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26.

Research article   Open Access Highly Accessed

Phylogenetic analysis of a gene cluster encoding an additional, rhizobial-like type III secretion system that is narrowly distributed among Pseudomonas syringae strains

Anastasia D Gazi, Panagiotis F Sarris, Vasiliki E Fadouloglou, Spyridoula N Charova, Nikolaos Mathioudakis, Nicholas J Panopoulos, Michael Kokkinidis BMC Microbiology 2012, 12:188 (2 September 2012)

Abstract | Full text | PDF | PubMed

27.

Methodology article   Open Access Highly Accessed

Normalization of a chromosomal contact map

Axel Cournac, Hervé Marie-Nelly, Martial Marbouty, Romain Koszul, Julien Mozziconacci BMC Genomics 2012, 13:436 (30 August 2012)

Abstract | Full text | PDF | PubMed

28.

Case report   Open Access Highly Accessed

The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

Eric Farfour, Frédéric Charlotte, Catherine Settegrana, Makoto Miyara, Pierre Buffet Malaria Journal 2012, 11:285 (20 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The case report describes the microscopic examination of a bone marrow biopsy. In the analysis, the majority of immature stages are found outside the vascular structure, unlike the (very few) mature stages, more frequently observed in the vascular spaces. This observation supports the intriguing hypothesis that most of sexual stage differentiation occurs extravascularly, while gametocyte maturation is associated to re-entry in circulation.

29.

Research article   Open Access

RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans

Sanjiveeni Dhamgaye, Maria Bernard, Gaelle Lelandais, Odile Sismeiro, Sophie Lemoine, Jean-Yves Coppée, Stéphane Le Crom, Rajendra Prasad, Frédéric Devaux BMC Genomics 2012, 13:396 (16 August 2012)

Abstract | Full text | PDF | PubMed

30.

Short report   Open Access

Entomological profile of yellow fever epidemics in the Central African Republic, 2006–2010

Carine Ngoagouni, Basile Kamgang, Alexandre Manirakiza, Auguste Nangouma, Christophe Paupy, Emmanuel Nakoune, Mirdad Kazanji Parasites & Vectors 2012, 5:175 (16 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This study described the wide diversity of vector species of yellow fever virus in five geographically distinct regions of the Central African Republic. Image: Entomological investigation in a natural site.

31.

Research   Open Access

Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia

Philippe S Boeuf, Séverine Loizon, Gordon A Awandare, John KA Tetteh, Michael M Addae, George O Adjei, Bamenla Goka, Jørgen AL Kurtzhals, Odile Puijalon, Lars Hviid, Bartholomew D Akanmori, Charlotte Behr Malaria Journal 2012, 11:253 (1 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

This paper mainly describes the degree of activation of monocytes and T cells from different malaria patient groups in Ghanaian children, and their capacity to generate TNF and IL-10.

32.

Research article   Open Access

RACK1, a clue to the diagnosis of cutaneous melanomas in horses

Cécile Campagne, Sophia Julé, Florence Bernex, Mercedes Estrada, Geneviève Aubin-Houzelstein, Jean-Jacques Panthier, Giorgia Egidy BMC Veterinary Research 2012, 8:95 (29 June 2012)

Abstract | Full text | PDF | PubMed

33.

Research   Open Access

High-functioning autism spectrum disorder and fragile X syndrome: report of two affected sisters

Pauline Chaste, Catalina Betancur, Marion Gérard-Blanluet, Anne Bargiacchi, Suzanne Kuzbari, Séverine Drunat, Marion Leboyer, Thomas Bourgeron, Richard Delorme Molecular Autism 2012, 3:5 (27 June 2012)

Abstract | Full text | PDF | PubMed

34.

Research article   Open Access

Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus

Nicolas Tchitchek, Béatrice Jacquelin, Patrick Wincker, Carole Dossat, Corinne Silva, Jean Weissenbach, Antoine Blancher, Michaela Müller-Trutwin, Arndt Benecke BMC Genomics 2012, 13:279 (22 June 2012)

Abstract | Full text | PDF | PubMed

35.

