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1.

Study protocol   Open Access

Partnership for fragility bone fracture care provision and prevention program (P4Bones): study protocol for a secondary fracture prevention pragmatic controlled trial

Isabelle Gaboury, Hélène Corriveau, Gilles Boire, François Cabana, Marie-Claude Beaulieu, Pierre Dagenais, Suzanne Gosselin, Earl Bogoch, Marie Rochette, Johanne Filiatrault, Sophie Laforest, Sonia Jean, Alvine Fansi, Diane Theriault, Bernard Burnand Implementation Science 2013, 8:10 (24 January 2013)

Abstract | Full text | PDF | PubMed

2.

Case report   Open Access

Fatal Mycobacterium colombiense/cytomegalovirus coinfection associated with acquired immunodeficiency due to autoantibodies against interferon gamma: a case report

Sébastien Poulin, Claude Corbeil, Mélanie Nguyen, Anik St-Denis, Lise Côté, Françoise Le Deist, Alex Carignan BMC Infectious Diseases 2013, 13:24 (22 January 2013)

Abstract | Full text | PDF | PubMed | 1 comment

3.

Research article   Open Access

Aggregation and neurotoxicity of recombinant alpha-synuclein aggregates initiated by dimerization

Alireza Roostaee, Simon Beaudoin, Antanas Staskevicius, Xavier Roucou Molecular Neurodegeneration 2013, 8:5 (22 January 2013)

Abstract | Provisional PDF | PubMed

4.

Research article   Open Access

Family physician enabling attitudes: a qualitative study of patient perceptions

Catherine Hudon, Denise St-Cyr Tribble, Gina Bravo, William Hogg, Mireille Lambert, Marie-Eve Poitras BMC Family Practice 2013, 14:8 (10 January 2013)

Abstract | Full text | PDF | PubMed

5.

Research article   Open Access Highly Accessed

Diffusion of a collaborative care model in primary care: a longitudinal qualitative study

Isabelle Vedel, Veronique Ghadi, Matthieu De Stampa, Christelle Routelous, Howard Bergman, Joel Ankri, Liette Lapointe BMC Family Practice 2013, 14:3 (4 January 2013)

Abstract | Full text | PDF | PubMed

6.

Research article   Open Access Highly Accessed

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos, Albert M Berghuis BMC Structural Biology 2012, 12:32 (12 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Three crystal structures of human farnesyl pyrophosphate synthase (FPPS) in ternary complex with a novel bisphosphonate inhibitor reveal mechanistic insight of the conformational change in the C-terminal tail closure that is essential for catalysis.

7.

Research   Open Access Highly Accessed

Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for detection of Leishmania DNA in buffy coat from visceral leishmaniasis patients

Md Gulam Musawwir Khan, Khondaker Rifat Hasan Bhaskar, Md Abdus Salam, Tania Akther, Gerd Pluschke, Dinesh Mondal Parasites & Vectors 2012, 5:280 (3 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Spleen tissue aspiration is an invasive and highly risky procedure which may cause life threatening internal bleeding in 1 of 1000 procedures, sometime with fatal outcomes. Thus there is a need for an accurate but risk-free diagnostic tool for VL. Image: Spleen tissue aspiration for diagnosis of VL.

8.

Opinion   Free Highly Accessed

Designing a post-genomics knowledge ecosystem to translate pharmacogenomics into public health action

Edward S Dove, Samer A Faraj, Eugene Kolker, Vural Özdemir Genome Medicine 2012, 4:91 (29 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Vural Ozdemir and colleagues discuss the need for narrators, such as philosophers and citizen scientists, to work with scientists to translate pharmacogenomic advances to the clinic.

9.

Research article   Open Access

DNA barcoding of Northern Nearctic Muscidae (Diptera) reveals high correspondence between morphological and molecular species limits

Anaïs K Renaud, Jade Savage, Sarah J Adamowicz BMC Ecology 2012, 12:24 (23 November 2012)

Abstract | Full text | PDF | PubMed

10.

Research article   Open Access

Suture restriction of the temporal bone as a risk factor for acute otitis media in children: cohort study

Chantal Morin, Dominique Dorion, Jean-Marie Moutquin, Mélanie Levasseur BMC Pediatrics 2012, 12:181 (20 November 2012)

Abstract | Full text | PDF | PubMed

11.

Research   Open Access

Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosis

Nadzeya Goncharenko-Khaider, Isabelle Matte, Denis Lane, Claudine Rancourt, Alain Piché Molecular Cancer 2012, 11:84 (17 November 2012)

Abstract | Full text | PDF | PubMed

12.

Research   Open Access

Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis

Denis Lane, Isabelle Matte, Claudine Rancourt, Alain Piché Journal of Ovarian Research 2012, 5:34 (15 November 2012)

Abstract | Full text | PDF | PubMed

13.

Original research   Open Access

Quantitative hormone therapy follow-up in an ER+/ERαKD mouse tumor model using FDG and [11C]-methionine PET imaging

Michel Paquette, Sébastien Tremblay, Francois Bénard, Roger Lecomte EJNMMI Research 2012, 2:61 (9 November 2012)

Abstract | Full text | PDF | PubMed

14.

