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1.

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

2.

Research   Open Access Highly Accessed

Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function

Xiaoming Zhang, Jing Xia, Yifan E Lii, Blanca E Barrera-Figueroa, Xuefeng Zhou, Shang Gao, Lu Lu, Dongdong Niu, Zheng Chen, Christy Leung, Timothy Wong, Huiming Zhang, Jianhua Guo, Yi Li, Renyi Liu, Wanqi Liang, Jian-Kang Zhu, Weixiong Zhang, Hailing Jin Genome Biology 2012, 13:R20 (22 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In Arabidopsis and rice, natural antisense transcripts are processed into siRNAs by DCL1 and DCL3

3.

Research   Open Access Highly Accessed

Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire

C André Lévesque, Henk Brouwer, Liliana Cano, John P Hamilton, Carson Holt, Edgar Huitema, Sylvain Raffaele, Gregg P Robideau, Marco Thines, Joe Win, Marcelo M Zerillo, Gordon W Beakes, Jeffrey L Boore, Dana Busam, Bernard Dumas, Steve Ferriera, Susan I Fuerstenberg, Claire MM Gachon, Elodie Gaulin, Francine Govers, Laura Grenville-Briggs, Neil Horner, Jessica Hostetler, Rays HY Jiang, Justin Johnson, Theerapong Krajaejun, Haining Lin, Harold JG Meijer, Barry Moore, Paul Morris et al. Genome Biology 2010, 11:R73 (13 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The genome sequence of the plant pathogenic oomycete, Pythium ultimum and a comparison with the related potato blight pathogen genome reveals differences in pathogenicity.

4.

Methods   Open Access

Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana

So Youn Won, Shengben Li, Binglian Zheng, Yuanyuan Zhao, Dongming Li, Xin Zhao, Huilan Yi, Lei Gao, Thanh Theresa Dinh, Xuemei Chen Silence 2012, 3:6 (7 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A luciferase-based reporter system, LUCH, is used to screen for bidirectional mutants that enhance or suppress transcriptional gene silencing, elucidating the mechanisms of DNA methylation and demethylation.

5.

Research   Open Access

Immunity and other defenses in pea aphids, Acyrthosiphon pisum

Nicole M Gerardo, Boran Altincicek, Caroline Anselme, Hagop Atamian, Seth M Barribeau, Martin de Vos, Elizabeth J Duncan, Jay D Evans, Toni Gabaldón, Murad Ghanim, Adelaziz Heddi, Isgouhi Kaloshian, Amparo Latorre, Andres Moya, Atsushi Nakabachi, Benjamin J Parker, Vincente Pérez-Brocal, Miguel Pignatelli, Yvan Rahbé, John S Ramsey, Chelsea J Spragg, Javier Tamames, Daniel Tamarit, Cecilia Tamborindeguy, Caroline Vincent-Monegat, Andreas Vilcinskas Genome Biology 2010, 11:R21 (23 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The genome of the pea aphid Acyrthosiphon pisum lacks genes thought to be crucial in other insects for recognition, signaling and killing of microbes.

6.

Research article   Open Access Highly Accessed

A fungal phylogeny based on 82 complete genomes using the composition vector method

Hao Wang, Zhao Xu, Lei Gao, Bailin Hao BMC Evolutionary Biology 2009, 9:195 (10 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research article   Open Access Highly Accessed

Development and implementation of high-throughput SNP genotyping in barley

Timothy J Close, Prasanna R Bhat, Stefano Lonardi, Yonghui Wu, Nils Rostoks, Luke Ramsay, Arnis Druka, Nils Stein, Jan T Svensson, Steve Wanamaker, Serdar Bozdag, Mikeal L Roose, Matthew J Moscou, Shiaoman Chao, Rajeev K Varshney, Péter Szűcs, Kazuhiro Sato, Patrick M Hayes, David E Matthews, Andris Kleinhofs, Gary J Muehlbauer, Joseph DeYoung, David F Marshall, Kavitha Madishetty, Raymond D Fenton, Pascal Condamine, Andreas Graner, Robbie Waugh BMC Genomics 2009, 10:582 (4 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A high-density consensus genetic map of barley based only on complete and error-free datasets and genic markers, enables a high resolution comparison of barley and rice genomes and will aid marker-assisted breeding and association studies.