Study protocol   Open Access Highly Accessed

Integrative study of pandemic A/H1N1 influenza infections: design and methods of the CoPanFlu-France cohort

Nathanael Lapidus, Xavier de Lamballerie, Nicolas Salez, Michel Setbon, Pascal Ferrari, Rosemary M Delabre, Marie-Lise Gougeon, Frédéric Vely, Marianne Leruez-Ville, Laurent Andreoletti, Simon Cauchemez, Pierre-Yves Boëlle, Eric Vivier, Laurent Abel, Michaël Schwarzinger, Michèle Legeas, Pierre Le Cann, Antoine Flahault, Fabrice Carrat BMC Public Health 2012, 12:417 (7 June 2012)

Abstract | Full text | PDF | PubMed

36.

Research article   Open Access Highly Accessed

Transcriptome of the adult female malaria mosquito vector Anopheles albimanus

Jesús Martínez-Barnetche, Rosa E Gómez-Barreto, Marbella Ovilla-Muñoz, Juan Téllez-Sosa, David E López, Rhoel R Dinglasan, Ceereena Mohien, Robert M MacCallum, Seth N Redmond, John G Gibbons, Antonis Rokas, Carlos A Machado, Febe E Cazares-Raga, Lilia González-Cerón, Salvador Hernández-Martínez, Mario H López BMC Genomics 2012, 13:207 (30 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

Commentary   Open Access Highly Accessed

Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma

Chloé Bertolus, Patrick Goudot, Antoine Gessain, Nicolas Berthet Infectious Agents and Cancer 2012, 7:13 (30 May 2012)

Abstract | Full text | PDF | PubMed

38.

Research   Open Access Highly Accessed

Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus

Nada Chaoul, Chantal Burelout, Sandrine Peruchon, Beatrice van Buu, Pascale Laurent, Alexis Proust, Martine Raphael, Olivier Garraud, Roger Le Grand, Sophie Prevot, Yolande Richard Retrovirology 2012, 9:43 (25 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

The authors report evidence that SIV is unable to initiate a T-dependent IgA response during the acute phase of infection and favors the production of IgG (ileum) or IgM (duodenum) plasma cells at the expense of IgA plasma cells.

39.

Poster presentation   Open Access

Emergence of IFN-alpha TRAIL-expressing killer pDCs (IKpDCs) as a consequence of a crosstalk with NK cells. Influence of HIV-1 infection and implication of HMGB1

Marlène Bras, Héla Saidi, Pauline Formaglio, Marie-Thérèse Melki, Marie-Lise Gougeon Retrovirology 2012, 9(Suppl 1):P15 (25 May 2012)

Full text | PDF

40.

Research   Open Access Highly Accessed

Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: The CRYSTMAS study

Bertrand Guidet, Olivier Martinet, Thierry Boulain, Francois Philippart, Jean Poussel, Julien Maizel, Xavier Forceville, Marc Feissel, Michel Hasselmann, Alexandra Heininger, Hugo Van Aken Critical Care 2012, 16:R94 (24 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology

41.

Research   Open Access

Molecular evidence of Culex pipiens form molestus and hybrids pipiens/molestus in Morocco, North Africa

Fadila Amraoui, Mhamed Tijane, Mhammed Sarih, Anna-Bella Failloux Parasites & Vectors 2012, 5:83 (27 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Our study shows that Cx. pipiens form molestus is present in Morocco and hybrids between pipiens and molestus form in North Africa. These findings have important epidemiological implications as hybrids with their opportunistic biting behavior may act as a bridge-vector for transmission of pathogens from birds to humans. Image: Larval breeding site of Culex pipiens in Morocco.

42.

Research   Open Access

Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria

Rémy Durand, Florence Migot-Nabias, Valérie Andriantsoanirina, Elise Seringe, Firmine Viwami, Gratien Sagbo, Francis Lalya, Philippe Deloron, Odile Mercereau-Puijalon, Serge Bonnefoy Malaria Journal 2012, 11:128 (25 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Possible association between a novel mutation in a pseudogene (RESA-2) and clinical malaria severity, based on a genetic analysis of isolates from a group of severe and mild malaria cases seen at the H¿pital Principal de Dakar, S¿n¿gal.

43.

