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351.

Poster presentation   Open Access

Recombinant Env proteins that bind the quaternary-specific, V1/V2-directed PGT antibodies

J Gorman, J McLellan, Y Yang, T Zhou, J Zhu, S Bangaru, N Bayless, P Alff, CP Marshall, PD Kwong Retrovirology 2012, 9(Suppl 2):P84 (13 September 2012)

Full text | PDF

352.

Poster presentation   Open Access

Structural comparison of somatically related PG9 and PG16 in complex with their epitope reveals differences in glycan recognition

M Pancera, JS McLellan, S Shahzad-ul-Hussan, N Doria-Rose, B Zhang, Y Yang, DR Burton, WC Koff, CA Bewley, PD Kwong Retrovirology 2012, 9(Suppl 2):P74 (13 September 2012)

Full text | PDF

353.

Oral presentation   Open Access

rAd5 prime/NYVAC-B boost regimen is superior to NYVAC-B prime/rAd5 boost regimen for both response rates and magnitude of CD4 and CD8 T-cell responses

P Bart, Y Huang, N Frahm, S Karuna, M Allen, NK Kochar, S Chappuis, J Gaillard, B Graham, G Pantaleo Retrovirology 2012, 9(Suppl 2):O72 (13 September 2012)

Full text | PDF

354.

Poster presentation   Open Access

Detection of antibodies to the α4β7 integrin binding site on HIV-1 gp120 V2 loop using a novel cell adhesion assay

M Rao, N Karasavvas, A Pinter, H Liao, M Bonsignori, B Mathieson, S Zolla-Pazner, BF Haynes, NL Michael, JH Kim, CR Alving, KK Peachman Retrovirology 2012, 9(Suppl 2):P71 (13 September 2012)

Full text | PDF

355.

Poster presentation   Open Access

Characteristics of HIV-1 gp120 molecules that bind ancestor, intermediate and mature forms of VRC01-like antibodies

M Joyce, B Zhang, T Zhou, S Moquin, X Wu, M Louder, Z Zhang, I Georgiev, J Zhu, L Shapiro, JR Mascola, GJ Nabel, PD Kwong Retrovirology 2012, 9(Suppl 2):P68 (13 September 2012)

Full text | PDF

356.

Poster presentation   Open Access

Structural definition for a new modality of broad and potent antibody neutralization at the CD4-binding site on HIV-1 gp120

T Zhou, S Moquin, R Lynch, X Wu, J Zhu, Y Yang, B Zhang, JR Mascola, PD Kwong Retrovirology 2012, 9(Suppl 2):P57 (13 September 2012)

Full text | PDF

357.

Poster presentation   Open Access

Design of epitope-specific probes for sera analysis and antibody isolation

I Georgiev, P Acharya, SD Schmidt, Y Li, D Wycuff, G Ofek, N Doria-Rose, TS Luongo, Y Yang, T Zhou, BR Donald, JR Mascola, PD Kwong Retrovirology 2012, 9(Suppl 2):P50 (13 September 2012)

Full text | PDF

358.

Oral presentation   Open Access

454 pyrosequencing and bioinformatics analysis of the lineage of the broad and potent gp41-directed antibody 10e8

G Ofek, J Zhu, Y Yang, B Zhang, K Mckee, M Louder, J Huang, L Laub, M Connors, J Mascola, PD Kwong Retrovirology 2012, 9(Suppl 2):O40 (13 September 2012)

Full text | PDF

359.

Oral presentation   Open Access

Deep sequencing with longitudinal sampling of a VRC01-like-antibody response in a chronically infected individual

Z Zhang, X Wu, N Longo, B Zhang, J Zhu, C NISC, JC Mullikin, L Wu, GJ Nabel, M Connors, PD Kwong, JR Mascola, L Shapiro Retrovirology 2012, 9(Suppl 2):O36 (13 September 2012)

Full text | PDF

360.

Oral presentation   Open Access

Structure-guided modification and optimization of antibody VRC07

Y Kwon, I Georgiev, S O'Dell, W Shi, G Chuang, Y Yang, B Zhang, J Zhu, GJ Nabel, JR Mascola, PD Kwong Retrovirology 2012, 9(Suppl 2):O34 (13 September 2012)

Full text | PDF

361.

Oral presentation   Open Access

Design of an HIV Env antigen that binds with high affinity to antibodies against linear, conformational and broadly neutralizing epitopes within V1/V2

L Liao, M Bonsignori, K Hwang, AM Moody, R Park, S Crawford, H Chen, TL Jeffries, M Cooper, X Lu, R De, N Karasavvas, S Rerks-Ngarm, S Nitayaphan, J Kaewkungwal, S Tovanabutra, P Pitisuttithum, J Tartaglia, F Sinangil, J Kim, NL Michael, GD Tomaras, Z Yang, K Dai, M Pancera, GJ Nabel, JR Mascola, PD Kwong, A Pinter, S Zolla-Pazner, MS Alam, BF Haynes et al. Retrovirology 2012, 9(Suppl 2):O31 (13 September 2012)

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362.

Oral presentation   Open Access

A short segment in the HIV-1 gp120 V1/V2 region is a major determinant of neutralization resistance to PG9-like antibodies

NA Doria-Rose, I Georgiev, RP Staupe, S O'Dell, G Chuang, J Gorman, JS McLellan, M Pancera, M Bonsignori, BF Haynes, DR Burton, WC Koff, PD Kwong, JR Mascola Retrovirology 2012, 9(Suppl 2):O29 (13 September 2012)

Full text | PDF

363.

