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1.

Research   Open Access

Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study

Andrea M Harriott, Nicole Dueker, Yu-Ching Cheng, Kathleen A Ryan, Jeffrey R O’Connell, O Colin Stine, Patrick F McArdle, Marcella A Wozniak, Barney J Stern, Braxton D Mitchell, Steven J Kittner, John W Cole SpringerPlus 2013, 2:46 (11 February 2013)

Abstract | Full text | PDF

2.

Methodology   Open Access

CloVR-ITS: Automated internal transcribed spacer amplicon sequence analysis pipeline for the characterization of fungal microbiota

James Robert White, Cynthia Maddox, Owen White, Samuel V Angiuoli, W Florian Fricke Microbiome 2013, 1:6 (4 February 2013)

Abstract | Full text | PDF

3.

Research   Open Access

Self-triggered assistive stimulus training improves step initiation in persons with Parkinson’s disease

Robert A Creath, Michelle Prettyman, Lisa Shulman, Marjorie Hilliard, Katherine Martinez, Colum D MacKinnon, Marie-Laure Mille, Tanya Simuni, Jane Zhang, Mark W Rogers Journal of NeuroEngineering and Rehabilitation 2013, 10:11 (30 January 2013)

Abstract | Full text | PDF | PubMed

4.

Research article   Open Access Highly Accessed

Cloning, overexpression, purification, and characterization of a polyextremophilic β-galactosidase from the Antarctic haloarchaeon Halorubrum lacusprofundi

Ram Karan, Melinda D Capes, Priya DasSarma, Shiladitya DasSarma BMC Biotechnology 2013, 13:3 (16 January 2013)

Abstract | Full text | PDF | PubMed

5.

Editorial   Open Access

Microbiome, demystifying the role of microbial communities in the biosphere

K Eric Wommack, Jacques Ravel Microbiome 2013, 1:1 (9 January 2013)

Abstract | Full text | PDF

6.

Research article   Open Access

Development and pilot testing of an online module for ethics education based on the Nigerian National Code for Health Research Ethics

Olubunmi A Ogunrin, Temidayo O Ogundiran, Clement Adebamowo BMC Medical Ethics 2013, 14:1 (2 January 2013)

Abstract | Full text | PDF | PubMed

7.

Research   Open Access

Non-local competition drives both rapid divergence and prolonged stasis in a model of speciation in populations with degenerate resource consumption

Nicholas Atamas, Michael S Atamas, Faina Atamas, Sergei P Atamas Theoretical Biology and Medical Modelling 2012, 9:56 (27 December 2012)

Abstract | Full text | PDF | PubMed

8.

Research   Open Access

Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study

Roberto Flores, Jianxin Shi, Barbara Fuhrman, Xia Xu, Timothy D Veenstra, Mitchell H Gail, Pawel Gajer, Jacques Ravel, James J Goedert Journal of Translational Medicine 2012, 10:253 (21 December 2012)

Abstract | Full text | PDF | PubMed

9.

Review   Open Access Highly Accessed

From concepts, theory, and evidence of heterogeneity of treatment effects to methodological approaches: a primer

Richard J Willke, Zhiyuan Zheng, Prasun Subedi, Rikard Althin, C Daniel Mullins BMC Medical Research Methodology 2012, 12:185 (13 December 2012)

Abstract | Full text | PDF | PubMed

10.

Research article   Open Access Highly Accessed

Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability

Vinita Joardar, Natalie F Abrams, Jessica Hostetler, Paul J Paukstelis, Suchitra Pakala, Suman B Pakala, Nikhat Zafar, Olukemi O Abolude, Gary Payne, Alex Andrianopoulos, David W Denning, William C Nierman BMC Genomics 2012, 13:698 (12 December 2012)

Abstract | Full text | PDF | PubMed

11.

Research article   Open Access

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

Chander Peddaboina, Daniel Jupiter, Steven Fletcher, Jeremy L Yap, Arun Rai, Richard P Tobin, Weihua Jiang, Philip Rascoe, M Karen Rogers, W Smythe, Xiaobo Cao BMC Cancer 2012, 12:541 (21 November 2012)

Abstract | Full text | PDF | PubMed

12.

Primary research   Open Access

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro

Henry I C Lowe, Charah T Watson, Simone Badal, Ngeh J Toyang, Joseph Bryant Cancer Cell International 2012, 12:46 (14 November 2012)

Abstract | Full text | PDF | PubMed

13.

