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226.

Review   Open Access

State of the art and challenges in sequence based T-cell epitope prediction

Claus Lundegaard, Ilka Hoof, Ole Lund, Morten Nielsen Immunome Research 2010, 6(Suppl 2):S3 (3 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

227.

Research   Open Access

HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression

Douglas Conrad, Angela Wang, Raymond Pieters , Ferdinando Nicoletti, Katia Mangano, Anna M van Heeckeren, Steven K White, James M Frincke, Christopher L Reading, Dwight Stickney, Dominick L Auci Journal of Inflammation 2010, 7:52 (30 October 2010)

Abstract | Full text | PDF | PubMed

228.

Study protocol   Open Access Highly Accessed

A multidisciplinary cognitive behavioural programme for coping with chronic neuropathic pain following spinal cord injury: the protocol of the CONECSI trial

Matagne Heutink, Marcel WM Post, Peter Luthart, Lilian EMA Pfennings, Catja A Dijkstra, Eline Lindeman BMC Neurology 2010, 10:96 (20 October 2010)

Abstract | Full text | PDF | PubMed

229.

Study protocol   Open Access

The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037)

Hilko A Swank, Jefrey Vermeulen, Johan F Lange, Irene M Mulder, Joost AB van der Hoeven, Laurents PS Stassen, Rogier MPH Crolla, Meindert N Sosef, Simon W Nienhuijs, Robbert JI Bosker, Maarten J Boom, Philip M Kruyt, Dingeman J Swank, Willem H Steup, Eelco JR de Graaf, Wibo F Weidema, Robert EGJM Pierik, Hubert A Prins, Hein BAC Stockmann, Rob AEM Tollenaar, Bart A van Wagensveld, Peter-Paul LO Coene, Gerrit D Slooter, Esther CJ Consten, Eino B van Duijn, Michael F Gerhards, Anton GM Hoofwijk, Thomas M Karsten, Peter A Neijenhuis, Charlotte FJM Blanken-Peeters et al. BMC Surgery 2010, 10:29 (18 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

230.

Research article   Open Access Highly Accessed

The global pediatric antiretroviral market: analyses of product availability and utilization reveal challenges for development of pediatric formulations and HIV/AIDS treatment in children

Brenda Waning, Ellen Diedrichsen, Elodie Jambert, Till Bärnighausen, Yun Li, Mieke Pouw, Suerie Moon BMC Pediatrics 2010, 10:74 (17 October 2010)

Abstract | Full text | PDF | PubMed

231.

Study protocol   Open Access Highly Accessed

A randomized two arm phase III study in patients post radical resection of liver metastases of colorectal cancer to investigate bevacizumab in combination with capecitabine plus oxaliplatin (CAPOX) vs CAPOX alone as adjuvant treatment

Nikol Snoeren, Emile E Voest, Andre M Bergman, Otilia Dalesio, Henk M Verheul, Rob AEM Tollenaar, Joost RM van der Sijp, Sander B Schouten, Inne Rinkes, R van Hillegersberg BMC Cancer 2010, 10:545 (11 October 2010)

Abstract | Full text | PDF | PubMed

232.

Research article   Open Access Highly Accessed

Receptor conversion in distant breast cancer metastases

Laurien DC Hoefnagel, Marc J van de Vijver, Henk-Jan van Slooten, Pieter Wesseling, Jelle Wesseling, Pieter J Westenend, Joost Bart, Cornelis A Seldenrijk, Iris D Nagtegaal, Joost Oudejans, Paul van der Valk, Petra van der Groep, Elisabeth GE de Vries, Elsken van der Wall, Paul J van Diest Breast Cancer Research 2010, 12:R75 (23 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

233.

Research article   Open Access

Time-to-pregnancy and pregnancy outcomes in a South African population

Braimoh Bello, Danuta Kielkowski, Dick Heederik, Kerry Wilson BMC Public Health 2010, 10:565 (21 September 2010)

Abstract | Full text | PDF | PubMed

234.

