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1.

Method   Open Access Highly Accessed

Ray Meta: scalable de novo metagenome assembly and profiling

Sébastien Boisvert, Frédéric Raymond, Élénie Godzaridis, François Laviolette, Jacques Corbeil Genome Biology 2012, 13:R122 (22 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A scalable, de novo metagenomic assembly method that couples taxonomic and ontology profiling

2.

Systematic Review   Open Access Highly Accessed

Healthcare professionals' intentions and behaviours: A systematic review of studies based on social cognitive theories

Gaston Godin, Ariane Bélanger-Gravel, Martin Eccles, Jeremy Grimshaw Implementation Science 2008, 3:36 (16 July 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

Systematic Review   Open Access Highly Accessed

Barriers and facilitators to implementing shared decision-making in clinical practice: a systematic review of health professionals' perceptions

Karine Gravel, France Légaré, Ian D Graham Implementation Science 2006, 1:16 (9 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

Research   Open Access Highly Accessed

Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies

Philippe Desjardins, Alexis F Turgeon, Marie-Hélène Tremblay, François Lauzier, Ryan Zarychanski, Amélie Boutin, Lynne Moore, Lauralyn A McIntyre, Shane W English, Andrea Rigamonti, Jacques Lacroix, Dean A Fergusson Critical Care 2012, 16:R54 (2 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology

5.

Research article   Open Access Highly Accessed

Development of a theory of implementation and integration: Normalization Process Theory

Carl R May, Frances Mair, Tracy Finch, Anne MacFarlane, Christopher Dowrick, Shaun Treweek, Tim Rapley, Luciana Ballini, Bie Ong, Anne Rogers, Elizabeth Murray, Glyn Elwyn, France Légaré, Jane Gunn, Victor M Montori Implementation Science 2009, 4:29 (21 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

6.

Research article   Open Access Highly Accessed

Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial

Neil C Thomson, Adalberto S Rubin, Robert M Niven, Paul A Corris, Hans Siersted, Ronald Olivenstein, Ian D Pavord, David McCormack, Michel Laviolette, Narinder S Shargill, Gerard Cox, BMC Pulmonary Medicine 2011, 11:8 (11 February 2011)

Abstract | Full text | PDF | PubMed | 1 comment

7.

Research article   Open Access Highly Accessed

Global asthma prevalence in adults: findings from the cross-sectional world health survey

Teresa To, Sanja Stanojevic, Ginette Moores, Andrea S Gershon, Eric D Bateman, Alvaro A Cruz, Louis-Philippe Boulet BMC Public Health 2012, 12:204 (19 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

Research   Open Access Highly Accessed

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

Maxim Isabelle, Xavier Moreel, Jean-Philippe Gagné, Michèle Rouleau, Chantal Ethier, Pierre Gagné, Michael J Hendzel, Guy G Poirier Proteome Science 2010, 8:22 (13 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

Research article   Open Access Highly Accessed

Advanced practice physiotherapy in patients with musculoskeletal disorders: a systematic review

François Desmeules, Jean-Sébastien Roy, Joy C MacDermid, François Champagne, Odette Hinse, Linda June Woodhouse BMC Musculoskeletal Disorders 2012, 13:107 (21 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

Research article   Open Access

A spruce gene map infers ancient plant genome reshuffling and subsequent slow evolution in the gymnosperm lineage leading to extant conifers

Nathalie Pavy, Betty Pelgas, Jérôme Laroche, Philippe Rigault, Nathalie Isabel, Jean Bousquet BMC Biology 2012, 10:84 (26 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

