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1.

Research   Open Access Highly Accessed

CRISPR-Cas systems target a diverse collection of invasive mobile genetic elements in human microbiomes

Quan Zhang, Mina Rho, Haixu Tang, Thomas G Doak, Yuzhen Ye Genome Biology 2013, 14:R40 (29 April 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Analysis of CRISPR sequences contained in human metagenomic datasets reveals a variety of different targeted mobile genetic elements

2.

Research   Open Access Highly Accessed

Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury

Ravindra L Mehta, John A Kellum, Sudhir V Shah, Bruce A Molitoris, Claudio Ronco, David G Warnock, Adeera Levin, Critical Care 2007, 11:R31 (1 March 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

3.

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

4.

Research   Open Access Highly Accessed

National, regional, and global trends in adult overweight and obesity prevalences

Gretchen A Stevens, Gitanjali M Singh, Yuan Lu, Goodarz Danaei, John K Lin, Mariel M Finucane, Adil N Bahalim, Russell K McIntire, Hialy R Gutierrez, Melanie Cowan, Christopher J Paciorek, Farshad Farzadfar, Leanne Riley, Majid Ezzati, Population Health Metrics 2012, 10:22 (20 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

5.

Research article   Open Access Highly Accessed

The “fossilized” mitochondrial genome of Liriodendron tulipifera: ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate

Aaron O Richardson, Danny W Rice, Gregory J Young, Andrew J Alverson, Jeffrey D Palmer BMC Biology 2013, 11:29 (15 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The mitochondrial genome of the tulip tree has a remarkably slow rate of nucleotide substitution, and could offer insight into the content and organisation of this genome in the ancestral flowering plant.

6.

Review   Open Access Highly Accessed

Exogenous endothelial cells as accelerators of hematopoietic reconstitution

J Mizer, Thomas E Ichim, Doru T Alexandrescu, Constantin A Dasanu, Famela Ramos, Andrew Turner, Erik J Woods, Vladimir Bogin, Michael P Murphy, David Koos, Amit N Patel Journal of Translational Medicine 2012, 10:231 (21 November 2012)

Abstract | Full text | PDF | PubMed

7.

Research article   Open Access Highly Accessed

Estimating the mean and variance from the median, range, and the size of a sample

Stela Hozo, Benjamin Djulbegovic, Iztok Hozo BMC Medical Research Methodology 2005, 5:13 (20 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Distribution free estimation of mean and variance for trials where the median, range and size are all that is reported should enable inclusion of more trials in meta-analysis.

8.

Research article   Open Access

Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity

Sara Martinez-Pasamar, Elena Abad, Beatriz Moreno, Nieves Velez de Mendizabal, Ivan Martinez-Forero, Jordi Garcia-Ojalvo, Pablo Villoslada BMC Systems Biology 2013, 7:34 (26 April 2013)

Abstract | Full text | PDF | PubMed

9.

Research article   Open Access Highly Accessed

When is it rational to participate in a clinical trial? A game theory approach incorporating trust, regret and guilt

Benjamin Djulbegovic, Iztok Hozo BMC Medical Research Methodology 2012, 12:85 (22 June 2012)

Abstract | Full text | PDF | PubMed

10.

Research article   Open Access Highly Accessed

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

Carol Sheridan, Hiromitsu Kishimoto, Robyn K Fuchs, Sanjana Mehrotra, Poornima Bhat-Nakshatri, Charles H Turner, Robert Goulet, Sunil Badve, Harikrishna Nakshatri Breast Cancer Research 2006, 8:R59 (24 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

Research   Open Access

The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells

Hui Cai, Yan Xu Cell Communication and Signaling 2013, 11:31 (24 April 2013)

Abstract | Full text | PDF | PubMed

12.

Research   Open Access

The housing first model (HFM) fidelity index: designing and testing a tool for measuring integrity of housing programs that serve active substance users

Dennis P Watson, John Orwat, Dana E Wagner, Valery Shuman, Randi Tolliver Substance Abuse Treatment, Prevention, and Policy 2013, 8:16 (3 May 2013)

Abstract | Full text | PDF | PubMed

13.

Research   Open Access Highly Accessed

Biogeography of the ecosystems of the healthy human body

Yanjiao Zhou, Hongyu Gao, Kathie A Mihindukulasuriya, Patricio S La Rosa, Kristine M Wylie, Tatiana Vishnivetskaya, Mircea Podar, Barb Warner, Phillip I Tarr, David E Nelson, J Fortenberry, Martin J Holland, Sarah E Burr, William D Shannon, Erica Sodergren, George M Weinstock Genome Biology 2013, 14:R1 (14 January 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

As part of the Human Microbiome Project, taxonomic analyses were performed on the bacteria from 22 body sites on 279 subjects

14.