Editorial   Open Access Highly Accessed

MIQE précis: Practical implementation of minimum standard guidelines for fluorescence-based quantitative real-time PCR experiments

Stephen A Bustin, Jean-François Beaulieu, Jim Huggett, Rolf Jaggi, Frederick SB Kibenge, Pål A Olsvik, Louis C Penning, Stefan Toegel BMC Molecular Biology 2010, 11:74 (21 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

The Editorial Board of BMC Molecular Biology endorse a new set of essential MIQE-light guidelines for the reporting of quantitative PCR data: "MIQE precis", and provide guidance for the suitability of pure reference gene papers to the journal.

235.

Original investigation   Open Access

Modulation of TGF-β/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model

Peter E Westerweel, Cindy TJ van Velthoven, Tri Q Nguyen, Krista den Ouden, Dominique PV de Kleijn, Marie Goumans, Roel Goldschmeding, Marianne C Verhaar Cardiovascular Diabetology 2010, 9:55 (21 September 2010)

Abstract | Full text | PDF | PubMed

236.

Meeting report   Free

Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice

Anke-Hilse Maitland-van der Zee, Ana Alfirevic Genome Medicine 2010, 2:69 (21 September 2010)

Abstract | Full text | PDF | PubMed

237.

Research   Open Access Highly Accessed

Detecting exacerbations using the Clinical COPD Questionnaire

Jaap CA Trappenburg, Irene Touwen, Gerdien H de Weert-van Oene, Jean Bourbeau, Evelyn M Monninkhof, Theo JM Verheij, Jan-Willem J Lammers, Augustinus JP Schrijvers Health and Quality of Life Outcomes 2010, 8:102 (16 September 2010)

Abstract | Full text | PDF | PubMed

238.

Short report   Open Access Highly Accessed

A lifeline to treatment: the role of Indian generic manufacturers in supplying antiretroviral medicines to developing countries

Brenda Waning, Ellen Diedrichsen, Suerie Moon Journal of the International AIDS Society 2010, 13:35 (14 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

239.

Research article   Open Access

OCP3 is an important modulator of NPR1-mediated jasmonic acid-dependent induced defenses in Arabidopsis

Vicente Ramírez, Sjoerd Van der Ent, Javier García-Andrade, Alberto Coego, Corné MJ Pieterse, Pablo Vera BMC Plant Biology 2010, 10:199 (13 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

240.

Research article   Open Access

Internet and game behaviour at a secondary school and a newly developed health promotion programme: a prospective study

J Rob J de Leeuw, Marieke de Bruijn, Gerdien H de Weert-van Oene, August JP Schrijvers BMC Public Health 2010, 10:544 (9 September 2010)

Abstract | Full text | PDF | PubMed

241.

Study protocol   Open Access

Effectiveness of the universal prevention program 'Healthy School and Drugs': Study protocol of a randomized clustered trial

Monique Malmberg, Geertjan Overbeek, Marloes Kleinjan, Ad Vermulst, Karin Monshouwer, Jeroen Lammers, Wilma AM Vollebergh, Rutger CME Engels BMC Public Health 2010, 10:541 (8 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

242.

Research article   Open Access Highly Accessed

Manipulative therapy in addition to usual medical care accelerates recovery of shoulder complaints at higher costs: economic outcomes of a randomized trial

Gert JD Bergman, Jan C Winter, Maurits W van Tulder, Betty Meyboom-de Jong, Klaas Postema, Geert JMG van der Heijden BMC Musculoskeletal Disorders 2010, 11:200 (6 September 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

243.

Research   Open Access

Interferon-β attenuates lung inflammation following experimental subarachnoid hemorrhage

Pieter M Cobelens, Ivo ACW Tiebosch, Rick M Dijkhuizen, Peter H van der Meide, René Zwartbol, Cobi J Heijnen, Jozef Kesecioglu, Walter M van den Bergh Critical Care 2010, 14:R157 (23 August 2010)

Abstract | Full text | PDF | PubMed

244.

