Comparison of cardiovascular magnetic resonance of late gadolinium enhancement and diastolic wall thickness to predict recovery of left ventricular function after coronary artery bypass surgery
Journal of Cardiovascular Magnetic Resonance 2008, 10:41 (22 September 2008)
Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate
BMC Genomics 2008, 9:388 (18 August 2008)
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
Malaria Journal 2008, 7:149 (2 August 2008)
An accurate and robust conversion factor, both in acute malaria and in convalescence, was obtained, based on a large data set
Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum
Malaria Journal 2008, 7:148 (2 August 2008)
A large, logistically difficult, malaria survey incorporating facility and community based data. It has interest not only as a description of the malaria epidemiology of the specific geographic area, but as one of the few sites where Plasmodium falciparum and Plasmodium vivax co-transmission has been examined in detail.
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection
Malaria Journal 2008, 7:113 (26 June 2008)
A case report describing the inhibitory effect on parasite cultures by the serum from a volunteer experimentally infected with Plasmodium vivax
Polymorphism patterns in Duffy-binding protein among Thai Plasmodium vivax isolates
Malaria Journal 2008, 7:112 (26 June 2008)
PvDBPII is an important vaccine candidate for vivax malaria. Studies on the polymorphism in the erythrocyte binding domain of this protein are thus significant. The authors describe high rate of variation in this region among Thai isolates of P.vivax population where non-synonymous mutations predominate over the synonymous mutations
Reliability and validity of the Thai version of the PHQ-9
BMC Psychiatry 2008, 8:46 (20 June 2008)
The insecticide resistance status of malaria vectors in the Mekong region
Malaria Journal 2008, 7:102 (5 June 2008)
A useful paper describing the current baseline resistance status of the major anopheline species in the Mekong region.
Longitudinal study of Plasmodium falciparum and Plasmodium vivax in a Karen population in Thailand
Malaria Journal 2008, 7:99 (2 June 2008)
A study looking at interactions between the two parasites and the potential interference of control interventions with distribution patterns
Access to artemisinin combination therapy for malaria in remote areas of Cambodia
Malaria Journal 2008, 7:96 (29 May 2008)
Despite antimalarial protocol change, appropriate diagnostic and ACT treatment coverage remains low in Cambodia, while the use of artemisinin monotherapy is alarmingly high.
Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development
BMC Developmental Biology 2008, 8:58 (28 May 2008)
Plasmodium vivax trophozoites insensitive to chloroquine
Malaria Journal 2008, 7:94 (27 May 2008)
A study that provides important data about the action of chloroquine in Plasmodium vivax and highlights the fundamental differences with Plasmodium falciparum.
Cost of increasing access to artemisinin combination therapy: the Cambodian experience
Malaria Journal 2008, 7:84 (20 May 2008)
An interesting paper that presents financial costs associated with two distinct interventions to improve access to ACTs in Cambodia. The authors conclude that in addition to the costs of the drugs themselves, substantial investment may be needed to ensure that they affordably reach those most in need of them.
Burkholderia pseudomallei genome plasticity associated with genomic island variation
BMC Genomics 2008, 9:190 (25 April 2008)
Genome-wide subcellular localization of putative outer membrane and extracellular proteins in Leptospira interrogans serovar Lai genome using bioinformatics approaches
BMC Genomics 2008, 9:181 (21 April 2008)
Maternal separation alters the open field behavior of diazepam-treated rats
Annals of General Psychiatry 2008, 7(Suppl 1):S236 (17 April 2008)
Social isolation stress enhances the effect of 5-HT1A agonist 8-OH-DPAT on the rat elevated plus-maze
Annals of General Psychiatry 2008, 7(Suppl 1):S24 (17 April 2008)
Clinically uncomplicated Plasmodium falciparum malaria with high schizontaemia: A case report
Malaria Journal 2008, 7:57 (11 April 2008)
Because of sequestration, the blood film sometimes gives a poor estimate of total parasite biomass. The presence of schizonts in the peripheral circulation is warning signal that the patient requires close supervision and prompt treatment
Potential factors affecting semen quality in the Asian elephant (Elephas maximus)
Reproductive Biology and Endocrinology 2008, 6:9 (17 March 2008)
In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand
Malaria Journal 2008, 7:23 (28 January 2008)
The absence of cross-resistance between atovaquone and most available drugs in 83 isolates suggests that AP could be used as an alternative antimalarial drug in Thailand.
