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BMC  Member - Howard Hughes Medical Institute HHMI

Howard Hughes Medical Institute, a biomedical research organization, serves society by investigating human health and disease and by providing support to improve science education at all levels.

http://www.hhmi.org


Research staff and students at Howard Hughes Medical Institute HHMI:
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Work published with BioMed Central in the last 12 months by researchers at Howard Hughes Medical Institute HHMI


Order by: Date published / Most viewed (30 days) / Most viewed (past year)


Research article    
Considering scores between unrelated proteins in the search database improves profile comparison
Sadreyev RI, Wang Y, Grishin NV
BMC Bioinformatics 2009, 10:399 (4 December 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article    
Analysis of recent segmental duplications in the bovine genome
Liu GE, Ventura M, Cellamare A, Chen L, Cheng Z, Zhu B, Li C, Song J, Eichler EE
BMC Genomics 2009, 10:571 (1 December 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Correction    
Correction: Digital PCR provides sensitive and absolute calibration for high throughput sequencing
White RA, Blainey PC, Fan HC, Quake SR
BMC Genomics 2009, 10:541 (19 November 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article    
Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila
Zhou B, Williams DW, Altman J, Riddiford LM, Truman JW
Neural Development 2009, 4:39 (2 November 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Editorial    
Epigenetics & Chromatin celebrates its first anniversary
Henikoff S, Grosveld F
Epigenetics & Chromatin 2009, 2:13 (2 November 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Review    
Synthetic lethality: a framework for the development of wiser cancer therapeutics
Kaelin WG
Genome Medicine 2009, 1:99 (27 October 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Poster presentation    
P09-11. Reduced replication capacity of NL4-3 chimeric viruses encoding RT-Integrase sequences from HIV-1 elite controllers
Li C, Brumme ZL, Miura T, Rosato PC, Sela J, Brumme CJ, Heckerman D, Pereyra F, Walker BD, Brockman MA
Retrovirology 2009, 6(Suppl 3):P124 (22 October 2009)
[Abstract] [Full text] [PDF]

Research article    
Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye
Wu Y, Zhuang Y, Han M, Xu T, Deng K
BMC Developmental Biology 2009, 9:53 (20 October 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article    
Automated DNA mutation detection using universal conditions direct sequencing: application to ten muscular dystrophy genes
Bennett RR, Schneider HE, Estrella E, Burgess S, Cheng AS, Barrett C, Lip V, Lai PS, Shen Y, Wu BL, Darras BT, Beggs AH, Kunkel LM
BMC Genetics 2009, 10:66 (18 October 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Invited speaker presentation    
Retroviral restriction factors: new mechanisms of innate immunity
Wolf D, Gao G, Guo X, Bick MJ, Carroll JWN, MacDonald MR, Goff SP
Retrovirology 2009, 6(Suppl 2):I1 (24 September 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Oral presentation    
Targeting of MuLV Gag to the plasma membrane is mediated by PI(4,5)P2 and PhosphatidylSerine
Hamard-Peron E, Juilliard F, Saad JS, Roy C, Roingeard P, Summers MF, Darlix JL, Picart C, Muriaux D
Retrovirology 2009, 6(Suppl 2):O15 (24 September 2009)
[Abstract] [Full text] [PDF]

Poster presentation    
Identification of the 'basal' human LINE-1 retrotransposition complex
Doucet AJ, Sahinovic E, Bucheton A, Moran JV, Gilbert N
Retrovirology 2009, 6(Suppl 2):P32 (24 September 2009)
[Abstract] [Full text] [PDF]

Poster presentation    
The first crystal structure of cyclic GMP-dependent protein kinase I dimerization/docking domain reveals molecular details of isoform-specific anchoring
Casteel DE, Smith-Nguyen EV, Sankaran B, Spraggon G, Hampton EN, Pilz RB, Taylor SS, Kim C
BMC Pharmacology 2009, 9(Suppl 1):P6 (11 August 2009)
[Abstract] [Full text] [PDF]

