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1.

Editorial   Free

Proteomics: improving biomarker translation to modern medicine?

Paul C Guest, Michael G Gottschalk, Sabine Bahn Genome Medicine 2013, 5:17 (27 February 2013)

Abstract | Full text | PDF |  Editor’s summary

Guest, Gottschalk and Bahn highlight the challenges and prospects for translational biomarker research in an Editorial introducing the "Proteomic applications in medicine" series.

2.

Comment   Open Access

Open questions: What is there left for cell biologists to do?

Sean Munro BMC Biology 2013, 11:16 (27 February 2013)

Abstract | Full text | PDF |  Editor’s summary

In a contribution to the 10th anniversary series on open questions in biology, Sean Munro asks provocatively what there is left for cell biologists to do, and with great elan and a touch of waspish humor produces five unanswered questions on issues from the special properties of non-dividing cells to the architecture of the brain.

3.

Research article   Open Access

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts

Badri Vardarajan, David Vergote, Fadel Tissir, Mark Logue, Jing Yang, Nathalie Daude, Kunie Ando, Ekaterina Rogaeva, Joseph Lee, Rong Cheng, Jean-Pierre Brion, Mahdi Ghani, Beipei Shi, Clinton T Baldwin, Satyabrata Kar, Richard Mayeux, Paul Fraser, André M Goffinet, Peter St George-Hyslop, Lindsay A Farrer, David Westaway Molecular Neurodegeneration 2013, 8:10 (15 February 2013)

Abstract | Provisional PDF | PubMed

4.

Research article   Open Access

Systems chemistry: using thermodynamically controlled networks to assess molecular similarity

Vittorio Saggiomo, Yana R Hristova, R Frederick Ludlow, Sijbren Otto Journal of Systems Chemistry 2013, 4:2 (12 February 2013)

Abstract | Provisional PDF |  Editor’s summary | Graphical abstract

A dynamic molecular network has been developed that represents the first experimental approach towards predicting bioactivity based on an assessment of molecular similarity

5.

Review   Free

B-cell depletion in SLE: clinical and trial experience with rituximab and ocrelizumab and implications for study design

Venkat Reddy, David Jayne, David Close, David Isenberg Arthritis Research & Therapy 2013, 15(Suppl 1):S2 (11 February 2013)

Abstract | Full text | PDF

6.

Review   Open Access

The 3rd DBCLS BioHackathon: improving life science data integration with semantic Web technologies

Toshiaki Katayama, Mark D Wilkinson, Gos Micklem, Shuichi Kawashima, Atsuko Yamaguchi, Mitsuteru Nakao, Yasunori Yamamoto, Shinobu Okamoto, Kenta Oouchida, Hong-Woo Chun, Jan Aerts, Hammad Afzal, Erick Antezana, Kazuharu Arakawa, Bruno Aranda, Francois Belleau, Jerven Bolleman, Raoul Jean Bonnal, Brad Chapman, Peter Cock, Tore Eriksson, Paul Gordon, Naohisa Goto, Kazuhiro Hayashi, Heiko Horn, Ryosuke Ishiwata, Eli Kaminuma, Arek Kasprzyk, Hideya Kawaji, Nobuhiro Kido et al. Journal of Biomedical Semantics 2013, 4:6 (11 February 2013)

Abstract | Provisional PDF | PubMed

7.

Research   Open Access

Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease

Jonathan J Powell, William B Cook, Mark Chatfield, Carol Hutchinson, Dora IA Pereira, Miranda CE Lomer Nutrition & Metabolism 2013, 10:18 (1 February 2013)

Abstract | Full text | PDF | PubMed

8.

Comment   Open Access

Open questions: missing pieces from the immunological jigsaw puzzle

Gillian M Griffiths BMC Biology 2013, 11:10 (31 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Gillian Griffiths, in her ‘Open questions’ contribution for BMC Biology, pinpoints some critical missing links in the cell-biological specializations of immune cells

9.

Poster presentation   Open Access

Assessment of myocardial and LV blood pool post-contrast T1 evolution: comparison between healthy subjects and patients with hypertrophic cardiomyopathy

Nadjia Kachenoura, Laila Besson-Hajji, Martin J Graves, Scott Reid, Golmehr Ashrafpoor, Laurent Macron, Arshid Azarine, Alban Redheuil, Elie Mousseaux Journal of Cardiovascular Magnetic Resonance 2013, 15(Suppl 1):E44 (30 January 2013)

Full text | PDF

10.

Research article   Open Access

Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States

Damian Cruse, Aurore Thibaut, Athena Demertzi, Julia C Nantes, Marie-Aurelie Bruno, Olivia Gosseries, Audrey Vanhaudenhuyse, Tristan A Bekinschtein, Adrian M Owen, Steven Laureys BMC Medicine 2013, 11:18 (24 January 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Wrist actigraphy indicates that the sleep-wake cycles of patients in Vegetative states are more impaired than those in Minimally Conscious states indicating a need for improved guidelines in assessing the circadian rhythms of these patients.

11.

Research   Open Access

Genome-wide mapping of FOXM1 binding reveals co binding with estrogen receptor alpha in breast cancer cells

Deborah A Sanders, Caryn S Ross-Innes, Dario Beraldi, Jason S Carroll, Shankar Balasubramanian Genome Biology 2013, 14:R6 (24 January 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Binding sites for FOXM1 are mapped in breast cancer cell lines with and without estrogen receptor

12.

