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1.

Research article   Open Access Highly Accessed

Comparative analysis of fungal genomes reveals different plant cell wall degrading capacity in fungi

Zhongtao Zhao, Huiquan Liu, Chenfang Wang, Jin-Rong Xu BMC Genomics 2013, 14:274 (23 April 2013)

Abstract | Full text | PDF | PubMed

2.

Research   Open Access Highly Accessed

Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function

Xiaoming Zhang, Jing Xia, Yifan E Lii, Blanca E Barrera-Figueroa, Xuefeng Zhou, Shang Gao, Lu Lu, Dongdong Niu, Zheng Chen, Christy Leung, Timothy Wong, Huiming Zhang, Jianhua Guo, Yi Li, Renyi Liu, Wanqi Liang, Jian-Kang Zhu, Weixiong Zhang, Hailing Jin Genome Biology 2012, 13:R20 (22 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In Arabidopsis and rice, natural antisense transcripts are processed into siRNAs by DCL1 and DCL3

3.

Research   Open Access Highly Accessed

A childhood obesity intervention developed by families for families: results from a pilot study

Kirsten K Davison, Janine M Jurkowski, Kaigang Li, Sibylle Kranz, Hal A Lawson International Journal of Behavioral Nutrition and Physical Activity 2013, 10:3 (5 January 2013)

Abstract | Full text | PDF | PubMed

4.

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

5.

Research   Open Access

The housing first model (HFM) fidelity index: designing and testing a tool for measuring integrity of housing programs that serve active substance users

Dennis P Watson, John Orwat, Dana E Wagner, Valery Shuman, Randi Tolliver Substance Abuse Treatment, Prevention, and Policy 2013, 8:16 (3 May 2013)

Abstract | Full text | PDF | PubMed

6.

Research article   Open Access Highly Accessed

The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels

Mike Spillane, Ryan Schoch, Matt Cooke, Travis Harvey, Mike Greenwood, Richard Kreider, Darryn S Willoughby Journal of the International Society of Sports Nutrition 2009, 6:6 (19 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Review   Open Access

Application of RNA silencing to plant disease resistance

Cheng-Guo Duan, Chun-Han Wang, Hui-Shan Guo Silence 2012, 3:5 (31 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Hui-Shan Guo and colleagues review the application of RNA silencing in engineering plants that are resistant to plant viruses, viroids, insects and, more recently, fungal pathogens.

8.

Research   Open Access

Comparison of DNA extraction kits for PCR-DGGE analysis of human intestinal microbial communities from fecal specimens

Merlin W Ariefdjohan, Dennis A Savaiano, Cindy H Nakatsu Nutrition Journal 2010, 9:23 (22 May 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

Methodology   Open Access Highly Accessed

Tape-Arabidopsis Sandwich - a simpler Arabidopsis protoplast isolation method

Fu-Hui Wu, Shu-Chen Shen, Lan-Ying Lee, Shu-Hong Lee, Ming-Tsar Chan, Choun-Sea Lin Plant Methods 2009, 5:16 (24 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology

10.

Research article   Open Access Highly Accessed

Effect of carboxymethyl cellulose concentration on physical properties of biodegradable cassava starch-based films

Wirongrong Tongdeesoontorn, Lisa J Mauer, Sasitorn Wongruong, Pensiri Sriburi, Pornchai Rachtanapun Chemistry Central Journal 2011, 5:6 (10 February 2011)

Abstract | Full text | PDF | PubMed

11.

Review   Open Access

An overview of cardiovascular risk factor burden in sub-Saharan African countries: a socio-cultural perspective

Rhonda BeLue, Titilayo A Okoror, Juliet Iwelunmor, Kelly D Taylor, Arnold N Degboe, Charles Agyemang, Gbenga Ogedegbe Globalization and Health 2009, 5:10 (22 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

Technical Note   Open Access Highly Accessed

The bench scientist's guide to statistical analysis of RNA-Seq data

Craig R Yendrek, Elizabeth A Ainsworth, Jyothi Thimmapuram BMC Research Notes 2012, 5:506 (14 September 2012)

Abstract | Full text | PDF | PubMed

13.

Original investigation   Open Access

Protein Kinase C inhibition ameliorates functional endothelial insulin resistance and Vascular Smooth Muscle Cell hypersensitivity to insulin in diabetic hypertensive rats

Xiao Lu, James S Bean, Ghassan S Kassab, Mark D Rekhter Cardiovascular Diabetology 2011, 10:48 (2 June 2011)

Abstract | Full text | PDF | PubMed

14.

