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1.

Research   Open Access Highly Accessed

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples

Nicola Segata, Susan Haake, Peter Mannon, Katherine P Lemon, Levi Waldron, Dirk Gevers, Curtis Huttenhower, Jacques Izard Genome Biology 2012, 13:R42 (14 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Human Microbiome Project's analysis of ten sites in the digestive tract of healthy human adults

2.

Review   Open Access Highly Accessed

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

Reason Wilken, Mysore S Veena, Marilene B Wang, Eri S Srivatsan Molecular Cancer 2011, 10:12 (7 February 2011)

Abstract | Full text | PDF | PubMed

3.

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

4.

Research article   Open Access Highly Accessed

Perinatal nicotine exposure induces asthma in second generation offspring

Virender K Rehan, Jie Liu, Erum Naeem, Jia Tian, Reiko Sakurai, Kenny Kwong, Omid Akbari, John S Torday BMC Medicine 2012, 10:129 (30 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Smoking during pregnancy induces asthma in offspring, and the effects are permanently transmitted to subsequent generations via epigenetic changes in germ cells, providing a breakthrough in studying transgenerational effects of toxins.

5.

Research   Open Access Highly Accessed

The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage

John Abramyan, Daleen Badenhorst, Kyle K Biggar, Glen M Borchert, Christopher W Botka, Rachel M Bowden, Edward L Braun, Anne M Bronikowski, Benoit G Bruneau, Leslie T Buck, Blanche Capel, Todd A Castoe, Mike Czerwinski, Kim D Delehaunty, Scott V Edwards, Catrina C Fronick, Matthew K Fujita, Lucinda Fulton, Tina A Graves, Richard E Green, Wilfried Haerty, Ramkumar Hariharan, LaDeana H Hillier, Alisha K Holloway, Daniel Janes, Fredric J Janzen, Cyriac Kandoth, Lesheng Kong, Jason de Koning, Yang Li et al. Genome Biology 2013, 14:R28 (28 March 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

The genome of the western painted turtle, Chrysemys picta bellii, reveals insights into its extreme tolerance to anoxia and freezing

6.

Review   Open Access Highly Accessed

A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): A review of clinical studies on weight loss and glycemic control

Marilyn L Barrett, Jay K Udani Nutrition Journal 2011, 10:24 (17 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research   Open Access Highly Accessed

Aging effects on DNA methylation modules in human brain and blood tissue

Steve Horvath, Yafeng Zhang, Peter Langfelder, René S Kahn, Marco PM Boks, Kristel van Eijk, Leonard H van den Berg, Roel A Ophoff Genome Biology 2012, 13:R97 (3 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An age-related co-methylation module in human brain and blood tissue includes genes associated with Alzheimer's disease

8.

Review   Open Access Highly Accessed

Acute cough: a diagnostic and therapeutic challenge

Peter V Dicpinigaitis, Gene L Colice, Mary Goolsby, Gary I Rogg, Sheldon L Spector, Birgit Winther Cough 2009, 5:11 (16 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

Research article   Open Access Highly Accessed

Meta-analysis: Neither quick nor easy

Nancy G Berman, Robert A Parker BMC Medical Research Methodology 2002, 2:10 (9 August 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

Review   Open Access Highly Accessed

Klinefelter syndrome and other sex chromosomal aneuploidies

Jeannie Visootsak, John M Graham Orphanet Journal of Rare Diseases 2006, 1:42 (24 October 2006)

Abstract | Full text | PDF | PubMed

11.

Review   Open Access Highly Accessed

The six most essential questions in psychiatric diagnosis: a pluralogue part 1: conceptual and definitional issues in psychiatric diagnosis

James Phillips, Allen Frances, Michael A Cerullo, John Chardavoyne, Hannah S Decker, Michael B First, Nassir Ghaemi, Gary Greenberg, Andrew C Hinderliter, Warren A Kinghorn, Steven G LoBello, Elliott B Martin, Aaron L Mishara, Joel Paris, Joseph M Pierre, Ronald W Pies, Harold A Pincus, Douglas Porter, Claire Pouncey, Michael A Schwartz, Thomas Szasz, Jerome C Wakefield, G Scott Waterman, Owen Whooley, Peter Zachar Philosophy, Ethics, and Humanities in Medicine 2012, 7:3 (13 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

Research   Open Access Highly Accessed

A controlled trial of protein enrichment of meal replacements for weight reduction with retention of lean body mass

Leo Treyzon, Steve Chen, Kurt Hong, Eric Yan, Catherine L Carpenter, Gail Thames, Susan Bowerman, He-Jing Wang, Robert Elashoff, Zhaoping Li Nutrition Journal 2008, 7:23 (27 August 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

Review   Open Access

The six most essential questions in psychiatric diagnosis: a pluralogue part 3: issues of utility and alternative approaches in psychiatric diagnosis

James Phillips, Allen Frances, Michael A Cerullo, John Chardavoyne, Hannah S Decker, Michael B First, Nassir Ghaemi, Gary Greenberg, Andrew C Hinderliter, Warren A Kinghorn, Steven G LoBello, Elliott B Martin, Aaron L Mishara, Joel Paris, Joseph M Pierre, Ronald W Pies, Harold A Pincus, Douglas Porter, Claire Pouncey, Michael A Schwartz, Thomas Szasz, Jerome C Wakefield, G Waterman, Owen Whooley, Peter Zachar Philosophy, Ethics, and Humanities in Medicine 2012, 7:9 (23 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Research   Open Access Highly Accessed

Food consumption frequency and perceived stress and depressive symptoms among students in three European countries

Rafael T Mikolajczyk, Walid El Ansari, Annette E Maxwell Nutrition Journal 2009, 8:31 (15 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

Research   Open Access Highly Accessed

Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: A pilot study

Jay K Udani, Betsy B Singh, Vijay J Singh, Marilyn L Barrett Nutrition Journal 2011, 10:45 (12 May 2011)

Abstract | Full text | PDF | PubMed

16.