Research   Open Access

A novel pathogenic MLH1 missense mutation, c.112A > C, p.Asn38His, in six families with Lynch syndrome

Els van Riel, Margreet GEM Ausems, Frans BL Hogervorst, Irma Kluijt, Marielle E van Gijn, Jeanne van Echtelt, Karen Scheidel-Jacobse, Eric FAM Hennekam, Rein P Stulp, Yvonne J Vos, G Johan A Offerhaus, Fred H Menko, Johan JP Gille Hereditary Cancer in Clinical Practice 2010, 8:7 (12 August 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In this study, six Dutch families with Lynch syndrome sharing the c.112A>C, p.Asn38His MLH1 mutation were reported. The authors combined data from literature with family data like co-segregation of the MSI/IHC results and the MLH1 variant with disease, germline mutation analysis of all MMR genes, haplotype analysis, geneaology, and germline mutation testing of healthy controls. The authors conclude that c.112A>C is a pathogenic MLH1 founder mutation.

245.

Research   Open Access

Application of highly sensitive saturation labeling to the analysis of differential protein expression in infected ticks from limited samples

Margarita Villar, Alessandra Torina, Yolanda Nuñez, Zorica Zivkovic, Anabel Marina, Angela Alongi, Salvatore Scimeca, Giuseppa La Barbera, Santo Caracappa, Jesús Vázquez, José de la Fuente Proteome Science 2010, 8:43 (12 August 2010)

Abstract | Full text | PDF | PubMed

246.

Methodology article   Open Access Highly Accessed

Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion

Marijke WA de Backer, Maike AD Brans, Mieneke CM Luijendijk, Keith M Garner, Dianne MA van den Heuvel, R Jeroen Pasterkamp, Roger AH Adan BMC Neuroscience 2010, 11:94 (11 August 2010)

Abstract | Full text | PDF | PubMed

247.

Research article   Open Access

Primary care nurses: effects on secondary care referrals for diabetes

Christel E van Dijk, Robert A Verheij, Johan Hansen, Lud van der Velden, Giel Nijpels, Peter P Groenewegen, Dinny H de Bakker BMC Health Services Research 2010, 10:230 (6 August 2010)

Abstract | Full text | PDF | PubMed

248.

Study protocol   Open Access Highly Accessed

DIRECT trial. Diverticulitis recurrences or continuing symptoms: Operative versus conservative Treatment. A MULTICENTER RANDOMISED CLINICAL TRIAL

Bryan JM van de Wall, Werner A Draaisma, Esther CJ Consten, Yolanda van der Graaf, Marten H Otten, G de Wit, Henk F van Stel, Michael F Gerhards, Marinus J Wiezer, Huib A Cense, Hein BAC Stockmann, Jeroen WA Leijtens, David DE Zimmerman, Eric Belgers, Bart A van Wagensveld, Eric DJA Sonneveld, Hubert A Prins, Peter PLO Coene, Tom M Karsten, Joost M Klaase, Markwin G Statius Muller, Rogier MPH Crolla, Ivo AMJ Broeders, BMC Surgery 2010, 10:25 (6 August 2010)

Abstract | Full text | PDF | PubMed

249.

Research   Open Access Highly Accessed

A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients

Nicole E Spruijt, Tjaakje Visser, Luke PH Leenen Critical Care 2010, 14:R150 (5 August 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The administration of immunoglobulin, interferon-γ or glucan may improve outcomes in trauma patients, for whom inflammatory complications such as multiple organ failure are the most common cause of late death.

250.

Research   Open Access Highly Accessed

Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation

Saskia Braber, Paul AJ Henricks, Frans P Nijkamp, Aletta D Kraneveld, Gert Folkerts Respiratory Research 2010, 11:99 (22 July 2010)

Abstract | Full text | PDF | PubMed

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