Review   Open Access Highly Accessed

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

Tom Bowen, Marco Cicardi, Henriette Farkas, Konrad Bork, Hilary J Longhurst, Bruce Zuraw, Emel Aygoeren-Pürsün, Timothy Craig, Karen Binkley, Jacques Hebert, Bruce Ritchie, Laurence Bouillet, Stephen Betschel, Della Cogar, John Dean, Ramachand Devaraj, Azza Hamed, Palinder Kamra, Paul K Keith, Gina Lacuesta, Eric Leith, Harriet Lyons, Sean Mace, Barbara Mako, Doris Neurath, Man-Chiu Poon, Georges-Etienne Rivard, Robert Schellenberg, Dereth Rowan, Anne Rowe et al. Allergy, Asthma & Clinical Immunology 2010, 6:24 (28 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

Research   Open Access

Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels

Véronique Garneau, Iwona Rudkowska, Ann-Marie Paradis, Gaston Godin, Pierre Julien, Louis Pérusse, Marie-Claude Vohl Nutrition Journal 2012, 11:46 (9 July 2012)

Abstract | Full text | PDF | PubMed

13.

Research article   Open Access Highly Accessed

Rehabilitation needs for older adults with stroke living at home: perceptions of four populations

Claude Vincent, Isabelle Deaudelin, Line Robichaud, Jacqueline Rousseau, Chantal Viscogliosi, Lise R Talbot, Johanne Desrosiers, BMC Geriatrics 2007, 7:20 (13 August 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Original investigation   Open Access Highly Accessed

Telmisartan/hydrochlorothiazide versus valsartan/hydrochlorothiazide in obese hypertensive patients with type 2 diabetes: the SMOOTH study

Arya M Sharma, Jaime Davidson, Stephen Koval, Yves Lacourcière Cardiovascular Diabetology 2007, 6:28 (2 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

Research article   Open Access Highly Accessed

Conifer R2R3-MYB transcription factors: sequence analyses and gene expression in wood-forming tissues of white spruce (Picea glauca)

Frank Bedon, Jacqueline Grima-Pettenati, John Mackay BMC Plant Biology 2007, 7:17 (30 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Research article   Open Access Highly Accessed

The spiritual distress assessment tool: an instrument to assess spiritual distress in hospitalised elderly persons

Stefanie M Monod, Etienne Rochat, Christophe J Büla, Guy Jobin, Estelle Martin, Brenda Spencer BMC Geriatrics 2010, 10:88 (13 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The newly developed Spiritual Distress Assessment Tool defines four dimensions of spirituality and is a clinically acceptable instrument for assessing spiritual distress in hospitalized elderly patients.

17.

Research   Open Access

A qualitative study of the promotion of exclusive breastfeeding by health professionals in Niamey, Niger

Aïssata Moussa Abba, Maria De Koninck, Anne-Marie Hamelin International Breastfeeding Journal 2010, 5:8 (8 August 2010)

Abstract | Full text | PDF | PubMed | 1 comment

18.

Research   Open Access Highly Accessed

The breastfeeding experience of women with major difficulties who use the services of a breastfeeding clinic: a descriptive study

Caroline Lamontagne, Anne-Marie Hamelin, Monik St-Pierre International Breastfeeding Journal 2008, 3:17 (5 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

Study protocol   Open Access

How to integrate individual patient values and preferences in clinical practice guidelines? A research protocol

Trudy van der Weijden, France Légaré, Antoine Boivin, Jako S Burgers, Haske van Veenendaal, Anne M Stiggelbout, Marjan Faber, Glyn Elwyn Implementation Science 2010, 5:10 (2 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

Proceedings   Open Access

Bacteriophages of lactic acid bacteria and their impact on milk fermentations

Josiane E Garneau, Sylvain Moineau Microbial Cell Factories 2011, 10(Suppl 1):S20 (30 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

Study protocol   Open Access Highly Accessed

Healthcare professionals' intentions to use wiki-based reminders to promote best practices in trauma care: a survey protocol

Patrick M Archambault, France Légaré, André Lavoie, Marie-Pierre Gagnon, Jean Lapointe, Sylvie St-Jacques, Julien Poitras, Karine Aubin, Sylvain Croteau, Martin Pham-Dinh Implementation Science 2010, 5:45 (11 June 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

