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1.

Opinion   Open Access Highly Accessed

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

Anna Sapone, Julio C Bai, Carolina Ciacci, Jernej Dolinsek, Peter HR Green, Marios Hadjivassiliou, Katri Kaukinen, Kamran Rostami, David S Sanders, Michael Schumann, Reiner Ullrich, Danilo Villalta, Umberto Volta, Carlo Catassi, Alessio Fasano BMC Medicine 2012, 10:13 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Fasano and colleagues propose new nomenclature and classifications within the spectrum of gluten-related disorders (GRDs), prompted by indications from the past decade that reactions to gluten may be caused by conditions other than celiac disease.

2.

Research article   Open Access Highly Accessed

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.

3.

Review   Open Access Highly Accessed

A review of wearable sensors and systems with application in rehabilitation

Shyamal Patel, Hyung Park, Paolo Bonato, Leighton Chan, Mary Rodgers Journal of NeuroEngineering and Rehabilitation 2012, 9:21 (20 April 2012)

Abstract | Full text | PDF | PubMed

4.

Review   Open Access Highly Accessed

Hereditary thrombophilia

Salwa Khan, Joseph D Dickerman Thrombosis Journal 2006, 4:15 (12 September 2006)

Abstract | Full text | PDF | PubMed

5.

Research   Open Access Highly Accessed

Moving pictures of the human microbiome

J Gregory Caporaso, Christian L Lauber, Elizabeth K Costello, Donna Berg-Lyons, Antonio Gonzalez, Jesse Stombaugh, Dan Knights, Pawel Gajer, Jacques Ravel, Noah Fierer, Jeffrey I Gordon, Rob Knight Genome Biology 2011, 12:R50 (30 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The dynamism of microbiome populations is seen in daily samples from a landmark multi-body site, multi-individual study

6.

Research article   Open Access Highly Accessed

Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications

Jorge Valdés, Inti Pedroso, Raquel Quatrini, Robert J Dodson, Herve Tettelin, Robert Blake, Jonathan A Eisen, David S Holmes BMC Genomics 2008, 9:597 (11 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Sequence, annotation and bioinformatic analysis extends understanding of the metabolic pathways of the bacterium Acidithiobacillus ferrooxidans including those used during the industrial recovery of copper by bioleaching.

7.

Research   Open Access Highly Accessed

Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates

Sean Conlan, Lilia A Mijares, Jesse Becker, Robert W Blakesley, Gerard G Bouffard, Shelise Brooks, Holly Coleman, Jyoti Gupta, Natalie Gurson, Morgan Park, Brian Schmidt, Pamela J Thomas, Michael Otto, Heidi H Kong, Patrick R Murray, Julia A Segre Genome Biology 2012, 13:R64 (25 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Comparative genomics of skin commensal and hospital infection-associated isolates uncovers a putative clinical biomarker

8.

Review   Open Access Highly Accessed

Molecular and cellular mechanisms of pulmonary fibrosis

Nevins W Todd, Irina G Luzina, Sergei P Atamas Fibrogenesis & Tissue Repair 2012, 5:11 (23 July 2012)

Abstract | Full text | PDF | PubMed

9.

Research   Open Access Highly Accessed

A three-country comparison of psychotropic medication prevalence in youth

Julie M Zito, Daniel J Safer, Lolkje Berg, Katrin Janhsen, Joerg M Fegert, James F Gardner, Gerd Glaeske, Satish C Valluri Child and Adolescent Psychiatry and Mental Health 2008, 2:26 (25 September 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Significant differences exist in the prescribing of psychotropic drugs to children and young people in the US and Western Europe and are important when considering policies affecting these medications.

10.

Software   Open Access Highly Accessed

CloVR: A virtual machine for automated and portable sequence analysis from the desktop using cloud computing

Samuel V Angiuoli, Malcolm Matalka, Aaron Gussman, Kevin Galens, Mahesh Vangala, David R Riley, Cesar Arze, James R White, Owen White, W Florian Fricke BMC Bioinformatics 2011, 12:356 (30 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Cloud Virtual Resource (CloVR) is a new desktop application for large-scale sequence analysis using remote computing resources that provides several automated pipelines for microbial genomics, including 16S, whole genome and metagenome sequence analysis.

11.

Research   Open Access Highly Accessed

Recent advances in basic neurosciences and brain disease: from synapses to behavior

Guo-Qiang Bi, Vadim Bolshakov, Guojun Bu, Catherine M Cahill, Zhou-Feng Chen, Graham L Collingridge, Robin L Cooper, Jens R Coorssen, Alaa El-Husseini, Vasco Galhardo, Wen-Biao Gan, Jianguo Gu, Kazuhide Inoue, John Isaac, Koichi Iwata, Zhengping Jia, Bong-Kiun Kaang, Mikito Kawamata, Satoshi Kida, Eric Klann, Tatsuro Kohno, Min Li, Xiao-Jiang Li, John F MacDonald, Karim Nader, Peter V Nguyen, Uhtaek Oh, Ke Ren, John C Roder, Michael W Salter et al. Molecular Pain 2006, 2:38 (30 December 2006)

Abstract | Full text | PDF | PubMed

12.

Methodology article   Open Access Highly Accessed

Differential expression analysis for paired RNA-seq data

Lisa M Chung, John P Ferguson, Wei Zheng, Feng Qian, Vincent Bruno, Ruth R Montgomery, Hongyu Zhao BMC Bioinformatics 2013, 14:110 (27 March 2013)

Abstract | Provisional PDF | PubMed

13.

