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26.

Research   Open Access Highly Accessed

Genetic adaptation to high altitude in the Ethiopian highlands

Laura B Scheinfeldt, Sameer Soi, Simon Thompson, Alessia Ranciaro, Dawit Woldemeskel, William Beggs, Charla Lambert, Joseph P Jarvis, Dawit Abate, Gurja Belay, Sarah A Tishkoff Genome Biology 2012, 13:R1 (20 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The genetics of hypoxia selection in an Ethiopian high-altitude population are distinct from Andean and Tibetan genotypes, suggestive of convergent evolution

27.

Research article   Open Access

Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesis

Emily Greenfest-Allen, Jeffrey Malik, James Palis, Christian J Stoeckert BMC Systems Biology 2013, 7:38 (15 May 2013)

Abstract | Provisional PDF | PubMed

28.

Research article   Open Access Highly Accessed

Toward reconstructing the evolution of advanced moths and butterflies (Lepidoptera: Ditrysia): an initial molecular study

Jerome C Regier, Andreas Zwick, Michael P Cummings, Akito Y Kawahara, Soowon Cho, Susan Weller, Amanda Roe, Joaquin Baixeras, John W Brown, Cynthia Parr, Donald R Davis, Marc Epstein, Winifred Hallwachs, Axel Hausmann, Daniel H Janzen, Ian J Kitching, M Alma Solis, Shen-Horn Yen, Adam L Bazinet, Charles Mitter BMC Evolutionary Biology 2009, 9:280 (2 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A phylogeny of the Lepidopteran clade Ditrysia based on five nuclear genes broadly confirms the previous morphology-based tree, but some features including the position of the butterflies need to be resolved.

29.

Research article   Open Access Highly Accessed

Common stressful life events and difficulties are associated with mental health symptoms and substance use in young adolescents

Nancy CP Low, Erika Dugas, Erin O’Loughlin, Daniel Rodriguez, Gisele Contreras, Michael Chaiton, Jennifer O’Loughlin BMC Psychiatry 2012, 12:116 (17 August 2012)

Abstract | Full text | PDF | PubMed

30.

Study protocol   Open Access Highly Accessed

NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol

Lisa M Askie, Peter Brocklehurst, Brian A Darlow, Neil Finer, Barbara Schmidt, William Tarnow-Mordi, BMC Pediatrics 2011, 11:6 (17 January 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

31.

Research   Open Access Highly Accessed

The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods

Jennifer B Freeman, Molly L Choate-Summers, Abbe M Garcia, Phoebe S Moore, Jeffrey J Sapyta, Muniya S Khanna, John S March, Edna B Foa, Martin E Franklin Child and Adolescent Psychiatry and Mental Health 2009, 3:4 (30 January 2009)

Abstract | Full text | PDF | PubMed

32.

Research article   Open Access Highly Accessed

Bereavement care interventions: a systematic review

Amanda L Forte, Malinda Hill, Rachel Pazder, Chris Feudtner BMC Palliative Care 2004, 3:3 (26 July 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

Review   Open Access Highly Accessed

Acute lung injury and the acute respiratory distress syndrome in the injured patient

Magdalena Bakowitz, Brandon Bruns, Maureen McCunn Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012, 20:54 (10 August 2012)

Abstract | Full text | PDF | PubMed

34.

Review   Open Access Highly Accessed

A unified phylogeny-based nomenclature for histone variants

Paul B Talbert, Kami Ahmad, Geneviève Almouzni, Juan Ausió, Frederic Berger, Prem L Bhalla, William M Bonner, W Cande, Brian P Chadwick, Simon W L Chan, George A M Cross, Liwang Cui, Stefan I Dimitrov, Detlef Doenecke, José M Eirin-López, Martin A Gorovsky, Sandra B Hake, Barbara A Hamkalo, Sarah Holec, Steven E Jacobsen, Kinga Kamieniarz, Saadi Khochbin, Andreas G Ladurner, David Landsman, John A Latham, Benjamin Loppin, Harmit S Malik, William F Marzluff, John R Pehrson, Jan Postberg et al. Epigenetics & Chromatin 2012, 5:7 (31 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In response to an urgent need to rationalize the current schemes for naming histone variants, researchers from over 30 institutions worldwide have developed consistent but flexible naming rules that are informative and database-searchable.

