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1.

Methodology article   Open Access Highly Accessed

Using cited references to improve the retrieval of related biomedical documents

Francisco M Ortuño, Ignacio Rojas, Miguel A Andrade-Navarro, Jean-Fred Fontaine BMC Bioinformatics 2013, 14:113 (27 March 2013)

Abstract | Full text | PDF | PubMed

2.

Research article   Open Access

Wdr66 is a novel marker for risk stratification and involved in epithelial-mesenchymal transition of esophageal squamous cell carcinoma

Qing Wang, Chenming Ma, Wolfgang Kemmner BMC Cancer 2013, 13:137 (21 March 2013)

Abstract | Full text | PDF | PubMed

3.

Correction   Open Access

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers

Orsolya Kolacsek, Virág Krízsik, Anita Schamberger, Zsuzsa Erdei, Ágota Apáti, György Várady, Lajos Mátés, Zsuzsanna Izsvák, Zoltán Ivics, Balázs Sarkadi, Tamás I Orbán Mobile DNA 2013, 4:11 (15 March 2013)

Abstract | Full text | PDF | PubMed

4.

Research   Open Access Highly Accessed

Assessment of the right ventricle with cardiovascular magnetic resonance at 7 Tesla

Florian von Knobelsdorff-Brenkenhoff, Valeriy Tkachenko, Lukas Winter, Jan Rieger, Christof Thalhammer, Fabian Hezel, Andreas Graessl, Matthias A Dieringer, Thoralf Niendorf, Jeanette Schulz-Menger Journal of Cardiovascular Magnetic Resonance 2013, 15:23 (14 March 2013)

Abstract | Full text | PDF | PubMed

5.

Short Report   Open Access

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line

Yi Xie, Lajos Mates, Zoltán Ivics, Zsuzsanna Izsvák, Sandra L Martin, Wenfeng An Mobile DNA 2013, 4:10 (6 March 2013)

Abstract | Full text | PDF | PubMed

6.

Review   Open Access

Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?

Anja Mähler, Silvia Mandel, Mario Lorenz, Urs Ruegg, Erich E Wanker, Michael Boschmann, Friedemann Paul EPMA Journal 2013, 4:5 (18 February 2013)

Abstract | Full text | PDF | PubMed

7.

Workshop presentation   Open Access

High spatial and temporal myocardial CINE T2* mapping at 7.0 T: a feasibility study

F Hezel, C Thalhammer, S Waiczies, J Schulz-Menger, T Niendorf Journal of Cardiovascular Magnetic Resonance 2013, 15(Suppl 1):W29 (30 January 2013)

Full text | PDF

8.

Hypothesis   Open Access Highly Accessed

Closing the circle of germline and stem cells: the Primordial Stem Cell hypothesis

Jordi Solana EvoDevo 2013, 4:2 (8 January 2013)

Abstract | Full text | PDF | PubMed

9.

Research highlight   Subscription

Mining the literature: new methods to exploit keyword profiles

Miguel A Andrade-Navarro Genome Medicine 2012, 4:81 (30 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Miguel Andrade-Navarro highlights two recent publications by Wasserman et al. demonstrating that keyword profiles can be used to detect new associations between genes and inherited diseases.

10.

Research   Open Access Highly Accessed

Peer2ref: a peer-reviewer finding web tool that uses author disambiguation

Miguel A Andrade-Navarro, Gareth A Palidwor, Carol Perez-Iratxeta BioData Mining 2012, 5:14 (7 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A new web tool which uses author disambiguation and usage based keywords is shown to enhance the automated search of peer reviewers, particularly those who operate in narrow areas of research.

11.

Research article   Open Access Highly Accessed

Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds

Aimée Zuniga, Frédéric Laurent, Javier Lopez-Rios, Christian Klasen, Nicolas Matt, Rolf Zeller BMC Developmental Biology 2012, 12:23 (13 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Distant cis-regulatory regions scattered through a larger genome region control the highly dynamic expression of Gremlin1 (GREM1), a Bone Morphogenetic Protein (BMP) antagonist, which is key to normal progression of mouse limb bud development.

12.

Research   Open Access Highly Accessed

SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer

Felicitas Schmid, Susen Burock, Konrad Klockmeier, Peter M Schlag, Ulrike Stein Molecular Cancer 2012, 11:49 (29 July 2012)

Abstract | Full text | PDF | PubMed

13.

Research article   Open Access

Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease

Angelyn Lao, Vanessa Schmidt, Yvonne Schmitz, Thomas E Willnow, Olaf Wolkenhauer BMC Systems Biology 2012, 6:74 (22 June 2012)

Abstract | Full text | PDF | PubMed

14.