Research article   Open Access Highly Accessed

Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes

Torsten Hain, Rohit Ghai, André Billion, Carsten Kuenne, Christiane Steinweg, Benjamin Izar, Walid Mohamed, Mobarak Mraheil, Eugen Domann, Silke Schaffrath, Uwe Kärst, Alexander Goesmann, Sebastian Oehm, Alfred Pühler, Rainer Merkl, Sonja Vorwerk, Philippe Glaser, Patricia Garrido, Christophe Rusniok, Carmen Buchrieser, Werner Goebel, Trinad Chakraborty BMC Genomics 2012, 13:144 (24 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

Research   Open Access

Stable multi-infection of splenocytes during SIV infection - the basis for continuous recombination

Anke Schultz, Sieghart Sopper, Ulrike Sauermann, Andreas Meyerhans, Rodolphe Suspène Retrovirology 2012, 9:31 (23 April 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

SIV multi-infection of single splenocytes was readily detected in all monkeys and all stages of the infection. Single-infected cells were more frequent than double or triple infected cells. There was no strong trend linking the copy number distribution to plasma viral load, disease stage or CD4 cell counts.

45.

Research   Open Access Highly Accessed

West Nile virus: characterization and diagnostic applications of monoclonal antibodies

Davide Lelli, Ana Moreno, Emiliana Brocchi, Enrica Sozzi, Lorenzo Capucci, Elena Canelli, Ilaria Barbieri, Herve Zeller, Paolo Cordioli Virology Journal 2012, 9:81 (13 April 2012)

Abstract | Full text | PDF | PubMed

46.

Research   Open Access

Assessment of the risk of malaria re-introduction in the Maremma plain (Central Italy) using a multi-factorial approach

Roberto Romi, Daniela Boccolini, Roberto Vallorani, Francesco Severini, Luciano Toma, Maurizio Cocchi, Angelo Tamburro, Gianni Messeri, Antonio Crisci, Luca Angeli, Roberto Costantini, Irene Raffaelli, Giorgio Pontuale, Isabelle Thiéry, Annie Landier, Gilbert Le Goff, Anna Fausto, Marco Di Luca Malaria Journal 2012, 11:98 (30 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The manuscript presents a longitudinal study, which is of importance, more specifically now with the re-emergence of malaria in Greece of P. vivax and the threat for Southern Europe. The study details the main parameters to consider for the risk assessment: receptivity, susceptibility and vulnerability focussing on An. labranchiae potential vector for P. falciparum in Maremma area.

47.

Research   Open Access Highly Accessed

Hepatitis C virus-specific cellular immune responses in individuals with no evidence of infection

Yves Rivière, Thomas Montange, Geneviève Janvier, Caroline Marnata, Ludovic Durrieu, Marie-Laure Chaix, Maria Isaguliants, Odile Launay, Jean-Louis Bresson, Stanislas Pol Virology Journal 2012, 9:76 (28 March 2012)

Abstract | Full text | PDF | PubMed

48.

Commentary   Free Highly Accessed

Good and bad fever

Jean-Marc Cavaillon Critical Care 2012, 16:119 (20 March 2012)

Abstract | Full text | PDF | PubMed

49.

Research article   Open Access

Prevalence, genetic diversity and antiretroviral drugs resistance-associated mutations among untreated HIV-1-infected pregnant women in Gabon, central Africa

Mélanie Caron, Sonia Lekana-Douki, Maria Makuwa, Guy-Patrick Obiang-Ndong, Olivia Biba, Dieudonné Nkoghé, Mirdad Kazanji BMC Infectious Diseases 2012, 12:64 (20 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

Research   Open Access

Biogeography of the two major arbovirus mosquito vectors, Aedes aegypti and Aedes albopictus (Diptera, Culicidae), in Madagascar

Fara Raharimalala, Lala Ravaomanarivo, Pierre Ravelonandro, Lala Rafarasoa, Karima Zouache, Van Tran-Van, Laurence Mousson, Anna-Bella Failloux, Eléonore Hellard, Claire Moro, Bakoly Ralisoa, Patrick Mavingui Parasites & Vectors 2012, 5:56 (20 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Entomological surveys reveal invasion of the Asian tiger mosquito vector Aedes albopictus, outcompeting the closer species Aedes. aegypti, in Madagascar. This raises questions about its implication in recent arbovirus outbreaks. Image : Natural and man-made breeding sites of Aedes albopictus

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