Research   Open Access

Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts

Kazuki Kuroda, Shihuan Kuang, Makoto M Taketo, Michael A Rudnicki Skeletal Muscle 2013, 3:5 (5 March 2013)

Abstract | Full text | PDF | PubMed

15.

Study protocol   Open Access Highly Accessed

Improving delirium care in the intensive care unit: The design of a pragmatic study

Noll L Campbell, Babar A Khan, Mark Farber, Tiffany Campbell, Anthony J Perkins, Siu L Hui, Greg Abernathy, John Buckley, Regg Sing, Jason Tricker, Mohammad Zawahiri, Malaz A Boustani Trials 2011, 12:139 (6 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Research   Open Access

Metabolic markers in Ossabaw pigs fed high fat diets enriched in regular or low α-linolenic acid soy oil

Ramesh B Potu, Hang Lu, Olayiwola Adeola, Kolapo M Ajuwon Nutrition & Metabolism 2013, 10:27 (14 March 2013)

Abstract | Full text | PDF | PubMed

17.

Research   Open Access Highly Accessed

A novel mode of chromosomal evolution peculiar to filamentous Ascomycete fungi

James K Hane, Thierry Rouxel, Barbara J Howlett, Gert HJ Kema, Stephen B Goodwin, Richard P Oliver Genome Biology 2011, 12:R45 (24 May 2011)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Mesosynteny, in which genes are maintained on the same chromosome but in different orders, is revealed in different ascomycete species

18.

Research article   Open Access

Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis

Yoony YJ Gent, Karin Weijers, Carla FM Molthoff, Albert D Windhorst, Marc C Huisman, Desirée EC Smith, Sumith A Kularatne, Gerrit Jansen, Philip S Low, Adriaan A Lammertsma, Conny J van der Laken Arthritis Research & Therapy 2013, 15:R37 (1 March 2013)

Abstract | Full text | PDF | PubMed

19.

Study protocol   Open Access

Medication adherence and tolerability of Alzheimer’s disease medications: study protocol for a randomized controlled trial

Noll L Campbell, Paul Dexter, Anthony J Perkins, Sujuan Gao, Lang Li, Todd C Skaar, Amie Frame, Hugh C Hendrie, Chris M Callahan, Malaz A Boustani Trials 2013, 14:125 (4 May 2013)

Abstract | Full text | PDF

20.

Research   Open Access

Oscillometric measurement of systolic and diastolic blood pressures validated in a physiologic mathematical model

Charles F Babbs BioMedical Engineering OnLine 2012, 11:56 (22 August 2012)

Abstract | Full text | PDF | PubMed

21.

Methodology   Open Access Highly Accessed

Vectors for multi-color bimolecular fluorescence complementation to investigate protein-protein interactions in living plant cells

Lan-Ying Lee, Mei-Jane Fang, Lin-Yun Kuang, Stanton B Gelvin Plant Methods 2008, 4:24 (15 October 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

Research   Open Access

Behavior of a viscoelastic valveless pump: a simple theory with experimental validation

Charles F Babbs BioMedical Engineering OnLine 2010, 9:42 (31 August 2010)

Abstract | Full text | PDF | PubMed

23.

Research   Open Access

Ammonia-oxidizing archaea and bacteria are structured by geography in biological soil crusts across North American arid lands

Yevgeniy Marusenko, Scott T Bates, Ian Anderson, Shannon L Johnson, Tanya Soule, Ferran Garcia-Pichel Ecological Processes 2013, 2:9 (26 April 2013)

Abstract | Full text | PDF

24.

Research   Open Access

Mycoplasma haemocanis – the canine hemoplasma and its feline counterpart in the genomic era

Naíla C do Nascimento, Andrea P Santos, Ana MS Guimaraes, Phillip J SanMiguel, Joanne B Messick Veterinary Research 2012, 43:66 (28 September 2012)

Abstract | Full text | PDF | PubMed

25.

Research article   Open Access Highly Accessed

Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii

Nanette R Boyle, John A Morgan BMC Systems Biology 2009, 3:4 (7 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

26.

Research   Open Access

Acute and second-meal effects of almond form in impaired glucose tolerant adults: a randomized crossover trial

Alisa M Mori, Robert V Considine, Richard D Mattes Nutrition & Metabolism 2011, 8:6 (28 January 2011)

Abstract | Full text | PDF | PubMed

27.