Regular article   Open Access Highly Accessed

A large-scale community structure analysis in Facebook

Emilio Ferrara EPJ Data Science 2012, 1:9 (6 November 2012)

Abstract | Full text | PDF

15.

Systematic Review   Open Access Highly Accessed

A critical synthesis of literature on the promoting action on research implementation in health services (PARIHS) framework

Christian D Helfrich, Laura J Damschroder, Hildi J Hagedorn, Ginger S Daggett, Anju Sahay, Mona Ritchie, Teresa Damush, Marylou Guihan, Philip M Ullrich, Cheryl B Stetler Implementation Science 2010, 5:82 (25 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Review   Free Highly Accessed

Breast cancer prognostic classification in the molecular era: the role of histological grade

Emad A Rakha, Jorge S Reis-Filho, Frederick Baehner, David J Dabbs, Thomas Decker, Vincenzo Eusebi, Stephen B Fox, Shu Ichihara, Jocelyne Jacquemier, Sunil R Lakhani, José Palacios, Andrea L Richardson, Stuart J Schnitt, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Sunil Badve, Ian O Ellis Breast Cancer Research 2010, 12:207 (30 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

Research article   Open Access Highly Accessed

Phylogeographic analysis reveals significant spatial genetic structure of Incarvillea sinensis as a product of mountain building

Shaotian Chen, Yaowu Xing, Tao Su, Zhekun Zhou, Emeritus David L Dilcher, Douglas E Soltis BMC Plant Biology 2012, 12:58 (30 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

Review   Open Access Highly Accessed

Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis

Neil H Riordan, Thomas E Ichim, Wei-Ping Min, Hao Wang, Fabio Solano, Fabian Lara, Miguel Alfaro, Jorge Rodriguez, Robert J Harman, Amit N Patel, Michael P Murphy, Roland R Lee, Boris Minev Journal of Translational Medicine 2009, 7:29 (24 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Mesenchymal stem cells derived from the stromal vascular fraction of adipose tissue show promise in the treatment of multiple sclerosis and warrant further clinical evaluation.

19.

Review   Open Access Highly Accessed

Physical therapies for Achilles tendinopathy: systematic review and meta-analysis

Samuel P Sussmilch-Leitch, Natalie J Collins, Andrea E Bialocerkowski, Stuart J Warden, Kay M Crossley Journal of Foot and Ankle Research 2012, 5:15 (2 July 2012)

Abstract | Full text | PDF | PubMed

20.

Original investigation   Open Access

Protein Kinase C inhibition ameliorates functional endothelial insulin resistance and Vascular Smooth Muscle Cell hypersensitivity to insulin in diabetic hypertensive rats

Xiao Lu, James S Bean, Ghassan S Kassab, Mark D Rekhter Cardiovascular Diabetology 2011, 10:48 (2 June 2011)

Abstract | Full text | PDF | PubMed

21.

Editorial   Open Access Highly Accessed

Grand challenges for cheminformatics

David J Wild Journal of Cheminformatics 2009, 1:1 (17 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

22.

Case report   Open Access Highly Accessed

Traumatic deep vein thrombosis in a soccer player: A case study

Paul S Echlin, Ross EG Upshur, Douglas B McKeag, Harsha P Jayatilake Thrombosis Journal 2004, 2:8 (14 October 2004)

Abstract | Full text | PDF | PubMed

23.

Research article   Open Access

Molecular cloning of doublesex genes of four cladocera (water flea) species

Kenji Toyota, Yasuhiko Kato, Masaru Sato, Naomi Sugiura, Shinichi Miyagawa, Hitoshi Miyakawa, Hajime Watanabe, Shigeto Oda, Yukiko Ogino, Chizue Hiruta, Takeshi Mizutani, Norihisa Tatarazako, Susanne Paland, Craig Jackson, John K Colbourne, Taisen Iguchi BMC Genomics 2013, 14:239 (10 April 2013)

Abstract | Full text | PDF | PubMed

24.

Study protocol   Open Access Highly Accessed

Improving delirium care in the intensive care unit: The design of a pragmatic study

Noll L Campbell, Babar A Khan, Mark Farber, Tiffany Campbell, Anthony J Perkins, Siu L Hui, Greg Abernathy, John Buckley, Regg Sing, Jason Tricker, Mohammad Zawahiri, Malaz A Boustani Trials 2011, 12:139 (6 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

Review   Open Access

Drug-induced uveitis

Nikolas JS London, Sunir J Garg, Ramana S Moorthy, Emmett T Cunningham Journal of Ophthalmic Inflammation and Infection 2013, 3:43 (25 March 2013)

Abstract | Full text | PDF | PubMed

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