Poster presentation   Open Access

Hyperglycosylated resurfaced stabilized GP120 core as an immunogen elicits antibodies targeted at the CD4-binding site

K Dai, JC Boyington, W Shi, SD Schmidt, I Georgiev, D Lingwood, PD Kwong, JR Mascola, Z Yang, GJ Nabel Retrovirology 2012, 9(Suppl 2):P23 (13 September 2012)

Full text | PDF

364.

Research article   Open Access Highly Accessed

The functional comorbidity index had high inter-rater reliability in patients with acute lung injury

Eddy Fan, Jeneen M Gifford, Satish Chandolu, Elizabeth Colantuoni, Peter J Pronovost, Dale M Needham BMC Anesthesiology 2012, 12:21 (13 September 2012)

Abstract | Full text | PDF | PubMed

365.

Poster presentation   Open Access

NMR spectroscopy of HIV-1 gp120 outer domain

M Sastry, L Xu, S Bhattacharya, GJ Nabel, CA Bewley, PD Kwong Retrovirology 2012, 9(Suppl 2):P20 (13 September 2012)

Full text | PDF

366.

Oral presentation   Open Access

Infiltration of dendritic cells and antigen uptake in the muscle after injection of HIV-1 Env gp120 in adjuvant

F Liang, KJ Sandgren, H Fausther-Bovendo, D O'hagan, A Seubert, E De Gregorio, S Rao, N Sullivan, RA Seder, RA Koup, K Loré Retrovirology 2012, 9(Suppl 2):O16 (13 September 2012)

Full text | PDF

367.

Oral presentation   Open Access

RV144-like trial in macaques using ALVAC-SIV & gp120 induces innate immunity and increases the frequency of NK22 & NKG2A+ cells in mucosal tissues

NP Liyanage, P Pegu, S Gordon, M Cameron, K Foulds, M Doster, M Vaccari, R Koup, M Roederer, R Sékaly, G Franchini Retrovirology 2012, 9(Suppl 2):O14 (13 September 2012)

Full text | PDF

368.

Oral presentation   Open Access

Antibodies to the envelope protein protect macaques from SIVmac251 acquisition in an immunization regimen that mimics the RV-144 Thai trial

G Franchini, P Pegu, S Gordon, B Keele, M Doster, Y Guan, G Ferrari, R Pal, MG Ferrari, S Whitney, L Hudacik, E Billings, M Rao, D Montefiori, D Venzon, C Fenizia, J Lifson, D Stablein, J Tartaglia, N Michael, J Kim Retrovirology 2012, 9(Suppl 2):O2 (13 September 2012)

Full text | PDF

369.

Research article   Open Access

Ranked retrieval of segmented nuclei for objective assessment of cancer gene repositioning

William J Cukierski, Kaustav Nandy, Prabhakar Gudla, Karen J Meaburn, Tom Misteli, David J Foran, Stephen J Lockett BMC Bioinformatics 2012, 13:232 (12 September 2012)

Abstract | Full text | PDF | PubMed

370.

Research article   Open Access

Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer

Christopher H Switzer, Robert Y-S Cheng, Lisa A Ridnour, Sharon A Glynn, Stefan Ambs, David A Wink Breast Cancer Research 2012, 14:R125 (12 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

371.

Research   Open Access Highly Accessed

Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience

Peter Kellman, Joel R Wilson, Hui Xue, W Bandettini, Sujata M Shanbhag, Kirk M Druey, Martin Ugander, Andrew E Arai Journal of Cardiovascular Magnetic Resonance 2012, 14:64 (11 September 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

372.

Research   Open Access

Effects of a 6-month multimodal training intervention on retention of functional fitness in older adults: A randomized-controlled cross-over design

Janus Gudlaugsson, Vilmundur Gudnason, Thor Aspelund, Kristin Siggeirsdottir, Anna S Olafsdottir, Palmi V Jonsson, Sigurbjorn A Arngrimsson, Tamara B Harris, Erlingur Johannsson International Journal of Behavioral Nutrition and Physical Activity 2012, 9:107 (10 September 2012)

Abstract | Full text | PDF | PubMed

373.

Research   Open Access Highly Accessed

Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method

Peter Kellman, Joel R Wilson, Hui Xue, Martin Ugander, Andrew E Arai Journal of Cardiovascular Magnetic Resonance 2012, 14:63 (10 September 2012)

Abstract | Full text | PDF | PubMed

374.

Research   Open Access

Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study

Sara Galimberti, Francesca Guerrini, Flavia Salvi, Iacopo Petrini, Daniela Gioia, Emanuela Messa, Giuseppe A Palumbo, Daniela Cilloni, Mario Petrini, Alessandro Levis Journal of Hematology & Oncology 2012, 5:53 (10 September 2012)

Abstract | Full text | PDF | PubMed

375.

Research article   Open Access Highly Accessed

A molecular computational model improves the preoperative diagnosis of thyroid nodules

Sara Tomei, Ivo Marchetti, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio, Generoso Bevilacqua, Chiara Mazzanti BMC Cancer 2012, 12:396 (7 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A molecular computational model based on the expression of 8 genes can preoperatively distinguish benign from malignant thyroid lesions and could help identify patients with thyroid nodules who do not require radical surgery.

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