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The Stowers Institute for Medical Research seeks more effective means of preventing and curing disease through basic research on genes and proteins that control fundamental processes of cellular life. Scientists at the Institute study the way genes determine biological fate and how they can be altered to prevent or slow disease.

http://www.stowers-institute.org/

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Work published with BioMed Central, Chemistry Central and SpringerOpen by researchers at Stowers Institute for Medical Research

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	1.	Question and Answer Q&A: What is regeneration, and why look to planarians for answers? Alejandro Sánchez Alvarado BMC Biology 2012, 10:88 (8 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary What controls regeneration? Alejandro Sanchez Alvarado explores this old question in biology in a Q&A explaining what we understand from planarians - non-parasitic flatworms all of whose tissues can regenerate.
	2.	Research article *Evolution of anterior Hox* regulatory elements among chordates** Alfonso Natale, Carrie Sims, Maria L Chiusano, Alessandro Amoroso, Enrico D'Aniello, Laura Fucci, Robb Krumlauf, Margherita Branno, Annamaria Locascio BMC Evolutionary Biology 2011, 11:330 (15 November 2011) Abstract \| Full text \| PDF \| PubMed
	3.	Poster presentation Systems biology of bacteriophage proteins and new dimensions of the virus world discovered through metagenomics David M Kristensen, Arcady R Mushegian, Eugene V Koonin Genome Biology 2011, 12(Suppl 1):P9 (19 September 2011) Full text \| PDF
	4.	Research article Lipid droplets as ubiquitous fat storage organelles in C. elegans Shaobing O Zhang, Rhonda Trimble, Fengli Guo, Ho Mak BMC Cell Biology 2010, 11:96 (8 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A combination of biochemical, histological and microscopy approaches demonstrates that C. elegans uses lipid droplets as ubiquitous fat storage organelles, with promising implications for the study of fat metabolism in this model organism.
	5.	Research article Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila Anja H Schiemann, Fang Li, Vikki M Weake, Esther J Belikoff, Kent C Klemmer, Stanley A Moore, Maxwell J Scott BMC Molecular Biology 2010, 11:80 (9 November 2010) Abstract \| Full text \| PDF \| PubMed
	6.	Methodology article Multispectral fingerprinting for improved in vivo cell dynamics analysis Paul M Kulesa, Jessica M Teddy, Miranda Smith, Richard Alexander, Cameron HJ Cooper, Rusty Lansford, Rebecca McLennan BMC Developmental Biology 2010, 10:101 (24 September 2010) Abstract \| Full text \| PDF \| PubMed
	7.	Research article The role of noise and positive feedback in the onset of autosomal dominant diseases William J Bosl, Rong Li BMC Systems Biology 2010, 4:93 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	8.	Research article *Expression profiling of S. pombe* acetyltransferase mutants identifies redundant pathways of gene regulation** Rebecca L Nugent, Anna Johnsson, Brian Fleharty, Madelaine Gogol, Yongtao Xue-Franzén, Chris Seidel, Anthony PH Wright, Susan L Forsburg BMC Genomics 2010, 11:59 (22 January 2010) Abstract \| Full text \| PDF \| PubMed
	9.	Research article Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos Shaobing O Zhang, Sachin Mathur, Gaye Hattem, Olivier Tassy, Olivier Pourquié BMC Genomics 2010, 11:13 (7 January 2010) Abstract \| Full text \| PDF \| PubMed
	10.	Research article *Evolutionary history of the iroquois/Irx* genes in metazoans** Pierre Kerner, Aissam Ikmi, Dario Coen, Michel Vervoort BMC Evolutionary Biology 2009, 9:74 (15 April 2009) Abstract \| Full text \| PDF \| PubMed
	11.	Research article Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress Xinkun Wang, Asma Zaidi, Ranu Pal, Alexander S Garrett, Rogelio Braceras, Xue-wen Chen, Mary L Michaelis, Elias K Michaelis BMC Neuroscience 2009, 10:12 (19 February 2009) Abstract \| Full text \| PDF \| PubMed
	12.	Research Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes Kenneth K Lee, Selene K Swanson, Laurence Florens, Michael P Washburn, Jerry L Workman Epigenetics & Chromatin 2009, 2:2 (18 February 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	13.	Research *Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila* cells** Britta Hartmann, Robert Castelo, Marco Blanchette, Stephanie Boue, Donald C Rio, Juan Valcárcel Genome Biology 2009, 10:R11 (29 January 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A genome-wide analysis of the response to insulin and wingless activation using splicing-sensitive microarrays shows distinct but overlapping programs of transcriptional and posttranscriptional regulation.