35.

Review   Open Access Highly Accessed

The six most essential questions in psychiatric diagnosis: A pluralogue part 2: Issues of conservatism and pragmatism in psychiatric diagnosis

James Phillips, Allen Frances, Michael A Cerullo, John Chardavoyne, Hannah S Decker, Michael B First, Nassir Ghaemi, Gary Greenberg, Andrew C Hinderliter, Warren A Kinghorn, Steven G LoBello, Elliott B Martin, Aaron L Mishara, Joel Paris, Joseph M Pierre, Ronald W Pies, Harold A Pincus, Douglas Porter, Claire Pouncey, Michael A Schwartz, Thomas Szasz, Jerome C Wakefield, G Waterman, Owen Whooley, Peter Zachar Philosophy, Ethics, and Humanities in Medicine 2012, 7:8 (18 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

Review   Subscription Highly Accessed

Clinical review: Neuromonitoring - an update

Nino Stocchetti, Peter Roux, Paul Vespa, Mauro Oddo, Giuseppe Citerio, Peter J Andrews, Robert D Stevens, Tarek Sharshar, Fabio S Taccone, Jean-Louis Vincent Critical Care 2013, 17:201 (15 January 2013)

Abstract | Full text | PDF | PubMed

37.

Research article   Open Access Highly Accessed

The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial

Michael A Becker, H Ralph Schumacher, Luis R Espinoza, Alvin F Wells, Patricia MacDonald, Eric Lloyd, Christopher Lademacher Arthritis Research & Therapy 2010, 12:R63 (6 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

38.

Commentary   Open Access Highly Accessed

Defining the critical hurdles in cancer immunotherapy

Bernard A Fox, Dolores J Schendel, Lisa H Butterfield, Steinar Aamdal, James P Allison, Paolo Ascierto, Michael B Atkins, Jirina Bartunkova, Lothar Bergmann, Neil Berinstein, Cristina C Bonorino, Ernest Borden, Jonathan L Bramson, Cedrik M Britten, Xuetao Cao, William E Carson, Alfred E Chang, Dainius Characiejus, A Raja Choudhury, George Coukos, Tanja de Gruijl, Robert O Dillman, Harry Dolstra, Glenn Dranoff, Lindy G Durrant, James H Finke, Jerome Galon, Jared A Gollob, Cécile Gouttefangeas, Fabio Grizzi et al. Journal of Translational Medicine 2011, 9:214 (14 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

Review   Open Access Highly Accessed

Tissue Doppler imaging for diagnosis of coronary artery disease: a systematic review and meta-analysis

Rajender Agarwal, Priyanka Gosain, James N Kirkpatrick, Tareq Alyousef, Rami Doukky, Gurpreet Singh, Craig A Umscheid Cardiovascular Ultrasound 2012, 10:47 (30 November 2012)

Abstract | Full text | PDF | PubMed

40.

Research article   Open Access

Genomic deletion of CNGB3 is identical by descent in multiple canine breeds and causes achromatopsia

Connie Y Yeh, Orly Goldstein, Anna V Kukekova, Debbie Holley, Amy M Knollinger, Heather J Huson, Susan E Pearce-Kelling, Gregory M Acland, András M Komáromy BMC Genetics 2013, 14:27 (20 April 2013)

Abstract | Full text | PDF | PubMed

41.

Commentary   Open Access Highly Accessed

Role of aerobic glycolysis in genetically engineered mouse models of cancer

Chi V Dang BMC Biology 2013, 11:3 (23 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Chi Van Dang gives his perspective on research published in the newly launched Cancer and Metabolism suggesting a new target for intervention in the aerobic glycolysis that supports tumor development.

42.

