1.
Delivering at home or in a health facility? health-seeking behaviour of women and the role of traditional birth attendants in Tanzania
Constanze
Pfeiffer,
Rosemarie
Mwaipopo
BMC Pregnancy and Childbirth 2013, 13 :55 (28 February 2013)
Abstract | Provisional PDF
2.
Effects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets: a modelling study
Olivier
JT
Briët,
Melissa
A
Penny,
Diggory
Hardy,
Taiwo
S
Awolola,
Wim
Van Bortel,
Vincent
Corbel,
Roch
K
Dabiré,
Josiane
Etang,
Benjamin
G
Koudou,
Patrick
K
Tungu,
Nakul
Chitnis
Malaria Journal 2013, 12 :77 (25 February 2013)
Abstract | Provisional PDF
| PubMed
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Editor’s summary
The paper shows that standard and combination LLINs are likely to be cost effective against malaria even in areas with strong pyrethroid resistance. There is a strong message to funders and national malaria control programmes not abandon LLINs as the control tool of choice, because of fears that they might no longer be effective due to resistance.
3.
Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae
David
Wimmersberger,
Lucienne
Tritten,
Jennifer
Keiser
Parasites & Vectors 2013, 6 :42 (22 February 2013)
Abstract | Provisional PDF
| PubMed
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Editor’s summary
We describe the development of a novel drug sensitivity assay for Trichuris muris first-stage larvae (L1). The established L1 motility assay provided accurate and reproducible drug effect data in vitro and will therefore serve as a useful tool in drug discovery for trichuriasis. Image: Trichuris muris first-stage larva.
4.
In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains
Oyindamola
O
Abiodun,
Reto
Brun,
Sergio
Wittlin
Malaria Journal 2013, 12 :43 (31 January 2013)
Abstract | Full text | PDF | PubMed
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Editor’s summary
The study assessed the in vitro interaction of artemisin derivatives with thapsigargin using in vitro P. falciparum cultures. It demonstrated an additive effect of these compounds, suggesting that they do not interact at the same target site, as had previously been suggested.
5.
A new rapid diagnostic test for detection of anti-Schistosoma mansoni and anti-Schistosoma haematobium antibodies
Jean
T
Coulibaly,
Eliézer
K
N’Goran,
Jürg
Utzinger,
Michael
J
Doenhoff,
Emily
M
Dawson
Parasites & Vectors 2013, 6 :29 (29 January 2013)
Abstract | Full text | PDF | PubMed
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Editor’s summary
In this study, we assessed the diagnostic performance of a new rapid diagnostic test that incorporates Schistosoma mansoni cercarial transformation fluid (SmCTF-RDT) for the detection of anti-S. mansoni and anti-S. haematobium antibodies by comparing it with microscopy for egg detection .Image: Two SmCTF-RDTs after adding a drop of whole blood and buffer in the cassette hole.
6.
Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests
Sören
L
Becker,
Jürg
Vogt,
Stefanie
Knopp,
Marcus
Panning,
David
C
Warhurst,
Katja
Polman,
Hanspeter
Marti,
Lutz
von Müller,
Cedric
P
Yansouni,
Jan
Jacobs,
Emmanuel
Bottieau,
Moussa
Sacko,
Suman
Rijal,
Fransiska
Meyanti,
Michael
A
Miles,
Marleen
Boelaert,
Pascal
Lutumba,
Lisette
van Lieshout,
Eliézer
K
N’Goran,
François
Chappuis,
Jürg
Utzinger
BMC Infectious Diseases 2013, 13 :37 (24 January 2013)
Abstract | Full text | PDF | PubMed
7.
Local perceptions of cholera and anticipated vaccine acceptance in Katanga province, democratic republic of Congo
Sonja
Merten,
Christian
Schaetti,
Cele
Manianga,
Bruno
Lapika,
Claire-Lise
Chaignat,
Raymond
Hutubessy,
Mitchell
G
Weiss
BMC Public Health 2013, 13 :60 (22 January 2013)
Abstract | Provisional PDF
| PubMed
8.
Somatostatin-based radiotherapy with [90 Y-DOTA]-TOC in neuroendocrine tumors: long-term outcome of a phase I dose escalation study
Nicolas
Marincek,
Ann-Catherine
Jörg,
Philippe
Brunner,
Christian
Schindler,
Michael
T
Koller,
Christoph
Rochlitz,
Jan
Müller-Brand,
Helmut
R
Maecke,
Matthias
Briel,
Martin
A
Walter
Journal of Translational Medicine 2013, 11 :17 (15 January 2013)
Abstract | Full text | PDF | PubMed
9.
Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a malaria-endemic region
Salim
Abdulla,
Nahya
Salim,
Francisca
Machera,
Richard
Kamata,
Omar
Juma,
Mwanajaa
Shomari,
Sulende
Kubhoja,
Ali
Mohammed,
Grace
Mwangoka,
Thomas
Aebi,
Hassan
Mshinda,
David
Schellenberg,
Terrell
Carter,
Tonya
Villafana,
Marie-Claude
Dubois,
Amanda
Leach,
Marc
Lievens,
Johan
Vekemans,
Joe
Cohen,
W Ripley
Ballou,
Marcel
Tanner
Malaria Journal 2013, 12 :11 (8 January 2013)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Data from a well designed and rigorously conducted phase II trial as part of RTS,S/AS vaccine clinical development to prevent malaria in sub-Saharan African children, with further results on safety immunogenicity and efficacy of the RTSS vaccine with the AS02 adjuvant.
10.
Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide
Benjamin
Speich,
Hanspeter
Marti,
Shaali
M
Ame,
Said
M
Ali,
Isaac
I
Bogoch,
Jürg
Utzinger,
Marco
Albonico,
Jennifer
Keiser
Parasites & Vectors 2013, 6 :3 (4 January 2013)
Abstract | Full text | PDF | PubMed
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Editor’s summary
In a randomised controlled trial using albendazole and nitazoxanide, 550 school-aged children on Pemba Island had formalin-fixed stool samples examined with an ether-concentration method before and 3 weeks after treatment. Three-quarters of the children were diagnosed with at least one intestinal protozoa species. Image: A child on Pemba Island during drug administration.
11.
Modelling the cost-effectiveness of mass screening and treatment for reducing Plasmodium falciparum malaria burden
Valerie
Crowell,
Olivier
JT
Briët,
Diggory
Hardy,
Nakul
Chitnis,
Nicolas
Maire,
Aurelio
Pasquale,
Thomas
A
Smith
Malaria Journal 2013, 12 :4 (3 January 2013)
Abstract | Full text | PDF | PubMed
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Editor’s summary
This paper presents a cost-effectiveness modelling study on the introduction of mass screening and treatment in a sub-Saharan African setting, in various transmission contexts and with varying ITN and case management coverage. This is an important potential policy question, with a thoughtful discussion of the limitations.
12.
Elimination of tropical disease through surveillance and response
Xiao-Nong
Zhou,
Robert
Bergquist,
Marcel
Tanner
Infectious Diseases of Poverty 2013, 2 :1 (3 January 2013)
Abstract | Full text | PDF
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Editor’s summary
It is recommended that the surveillance-response systems to take place in two different stages corralling the basic components of the surveillance-response system for NTD elimination in developing countries, based on the innovative and effective One world-One health perspective to detect, report, analyze, interpret and take action. Image: taking surveillance of zoonotic diseases.
13.
Concordances and discrepancies between ICD-10 and DSM-IV criteria for anxiety disorders in childhood and adolescence
Carmen
Adornetto,
Andrea
Suppiger,
Tina
In-Albon,
Murielle
Neuschwander,
Silvia
Schneider
Child and Adolescent Psychiatry and Mental Health 2012, 6 :40 (26 December 2012)
Abstract | Full text | PDF | PubMed
14.
Malaria surveillance-response strategies in different transmission zones of the People's Republic of China: preparing for climate change
Guo-Jing
Yang,
Marcel
Tanner,
Jürg
Utzinger,
John
B
Malone,
Robert
Bergquist,
Emily
YY Chan,
Qi
Gao,
Xiao-Nong
Zhou
Malaria Journal 2012, 11 :426 (21 December 2012)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The authors present a prediction map of P. vivax malaria transmission in China and discuss its implications for future malaria control and elimination within the country, particularly within the context of past and future climate scenarios.
15.
Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children
Katarina
Stete,
Stefanie
J
Krauth,
Jean
T
Coulibaly,
Stefanie
Knopp,
Jan
Hattendorf,
Ivan
Müller,
Laurent
K
Lohourignon,
Winfried
V
Kern,
Eliézer
K
N’Goran,
Jürg
Utzinger
Parasites & Vectors 2012, 5 :298 (21 December 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
This study, conducted in south Cote d' Ivoire, assessed the dynamics of Schistosoma haematobium egg output and other infection parameters after praziquantel treatment in order to determine the optimal time point for measuring treatment efficacy in urogenital schistosomiasis. Image: Urine sample from a schoolchild in south Cote d' Ivoire, subjected to the filtration method.
16.