Methodology article   Open Access Highly Accessed

Identifying structural domains of proteins using clustering

Howard J Feldman BMC Bioinformatics 2012, 13:286 (1 November 2012)

Abstract | Full text | PDF | PubMed

15.

Review   Open Access

CMV and Immunosenescence: from basics to clinics

Rafael Solana, Raquel Tarazona, Allison E Aiello, Arne N Akbar, Victor Appay, Mark Beswick, Jos A Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein, Ann Hill, Mikko Hurme, Florian Kern, Anis Larbi, Miguel López-Botet, Andrea B Maier, Janet E McElhaney, Paul Moss, Elissaveta Naumova, Janko Nikolich-Zugich, Alejandra Pera, Jerrald L Rector, Natalie Riddell, Beatriz Sanchez-Correa, Paolo Sansoni, Delphine Sauce, Rene van Lier, George C Wang, Mark R Wills, Maciej Zieliński, Graham Pawelec et al. Immunity & Ageing 2012, 9:23 (31 October 2012)

Abstract | Full text | PDF | PubMed

16.

Research article   Open Access

A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine

Joanne M Langley, Louise Frenette, Laurence Chu, Shelly McNeil, Scott Halperin, Ping Li, David Vaughn BMC Infectious Diseases 2012, 12:279 (30 October 2012)

Abstract | Full text | PDF | PubMed

17.

Research article   Open Access Highly Accessed

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde Molecular Neurodegeneration 2012, 7:54 (24 October 2012)

Abstract | Full text | PDF | PubMed

18.

Meeting abstract   Open Access

Integration of early identification and brief intervention in frontline health services: the case of Quebec

Marianne Saint-Jacques, Thomas G Brown, Sarah Filion-Bilodeau, John Topp, David Ross, Lucie Legault Addiction Science & Clinical Practice 2012, 7(Suppl 1):A74 (9 October 2012)

Full text | PDF

19.

Review   Open Access

Aging, immunosenescence and membrane rafts: the lipid connection

Tamas Fulop, Aurélie Le Page, Hugo Garneau, Naheed Azimi, Sarra Baehl, Gilles Dupuis, Graham Pawelec, Anis Larbi Longevity & Healthspan 2012, 1:6 (4 October 2012)

Abstract | Full text | PDF

20.

Research article   Open Access Highly Accessed

Obstructive sleep apnea and multimorbidity

Laurence Robichaud-Hallé, Michel Beaudry, Martin Fortin BMC Pulmonary Medicine 2012, 12:60 (24 September 2012)

Abstract | Full text | PDF | PubMed

21.

Research article   Open Access

Quality of care for major depression and its determinants: a multilevel analysis

Arnaud Duhoux, Louise Fournier, Lise Gauvin, Pasquale Roberge BMC Psychiatry 2012, 12:142 (17 September 2012)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access

Users’ perspectives of key factors to implementing electronic health records in Canada: a Delphi study

Carrie McGinn, Marie-Pierre Gagnon, Nicola Shaw, Claude Sicotte, Luc Mathieu, Yvan Leduc, Sonya Grenier, Julie Duplantie, Anis Abdeljelil, France Légaré BMC Medical Informatics and Decision Making 2012, 12:105 (11 September 2012)

Abstract | Full text | PDF | PubMed

23.

Research article   Open Access Highly Accessed

A taxonomy of nursing care organization models in hospitals

Carl-Ardy Dubois, Danielle D’Amour, Eric Tchouaket, Michèle Rivard, Sean Clarke, Régis Blais BMC Health Services Research 2012, 12:286 (28 August 2012)

Abstract | Full text | PDF | PubMed

24.

Study protocol   Open Access

Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

Benjamin Kasenda, Erik B von Elm, John You, Anette Blümle, Yuki Tomonaga, Ramon Saccilotto, Alain Amstutz, Theresa Bengough, Jörg Meerpohl, Mihaela Stegert, Kari A O Tikkinen, Ignacio Neumann, Alonso Carrasco-Labra, Markus Faulhaber, Sohail Mulla, Dominik Mertz, Elie A Akl, Dirk Bassler, Jason W Busse, Ignacio Ferreira-González, Francois Lamontagne, Alain Nordmann, Rachel Rosenthal, Stefan Schandelmaier, Xin Sun, Per O Vandvik, Bradley C Johnston, Martin A Walter, Bernard Burnand, Matthias Schwenkglenks, Heiner C Bucher, Gordon H Guyatt, Matthias Briel et al. BMC Medical Research Methodology 2012, 12:131 (28 August 2012)

Abstract | Full text | PDF | PubMed

25.

Correspondence   Open Access Highly Accessed

A qualitative study on the term CAM: is there a need to reinvent the wheel?

Isabelle Gaboury, Karine April, Marja Verhoef BMC Complementary and Alternative Medicine 2012, 12:131 (21 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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