Research   Open Access Highly Accessed

Cancer and non-cancer health effects from food contaminant exposures for children and adults in California: a risk assessment

Rainbow Vogt, Deborah Bennett, Diana Cassady, Joshua Frost, Beate Ritz, Irva Hertz-Picciotto Environmental Health 2012, 11:83 (9 November 2012)

Abstract | Full text | PDF | PubMed

17.

Research article   Open Access Highly Accessed

Cyclic Vomiting Syndrome in 41 adults: the illness, the patients, and problems of management

David R Fleisher, Blake Gornowicz, Kathleen Adams, Richard Burch, Edward J Feldman BMC Medicine 2005, 3:20 (21 December 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Cyclical Vomiting Syndrome is a little studied but disabling condition, occurring in adults as well as children; appreciation of comorbidities such as migraine, anxiety and inter-episodic dyspeptic nausea may improve diagnosis.

18.

Research   Open Access Highly Accessed

Common genetic variants, acting additively, are a major source of risk for autism

Lambertus Klei, Stephan J Sanders, Michael T Murtha, Vanessa Hus, Jennifer K Lowe, A Willsey, Daniel Moreno-De-Luca, Timothy W Yu, Eric Fombonne, Daniel Geschwind, Dorothy E Grice, David H Ledbetter, Catherine Lord, Shrikant M Mane, Christa Martin, Donna M Martin, Eric M Morrow, Christopher A Walsh, Nadine M Melhem, Pauline Chaste, James S Sutcliffe, Matthew W State, Edwin H Cook, Kathryn Roeder, Bernie Devlin Molecular Autism 2012, 3:9 (15 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Common genetic variants have a substantial additive genetic effect on autism spectrum disorder liability and this effect differs between simplex and multiplex families.

19.

Review   Subscription Highly Accessed

Autism genetics: searching for specificity and convergence

Jamee M Berg, Daniel H Geschwind Genome Biology 2012, 13:247 (31 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Daniel Geschwind and Jamee Berg review the genes associated with autism spectrum disorders: how might their functions relate to one another?

20.

Case report   Open Access Highly Accessed

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

Edward L Tobinick, Hyman Gross Journal of Neuroinflammation 2008, 5:2 (9 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Report of rapid cognitive improvement in an Alzheimer's patient within minutes following delivery of an anti-tumor necrosis factor-alpha (TNF) therapeutic, etanercept.

21.

Methodology   Open Access Highly Accessed

A BioBrick compatible strategy for genetic modification of plants

Patrick M Boyle, Devin R Burrill, Mara C Inniss, Christina M Agapakis, Aaron Deardon, Jonathan G DeWerd, Michael A Gedeon, Jacqueline Y Quinn, Morgan L Paull, Anugraha M Raman, Mark R Theilmann, Lu Wang, Julia C Winn, Oliver Medvedik, Kurt Schellenberg, Karmella A Haynes, Alain Viel, Tamara J Brenner, George M Church, Jagesh V Shah, Pamela A Silver Journal of Biological Engineering 2012, 6:8 (20 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

Review   Open Access Highly Accessed

A unified phylogeny-based nomenclature for histone variants

Paul B Talbert, Kami Ahmad, Geneviève Almouzni, Juan Ausió, Frederic Berger, Prem L Bhalla, William M Bonner, W Cande, Brian P Chadwick, Simon W L Chan, George A M Cross, Liwang Cui, Stefan I Dimitrov, Detlef Doenecke, José M Eirin-López, Martin A Gorovsky, Sandra B Hake, Barbara A Hamkalo, Sarah Holec, Steven E Jacobsen, Kinga Kamieniarz, Saadi Khochbin, Andreas G Ladurner, David Landsman, John A Latham, Benjamin Loppin, Harmit S Malik, William F Marzluff, John R Pehrson, Jan Postberg et al. Epigenetics & Chromatin 2012, 5:7 (31 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In response to an urgent need to rationalize the current schemes for naming histone variants, researchers from over 30 institutions worldwide have developed consistent but flexible naming rules that are informative and database-searchable.

23.

Commentary   Open Access Highly Accessed

Defining the critical hurdles in cancer immunotherapy

Bernard A Fox, Dolores J Schendel, Lisa H Butterfield, Steinar Aamdal, James P Allison, Paolo Ascierto, Michael B Atkins, Jirina Bartunkova, Lothar Bergmann, Neil Berinstein, Cristina C Bonorino, Ernest Borden, Jonathan L Bramson, Cedrik M Britten, Xuetao Cao, William E Carson, Alfred E Chang, Dainius Characiejus, A Raja Choudhury, George Coukos, Tanja de Gruijl, Robert O Dillman, Harry Dolstra, Glenn Dranoff, Lindy G Durrant, James H Finke, Jerome Galon, Jared A Gollob, Cécile Gouttefangeas, Fabio Grizzi et al. Journal of Translational Medicine 2011, 9:214 (14 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Research article   Open Access Highly Accessed

Outdoor advertising, obesity, and soda consumption: a cross-sectional study

Lenard I Lesser, Frederick J Zimmerman, Deborah A Cohen BMC Public Health 2013, 13:20 (10 January 2013)

Abstract | Full text | PDF | PubMed

25.

Research   Open Access Highly Accessed

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

Gentao Liu, Xiangpeng Yuan, Zhaohui Zeng, Patrizia Tunici, Hiushan Ng, Iman R Abdulkadir, Lizhi Lu, Dwain Irvin, Keith L Black, John S Yu Molecular Cancer 2006, 5:67 (2 December 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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