8.

Research article   Open Access Highly Accessed

High throughput sequencing reveals novel and abiotic stress-regulated microRNAs in the inflorescences of rice

Blanca E Barrera-Figueroa, Lei Gao, Zhigang Wu, Xuefeng Zhou, Jianhua Zhu, Hailing Jin, Renyi Liu, Jian-Kang Zhu BMC Plant Biology 2012, 12:132 (3 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

Research   Open Access

Rapid selection and identification of Miscanthus genotypes with enhanced glucan and xylan yields from hydrothermal pretreatment followed by enzymatic hydrolysis

Taiying Zhang, Charles E Wyman, Katrin Jakob, Bin Yang Biotechnology for Biofuels 2012, 5:56 (3 August 2012)

Abstract | Full text | PDF | PubMed

10.

Research   Open Access

Supplementation with xylanase and β-xylosidase to reduce xylo-oligomer and xylan inhibition of enzymatic hydrolysis of cellulose and pretreated corn stover

Qing Qing, Charles E Wyman Biotechnology for Biofuels 2011, 4:18 (24 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

Research article   Open Access Highly Accessed

A supermatrix analysis of genomic, morphological, and paleontological data from crown Cetacea

Jonathan H Geisler, Michael R McGowen, Guang Yang, John Gatesy BMC Evolutionary Biology 2011, 11:112 (25 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The most complete morphological and molecular super matrix for Cetacea to date reveals that many character states shared by river dolphins evolved in their oceanic ancestors contrary to previous views.

12.

Review   Open Access Highly Accessed

Misuse of "study drugs:" prevalence, consequences, and implications for policy

Steve Sussman, Mary Pentz, Donna Spruijt-Metz, Toby Miller Substance Abuse Treatment, Prevention, and Policy 2006, 1:15 (9 June 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

Review   Open Access Highly Accessed

Smoking and reproduction: The oviduct as a target of cigarette smoke

Prue Talbot, Karen Riveles Reproductive Biology and Endocrinology 2005, 3:52 (28 September 2005)

Abstract | Full text | PDF | PubMed

14.

Research   Open Access Highly Accessed

Cloning and characterization of microRNAs from wheat (Triticum aestivum L.)

Yingyin Yao, Ganggang Guo, Zhongfu Ni, Ramanjulu Sunkar, Jinkun Du, Jian-Kang Zhu, Qixin Sun Genome Biology 2007, 8:R96 (1 June 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A small RNA library was used to identify 58 miRNAs from 43 miRNA families from wheat (Triticum aestivum L.), and 46 potential targets were predicted.

15.

Research   Open Access Highly Accessed

Multiple distinct small RNAs originate from the same microRNA precursors

Weixiong Zhang, Shang Gao, Xuefeng Zhou, Jing Xia, Padmanabhan Chellappan, Xiang Zhou, Xiaoming Zhang, Hailing Jin Genome Biology 2010, 11:R81 (9 August 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Deep sequencing of Arabidopsis small RNAs reveals the existence of novel miRNA-like RNAs generated from miRNA precursor hairpins.

16.

Research article   Open Access Highly Accessed

Identification of novel and candidate miRNAs in rice by high throughput sequencing

Ramanjulu Sunkar, Xuefeng Zhou, Yun Zheng, Weixiong Zhang, Jian-Kang Zhu BMC Plant Biology 2008, 8:25 (29 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

Research   Open Access

Genome-wide analysis reveals rapid and dynamic changes in miRNA and siRNA sequence and expression during ovule and fiber development in allotetraploid cotton (Gossypium hirsutum L.)

