Signal analysis of behavioral and molecular cycles
BMC Neuroscience 2002, 3:1 (18 January 2002)
An integrated set of computational tools allows the analysis of behavioural and molecular rhythms, and is likely to offer insights into the biology of circadian timing systems.
Food of the dogs
Genome Biology 2011, 12:122 (25 July 2011)
Human evolution and the Paleofood movement
Letter to the editor: reply to Destaillats, interesterified fats to replace trans fat
Nutrition & Metabolism 2007, 4:13 (14 May 2007)
The neural processing of taste
BMC Neuroscience 2007, 8(Suppl 3):S5 (18 September 2007)
And the second shall be first
Genome Biology 2007, 8:103 (26 February 2007)
The retraction of 5 protein crystal structures has held back an entire sub-field for years due to the inordinately persuasive power of the pretty pictures that structural biology produces. All too often the first report is sketchy, superficial in its analysis, and prone to error. The second report is often more thoughtful, more useful, and is essential to the scientific process of validation and self-correction.
A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila
Genome Biology 2007, 8:R203 (28 September 2007)
A second generation dsRNA library was used to re-assess factors that influence the outcome of transcriptional reporter-based whole-genome RNAi screens for the Wnt/Wingless (wg) and Hedgehog (hh)-signaling pathways.
Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster
BMC Genomics 2011, 12:475 (29 September 2011)
Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice
BMC Neuroscience 2005, 6:5 (27 January 2005)
A mouse model of Leber¿s congenital amaurosis, with a mutation in the photoreceptor transcription factor Crx, shows the developing retina has disrupted outer segment formation and a synaptogenesis defect.
Statins stimulate arachidonic acid release and prostaglandin I 2 production in rat liver cells
Lipids in Health and Disease 2003, 2:1 (12 March 2003)
When failure should be the option
BMC Biology 2010, 8:61 (21 May 2010)
Most clinical trials for new drugs fail Phase II trials for efficacy. Gregory Petsko argues that such failures are a crucial resource for accelerating the development of new drugs for other targets.
The dog days of autumn
Genome Biology 2009, 10:112 (4 November 2009)
Greg's two dogs are impressed that only a few genes control the different lengths, growth patterns and curl of their coats.
Genome Biology 2011, 12:131 (29 October 2011)
Let us shout to the public and private sectors, this is not the time to be bailing out
It is alive
Genome Biology 2008, 9:106 (23 June 2008)
We need to familiarize ourselves with the facts of evolution, so that we can mount a spirited defense against creationism and the forces of ignorance.
Dog eat dogma
Genome Biology 2000, 1:comment1002-comment1002.2 (28 July 2000)
It is human nature to inflate one's ideas and contributions. It is also human nature to hang onto one's ideas long after they have outlived their usefulness, in much the same way that a parent will still support a child who has grown up to be a menace to society. Both traits are at work whenever a scientist makes sweeping statements.
And they said it wouldn't last...
Genome Biology 2010, 11:121 (5 May 2010)
In the 10 years that
Genome Biology has been published the scientific changes have been amazing, as have the changes in the culture of science.
Rising in the East
Genome Biology 2010, 11:102 (29 January 2010)
The genome sequence of the giant panda using next- generation sequencing marks a watershed in genome sequencing - in more ways than one.
What my genome told me - and what it didn't
Genome Biology 2009, 10:108 (29 June 2009)
Lessons in personal genome analysis, social networking or health information?
What if Watson had said "Apes evolved from man"?
Genome Biology 2007, 8:113 (30 November 2007)
Our status as genome biologists gives us both ammunition and a powerful line of attack when we are confronted with ignorance, prejudice, and bigotry.
Render unto Darwin
Genome Biology 2009, 10:106 (1 June 2009)
Science and religion; never the twain shall meet.
Genome Biology 2008, 9:111 (3 November 2008)
Meta-analysis is a popular way to try to get the most out of different studies linking genes and disease. But there are cons as well as pros.
A harsh climate
Genome Biology 2009, 10:115 (30 December 2009)
We should not be distracted by the debate about whether or not global warming is caused by humans; whatever the answer is, we urgently need to retard or reverse the trend.
ClC chloride channels
Genome Biology 2001, 2:reviews3003-reviews3003.6 (7 February 2001)
ClC-type chloride-conducting ion channels are integral components of physiological processes throughout the biological world. These channels are fundamentally different in molecular architecture and mechanism from the better-known cation-conducting channels, as well as from other anion-conducting channels: as such they comprise a single protein family.
An Asilomar moment
Genome Biology 2002, 3:comment1014-comment1014.3 (25 September 2002)
As governments in the US and Europe contemplate legislation that would divert funding of some genomics-driven research to Offices of Homeland Security and the like, and that would restrict the freedom of biologists to publish and share some of their data, we of the scientific community are facing a crisis, brought on by fears of bioterrorism, that eerily mirrors the early days of recombinant DNA research.
Tetrandrine and thapsigargin release arachidonic acid from cells in culture and stimulate prostacyclin production in rat liver cells, but may do so by different pathways
BMC Pharmacology 2005, 5:12 (24 June 2005)
Tetrandine and thapsigargin, two drugs that affect potassium and calcium channels, also both show some potential in cancer chemoprevention - but experiments in human and rat cells in culture suggest that although both stimulate arachidonic acid release they may operate by different pathways.
Genome Biology 2011, 12:119 (30 June 2011)
Greater risk in funding scientific research could lead to better results