Research article   Open Access

Divergent gene expression in the conserved dauer stage of the nematodes Pristionchus pacificus and Caenorhabditis elegans

Amit Sinha, Ralf J Sommer, Christoph Dieterich BMC Genomics 2012, 13:254 (19 June 2012)

Abstract | Full text | PDF | PubMed

15.

Research article   Open Access Highly Accessed

MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells

Lea H Gregersen, Anders Jacobsen, Lisa B Frankel, Jiayu Wen, Anders Krogh, Anders H Lund BMC Cancer 2012, 12:232 (12 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Research article   Open Access

Proteome dynamics and early salt stress response of the photosynthetic organism Chlamydomonas reinhardtii

Guido Mastrobuoni, Susann Irgang, Matthias Pietzke, Heike E Aßmus, Markus Wenzel, Waltraud X Schulze, Stefan Kempa BMC Genomics 2012, 13:215 (31 May 2012)

Abstract | Full text | PDF | PubMed

17.

Research   Open Access

Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNA-seq, RNA interference and irradiation approach

Jordi Solana, Damian Kao, Yuliana Mihaylova, Farah Jaber-Hijazi, Sunir Malla, Ray Wilson, Aziz Aboobaker Genome Biology 2012, 13:R19 (22 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Planarian stem cells are ablated by RNAi against histone 2B and the neoblast-specific transcriptome is determined

18.

Research   Open Access Highly Accessed

Insights into the structure and activity of prototype foamy virus RNase H

Berit Leo, Maximilian J Hartl, Kristian Schweimer, Florian Mayr, Birgitta M Wöhrl Retrovirology 2012, 9:14 (10 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

This paper demonstrates that the independent PFV RNase H domain is structured and active. The presence of the C-helix in PFV RNase H could be confirmed by assigning the protein backbone and calculating the chemical shift index using NMR spectroscopy.

19.

Software article   Open Access Highly Accessed

Caipirini: using gene sets to rank literature

Theodoros G Soldatos, Seán I O'Donoghue, Venkata P Satagopam, Adriano Barbosa-Silva, Georgios A Pavlopoulos, Ana Wanderley-Nogueira, Nina Soares-Cavalcanti, Reinhard Schneider BioData Mining 2012, 5:1 (1 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

'Caipirini', a new software program, allows ranking of biomedical literature based on biological relevance to gene sets, thereby enabling data from these high-throughput experiments to be more easily accessed.

20.

Research article   Open Access Highly Accessed

Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis

Sven Knüppel, Jorge Esparza-Gordillo, Ingo Marenholz, Hermann-Georg Holzhütter, Anja Bauerfeind, Andreas Ruether, Stephan Weidinger, Young-Ae Lee, Klaus Rohde BMC Medical Genetics 2012, 13:8 (27 January 2012)

Abstract | Full text | PDF | PubMed

21.

Research article   Open Access Highly Accessed

Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions

Gonzalo Alvarez-Bolado, Fabian A Paul, Sandra Blaess Neural Development 2012, 7:4 (20 January 2012)

Abstract | Full text | PDF | PubMed

22.

Proceedings   Open Access

Preimplantation development regulatory pathway construction through a text-mining approach

Elisa Donnard, Adriano Barbosa-Silva, Rafael LM Guedes, Gabriel R Fernandes, Henrique Velloso, Matthew J Kohn, Miguel A Andrade-Navarro, J Ortega BMC Genomics 2011, 12(Suppl 4):S3 (22 December 2011)

Abstract | Full text | PDF | PubMed

23.

Software   Open Access Highly Accessed

PESCADOR, a web-based tool to assist text-mining of biointeractions extracted from PubMed queries

Adriano Barbosa-Silva, Jean-Fred Fontaine, Elisa R Donnard, Fernanda Stussi, J Ortega, Miguel A Andrade-Navarro BMC Bioinformatics 2011, 12:435 (9 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Research   Open Access

The Protein-Protein Interaction tasks of BioCreative III: classification/ranking of articles and linking bio-ontology concepts to full text

Martin Krallinger, Miguel Vazquez, Florian Leitner, David Salgado, Andrew Chatr-aryamontri, Andrew Winter, Livia Perfetto, Leonardo Briganti, Luana Licata, Marta Iannuccelli, Luisa Castagnoli, Gianni Cesareni, Mike Tyers, Gerold Schneider, Fabio Rinaldi, Robert Leaman, Graciela Gonzalez, Sergio Matos, Sun Kim, W Wilbur, Luis Rocha, Hagit Shatkay, Ashish V Tendulkar, Shashank Agarwal, Feifan Liu, Xinglong Wang, Rafal Rak, Keith Noto, Charles Elkan, Zhiyong Lu et al. BMC Bioinformatics 2011, 12(Suppl 8):S3 (3 October 2011)

Abstract | Full text | PDF | PubMed

25.