Mingxiong Pang, Andrew W Woodward, Vikram Agarwal, Xueying Guan, Misook Ha, Vanitharani Ramachandran, Xuemei Chen, Barbara A Triplett, David M Stelly, Z Jeffrey Chen Genome Biology 2009, 10:R122 (4 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Rapid and dynamic changes in the expression of small RNAs are seen during ovule and fiber development in allotetraploid cotton.

18.

Research article   Open Access Highly Accessed

Identification and comparative analysis of drought-associated microRNAs in two cowpea genotypes

Blanca E Barrera-Figueroa, Lei Gao, Ndeye N Diop, Zhigang Wu, Jeffrey D Ehlers, Philip A Roberts, Timothy J Close, Jian-Kang Zhu, Renyi Liu BMC Plant Biology 2011, 11:127 (17 September 2011)

Abstract | Full text | PDF | PubMed

19.

Research article   Open Access Highly Accessed

Novel and nodulation-regulated microRNAs in soybean roots

Senthil Subramanian, Yan Fu, Ramanjulu Sunkar, W Brad Barbazuk, Jian-Kang Zhu, Oliver Yu BMC Genomics 2008, 9:160 (10 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

Research article   Open Access Highly Accessed

454 sequencing put to the test using the complex genome of barley

Thomas Wicker, Edith Schlagenhauf, Andreas Graner, Timothy J Close, Beat Keller, Nils Stein BMC Genomics 2006, 7:275 (26 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

21.

Research   Open Access

Simultaneous cell growth and ethanol production from cellulose by an engineered yeast consortium displaying a functional mini-cellulosome

Garima Goyal, Shen-Long Tsai, Bhawna Madan, Nancy A DaSilva, Wilfred Chen Microbial Cell Factories 2011, 10:89 (1 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

Research   Open Access Highly Accessed

Separating metagenomic short reads into genomes via clustering

Olga Tanaseichuk, James Borneman, Tao Jiang Algorithms for Molecular Biology 2012, 7:27 (26 September 2012)

Abstract | Full text | PDF | PubMed

23.

Research article   Open Access Highly Accessed

Novel core promoter elements in the oomycete pathogen Phytophthora infestans and their influence on expression detected by genome-wide analysis

Sourav Roy, Laetitia Poidevin, Tao Jiang, Howard S Judelson BMC Genomics 2013, 14:106 (16 February 2013)

Abstract | Full text | PDF | PubMed

24.

Nano Express   Open Access Highly Accessed

Electro-synthesis of novel nanostructured PEDOT films and their application as catalyst support

Cuifeng Zhou, Zongwen Liu, Yushan Yan, Xusheng Du, Yiu-Wing Mai, Simon Ringer Nanoscale Research Letters 2011, 6:364 (27 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

Research article   Open Access

Partial sequencing of the bottle gourd genome reveals markers useful for phylogenetic analysis and breeding

Pei Xu, Xiaohua Wu, Jie Luo, Baogen Wang, Yonghua Liu, Jeffrey D Ehlers, Sha Wang, Zhongfu Lu, Guojing Li BMC Genomics 2011, 12:467 (27 September 2011)

Abstract | Full text | PDF | PubMed

26.

Research article   Open Access

Untangling spider silk evolution with spidroin terminal domains

Jessica E Garb, Nadia A Ayoub, Cheryl Y Hayashi BMC Evolutionary Biology 2010, 10:243 (9 August 2010)

Abstract | Full text | PDF | PubMed

27.

Research article   Open Access

Comparison of class 2 transposable elements at superfamily resolution reveals conserved and distinct features in cereal grass genomes

Yujun Han, Shanshan Qin, Susan R Wessler BMC Genomics 2013, 14:71 (31 January 2013)

Abstract | Full text | PDF | PubMed

28.

Research article   Open Access

Co-option of EDM2 to distinct regulatory modules in Arabidopsis thaliana development

Tokuji Tsuchiya, Thomas Eulgem BMC Plant Biology 2010, 10:203 (14 September 2010)

Abstract | Full text | PDF | PubMed

29.

