Deletions and duplications of the 22q11.2 region in spermatozoa from DiGeorge/velocardiofacial fathers
Molecular Cytogenetics 2014, 7:86 (25 November 2014)
Onchocerciasis transmission in Ghana: biting and parous rates of host-seeking sibling species of the Simulium damnosum complex
Parasites & Vectors 2014, 7:511 (21 November 2014)
Onchocerciasis control policy across Africa is shifting towards elimination. We elucidate bionomic features of vector species of importance for onchocerciasis elimination efforts in both savannah and forest regions. Image: Human-baited trap for host-seeking blackflies (Photo: Poppy Lamberton).
Genomic epidemiology of a protracted hospital outbreak caused by multidrug-resistant Acinetobacter baumannii in Birmingham, England
Genome Medicine 2014, 6:70 (20 November 2014)
Whole genome sequencing of multi-drug resistant
Acinetobacter baumannii in a prolonged hospital outbreak in Birmingham, UK, advises on control and prevention strategies.
An analysis of women’s and children’s health professional requirements in China in 2010 based on workload
BMC Health Services Research 2014, 14:589 (19 November 2014)
Genomic analysis offers insights into the evolution of the bovine TRA/TRD locus
BMC Genomics 2014, 15:994 (19 November 2014)
A library of mammalian effector modules for synthetic morphology
Journal of Biological Engineering 2014, 8:26 (19 November 2014)
Frontline health workers as brokers: provider perceptions, experiences and mitigating strategies to improve access to essential medicines in South Africa
BMC Health Services Research 2014, 14:520 (5 November 2014)
Gene flow in environmental Legionella pneumophila leads to genetic and pathogenic heterogeneity within a Legionnaires' disease outbreak
Genome Biology 2014, 15:504 (3 November 2014)
In this study, the authors investigate the etiology of the Legionnaires' disease outbreak in Edinburgh, UK, in 2012, using genomic approaches
Immunity, safety and protection of an Adenovirus 5 prime - modified Vaccinia virus Ankara boost subunit vaccine against Mycobacterium avium subspecies paratuberculosis infection in calves
Veterinary Research 2014, 45:112 (29 October 2014)
A murine macrofilaricide screening model for onchocerciasis and lymphatic filariasis
Parasites & Vectors 2014, 7:472 (24 October 2014)
Elimination of onchocerciasis in Africa would be accelerated by the development of a safe cure. Development of candidate drugs is constrained by the lack of an appropriate small animal infection system, which may lead to drug failure in the clinic. Here we report the validation of a scalable pre-clinical mouse model of onchocerciasis by the surgical implantation of adult Onchocerca ochengi isolated from naturally infected cattle in Cameroon. Image: Adult male Onchocerca ochengi.
Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus
BMC Pulmonary Medicine 2014, 14:164 (24 October 2014)
Choosing care homes as the least preferred place to die: a cross-national survey of public preferences in seven European countries
BMC Palliative Care 2014, 13:48 (23 October 2014)
Health systems and gender in post-conflict contexts: building back better?
Conflict and Health 2014, 8:19 (22 October 2014)
The prion protein protease sensitivity, stability and seeding activity in variably protease sensitive prionopathy brain tissue suggests molecular overlaps with sporadic Creutzfeldt-Jakob disease
Acta Neuropathologica Communications 2014, 2:152 (21 October 2014)
Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease
Acta Neuropathologica Communications 2014, 2:146 (21 October 2014)
Modules, networks and systems medicine for understanding disease and aiding diagnosis
Genome Medicine 2014, 6:82 (17 October 2014)
Mikael Benson and colleagues explain how and why systems medicine, and specifically network approaches, can be used to assist clinical decision making and identify underlying disease mechanisms
Not all cows are epidemiologically equal: quantifying the risks of bovine viral diarrhoea virus (BVDV) transmission through cattle movements
Veterinary Research 2014, 45:110 (17 October 2014)
The authors investigated bovine viral diarrhoea virus (BVDV) transmission risk by combining statistical analysis of real serological data from surveyed beef and dairy herds with simulated data from a dynamic model.