Research article   Open Access Highly Accessed

Roles of arabidopsis WRKY18, WRKY40 and WRKY60 transcription factors in plant responses to abscisic acid and abiotic stress

Han Chen, Zhibing Lai, Junwei Shi, Yong Xiao, Zhixiang Chen, Xinping Xu BMC Plant Biology 2010, 10:281 (19 December 2010)

Abstract | Full text | PDF | PubMed

28.

Protein family review   Free

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases

Jon A Friesen, Victor W Rodwell Genome Biology 2004, 5:248 (1 November 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate and is a target for anti-hypercholesterolemic drugs (statins).

29.

Research   Open Access

Lignin monomer composition affects Arabidopsis cell-wall degradability after liquid hot water pretreatment

Xu Li, Eduardo Ximenes, Youngmi Kim, Mary Slininger, Richard Meilan, Michael Ladisch, Clint Chapple Biotechnology for Biofuels 2010, 3:27 (2 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

Research   Open Access Highly Accessed

Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells

Pratik Banerjee, Glenn J Merkel, Arun K Bhunia Gut Pathogens 2009, 1:8 (27 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

Research article   Open Access Highly Accessed

Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension

Hisham Aljadhey, Wanzhu Tu, Richard A Hansen, Susan J Blalock, D Brater, Michael D Murray BMC Cardiovascular Disorders 2012, 12:93 (24 October 2012)

Abstract | Full text | PDF | PubMed

32.

Research   Open Access Highly Accessed

PPARδ regulates satellite cell proliferation and skeletal muscle regeneration

Alison R Angione, Chunhui Jiang, Dongning Pan, Yong-Xu Wang, Shihuan Kuang Skeletal Muscle 2011, 1:33 (1 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

Methodology   Open Access Highly Accessed

Using GPS-enabled cell phones to track the travel patterns of adolescents

Sarah E Wiehe, Aaron E Carroll, Gilbert C Liu, Kelly L Haberkorn, Shawn C Hoch, Jeffery S Wilson, J Dennis Fortenberry International Journal of Health Geographics 2008, 7:22 (21 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

Research   Open Access Highly Accessed

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression

Shyamala Ganesan, Andrea N Faris, Adam T Comstock, Sangbrita S Chattoraj, Asamanja Chattoraj, John R Burgess, Jeffrey L Curtis, Fernando J Martinez, Suzanna Zick, Marc B Hershenson, Uma S Sajjan Respiratory Research 2010, 11:131 (28 September 2010)

Abstract | Full text | PDF | PubMed

35.

Research article   Open Access Highly Accessed

Deep sequencing and genome-wide analysis reveals the expansion of MicroRNA genes in the gall midge Mayetiola destructor

Chitvan Khajuria, Christie E Williams, Mustapha El Bouhssini, R Jeff Whitworth, Stephen Richards, Jeffrey J Stuart, Ming-Shun Chen BMC Genomics 2013, 14:187 (18 March 2013)

Abstract | Full text | PDF | PubMed

36.

Research   Open Access

Effects of low carbohydrate diets high in red meats or poultry, fish and shellfish on plasma lipids and weight loss

Bridget A Cassady, Nicole L Charboneau, Emily E Brys, Kristin A Crouse, Donald C Beitz, Ted Wilson Nutrition & Metabolism 2007, 4:23 (31 October 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

Review   Open Access

Morphogenesis of the T4 tail and tail fibers

Petr G Leiman, Fumio Arisaka, Mark J van Raaij, Victor A Kostyuchenko, Anastasia A Aksyuk, Shuji Kanamaru, Michael G Rossmann Virology Journal 2010, 7:355 (3 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

Research   Open Access Highly Accessed

Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury

Youngnam Cho, Riyi Shi, Richard Ben Borgens Journal of Biological Engineering 2010, 4:2 (29 January 2010)

Abstract | Full text | PDF | PubMed

39.

Research   Open Access

A nanoparticle-based immobilization assay for prion-kinetics study

Gilles K Kouassi, Joseph Irudayaraj Journal of Nanobiotechnology 2006, 4:8 (17 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

40.