Technical Note   Open Access

QiSampler: evaluation of scoring schemes for high-throughput datasets using a repetitive sampling strategy on gold standards

Jean F Fontaine, Bernhard Suter, Miguel A Andrade-Navarro BMC Research Notes 2011, 4:57 (9 March 2011)

Abstract | Full text | PDF | PubMed

26.

Methodology   Open Access

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers

Orsolya Kolacsek, Virág Krízsik, Anita Schamberger, Zsuzsa Erdei, Ágota Apáti, György Várady, Lajos Mátés, Zsuzsanna Izsvák, Zoltán Ivics, Balázs Sarkadi, Tamás I Orbán Mobile DNA 2011, 2:5 (3 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

27.

Research   Open Access Highly Accessed

Identification of early molecular markers for breast cancer

Céline Kretschmer, Anja Sterner-Kock, Friederike Siedentopf, Winfried Schoenegg, Peter M Schlag, Wolfgang Kemmner Molecular Cancer 2011, 10:15 (11 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

Research article   Open Access Highly Accessed

Horizontal gene transfer of microbial cellulases into nematode genomes is associated with functional assimilation and gene turnover

Werner E Mayer, Lisa N Schuster, Gabi Bartelmes, Christoph Dieterich, Ralf J Sommer BMC Evolutionary Biology 2011, 11:13 (13 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Cellulases have been acquired by nematodes following horizontal gene transfer and analysis of their functional assimilation, gene turnover and selection provides further evidence to support models of horizontal gene transfer in eukaryotes.

29.

Review   Open Access Highly Accessed

The expanding universe of transposon technologies for gene and cell engineering

Zoltán Ivics, Zsuzsanna Izsvák Mobile DNA 2010, 1:25 (7 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

Methodology article   Open Access

Improved Tet-responsive promoters with minimized background expression

Rainer Loew, Niels Heinz , Mathias Hampf, Hermann Bujard, Manfred Gossen BMC Biotechnology 2010, 10:81 (24 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

Research   Open Access Highly Accessed

Acoustic cardiac triggering: a practical solution for synchronization and gating of cardiovascular magnetic resonance at 7 Tesla

Tobias Frauenrath, Fabian Hezel, Wolfgang Renz, Thibaut d'Orth, Matthias Dieringer, Florian von Knobelsdorff-Brenkenhoff, Marcel Prothmann, Jeanette Schulz-Menger, Thoralf Niendorf Journal of Cardiovascular Magnetic Resonance 2010, 12:67 (16 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

32.

Research article   Open Access

Pseudogenes as an alternative source of natural antisense transcripts

Enrique M Muro, Miguel A Andrade-Navarro BMC Evolutionary Biology 2010, 10:338 (3 November 2010)

Abstract | Full text | PDF | PubMed

33.

Research article   Open Access Highly Accessed

Novel strong tissue specific promoter for gene expression in human germ cells

Denis Kuzmin, Elena Gogvadze, Roman Kholodenko, Dawid P Grzela, Maxim Mityaev, Tatyana Vinogradova, Eugene Kopantzev, Galina Malakhova, Maria Suntsova, Dmitry Sokov, Zoltán Ivics, Anton Buzdin BMC Biotechnology 2010, 10:58 (17 August 2010)

Abstract | Full text | PDF | PubMed

34.

Research article   Open Access

Systems analysis of iron metabolism: the network of iron pools and fluxes

Tiago JS Lopes, Tatyana Luganskaja, Maja Vujić Spasić, Matthias W Hentze, Martina U Muckenthaler, Klaus Schümann, Jens G Reich BMC Systems Biology 2010, 4:112 (13 August 2010)

Abstract | Full text | PDF | PubMed

35.

Research article   Open Access Highly Accessed

Comprehensive survey of human brain microRNA by deep sequencing

Ning-Yi Shao, Hai Hu, Zheng Yan, Ying Xu, Hao Hu, Corinna Menzel, Na Li, Wei Chen, Philipp Khaitovich BMC Genomics 2010, 11:409 (30 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

Research   Open Access Highly Accessed

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

Susanne A Wolf, Anika Bick-Sander, Klaus Fabel, Perla Leal-Galicia, Svantje Tauber, Gerardo Ramirez-Rodriguez, Anke Müller, Andre Melnik, Tim P Waltinger, Oliver Ullrich, Gerd Kempermann Cell Communication and Signaling 2010, 8:12 (17 June 2010)

Abstract | Full text | PDF | PubMed

37.