Erratum to: On estimation of genetic variance within families using genome-wide identity-by-descent sharing
Genetics Selection Evolution 2014, 46:62 (15 October 2014)
Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance
BMC Cancer 2014, 14:762 (14 October 2014)
SuRFing the genomics wave: an R package for prioritising SNPs by functionality
Genome Medicine 2014, 6:79 (14 October 2014)
An R package that integrates functional annotation and biological knowledge to prioritize candidate functional variants, particularly in non-coding regions.
Effective Feedback to Improve Primary Care Prescribing Safety (EFIPPS) a pragmatic three-arm cluster randomised trial: designing the intervention (ClinicalTrials.gov registration NCT01602705)
Implementation Science 2014, 9:133 (11 October 2014)
Apoptotic cell administration is detrimental in murine renal ischaemia reperfusion injury
Journal of Inflammation 2014, 11:31 (10 October 2014)
Evidence of a high incidence of subclinically affected calves in a herd of cattle with fatal cases of Bovine Neonatal Pancytopenia (BNP)
BMC Veterinary Research 2014, 10:245 (8 October 2014)
Estimation of genomic breeding values using the Horseshoe prior
BMC Proceedings 2014, 8(Suppl 5):S6 (7 October 2014)
Regional Heritability Mapping to identify loci underlying genetic variation of complex traits
BMC Proceedings 2014, 8(Suppl 5):S3 (7 October 2014)
Wolbachia lipoproteins: abundance, localisation and serology of Wolbachia peptidoglycan associated lipoprotein and the Type IV Secretion System component, VirB6 from Brugia malayi and Aedes albopictus
Parasites & Vectors 2014, 7:462 (6 October 2014)
Two Wolbachia lipoproteins, wBmPAL and wBmVirB6, are present in extracts of Brugia malayi with wBmPAL among the most abundant of Wolbachia proteins. Both lipoproteins localised to bacterial membranes with wBmVirB6 present as a single cluster suggesting a single Type IV Secretory System. Image:A 3D image of PAL.
A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast
Genome Biology 2014, 15:481 (2 October 2014)
A systematic genetic screen identifies several new factors involved in RNAi-directed heterochromatin assembly in yeast
Human resource management in post-conflict health systems: review of research and knowledge gaps
Conflict and Health 2014, 8:18 (2 October 2014)
Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers
BMC Genomics 2014, 15:833 (1 October 2014)
Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98
BMC Medicine 2014, 12:164 (30 September 2014)
Strict adherence to the DSM-5 criteria results in fewer delirium diagnoses than when DSM-IV are used, whereas applying ‘relaxed’ DSM-5 criteria identifies a comparable number of cases, supporting a more relaxed approach for delirium diagnosis.
Error and attack tolerance of collective problem solving: The DARPA Shredder Challenge
EPJ Data Science 2014, 3:13 (30 September 2014)
Retinal changes in visceral leishmaniasis by retinal photography
Abu Hayat Md Waliur
BMC Infectious Diseases 2014, 14:527 (30 September 2014)
Does arthroscopic sub-acromial decompression really work for sub-acromial impingement syndrome: a cohort study
BMC Musculoskeletal Disorders 2014, 15:324 (29 September 2014)
Feasibility study of the effects of art as a creative engagement intervention during stroke rehabilitation on improvement of psychosocial outcomes: study protocol for a single blind randomized controlled trial: the ACES study
Trials 2014, 15:380 (28 September 2014)
Rapid bacterial colonization of low-density polyethylene microplastics in coastal sediment microcosms
BMC Microbiology 2014, 14:232 (23 September 2014)
Identifying motivators for state-pastoralist dialogue: Exploring the relationships between livestock services, self-organisation and conflict in Nigeria's pastoralist Fulani
Pastoralism 2014, 4:12 (12 September 2014)
A self-avoidance mechanism in patterning of the urinary collecting duct tree
BMC Developmental Biology 2014, 14:35 (10 September 2014)
Transition from the initial wide branching urinary collecting duct tree to narrower later branching is dependent on the proximity of other branch tips with bone morphogenetic protein 7 (BMP7) acting as a repelling molecule in this process.