Research   Open Access

Proteomic analysis of the metabolic adaptation of the biocontrol agent Pseudozyma flocculosa leading to glycolipid production

Walid Hammami, Florian Chain, Dominique Michaud, Richard R Bélanger Proteome Science 2010, 8:7 (9 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

Study protocol   Open Access Highly Accessed

Multi-level analysis of electronic health record adoption by health care professionals: A study protocol

Marie-Pierre Gagnon, Mathieu Ouimet, Gaston Godin, Michel Rousseau, Michel Labrecque, Yvan Leduc, Anis Ben Abdeljelil Implementation Science 2010, 5:30 (23 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Research article   Open Access Highly Accessed

Implementing telehealth to support medical practice in rural/remote regions: what are the conditions for success?

Marie-Pierre Gagnon, Julie Duplantie, Jean-Paul Fortin, Réjean Landry Implementation Science 2006, 1:18 (24 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

Research   Open Access

Associations between dietary patterns and gene expression profiles of healthy men and women: a cross-sectional study

Annie Bouchard-Mercier, Ann-Marie Paradis, Iwona Rudkowska, Simone Lemieux, Patrick Couture, Marie-Claude Vohl Nutrition Journal 2013, 12:24 (12 February 2013)

Abstract | Full text | PDF | PubMed

26.

Research   Open Access Highly Accessed

Decision boxes for clinicians to support evidence-based practice and shared decision making: the user experience

Anik Giguere, France Légaré, Roland Grad, Pierre Pluye, R Haynes, Michel Cauchon, François Rousseau, Juliana Argote, Michel Labrecque Implementation Science 2012, 7:72 (3 August 2012)

Abstract | Full text | PDF | PubMed

27.

Methodology   Open Access Highly Accessed

An evaluation of LSU rDNA D1-D2 sequences for their use in species identification

Rainer Sonnenberg, Arne W Nolte, Diethard Tautz Frontiers in Zoology 2007, 4:6 (16 February 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

28.

Research article   Open Access Highly Accessed

Violence against female sex workers in Karnataka state, south India: impact on health, and reductions in violence following an intervention program

Tara SH Beattie, Parinita Bhattacharjee, BM Ramesh, Vandana Gurnani, John Anthony, Shajy Isac, HL Mohan, Aparajita Ramakrishnan, Tisha Wheeler, Janet Bradley, James F Blanchard, Stephen Moses BMC Public Health 2010, 10:476 (11 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

29.

Research article   Open Access Highly Accessed

Comparison of user groups' perspectives of barriers and facilitators to implementing electronic health records: a systematic review

Carrie McGinn, Sonya Grenier, Julie Duplantie, Nicola Shaw, Claude Sicotte, Luc Mathieu, Yvan Leduc, France Légaré, Marie-Pierre Gagnon BMC Medicine 2011, 9:46 (28 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Electronic health record (EHR) implementation is affected by the user groups involved, meaning that an understanding of barriers and facilitators to EHR implementation requires detailed knowledge of all stakeholders’ perspectives on the process.

30.

Study protocol   Open Access Highly Accessed

Cervical radiculopathy: Study protocol of a randomised clinical trial evaluating the effect of mobilisations and exercises targeting the opening of intervertebral foramen [NCT01500044]

Pierre Langevin, Jean-Sébastien Roy, François Desmeules BMC Musculoskeletal Disorders 2012, 13:10 (31 January 2012)

Abstract | Full text | PDF | PubMed

31.

Research article   Open Access

Prevalence of physical and verbal aggressive behaviours and associated factors among older adults in long-term care facilities

Philippe Voyer, René Verreault, Ginette M Azizah, Johanne Desrosiers, Nathalie Champoux, Annick Bédard BMC Geriatrics 2005, 5:13 (10 November 2005)

Abstract | Full text | PDF | PubMed

32.