Outcomes of surgical treatment for upper urinary tract transitional cell carcinoma: Comparison of retroperitoneoscopic and open nephroureterectomy
World Journal of Surgical Oncology 2008, 6:3 (15 January 2008)
How antimalarial drug resistance affects post-treatment prophylaxis
Malaria Journal 2008, 7:9 (11 January 2008)
Slowly-eliminated antimalarial drugs suppress malaria reinfections for a period of time, an effect called post-treatment prophylaxis, which represents an important component of treatment responses. Antimalarial drug resistance shortens the period of post-treatment prophylaxis.
Rapid CD4 decline after interruption of non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy in a resource-limited setting
AIDS Research and Therapy 2007, 4:26 (21 November 2007)
Malignant fibrous histiocytoma of the face: report of a case
Head & Face Medicine 2007, 3:36 (18 October 2007)
Specific antibody response of mice after immunization with COS-7 cell derived avian influenza virus (H5N1) recombinant proteins
Journal of Immune Based Therapies and Vaccines 2007, 5:10 (3 October 2007)
Avian influenza virus H5N1 recombinant proteins (HA, NA, M, NS1) produced in the cos-7 mammalian cell system elicit a specific neutralizing antibody response against avian influenza virus (H5N1) antigen and may be suitable for development of a bird flu vaccine.
Comparison of three molecular methods for the detection and speciation of Plasmodium vivax and Plasmodium falciparum
Malaria Journal 2007, 6:124 (15 September 2007)
The comparison between different methods was performed using field samples collected from three sites in Thailand. The main conclusion was that the gold standard for parasite detection and identification should be based on a consensus from two or more molecular methods.
World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology
Malaria Journal 2007, 6:122 (6 September 2007)
The determinants of treatment response are multi-factorial, but reaching adequate blood concentrations is pivotal to cure. Pharmacokinetic data can inform on optimal dosing, but only small number of patients have been studied, with even less conducted in the most vulnerable populations. A better understanding of the pharmacokinetic properties of antimalarials and a more clear definition of what constitutes “therapeutic drug levels” would allow more precise use of the term “antimalarial resistance”, as it would indicate when treatment failure is not caused by intrinsic parasite resistance but is the result of inadequate drug levels.
World Antimalarial Resistance Network I: Clinical efficacy of antimalarial drugs
Malaria Journal 2007, 6:119 (6 September 2007)
Since the late 1970’s efforts have been made by WHO to create a monitoring system for the evaluation of the global development of drug resistance. The complexity of combination antimalarials and the multiplicity of interested parties in this field, now make a much broader and all inclusive monitoring/surveillance system essential.
Investigation of bifurcation properties of a model of myotonia caused by incomplete inactivation of sodium channels in skeletal muscle fibers
BMC Neuroscience 2007, 8(Suppl 2):P125 (6 July 2007)
In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border
Malaria Journal 2007, 6:81 (27 June 2007)
Getting more potential antimalarial drugs is a priority abd this new ferroquine compound has been shown here to have high anti-malarial activity in vitro against multi-drug resistant parasites
Sampling in health geography: reconciling geographical objectives and probabilistic methods. An example of a health survey in Vientiane (Lao PDR)
Emerging Themes in Epidemiology 2007, 4:6 (1 June 2007)
Comparison of short-term outcomes between laparoscopically-assisted vs. transverse-incision open right hemicolectomy for right-sided colon cancer: a retrospective study
World Journal of Surgical Oncology 2007, 5:49 (11 May 2007)
Does Family Medicine training in Thailand affect patient satisfaction with primary care doctors?