Research article   Open Access

Leaf morphology in Cowpea [Vigna unguiculata (L.) Walp]: QTL analysis, physical mapping and identifying a candidate gene using synteny with model legume species

Marti Pottorff, Jeffrey D Ehlers, Christian Fatokun, Philip A Roberts, Timothy J Close BMC Genomics 2012, 13:234 (12 June 2012)

Abstract | Full text | PDF | PubMed

30.

Research   Open Access

The ultrastructure of book lung development in the bark scorpion Centruroides gracilis (Scorpiones: Buthidae)

Roger D Farley Frontiers in Zoology 2011, 8:18 (27 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

Research article   Open Access Highly Accessed

Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties

Aliana López de Victoria, Chris A Kieslich, Apostolos K Rizos, Elias Krambovitis, Dimitrios Morikis BMC Biophysics 2012, 5:3 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The spatial distributions of electrostatic potentials and charges in the V3 loop of HIV-1 protein gp120 may be responsible for both long- and short-range interactions with co-receptors, ultimately affecting viral entry into cells

32.

Methodology article   Open Access

Generalized linear mixed model for segregation distortion analysis

Haimao Zhan, Shizhong Xu BMC Genetics 2011, 12:97 (11 November 2011)

Abstract | Full text | PDF | PubMed

33.

Editorial   Open Access

Welcome to Biotechnology for Biofuels

Bärbel Hahn-Hägerdal, Michael E Himmel, Chris Somerville, Charles Wyman Biotechnology for Biofuels 2008, 1:1 (15 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

34.

Research   Open Access

Ultrastructure of book gill development in embryos and first instars of the horseshoe crab Limulus polyphemus L. (Chelicerata, Xiphosura)

Roger D Farley Frontiers in Zoology 2012, 9:4 (21 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

Research article   Open Access Highly Accessed

Open-label add-on treatment trial of minocycline in fragile X syndrome

Carlo Paribello, Leeping Tao, Anthony Folino, Elizabeth Berry-Kravis, Michael Tranfaglia, Iryna M Ethell, Douglas W Ethell BMC Neurology 2010, 10:91 (11 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

Research article   Open Access Highly Accessed

Genome-wide SNPs and re-sequencing of growth habit and inflorescence genes in barley: implications for association mapping in germplasm arrays varying in size and structure

Alfonso Cuesta-Marcos, Péter Szűcs, Timothy J Close, Tanya Filichkin, Gary J Muehlbauer, Kevin P Smith, Patrick M Hayes BMC Genomics 2010, 11:707 (15 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

Research article   Open Access

Bilateral enucleation alters gene expression and intraneocortical connections in the mouse

Catherine A Dye, Charles W Abbott, Kelly J Huffman Neural Development 2012, 7:5 (30 January 2012)

Abstract | Full text | PDF | PubMed

38.

Research   Open Access

Predominant constitutive CFTR conductance in small airways

Xiaofei Wang, Christian Lytle, Paul M Quinton Respiratory Research 2005, 6:7 (17 January 2005)

Abstract | Full text | PDF | PubMed

39.

Research article   Open Access

Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing

Yan Liu, Melissa Petreaca, Min Yao, Manuela Martins-Green BMC Cell Biology 2009, 10:1 (12 January 2009)

Abstract | Full text | PDF | PubMed

40.

Research article   Open Access

Phylogeny and adaptive evolution of the brain-development gene microcephalin (MCPH1) in cetaceans

Michael R McGowen, Stephen H Montgomery, Clay Clark, John Gatesy BMC Evolutionary Biology 2011, 11:98 (14 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

Review   Open Access

Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation

Shahani Noor, Emma H Wilson Journal of Neuroinflammation 2012, 9:77 (25 April 2012)

Abstract | Full text | PDF | PubMed

42.

Research article   Open Access Highly Accessed

A quantitative analysis of the mechanism that controls body size in Manduca sexta

HF Nijhout, G Davidowitz, DA Roff Journal of Biology 2006, 5:16 (2 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Final body size in the moth Manduca sexta can be predicted from the juvenile caterpillar by modeling three key growth measurements to reveal how growth rate, nutrition and temperature determine eventual body size.