	14.	Research A family of GFP-like proteins with different spectral properties in lancelet Branchiostoma floridae Diana Baumann, Malcolm Cook, Limei Ma, Arcady Mushegian, Erik Sanders, Joel Schwartz, C Ron Yu Biology Direct 2008, 3:28 (3 July 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	15.	Research Engineering bacteria to solve the Burnt Pancake Problem Karmella A Haynes, Marian L Broderick, Adam D Brown, Trevor L Butner, James O Dickson, W Lance Harden, Lane H Heard, Eric L Jessen, Kelly J Malloy, Brad J Ogden, Sabriya Rosemond, Samantha Simpson, Erin Zwack, A Malcolm Campbell, Todd T Eckdahl, Laurie J Heyer, Jeffrey L Poet Journal of Biological Engineering 2008, 2:8 (20 May 2008) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary E. coli cells can be engineered to sort DNA fragments into a specific order and orientation, similar to the mathematical burnt pancake problem, providing a flexible new tool for manipulating transgenic DNA in vivo.
	16.	Research article A statistical framework for consolidating "sibling" probe sets for Affymetrix GeneChip data Hua Li, Dongxiao Zhu, Malcolm Cook BMC Genomics 2008, 9:188 (24 April 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	17.	Proceedings Detecting epistatic interactions contributing to human gene expression using the CEPH family data Hua Li, Guimin Gao, Jian Li, Grier P Page, Kui Zhang BMC Proceedings 2007, 1(Suppl 1):S67 (18 December 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	18.	Research Evolutionary history of bacteriophages with double-stranded DNA genomes Galina Glazko, Vladimir Makarenkov, Jing Liu, Arcady Mushegian Biology Direct 2007, 2:36 (6 December 2007) Abstract \| Full text \| PDF \| PubMed
	19.	Research article A topological algorithm for identification of structural domains of proteins Frank Emmert-Streib, Arcady Mushegian BMC Bioinformatics 2007, 8:237 (3 July 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	20.	Research article *The non-dosage compensated Lsp1α gene of Drosophila melanogaster* escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes** Vikki M Weake, Maxwell J Scott BMC Molecular Biology 2007, 8:35 (19 May 2007) Abstract \| Full text \| PDF \| PubMed
	21.	Research The Genopolis Microarray Database Andrea Splendiani, Marco Brandizi, Gael Even, Ottavio Beretta, Norman Pavelka, Mattia Pelizzola, Manuel Mayhaus, Maria Foti, Giancarlo Mauri, Paola Ricciardi-Castagnoli BMC Bioinformatics 2007, 8(Suppl 1):S21 (8 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	22.	Research article Characterization of the minimum domain required for targeting budding yeast myosin II to the site of cell division Ida MB Lister, Nicola J Tolliday, Rong Li BMC Biology 2006, 4:19 (26 June 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The budding yeast myosin II protein Myo1 is likely to exist as a trimer and within the Myo1 minimum localization domain as now defined, the hinge region is required for contraction of the contractile ring during cytokinesis.
	23.	Research Similarity searches in genome-wide numerical data sets Galina Glazko, Michael Coleman, Arcady Mushegian Biology Direct 2006, 1:13 (30 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology
	24.	Minireview Histone H4 lysine 16 acetylation breaks the genome's silence Wei-Jong Shia, Samantha G Pattenden, Jerry L Workman Genome Biology 2006, 7:217 (10 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The acetylation of histone H4 on lysine 16 is a crucial event in switching chromatin from a repressive to a transcriptionally active state.
	25.	Research article CBFβ is a facultative Runx partner in the sea urchin embryo Anthony J Robertson, Carrie Dickey-Sims, Andrew Ransick, Dawn E Rupp, John J McCarthy, James A Coffman BMC Biology 2006, 4:4 (9 February 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Like its mammalian homologs, sea urchin Core Binding Factor beta binds to a Runx partner, but although Runt-1 deficiency affects embryonic differentiation and cell survival, CBFbeta knockdown affects only differentiation.