, Ann Prentice, Terence Aspray Trials 2013, 14:299 (17 September 2013)

Abstract | Full text | PDF | PubMed

10.

Study protocol   Open Access

Preventing academic difficulties in preterm children: a randomised controlled trial of an adaptive working memory training intervention – IMPRINT study

Leona Pascoe, Gehan Roberts, Lex W Doyle, Katherine J Lee, Deanne K Thompson, Marc L Seal, Elisha K Josev, Chiara Nosarti, Susan Gathercole, Peter J Anderson BMC Pediatrics 2013, 13:144 (16 September 2013)

Abstract | Full text | PDF | PubMed

11.

Study protocol   Open Access

Muslim communities learning about second-hand smoke (MCLASS): study protocol for a pilot cluster randomised controlled trial

Hannah Ainsworth, Sarwat Shah, Faraz Ahmed, Amanda Amos, Ian Cameron, Caroline Fairhurst, Rebecca King, Ghazala Mir, Steve Parrott, Aziz Sheikh, David Torgerson, Heather Thomson, Kamran Siddiqi Trials 2013, 14:295 (13 September 2013)

Abstract | Full text | PDF | PubMed

12.

Research article   Open Access

Derivation and assessment of risk prediction models using case-cohort data

Jean Sanderson, Simon G Thompson, Ian R White, Thor Aspelund, Lisa Pennells BMC Medical Research Methodology 2013, 13:113 (13 September 2013)

Abstract | Full text | PDF | PubMed

13.

Database   Open Access

The mouse pathology ontology, MPATH; structure and applications

Paul N Schofield, John P Sundberg, Beth A Sundberg, Colin McKerlie, Georgios V Gkoutos Journal of Biomedical Semantics 2013, 4:18 (13 September 2013)

Abstract | Provisional PDF | PubMed

14.

Research   Open Access Highly Accessed

Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma

Christopher J Ricketts, Mark R Morris, Dean Gentle, Salwati Shuib, Michael Brown, Noel Clarke, Wenbin Wei, Paul Nathan, Farida Latif, Eamonn R Maher Clinical Epigenetics 2013, 5:16 (13 September 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Preclinical evidence that hypomethylating agent azacitidine reduces cancer cell growth in renal cell carcinoma.

15.

Oral presentation   Open Access

In situ studies of protein aggregation kinetics with multiparametric and superresolution imaging

Gabriele Kaminski Schierle, Claire Michel, Eric Rees, Dorothea Pinotsi, Clemens Kaminski Molecular Neurodegeneration 2013, 8(Suppl 1):O15 (13 September 2013)

Full text | PDF

16.

Research   Open Access

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse

Lucia Daxinger, Sarah K Harten, Harald Oey, Trevor Epp, Luke Isbel, Edward Huang, Nadia Whitelaw, Anwyn Apedaile, Anabel Sorolla, Joan Yong, Vandhana Bharti, Joanne Sutton, Alyson Ashe, Zhenyi Pang, Nathan Wallace, Daniel J Gerhardt, Marnie E Blewitt, Jeffrey A Jeddeloh, Emma Whitelaw Genome Biology 2013, 14:R96 (11 September 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A full characterization of the Momme screen for mouse genes regulating epigenetic processes includes three novel epigenetic regulators

17.

Research   Open Access

Test-retest reliability of the ‘Reading the Mind in the Eyes’ test: a one-year follow-up study

Enrique G Fernández-Abascal, Rosario Cabello, Pablo Fernández-Berrocal, Simon Baron-Cohen Molecular Autism 2013, 4:33 (11 September 2013)

Abstract | Full text | PDF | PubMed

18.

Research article   Open Access

The physical capability of community-based men and women from a British cohort: the European Prospective Investigation into Cancer (EPIC)-Norfolk study

Victoria L Keevil, Shabina Hayat, Nichola Dalzell, Stephanie Moore, Amit Bhaniani, Robert Luben, Nicholas J Wareham, Kay-Tee Khaw BMC Geriatrics 2013, 13:93 (10 September 2013)

Abstract | Full text | PDF | PubMed

19.

Original article   Open Access

A hydrophilic gel matrix for single-molecule super-resolution microscopy

Patrick JM Zessin, Carmen L Krüger, Sebastian Malkusch, Ulrike Endesfelder, Mike Heilemann Optical Nanoscopy 2013, 2:4 (10 September 2013)

Abstract | Full text | PDF

20.

Research article   Open Access Highly Accessed

Staphylococcus aureus small colony variants are susceptible to light activated antimicrobial agents

Sarah Tubby, Michael Wilson, John A Wright, Ping Zhang, Sean P Nair BMC Microbiology 2013, 13:201 (6 September 2013)

Abstract | Full text | PDF | PubMed

21.

Research   Open Access Highly Accessed

The legal imperative for treating rare disorders

Hanna I Hyry, Jonathan CP Roos, Jeremy Manuel, Timothy M Cox Orphanet Journal of Rare Diseases 2013, 8:135 (6 September 2013)

Abstract | Full text | PDF | PubMed

22.

Research   Open Access

Balancing exploration and exploitation in transferring research into practice: a comparison of five knowledge translation entity archetypes

Eivor Oborn, Michael Barrett, Karl Prince, Girts Racko Implementation Science 2013, 8:104 (5 September 2013)

Abstract | Full text | PDF | PubMed

23.

Research   Open Access

The process of developing evidence-based guidance in medicine and public health: a qualitative study of views from the inside

Lou Atkins, Jonathan A Smith, Michael P Kelly, Susan Michie Implementation Science 2013, 8:101 (4 September 2013)

Abstract | Full text | PDF | PubMed

24.

Meeting abstract   Open Access

Alcohol assessment and feedback by e-mail for university students: main findings from the AMADEUS-1 randomised controlled trial

Jim McCambridge, Marcus Bendtsen, Nadine Karlsson, Ian R White, Per Nilsen, Preben Bendtsen Addiction Science & Clinical Practice 2013, 8(Suppl 1):A48 (4 September 2013)

Full text | PDF

25.

Research article   Open Access Highly Accessed

Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila

Penelope Coggill, Ruth Y Eberhardt, Robert D Finn, Yuanyuan Chang, Lukasz Jaroszewski, Adam Godzik, Debanu Das, Qingping Xu, Herbert L Axelrod, L Aravind, Alexey G Murzin, Alex Bateman BMC Bioinformatics 2013, 14:265 (3 September 2013)

Abstract | Full text | PDF | PubMed

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