43.

Research   Open Access Highly Accessed

Notch regulates the angiogenic response via induction of VEGFR-1

Yasuhiro Funahashi, Carrie J Shawber, Marina Vorontchikhina, Anshula Sharma, Hasina H Outtz, Jan Kitajewski Journal of Angiogenesis Research 2010, 2:3 (26 January 2010)

Abstract | Full text | PDF | PubMed

44.

Research article   Open Access Highly Accessed

Molecular decay of enamel matrix protein genes in turtles and other edentulous amniotes

Robert W Meredith, John Gatesy, Mark S Springer BMC Evolutionary Biology 2013, 13:20 (23 January 2013)

Abstract | Full text | PDF | PubMed

45.

Methodology article   Open Access

Development and application of a 6.5 million feature Affymetrix Genechip® for massively parallel discovery of single position polymorphisms in lettuce (Lactuca spp.)

Kevin Stoffel, Hans van Leeuwen, Alexander Kozik, David Caldwell, Hamid Ashrafi, Xinping Cui, Xiaoping Tan, Theresa Hill, Sebastian Reyes-Chin-Wo, Maria-Jose Truco, Richard W Michelmore, Allen Van Deynze BMC Genomics 2012, 13:185 (14 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

46.

Research article   Open Access Highly Accessed

Effects of "second-hand" smoke on structure and function of fibroblasts, cells that are critical for tissue repair and remodeling

Lina S Wong, Harry Green, Jo Feugate, Madhav Yadav, Eugene A Nothnagel, Manuela Martins-Green BMC Cell Biology 2004, 5:13 (5 April 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

47.

Research article   Open Access

A reference genetic map of C. clementina hort. ex Tan.; citrus evolution inferences from comparative mapping

Patrick Ollitrault, Javier Terol, Chunxian Chen, Claire T Federici, Samia Lotfy, Isabelle Hippolyte, Frédérique Ollitrault, Aurélie Bérard, Aurélie Chauveau, Jose Cuenca, Gilles Costantino, Yildiz Kacar, Lisa Mu, Andres Garcia-Lor, Yann Froelicher, Pablo Aleza, Anne Boland, Claire Billot, Luis Navarro, François Luro, Mikeal L Roose, Frederick G Gmitter, Manuel Talon, Dominique Brunel BMC Genomics 2012, 13:593 (5 November 2012)

Abstract | Full text | PDF | PubMed

48.

Research article   Open Access Highly Accessed

5'-Serial Analysis of Gene Expression studies reveal a transcriptomic switch during fruiting body development in Coprinopsis cinerea

Chi Keung Cheng, Chun Hang Au, Sarah K Wilke, Jason E Stajich, Miriam E Zolan, Patricia J Pukkila, Hoi Shan Kwan BMC Genomics 2013, 14:195 (20 March 2013)

Abstract | Full text | PDF | PubMed

49.

Research article   Open Access

The mosquito Aedes aegypti has a large genome size and high transposable element load but contains a low proportion of transposon-specific piRNAs

Peter Arensburger, Robert H Hice, Jennifer A Wright, Nancy L Craig, Peter W Atkinson BMC Genomics 2011, 12:606 (15 December 2011)

Abstract | Full text | PDF | PubMed

50.

Research   Open Access

Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells

Gang Chen, Maiara S Severo, Mohammad Sohail, Olivia S Sakhon, Stephen K Wikel, Michail Kotsyfakis, Joao HF Pedra Parasites & Vectors 2012, 5:229 (10 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This study demonstrates that Ixodes scapularis saliva inhibits Toll-like (TLR) and Nod-like receptor (NLR) induced-inflammatory cytokine secretion by mouse and human immune cells. I. scapularis saliva also mitigates the cytokine response by macrophages during challenge with Anaplasma phagocytophilum. Image: Anaplasma phagocytophilum engulfed by macrophages [membranes (green), A. phagocytophilum (red), and nuclei (blue)]. Magnification is 600x4=2400.

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