Research   Open Access Highly Accessed

Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control

Robert S Coyne, Linda Hannick, Dhanasekaran Shanmugam, Jessica B Hostetler, Daniel Brami, Vinita S Joardar, Justin Johnson, Diana Radune, Irtisha Singh, Jonathan H Badger, Ujjwal Kumar, Milton Saier, Yufeng Wang, Hong Cai, Jianying Gu, Michael W Mather, Akhil B Vaidya, David E Wilkes, Vidyalakshmi Rajagopalan, David J Asai, Chad G Pearson, Robert C Findly, Harry W Dickerson, Martin Wu, Cindy Martens, Yves Van de Peer, David S Roos, Donna M Cassidy-Hanley, Theodore G Clark Genome Biology 2011, 12:R100 (17 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The genome of the pathogenic ciliate Ichthyophthirius multifiliis, which causes white spot disease in fish, is presented

43.

Review   Free Highly Accessed

Breast cancer in young women

Courtney A Gabriel, Susan M Domchek Breast Cancer Research 2010, 12:212 (28 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

Review   Open Access Highly Accessed

Initial Emergency Department Diagnosis and Management of Adult Patients with Severe Sepsis and Septic Shock

Sarah M Perman, Munish Goyal, David F Gaieski Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012, 20:41 (27 June 2012)

Abstract | Full text | PDF | PubMed

45.

Research   Open Access Highly Accessed

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

Michele Carbone, Laura Ferris, Francine Baumann, Andrea Napolitano, Christopher A Lum, Erin G Flores, Giovanni Gaudino, Amy Powers, Peter Bryant-Greenwood, Thomas Krausz, Elizabeth Hyjek, Rachael Tate, Joseph Friedberg, Tracey Weigel, Harvey I Pass, Haining Yang Journal of Translational Medicine 2012, 10:179 (30 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The presence of melanocytic tumors can provide physicians with a visual marker to identify individuals who may carry germline BAP1 mutations and so are at higher risk of developing melanoma and mesothelioma.

46.

Research article   Open Access Highly Accessed

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Anna Mulligan, Fergus J Couch, Daniel Barrowdale, Susan M Domchek, Diana Eccles, Heli Nevanlinna, Susan J Ramus, Mark Robson, Mark Sherman, Amanda B Spurdle, Barbara Wappenschmidt, Andrew Lee, Lesley McGuffog, Sue Healey, Olga M Sinilnikova, Ramunas Janavicius, Thomas vO Hansen, Finn C Nielsen, Bent Ejlertsen, Ana Osorio, Iván Muñoz-Repeto, Mercedes Durán, Javier Godino, Maroulio Pertesi, Javier Benítez, Paolo Peterlongo, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Elisa Cattaneo et al. Breast Cancer Research 2011, 13:R110 (2 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

47.

Review   Open Access

Experimental design, preprocessing, normalization and differential expression analysis of small RNA sequencing experiments

Kevin P McCormick, Matthew R Willmann, Blake C Meyers Silence 2011, 2:2 (28 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

Study protocol   Open Access

A pilot study of the effect of spironolactone therapy on exercise capacity and endothelial dysfunction in pulmonary arterial hypertension: study protocol for a randomized controlled trial

Jason M Elinoff, J Rame, Paul R Forfia, Mary K Hall, Junfeng Sun, Ahmed M Gharib, Khaled Abd-Elmoniem, Grace Graninger, Bonnie Harper, Robert L Danner, Michael A Solomon Trials 2013, 14:91 (2 April 2013)

Abstract | Full text | PDF | PubMed

49.

Research   Open Access Highly Accessed

NF-kB inhibitor blocks B cell development at two checkpoints

Biao Feng, Shuhua Cheng, Warren S Pear, Hsiou-Chi Liou Medical Immunology 2004, 3:1 (29 March 2004)

Abstract | Full text | PDF | PubMed

50.

Research   Open Access Highly Accessed

A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK

Joshua D Campbell, John E McDonough, Julie E Zeskind, Tillie L Hackett, Dmitri V Pechkovsky, Corry-Anke Brandsma, Masaru Suzuki, John V Gosselink, Gang Liu, Yuriy O Alekseyev, Ji Xiao, Xiaohui Zhang, Shizu Hayashi, Joel D Cooper, Wim Timens, Dirkje S Postma, Darryl A Knight, Lenburg E Marc, Hogg C James, Spira Avrum Genome Medicine 2012, 4:67 (31 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Gene expression profiles in chronic obstructive pulmonary disease, the fourth leading cause of death world-wide, were assessed and the tripeptide GHK identified as a possible therapeutic compound.

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