Scoping Review   Open Access

Epidemiology and interactions of Human Immunodeficiency Virus – 1 and Schistosoma mansoni in sub-Saharan Africa

Humphrey D Mazigo, Fred Nuwaha, Shona Wilson, Safari M Kinung'hi, Domenica Morona, Rebecca Waihenya, Jorg Heukelbach, David W Dunne Infectious Diseases of Poverty 2013, 2:2 (24 January 2013)

Abstract | Full text | PDF |  Editor’s summary

The fishing communities of Africa remain at higher risk of acquiring both infections and co-infections. The available evidence indicates that immunological interactions of the two diseases in single human host are associated with severe morbidities. Image: Fishermen at Kayenze village, one of the fishing villages on the southern shore of the Lake Victoria, north-western Tanzania.

13.

Research   Open Access

Comparing the accuracy of two secondary food environment data sources in the UK across socio-economic and urban/rural divides

Thomas Burgoine, Flo Harrison International Journal of Health Geographics 2013, 12:2 (17 January 2013)

Abstract | Full text | PDF | PubMed

14.

Research article   Open Access

Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis

Muna Affara, Debbie Sanders, Hiromitsu Araki, Yoshinori Tamada, Benjamin J Dunmore, Sally Humphreys, Seiya Imoto, Christopher Savoie, Satoru Miyano, Satoru Kuhara, David Jeffries, Cristin Print, D Stephen Charnock-Jones BMC Genomics 2013, 14:23 (16 January 2013)

Abstract | Full text | PDF | PubMed

15.

Research   Open Access

Dietary fortificant iron intake is negatively associated with quality of life in patients with mildly active inflammatory bowel disease

Jonathan J Powell, William B Cook, Carol Hutchinson, Zoe Tolkien, Mark Chatfield, Dora IA Pereira, Miranda CE Lomer Nutrition & Metabolism 2013, 10:9 (15 January 2013)

Abstract | Full text | PDF | PubMed

16.

Research article   Open Access

Regions of XY homology in the pig X chromosome and the boundary of the pseudoautosomal region

Benjamin M Skinner, Kim Lachani, Carole A Sargent, Nabeel A Affara BMC Genetics 2013, 14:3 (15 January 2013)

Abstract | Full text | PDF | PubMed

17.

Research   Open Access

Task-related functional connectivity in autism spectrum conditions: an EEG study using wavelet transform coherence

Ana Catarino, Alexandre Andrade, Owen Churches, Adam P Wagner, Simon Baron-Cohen, Howard Ring Molecular Autism 2013, 4:1 (12 January 2013)

Abstract | Full text | PDF | PubMed

18.

Review   Open Access Highly Accessed

Wrapping up the bad news – HIV assembly and release

Bo Meng, Andrew ML Lever Retrovirology 2013, 10:5 (10 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This review is a summary of our current understanding of the budding process of HIV, from genomic RNA capture through budding and on to viral maturation, but centering on the proteins of the ESCRT pathway and highlighting some recent advances in our understanding of the cellular components involved and the complex interplay between the Gag protein and the genomic RNA.

19.

Research article   Open Access Highly Accessed

Impact of plain packaging of tobacco products on smoking in adults and children: an elicitation of international experts’ estimates

Rachel Pechey, David Spiegelhalter, Theresa M Marteau BMC Public Health 2013, 13:18 (9 January 2013)

Abstract | Full text | PDF | PubMed

20.

Research article   Open Access

Contribution of the PALB2 c.2323C>T [p.Q775X] Founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent

Marc Tischkowitz, Nelly Sabbaghian, Nancy Hamel, Carly Pouchet, William D Foulkes, Anne-Marie Mes-Masson, Diane M Provencher, Patricia N Tonin BMC Medical Genetics 2013, 14:5 (9 January 2013)

Abstract | Full text | PDF | PubMed

21.

Opinion   Open Access

Network analysis and data mining in food science: the emergence of computational gastronomy

Sebastian E Ahnert Flavour 2013, 2:4 (9 January 2013)

Abstract | Full text | PDF

22.

Research article   Open Access

Testing a peer support intervention for people with type 2 diabetes: a pilot for a randomised controlled trial

David Simmons, Simon Cohn, Christopher Bunn, Kym Birch, Sarah Donald, Charlotte Paddison, Candice Ward, Peter Robins, A Toby Prevost, Jonathan Graffy BMC Family Practice 2013, 14:5 (8 January 2013)

Abstract | Full text | PDF | PubMed

23.

Research   Open Access

Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet

Jonathan Cedernaes, Johan Alsiö, Åke Västermark, Ulf Risérus, Helgi B Schiöth Lipids in Health and Disease 2013, 12:2 (8 January 2013)

Abstract | Full text | PDF | PubMed

24.

Research article   Open Access

Identifying targets of the Sox domain protein Dichaete in the Drosophila CNS via targeted expression of dominant negative proteins

Shih Pei Shen, Jelena Aleksic, Steven Russell BMC Developmental Biology 2013, 13:1 (5 January 2013)

Abstract | Full text | PDF | PubMed

25.

Short report   Open Access

Structural and functional characteristics of cGMP-dependent methionine oxidation in Arabidopsis thaliana proteins

Claudius Marondedze, Ilona Turek, Brian Parrott, Ludivine Thomas, Boris Jankovic, Kathryn S Lilley, Chris Gehring Cell Communication and Signaling 2013, 11:1 (5 January 2013)

Abstract | Full text | PDF | PubMed

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