Research   Open Access

Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial

Håkan Norell, Isabel Poschke, Jehad Charo, Wei Z Wei, Courtney Erskine, Marie P Piechocki, Keith L Knutson, Jonas Bergh, Elisabet Lidbrink, Rolf Kiessling Journal of Translational Medicine 2010, 8:53 (7 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

Short report   Open Access Highly Accessed

Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P

Ewan Smith, Gregory RC Blass, Gary R Lewin, Thomas J Park Molecular Pain 2010, 6:29 (24 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

Research article   Open Access

Comparison and consolidation of microarray data sets of human tissue expression

Jenny Russ, Matthias E Futschik BMC Genomics 2010, 11:305 (14 May 2010)

Abstract | Full text | PDF | PubMed | 1 comment

40.

Research article   Open Access

Deciphering the porcine intestinal microRNA transcriptome

Soroush Sharbati, Marc R Friedländer, Jutta Sharbati, Lena Hoeke, Wei Chen, Andreas Keller, Peer F Stähler, Nikolaus Rajewsky, Ralf Einspanier BMC Genomics 2010, 11:275 (30 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

Review   Open Access Highly Accessed

A reference guide for tree analysis and visualization

Georgios A Pavlopoulos, Theodoros G Soldatos, Adriano Barbosa-Silva, Reinhard Schneider BioData Mining 2010, 3:1 (22 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

42.

Software   Open Access Highly Accessed

LAITOR - Literature Assistant for Identification of Terms co-Occurrences and Relationships

Adriano Barbosa-Silva, Theodoros G Soldatos, Ivan LF Magalhães, Georgios A Pavlopoulos, Jean-Fred Fontaine, Miguel A Andrade-Navarro, Reinhard Schneider, J Miguel Ortega BMC Bioinformatics 2010, 11:70 (1 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

43.

Research article   Open Access

Periostin shows increased evolutionary plasticity in its alternatively spliced region

Sebastian Hoersch, Miguel A Andrade-Navarro BMC Evolutionary Biology 2010, 10:30 (28 January 2010)

Abstract | Full text | PDF | PubMed

44.

Software   Open Access

3PD: Rapid design of optimal primers for chromosome conformation capture assays

Sebastian Fröhler, Christoph Dieterich BMC Genomics 2009, 10:635 (29 December 2009)

Abstract | Full text | PDF | PubMed

45.

Research article   Open Access Highly Accessed

Genetical genomic determinants of alcohol consumption in rats and humans

Boris Tabakoff, Laura Saba, Morton Printz, Pam Flodman, Colin Hodgkinson, David Goldman, George Koob, Heather N Richardson, Katerina Kechris, Richard L Bell, Norbert Hübner, Matthias Heinig, Michal Pravenec, Jonathan Mangion, Lucie Legault, Maurice Dongier, Katherine M Conigrave, John B Whitfield, John Saunders, Bridget Grant, Paula L Hoffman, BMC Biology 2009, 7:70 (27 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Genetic pathways involving appetite, satiety and reward affect alcohol consumption in rats and humans, specifically GABAergic and dopaminergic signaling, but genes in these pathways are not linked to alcohol dependence or abuse in people.

46.

Research article   Open Access Highly Accessed

Sequence features associated with microRNA strand selection in humans and flies

Hai Hu, Zheng Yan, Ying Xu, Hao Hu, Corinna Menzel, Yan Zhou, Wei Chen, Philipp Khaitovich BMC Genomics 2009, 10:413 (4 September 2009)

Abstract | Full text | PDF | PubMed

47.

Poster presentation   Open Access

C-type natriuretic peptide is a bifurcation factor for sensory neurons

Hannes Schmidt, Agne Stonkute, René Jüttner, Doris Koesling, Andreas Friebe, Robert Feil, Franz Hofmann, Fritz G Rathjen BMC Pharmacology 2009, 9(Suppl 1):P64 (11 August 2009)

Full text | PDF

48.

Research article   Open Access Highly Accessed

Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina

Sabine Seipold, Florian C Priller, Paul Goldsmith, William A Harris, Herwig Baier, Salim Abdelilah-Seyfried BMC Developmental Biology 2009, 9:40 (8 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

49.

Meeting report   Free

Novel insights into proteomic technologies and their clinical perspective

Gunnar Dittmar, Matthias Selbach Genome Med 2009, 1:53 (21 May 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A report on the Proteomic Forum 2009 conference, Berlin, Germany, 29 March to 2 April, 2009.

50.

Meeting report   Free

Genomic parasites and genome evolution

Zoltán Ivics Genome Biology 2009, 10:306 (15 April 2009)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

A report of the Second International Conference/Workshop on the Genomic Impact of Eukaryotic Transposable Elements, Pacific Grove, USA, 6-10 February 2009.

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