Research article   Open Access Highly Accessed

Comparative genomic analysis and phylogenetic position of Theileria equi

Lowell S Kappmeyer, Mathangi Thiagarajan, David R Herndon, Joshua D Ramsay, Elisabet Caler, Appolinaire Djikeng, Joseph J Gillespie, Audrey OT Lau, Eric H Roalson, Joana C Silva, Marta G Silva, Carlos E Suarez, Massaro W Ueti, Vishvanath M Nene, Robert H Mealey, Donald P Knowles, Kelly A Brayton BMC Genomics 2012, 13:603 (9 November 2012)

Abstract | Full text | PDF | PubMed

14.

Research   Open Access

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury

Bryan Chai, Wei Guo, Feng Wei, Ronald Dubner, Ke Ren Molecular Pain 2012, 8:78 (23 October 2012)

Abstract | Full text | PDF | PubMed

15.

Research article   Open Access

SspA up-regulates gene expression of the LEE pathogenicity island by decreasing H-NS levels in enterohemorrhagic Escherichia coli

Anne-Marie Hansen, Ding Jin BMC Microbiology 2012, 12:231 (11 October 2012)

Abstract | Full text | PDF | PubMed

16.

Research   Open Access

Identification of rare X-linked neuroligin variants by massively parallel sequencing in males with autism spectrum disorder

Karyn Steinberg, Dhanya Ramachandran, Viren C Patel, Amol C Shetty, David J Cutler, Michael E Zwick Molecular Autism 2012, 3:8 (28 September 2012)

Abstract | Full text | PDF | PubMed

17.

Review   Open Access

Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapy

Hailiu Yang, Joseph Nkeze, Richard Y Zhao Cell & Bioscience 2012, 2:32 (12 September 2012)

Abstract | Full text | PDF | PubMed

18.

Research   Open Access Highly Accessed

Integrin αvβ3 and CD44 pathways in metastatic prostate cancer cells support osteoclastogenesis via a Runx2/Smad 5/receptor activator of NF-κB ligand signaling axis

Aditi Gupta, Wei Cao, Meenakshi A Chellaiah Molecular Cancer 2012, 11:66 (11 September 2012)

Abstract | Full text | PDF | PubMed

19.

Review   Open Access

Thalidomide and its analogues in the treatment of Multiple Myeloma

Tahir Latif, Nabeel Chauhan, Rashid Khan, Andrea Moran, Saad Z Usmani Experimental Hematology & Oncology 2012, 1:27 (11 September 2012)

Abstract | Full text | PDF | PubMed

20.

Research article   Open Access

Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice

Ajay Jain, Henrik S Olsen, Ravi Vyzasatya, Erin Burch, Yukimi Sakoda, Emmanuel Y Mérigeon, Ling Cai, Changwan Lu, Ming Tan, Koji Tamada, Dan Schulze, David S Block, Scott E Strome Arthritis Research & Therapy 2012, 14:R192 (20 August 2012)

Abstract | Full text | PDF | PubMed

21.

Primary research   Open Access

CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults

Amber L Beitelshees, Christina L Aquilante, Hooman Allayee, Taimour Y Langaee, Gregory J Welder, Richard S Schofield, Issam Zineh Human Genomics 2012, 6:9 (2 August 2012)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access

Microbial transformation from normal oral microbiota to acute endodontic infections

William W L Hsiao, Kevin L Li, Zhenqiu Liu, Cheron Jones, Claire M Fraser-Liggett, Ashraf F Fouad BMC Genomics 2012, 13:345 (28 July 2012)

Abstract | Full text | PDF | PubMed

23.

Research   Open Access Highly Accessed

Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates

Sean Conlan, Lilia A Mijares, Jesse Becker, Robert W Blakesley, Gerard G Bouffard, Shelise Brooks, Holly Coleman, Jyoti Gupta, Natalie Gurson, Morgan Park, Brian Schmidt, Pamela J Thomas, Michael Otto, Heidi H Kong, Patrick R Murray, Julia A Segre Genome Biology 2012, 13:R64 (25 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Comparative genomics of skin commensal and hospital infection-associated isolates uncovers a putative clinical biomarker

24.

Review   Open Access Highly Accessed

Molecular and cellular mechanisms of pulmonary fibrosis

Nevins W Todd, Irina G Luzina, Sergei P Atamas Fibrogenesis & Tissue Repair 2012, 5:11 (23 July 2012)

Abstract | Full text | PDF | PubMed

25.

Methodology article   Open Access

Automated hierarchical classification of protein domain subfamilies based on functionally-divergent residue signatures

Andrew F. Neuwald, Christopher J. Lanczycki, Aron Marchler-Bauer BMC Bioinformatics 2012, 13:144 (22 June 2012)

Abstract | Provisional PDF | PubMed

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