Willingness to use a rapid diagnostic test for malaria in a rural area of central Côte d’Ivoire
Colombe Coffie
Comoé,
Allassane
F
Ouattara,
Giovanna
Raso,
Marcel
Tanner,
Jürg
Utzinger,
Benjamin
G
Koudou
BMC Public Health 2012, 12 :1089 (18 December 2012)
Abstract | Full text | PDF | PubMed
17.
Sex-specific effects of a parasite evolving in a female-biased host population
David
Duneau,
Pepijn
Luijckx,
Ludwig
F
Ruder,
Dieter
Ebert
BMC Biology 2012, 10 :104 (18 December 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
A bacterial parasite of Daphnia magna castrates its hosts, apparently as an adaptation to the sex-bias in Daphnia populations towards females. Castration causes the female to grow larger, making it a better host for this parasite.
18.
Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo
Jennifer
Keiser,
Lucienne
Tritten,
Roberto
Adelfio,
Mireille
Vargas
Parasites & Vectors 2012, 5 :292 (11 December 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Drug combination effects of albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin were studied against Trichuris muris. Four synergistic and one additive combination were identified in vivo. Albendazole-mebendazole should be investigated further in preclinical studies. Image: SEM of anterior region of Trichuris muris.
19.
Molecular phylogeny of microhylid frogs (Anura: Microhylidae) with emphasis on relationships among New World genera
Rafael
O
de Sá,
Jeffrey
W
Streicher,
Relebohile
Sekonyela,
Mauricio
C
Forlani,
Simon
P
Loader,
Eli
Greenbaum,
Stephen
Richards,
Célio F
B
Haddad
BMC Evolutionary Biology 2012, 12 :241 (10 December 2012)
Abstract | Full text | PDF | PubMed
20.
Plasma lipoprotein-associated phospholipase A2 activity in Alzheimer's disease, amnestic mild cognitive impairment, and cognitively healthy elderly subjects: a cross-sectional study
Julie
E
Davidson,
Andrew
Lockhart,
Leslie
Amos,
Heide
A
Stirnadel-Farrant,
Vincent
Mooser,
Marc
Sollberger,
Axel
Regeniter,
Andreas
U
Monsch,
Michael
C
Irizarry
Alzheimer's Research & Therapy 2012, 4 :51 (7 December 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Levels of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) did not correlate with cerebrospinal fluid biomarkers such as Abeta and Tau in Alzheimer's disease patients in a cross-sectional study.
21.
Domestic dog demographic structure and dynamics relevant to rabies control planning in urban areas in Africa: the case of Iringa, Tanzania
Alena
S
Gsell,
Darryn
L
Knobel,
Rudovick
R
Kazwala,
Penelope
Vounatsou,
Jakob
Zinsstag
BMC Veterinary Research 2012, 8 :236 (5 December 2012)
Abstract | Full text | PDF | PubMed
22.
Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for detection of Leishmania DNA in buffy coat from visceral leishmaniasis patients
Md Gulam Musawwir
Khan,
Khondaker Rifat Hasan
Bhaskar,
Md Abdus
Salam,
Tania
Akther,
Gerd
Pluschke,
Dinesh
Mondal
Parasites & Vectors 2012, 5 :280 (3 December 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Spleen tissue aspiration is an invasive and highly risky procedure which may cause life threatening internal bleeding in 1 of 1000 procedures, sometime with fatal outcomes. Thus there is a need for an accurate but risk-free diagnostic tool for VL. Image: Spleen tissue aspiration for diagnosis of VL.
23.
Dicer partners expand the repertoire of miRNA targets
Lukasz
Jaskiewicz,
Mihaela
Zavolan
Genome Biology 2012, 13 :179 (29 November 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
A Research Highlight by Lukasz Jaskiewicz and Mihaela Zavolan discusses how cofactors modify Dicer processing and, consequently, transcriptional networks
24.
Differences in weight status and energy-balance related behaviors among schoolchildren in German-speaking Switzerland compared to seven countries in Europe
Michael
Herzig,
Alain
Dössegger,
Urs
Mäder,
Susi
Kriemler,
Tina
Wunderlin,
Leticia
Grize,
Johannes
Brug,
Yannis
Manios,
Charlotte
Braun-Fahrländer,
Bettina
Bringolf-Isler
International Journal of Behavioral Nutrition and Physical Activity 2012, 9 :139 (29 November 2012)
Abstract | Full text | PDF | PubMed
25.
Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells
Boonrat
Chantong,
Denise
V
Kratschmar,
Lyubomir
G
Nashev,
Zoltan
Balazs,
Alex
Odermatt
Journal of Neuroinflammation 2012, 9 :260 (28 November 2012)
Abstract | Full text | PDF | PubMed