BMC Family Practice 2007, 8:14 (29 March 2007)
Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis
BMC Microbiology 2007, 7:19 (15 March 2007)
Safety and efficacy of a generic fixed-dose combination of stavudine, lamivudine and nevirapine antiretroviral therapy between HIV-infected patients with baseline CD4 <50 versus CD4 ≥ 50 cells/mm 3
AIDS Research and Therapy 2007, 4:6 (13 March 2007)
Plasma nevirapine levels, adverse events and efficacy of antiretroviral therapy among HIV-infected patients concurrently receiving nevirapine-based antiretroviral therapy and fluconazole
BMC Infectious Diseases 2007, 7:14 (12 March 2007)
Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC 50 values using a Bayesian approach
Malaria Journal 2007, 6:4 (17 January 2007)
This paper addresses an important issue in monitoring in vitro drug susceptibility and predicting drug usefulness and policy. The concern raised is that standard methods tend to overestimate EC50s in a population because of the poor fit with the least susceptible (most resistant) parasite isolates. They propose that this can be corrected by using a Bayesian approach, which leads to lower (more realistic) estimates.
Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria
Malaria Journal 2006, 5:127 (22 December 2006)
The paper compares various statistical methods for looking at clinical efficacy of antimalarial drugs. Realistic data and scenarios show clearly how different approaches for the analysis yield very different estimates of the actual clinical efficacy. With highly efficacious ACTs in almost all regions, it is suggested that the appropriate trial design should now be a non-inferiority trial, rather than the conventional superiority trial, to estimate efficacy with any precision.
Spatio-temporal effects of estimated pollutants released from an industrial estate on the occurrence of respiratory disease in Maptaphut Municipality, Thailand
International Journal of Health Geographics 2006, 5:48 (8 November 2006)
Thoracoscopic enucleation of a large esophageal leiomyoma using a three thoracic ports technique
World Journal of Surgical Oncology 2006, 4:70 (4 October 2006)
Genetic diversity of Plasmodium vivax in Kolkata, India
Malaria Journal 2006, 5:71 (14 August 2006)
An extensive genetic survey of malaria parasites in Kolkota in India. Genotyping was carried out by PCR using DNA purified from admission samples, with three genetic markers targeted. The results indicate a high degree of diversity, though few of the isolates contained mixed parasite genotypes. This is interesting given the low transmission intensity characteristic of the site.
Psychiatric services in primary care settings: a survey of general practitioners in Thailand
BMC Family Practice 2006, 7:48 (24 July 2006)
Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus
Arthritis Research & Therapy 2006, 8:R48 (20 February 2006)
Studies of Human Herpes Virus-8 in Thailand
Retrovirology 2005, 2(Suppl 1):S47 (8 December 2005)
A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand
Malaria Journal 2005, 4:46 (22 September 2005)
A comparative study of the efficacy and tolerability of two artemisinin combination therapies which are very useful for treatment of P. falciparum malaria multidrug-resistant in Asia. These two ACTs are, currently, the best treatment for non-severe falciparum malaria and this trial provides base-line data for future longitudinal surveillance of efficacy.
Safety and tolerability of nevirapine-based antiretroviral therapy in HIV-infected patients receiving fluconazole for cryptococcal prophylaxis: a retrospective cohort study
BMC Infectious Diseases 2005, 5:67 (24 August 2005)
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand
Malaria Journal 2005, 4:38 (14 August 2005)
The role of polymorphisms in the IL-1 beta gene promoter in the development of severe malaria is controversial. Some papers suggest an association, others not. This paper failed to find any evidence of association of three putatively functional genetic polymorphisms in the IL1 beta gene cluster with cerebral malaria in Thai people
Differential localization of HPV16 E6 splice products with E6-associated protein
Virology Journal 2005, 2:50 (16 June 2005)
Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival
Critical Care 2005, 9:R294-R302 (28 April 2005)
Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1
Malaria Journal 2005, 4:20 (27 April 2005)
This methodology paper describes the development and subsequent evaluation of protocols for genotyping Plasmodium vivax isolates: in Thailand, parasite populations are highly diverse genetically, with mixed genotype infections found in 26 % of the samples.