Research article   Open Access Highly Accessed

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Anna Mulligan, Fergus J Couch, Daniel Barrowdale, Susan M Domchek, Diana Eccles, Heli Nevanlinna, Susan J Ramus, Mark Robson, Mark Sherman, Amanda B Spurdle, Barbara Wappenschmidt, Andrew Lee, Lesley McGuffog, Sue Healey, Olga M Sinilnikova, Ramunas Janavicius, Thomas vO Hansen, Finn C Nielsen, Bent Ejlertsen, Ana Osorio, Iván Muñoz-Repeto, Mercedes Durán, Javier Godino, Maroulio Pertesi, Javier Benítez, Paolo Peterlongo, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Elisa Cattaneo et al. Breast Cancer Research 2011, 13:R110 (2 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

Review   Open Access Highly Accessed

Psychosocial determinants of fruit and vegetable intake in adult population: a systematic review

Laurence Guillaumie, Gaston Godin, Lydi-Anne Vézina-Im International Journal of Behavioral Nutrition and Physical Activity 2010, 7:12 (2 February 2010)

Abstract | Full text | PDF | PubMed

34.

Research   Open Access

Engineering of papaya mosaic virus (PapMV) nanoparticles with a CTL epitope derived from influenza NP

Cindy Babin, Nathalie Majeau, Denis Leclerc Journal of Nanobiotechnology 2013, 11:10 (4 April 2013)

Abstract | Full text | PDF | PubMed

35.

Research   Open Access

Rotational strength, range of motion, and function in people with unaffected shoulders from various stages of life

Jean-Sébastien Roy, Joy C MacDermid, Kirsty Boyd, Kenneth J Faber, Darren Drosdowech, George S Athwal Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology 2009, 1:4 (2 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

Study protocol   Open Access Highly Accessed

Maximum recovery after knee replacement – the MARKER study rationale and protocol

Chung-Wei Lin, Lyn March, Jack Crosbie, Ross Crawford, Stephen Graves, Justine Naylor, Alison Harmer, Stephen Jan, Kim Bennell, Ian Harris, David Parker, Helene Moffet, Marlene Fransen BMC Musculoskeletal Disorders 2009, 10:69 (17 June 2009)

Abstract | Full text | PDF | PubMed

37.

Research article   Open Access

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

Antonis C Antoniou, Karoline B Kuchenbaecker, Penny Soucy, Jonathan Beesley, Xiaoqing Chen, Lesley McGuffog, Andrew Lee, Daniel Barrowdale, Sue Healey, Olga M Sinilnikova, Maria A Caligo, Niklas Loman, Katja Harbst, Annika Lindblom, Brita Arver, Richard Rosenquist, Per Karlsson, Kate Nathanson, Susan Domchek, Tim Rebbeck, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Elżbieta Złowowcka-Perłowska, Ana Osorio, Mercedes Durán, Raquel Andrés, Javier Benítez, Ute Hamann et al. Breast Cancer Research 2012, 14:R33 (20 February 2012)

Abstract | Full text | PDF | PubMed

38.

Research article   Open Access

Genetic discrimination and life insurance: a systematic review of the evidence

Yann Joly, Ida Ngueng Feze, Jacques Simard BMC Medicine 2013, 11:25 (31 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Evidence from a systematic review of genetic discrimination studies shows that individual cases of discrimination exist in the context of life insurance, but policy action cannot be justified at present due to limitations of the studies.

39.

Research article   Open Access

17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration

Juliette A Aka, Mouna Zerradi, François Houle, Jacques Huot, Sheng-Xiang Lin Breast Cancer Research 2012, 14:R92 (12 June 2012)

Abstract | Full text | PDF | PubMed

40.

Research   Open Access Highly Accessed

Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study

Eva C Bonefeld-Jorgensen, Manhai Long, Rossana Bossi, Pierre Ayotte, Gert Asmund, Tanja Krüger, Mandana Ghisari, Gert Mulvad, Peder Kern, Peter Nzulumiki, Eric Dewailly Environmental Health 2011, 10:88 (6 October 2011)

Abstract | Full text | PDF | PubMed

41.