Research   Open Access

Analysis of the proteome of human airway epithelial secretions

Mehboob Ali, Erik P Lillehoj, Yongsung Park, Yoshiyuki Kyo, K Kim Proteome Science 2011, 9:4 (20 January 2011)

Abstract | Full text | PDF | PubMed

14.

Research   Open Access Highly Accessed

Thymomas: a cytological and immunohistochemical study, with emphasis on lymphoid and neuroendocrine markers

Borislav A Alexiev, Cinthia B Drachenberg, Allen P Burke Diagnostic Pathology 2007, 2:13 (11 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

Review   Open Access Highly Accessed

Substance abuse and pharmacy practice: what the community pharmacist needs to know about drug abuse and dependence

Anthony C Tommasello Harm Reduction Journal 2004, 1:3 (20 April 2004)

Abstract | Full text | PDF | PubMed | 2 comments

16.

Review   Open Access Highly Accessed

Structure and assembly of bacteriophage T4 head

Venigalla B Rao, Lindsay W Black Virology Journal 2010, 7:356 (3 December 2010)

Abstract | Full text | PDF | PubMed

17.

Research article   Open Access Highly Accessed

Comparative effectiveness of nafcillin or cefazolin versus vancomycin in methicillin-susceptible Staphylococcus aureus bacteremia

Marin L Schweizer, Jon P Furuno, Anthony D Harris, J Kristie Johnson, Michelle D Shardell, Jessina C McGregor, Kerri A Thom, Sara E Cosgrove, George Sakoulas, Eli N Perencevich BMC Infectious Diseases 2011, 11:279 (19 October 2011)

Abstract | Full text | PDF | PubMed | F1000 Biology

18.

Research   Open Access Highly Accessed

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

Jason I Herschkowitz, Karl Simin, Victor J Weigman, Igor Mikaelian, Jerry Usary, Zhiyuan Hu, Karen E Rasmussen, Laundette P Jones, Shahin Assefnia, Subhashini Chandrasekharan, Michael G Backlund, Yuzhi Yin, Andrey I Khramtsov, Roy Bastein, John Quackenbush, Robert I Glazer, Powel H Brown, Jeffrey E Green, Levy Kopelovich, Priscilla A Furth, Juan P Palazzo, Olufunmilayo I Olopade, Philip S Bernard, Gary A Churchill, Terry Van Dyke, Charles M Perou Genome Biology 2007, 8:R76 (10 May 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human subtypes were conserved among mouse models.

19.

Review   Open Access Highly Accessed

Function and biotechnology of extremophilic enzymes in low water activity

Ram Karan, Melinda D Capes, Shiladitya DasSarma Aquatic Biosystems 2012, 8:4 (2 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

Research article   Open Access Highly Accessed

Cloning, overexpression, purification, and characterization of a polyextremophilic β-galactosidase from the Antarctic haloarchaeon Halorubrum lacusprofundi

Ram Karan, Melinda D Capes, Priya DasSarma, Shiladitya DasSarma BMC Biotechnology 2013, 13:3 (16 January 2013)

Abstract | Full text | PDF | PubMed

21.

Research article   Open Access Highly Accessed

In vivo bioluminescence imaging of Escherichia coli O104:H4 and role of aerobactin during colonization of a mouse model of infection

Alfredo G Torres, Roberto J Cieza, Maricarmen Rojas-Lopez, Carla A Blumentritt, Cristiane S Souza, R Johnston, Nancy Strockbine, James B Kaper, Elena Sbrana, Vsevolod L Popov BMC Microbiology 2012, 12:112 (20 June 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In vivo intestinal colonization by E. coli O104:H4 in the mouse model requires the aerobactin transport system for uptake of iron, which can be monitored using bioluminescence imaging to allow studies of persistence.

22.

Opinion   Open Access Highly Accessed

Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine

Myron M Levine BMC Biology 2010, 8:129 (4 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Oral vaccines are least effective where they are most needed, in developing countries with poor sanitation and limited resources of skilled medical personnel. Myron Levine draws on his experience with cholera vaccine to suggest why, and what can be done about it.

23.

Review   Open Access Highly Accessed

Human herpesvirus 8 – A novel human pathogen

Daniel C Edelman Virology Journal 2005, 2:78 (2 September 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Research   Open Access Highly Accessed

Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study

Borislav A Alexiev, Wenle Wang, Yi Ning, Saranya Chumsri, Ivana Gojo, William H Rodgers, Sanford A Stass, Xianfeng F Zhao Diagnostic Pathology 2007, 2:42 (31 October 2007)

Abstract | Full text | PDF | PubMed

25.

Research   Open Access Highly Accessed

Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

Claudio Donati, N Luisa Hiller, Hervé Tettelin, Alessandro Muzzi, Nicholas J Croucher, Samuel V Angiuoli, Marco Oggioni, Julie C Dunning Hotopp, Fen Z Hu, David R Riley, Antonello Covacci, Tim J Mitchell, Stephen D Bentley, Morgens Kilian, Garth D Ehrlich, Rino Rappuoli, E Richard Moxon, Vega Masignani Genome Biology 2010, 11:R107 (29 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Streptococcus pneumoniae genome analysis reveals that the presence of pathogenicity genes is not sufficient to determine virulence

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