Collateral benefits of restricted insecticide application for control of African trypanosomiasis on Theileria parva in cattle: a randomized controlled trial
Parasites & Vectors 2014, 7:432 (8 September 2014)
To guide future simultaneous tsetse and tick-borne disease (TTBD) control, the effect of restricting pyrethroid insecticides to the legs, belly and ears (RAP) of cattle for tsetse control on T.parva prevalence was determined. Image: Effect of graded pyrethroid insecticide application for tsetse control on T.parva prevalence.
Fragile and conflict affected states: report from the Consultation on Collaboration for Applied Health Research and Delivery
Conflict and Health 2014, 8:15 (8 September 2014)
The long-acting COX-2 inhibitor mavacoxib (Trocoxil™) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro
BMC Veterinary Research 2014, 10:184 (5 September 2014)
Mavacoxib (COX-2 inhibitor) induces significant cell growth arrest and apoptosis in a panel of canine cancer cell lines, and also inhibits cancer stem cell survival in an
in vitro osteosarcoma, highlighting the drug’s potential for canine cancer treatment.
Evolutionary dynamics of emblematic Araucaria species (Araucariaceae) in New Caledonia: nuclear and chloroplast markers suggest recent diversification, introgression, and a tight link between genetics and geography within species
BMC Evolutionary Biology 2014, 14:171 (5 September 2014)
Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells
Genome Biology 2014, 15:451 (4 September 2014)
Cfp1 crucially targets H3K4me3 to promoters and contributes to global H3K9 acetylation and is key in establishing active promoter chromatin states
Molecular characterization of DDT resistance in Anopheles gambiae from Benin
Parasites & Vectors 2014, 7:409 (29 August 2014)
Cotton area with significant amount of pesticides for crop protection. Pesticide treatments release active components into the environment of which some get directly into the breeding sites of mosquitoes and select insecticide resistance. Image: Mosquito breeding site in cotton area from Bohicon.
Prioritizing animals for dense genotyping in order to impute missing genotypes of sparsely genotyped animals
Genetics Selection Evolution 2014, 46:46 (26 August 2014)
Views and experiences of behaviour change techniques to encourage walking to work: a qualitative study
BMC Public Health 2014, 14:868 (23 August 2014)
The elephant in the room: reproducibility in toxicology
Particle and Fibre Toxicology 2014, 11:42 (22 August 2014)
Sodalis glossinidius prevalence and trypanosome presence in tsetse from Luambe National Park, Zambia
Parasites & Vectors 2014, 7:378 (19 August 2014)
Molecular analyses of three tsetse species showed inter-species variation of Sodalis glossinidius and the presence of important tsetse transmitted trypanosomes including Trypanosoma brucei rhodesiense within Luambe National Park, Zambia. Image: Epsilon trap in Mopane woodland.
Ovarian germline stem cells
Stem Cell Research & Therapy 2014, 5:98 (18 August 2014)
Multidimensional complexities of filariasis control in an era of large-scale mass drug administration programmes: a can of worms
Parasites & Vectors 2014, 7:363 (15 August 2014)
This paper addresses the complex nature of attempting to bring the many different control and elimination activities together in an holistic /integrated way across a rapidly changing epidemiological landscape. Image: Albendazole, ivermectin and praziquantel used in Mass Drug Administration (MDA) programmes for control of onchocerciasis, lymphatic filariasis and schistosomiasis on an impregnated bed net distributed for malaria control also impacting on filaria transmission.
Suicide in Sri Lanka 1975–2012: age, period and cohort analysis of police and hospital data
BMC Public Health 2014, 14:839 (13 August 2014)
The epidemiology of suicide in Sri Lanka has changed noticeably in the last 30 years with the introduction of pesticide regulations here coinciding with a reduction in suicide rates.