Study protocol   Open Access

A conceptual framework for interprofessional shared decision making in home care: Protocol for a feasibility study

France Légaré, Dawn Stacey, Nathalie Brière, Sophie Desroches, Serge Dumont, Kimberley Fraser, Mary-Anne Murray, Anne Sales, Denise Aubé BMC Health Services Research 2011, 11:23 (31 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

42.

Short report   Open Access

Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians

Thomas MS Wolever, Alison L Gibbs, Jennie Brand-Miller, Alison M Duncan, Valerie Hart, Benoît Lamarche, Susan M Tosh, Ruedi Duss Nutrition Journal 2011, 10:130 (25 November 2011)

Abstract | Full text | PDF | PubMed

43.

Research   Open Access Highly Accessed

Asthma and genes encoding components of the vitamin D pathway

Yohan Bossé, Mathieu Lemire, Audrey H Poon, Denise Daley, Jian-Qing He, Andrew Sandford, John H White, Alan L James, Arthur Musk, Lyle J Palmer, Benjamin A Raby, Scott T Weiss, Anita L Kozyrskyj, Allan Becker, Thomas J Hudson, Catherine Laprise Respiratory Research 2009, 10:98 (24 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

Short report   Open Access Highly Accessed

Core competencies in the science and practice of knowledge translation: description of a Canadian strategic training initiative

Sharon E Straus, Melissa Brouwers, David Johnson, John N Lavis, France Légaré, Sumit R Majumdar, K Ann McKibbon, Anne E Sales, Dawn Stacey, Gail Klein, Jeremy Grimshaw, Implementation Science 2011, 6:127 (9 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

45.

Research   Open Access Highly Accessed

Assessing availability of scientific journals, databases, and health library services in Canadian health ministries: a cross-sectional study

Grégory Léon, Mathieu Ouimet, John N Lavis, Jeremy Grimshaw, Marie-Pierre Gagnon Implementation Science 2013, 8:34 (21 March 2013)

Abstract | Full text | PDF | PubMed

46.

Research   Open Access

Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease

Fereshteh Fani, Philippe Leprohon, Danielle Légaré, Marc Ouellette Genome Biology 2011, 12:R115 (22 November 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Sequencing of antibiotic resistant Streptococcus pneumoniae reveals an initial mutation in an iron permease conferring tolerance to antibiotic-induced accumulation of oxidants

47.

Research   Open Access

Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population

Iwona Rudkowska, Catherine Ouellette, Eric Dewailly, Robert A Hegele, Véronique Boiteau, Ariane Dubé-Linteau, Belkacem Abdous, Françoise Proust, Yves Giguère, Pierre Julien, Marie-Ludivine Château-Degat, Marie-Claude Vohl Nutrition & Metabolism 2013, 10:26 (12 March 2013)

Abstract | Full text | PDF | PubMed

48.

Research   Open Access

LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes

Valérie Turcot, André Tchernof, Yves Deshaies, Louis Pérusse, Alexandre Bélisle, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho, Marie-Claude Vohl Clinical Epigenetics 2012, 4:10 (2 July 2012)

Abstract | Full text | PDF | PubMed

49.

Research   Open Access

Seasonal variations of cough reflex sensitivity in elite athletes training in cold air environment

Julie Turmel, Valérie Bougault, Louis-Philippe Boulet Cough 2012, 8:2 (26 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Winter athletes experience exercise-induced cough more frequently in the winter compared to the summer, and more so than sedentary individuals, findings that were not associated with cough reflex hypersensitivity, bronchoconstriction, or airway inflammation.

50.

Research article   Open Access Highly Accessed

Changes in Holstein cow milk and serum proteins during intramammary infection with three different strains of Staphylococcus aureus

Yunee Kim, Heba Atalla, Bonnie Mallard, Claude Robert, Niel Karrow BMC Veterinary Research 2011, 7:51 (1 September 2011)

Abstract | Full text | PDF | PubMed

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