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201.

Comment   Free

Perpetual motion of the worst kind

Gregory A Petsko Genome Biology 2000, 1:comment1004-comment1004.2 (13 October 2000)

Full text | PDF | PubMed |  Editor’s summary

A plea for less 'busyness' and more time for scientific pursuits.

202.

Review   Free

An overview of the potassium channel family

Christopher Miller Genome Biology 2000, 1:reviews0004-reviews0004.5 (13 October 2000)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K+ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K+ channel genes each. The structure of a bacterial K+ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.

203.

Comment   Free

The dark side

Gregory A Petsko Genome Biology 2000, 1:comment1003-comment1003.2 (15 September 2000)

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We will all face the dark side before long, as the emphasis in genomics shifts from identifying and sequencing genes to the problem of determining what their products do.

204.

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Dog eat dogma

Gregory A Petsko Genome Biology 2000, 1:comment1002-comment1002.2 (28 July 2000)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

It is human nature to inflate one's ideas and contributions. It is also human nature to hang onto one's ideas long after they have outlived their usefulness, in much the same way that a parent will still support a child who has grown up to be a menace to society. Both traits are at work whenever a scientist makes sweeping statements.

205.

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The Grail problem

Gregory A Petsko Genome Biology 2000, 1:comment002-comment002.2 (9 June 2000)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Holy Grail is a familiar metaphor in science. A current Holy Grail is the complete sequence of the human genome, but there seems to be one for every field of biology.

206.

Meeting report   Free

From sequence to consequence

Gregory A Petsko Genome Biology 2000, 1:reports406-reports406.1 (27 April 2000)

Abstract | Full text | PDF |  Editor’s summary

A report from the "Quantitative challenges in the post-genomic sequence era" workshop and symposium, San Diego, January 11-15, 2000

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