Nano Express   Open Access

Surface tension of Nanofluid-type fuels containing suspended nanomaterials

Saad Tanvir, Li Qiao Nanoscale Research Letters 2012, 7:226 (18 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

Research   Open Access Highly Accessed

Computational prediction of human metabolic pathways from the complete human genome

Pedro Romero, Jonathan Wagg, Michelle L Green, Dale Kaiser, Markus Krummenacker, Peter D Karp Genome Biology 2004, 6:R2 (22 December 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A computation pathway analysis of the human genome is presented that assigns enzymes encoded by the genome to predicted metabolic pathways. This analysis provides a genome-based view of human nutrition.

42.

Research article   Open Access Highly Accessed

Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets

Chuanwu Wang, Peter Hillsamer, Chang H Kim BMC Immunology 2011, 12:53 (13 September 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

PD-1 signaling restrains the B-cell helping function and proliferation of a PD-1-expressing, germinal center-localized, T cell subset by preventing excessive antibody response, supporting the role of PD-1 in promoting tolerance in humoral immunity.

43.

Research   Open Access

Screening for diabetes and hypertension in a rural low income setting in western Kenya utilizing home-based and community-based strategies

Sonak D Pastakia, Shamim M Ali, Jemima H Kamano, Constantine O Akwanalo, Samson K Ndege, Victor L Buckwalter, Rajesh Vedanthan, Gerald S Bloomfield Globalization and Health 2013, 9:21 (16 May 2013)

Abstract | Provisional PDF | PubMed

44.

Research article   Open Access Highly Accessed

Long term persistence of clonal malaria parasite Plasmodium falciparum lineages in the Colombian Pacific region

Diego F Echeverry, Shalini Nair, Lyda Osorio, Sanjay Menon, Claribel Murillo, Tim JC Anderson BMC Genetics 2013, 14:2 (7 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Analysis of Plasmodium falciparum parasites from malaria patients in Colombia reveals strong subdivision and long-term persistence of clonal populations, highlighting that these aspects of population structure should be taken into account when designing drug resistance studies.

45.

Research   Open Access Highly Accessed

Seroprevalence of Ehrlichia canis, Ehrlichia chaffeensis and Ehrlichia ewingii in dogs in North America

Melissa J Beall, A Rick Alleman, Ed B Breitschwerdt, Leah A Cohn, C Guillermo Couto, Michael W Dryden, Lynn C Guptill, Cristina Iazbik, Stephen A Kania, Patty Lathan, Susan E Little, Alma Roy, Katherine A Sayler, Brett A Stillman, Elizabeth G Welles, Wendy Wolfson, Michael J Yabsley Parasites & Vectors 2012, 5:29 (8 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The dog has been described as a sentinel for vector-borne infections. Serological results from dogs tested using Ehrlichia species-specific peptides revealed the geographic distribution of these organisms in the Eastern half of the U.S. and provided a gauge of the potential risk for human infection with these tick-transmitted pathogens. Image: Schematic of the study (courtesy of Lucienne Timblin)

46.

Review   Open Access

Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication

Bing Song, X Shawn Liu, Xiaoqi Liu Cell Division 2012, 7:3 (6 February 2012)

Abstract | Full text | PDF | PubMed

47.

Research article   Open Access

Genetic dissection of maize phenology using an intraspecific introgression library

Silvio Salvi, Simona Corneti, Massimo Bellotti, Nicola Carraro, Maria C Sanguineti, Sara Castelletti, Roberto Tuberosa BMC Plant Biology 2011, 11:4 (6 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

Original research   Open Access

Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response

Harm HogenEsch, Anisa Dunham, Bethany Hansen, Kathleen Anderson, Jean-Francois Maisonneuve, Stanley L Hem Journal of Immune Based Therapies and Vaccines 2011, 9:5 (29 July 2011)

Abstract | Full text | PDF | PubMed

49.

Research article   Open Access Highly Accessed

Genomic survey of the ectoparasitic mite Varroa destructor, a major pest of the honey bee Apis mellifera

R Cornman, Michael C Schatz, J Johnston, Yan-Ping Chen, Jeff Pettis, Greg Hunt, Lanie Bourgeois, Chris Elsik, Denis Anderson, Christina M Grozinger, Jay D Evans BMC Genomics 2010, 11:602 (25 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

Research article   Open Access

BATF regulates the development and function of IL-17 producing iNKT cells

Kimberly L Jordan-Williams, Stacie Poston, Elizabeth J Taparowsky BMC Immunology 2013, 14:16 (27 March 2013)

Abstract | Full text | PDF | PubMed

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