Methodology article    
Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates
Voehringer D, Wu D, Liang HE, Locksley RM
BMC Biotechnology 2009, 9:69 (28 July 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research    
Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
MacArthur S, Li XY, Li J, Brown JB, Chu HC, Zeng L, Grondona BP, Hechmer A, Simirenko L, Keränen SVE, Knowles DW, Stapleton M, Bickel P, Biggin MD, Eisen MB
Genome Biology 2009, 10:R80 (23 July 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article    
Semi-automated curation of protein subcellular localization: a text mining-based approach to Gene Ontology (GO) Cellular Component curation
Van Auken K, Jaffery J, Chan J, Müller HM, Sternberg PW
BMC Bioinformatics 2009, 10:228 (21 July 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research    
Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4
Gancz AY, Kistler AL, Greninger AL, Farnoushi Y, Mechani S, Perl S, Berkowitz A, Perez N, Clubb S, DeRisi JL, Ganem D, Lublin A
Virology Journal 2009, 6:100 (9 July 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Research article    
Coordination of opposing sex-specific and core muscle groups regulates male tail posture during Caenorhabditis elegans male mating behavior
Whittaker AJ, Sternberg PW
BMC Biology 2009, 7:33 (22 June 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research    
The complete genome of klassevirus a novel picornavirus in pediatric stool
Greninger AL, Runckel C, Chiu CY, Haggerty T, Parsonnet J, Ganem D, DeRisi JL
Virology Journal 2009, 6:82 (18 June 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Research article    
Identification of candidate structured RNAs in the marine organism 'Candidatus Pelagibacter ubique'
Meyer MM, Ames TD, Smith DP, Weinberg Z, Schwalbach MS, Giovannoni SJ, Breaker RR
BMC Genomics 2009, 10:268 (16 June 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research    
Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana
Zhang X, Bernatavichute YV, Cokus S, Pellegrini M, Jacobsen SE
Genome Biology 2009, 10:R62 (9 June 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research    
Tissue-specific variation in DNA methylation levels along human chromosome 1
De Bustos C, Ramos E, Young JM, Tran RK, Menzel U, Langford CF, Eichler EE, Hsu L, Henikoff S, Dumanski JP, Trask BJ
Epigenetics & Chromatin 2009, 2:7 (8 June 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Research    
Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice
Stowell NC, Seideman J, Raymond HA, Smalley KA, Lamb RJ, Egenolf DD, Bugelski PJ, Murray LA, Marsters PA, Bunting RA, Flavell RA, Alexopoulou L, San Mateo LR, Griswold DE, Sarisky RT, Mbow ML, Das AM
Respiratory Research 2009, 10:43 (1 June 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Research article    
Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays
Bloom JS, Khan Z, Kruglyak L, Singh M, Caudy AA
BMC Genomics 2009, 10:221 (12 May 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [1 comment]

Research    
PfeIK1, a eukaryotic initiation factor 2 kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation
Fennell C, Babbitt S, Russo I, Wilkes J, Ranford-Cartwright L, Goldberg DE, Doerig C
Malaria Journal 2009, 8:99 (12 May 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Technical advance    
Identification of microbial DNA in human cancer
Duncan CG, Leary RJ, Lin JCH, Cummins J, Di C, Schaefer CF, Wang TL, Riggins GJ, Edwards J, Bigner D, Kopelovich L, Vogelstein B, Kinzler KW, Velculescu VE, Yan H
BMC Medical Genomics 2009, 2:22 (8 May 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article    
Transcriptomic analysis of the entomopathogenic nematode Heterorhabditis bacteriophora TTO1
Bai X, Adams BJ, Ciche TA, Clifton S, Gaugler R, Hogenhout SA, Spieth J, Sternberg PW, Wilson RK, Grewal PS
BMC Genomics 2009, 10:205 (30 April 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Proceedings    
Identifying promoter features of co-regulated genes with similar network motifs
Harari O, del Val C, Romero-Zaliz R, Shin D, Huang H, Groisman EA, Zwir I
BMC Bioinformatics 2009, 10(Suppl 4):S1 (29 April 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Methodology article    
Profile analysis and prediction of tissue-specific CpG island methylation classes
Previti C, Harari O, Zwir I, del Val C
BMC Bioinformatics 2009, 10:116 (21 April 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Review    
Sheldon-Hall syndrome
Toydemir RM, Bamshad MJ
Orphanet Journal of Rare Diseases 2009, 4:11 (23 March 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Methodology article    
Digital PCR provides sensitive and absolute calibration for high throughput sequencing
White RA, Blainey PC, Fan HC, Quake SR
BMC Genomics 2009, 10:116 (19 March 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article    
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
Winger JA, Hantschel O, Superti-Furga G, Kuriyan J
BMC Structural Biology 2009, 9:7 (24 February 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article    
Sec61, a subunit of the Sec61 protein translocation channel at the Endoplasmic Reticulum, is involved in the transport of Gurken to the plasma membrane.
Kelkar A, Dobberstein B
BMC Cell Biology 2009, 10:11 (18 February 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article    
A circuit supporting concentration-invariant odor perception in Drosophila
Asahina K, Louis M, Piccinotti S, Vosshall LB
Journal of Biology 2009, 8:9 (26 January 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research    
The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif
Kinch LN, Grishin NV
Biology Direct 2009, 4:2 (21 January 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles] [1 comment]

Research    
Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo
Michel N, Goffinet C, Ganter K, Allespach I, KewalRamani VN, Saifuddin M, Littman DR, Greene WC, Goldsmith MA, Keppler OT
Retrovirology 2009, 6:2 (13 January 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]

Research    
Studying alternative splicing regulatory networks through partial correlation analysis
Chen L, Zheng S
Genome Biology 2009, 10:R3 (9 January 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Research article    
Heterogeneity in the developmental potential of motor neuron progenitors revealed by clonal analysis of single cells in vitro
Agalliu D, Schieren I
Neural Development 2009, 4:2 (5 January 2009)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]


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