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151.

Research article   Open Access Highly Accessed

Predicting outcomes of steady-state 13C isotope tracing experiments using Monte Carlo sampling

Jan Schellenberger, Daniel C Zielinski, Wing Choi, Sunthosh Madireddi, Vasiliy Portnoy, David A Scott, Jennifer L Reed, Andrei L Osterman, Bernhard ∅ Palsson BMC Systems Biology 2012, 6:9 (30 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A new Monte Carlo sampling algorithm determines the capability of 13C labeling experiments to resolve fluxes in metabolic networks, and is demonstrated on an E. coli isotopomer model to determine reaction fluxes.

152.

Research article   Open Access

Effects of adenosine A2A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice

Cirle Warren, Gina M Calabrese, Yuesheng Li, Sean W Pawlowski, Robert A Figler, Jayson Rieger, Peter B Ernst, Joel Linden, Richard L Guerrant BMC Infectious Diseases 2012, 12:13 (20 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

153.

Database   Open Access Highly Accessed

IntegromeDB: an integrated system and biological search engine

Michael Baitaluk, Sergey Kozhenkov, Yulia Dubinina, Julia Ponomarenko BMC Genomics 2012, 13:35 (19 January 2012)

Abstract | Full text | PDF | PubMed

154.

Research article   Open Access Highly Accessed

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

Mikkel Noerholm, Leonora Balaj, Tobias Limperg, Afshin Salehi, Lin Zhu, Fred H Hochberg, Xandra O Breakefield, Bob S Carter, Johan Skog BMC Cancer 2012, 12:22 (17 January 2012)

Abstract | Full text | PDF | PubMed

155.

Research   Open Access

Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn

Jeong IL Choi, Fred J Koehrn, Linda S Sorkin Molecular Pain 2012, 8:4 (13 January 2012)

Abstract | Full text | PDF | PubMed

156.

Research article   Open Access

Modularity detection in protein-protein interaction networks

Tejaswini Narayanan, Merril Gersten, Shankar Subramaniam, Ananth Grama BMC Research Notes 2011, 4:569 (29 December 2011)

Abstract | Full text | PDF | PubMed

157.

Opinion   Free Highly Accessed

Genomics in 2011: challenges and opportunities

David J Adams, Bonnie Berger, Olivier Harismendy, Curtis Huttenhower, X Shirley Liu, Chad L Myers, Alicia Oshlack, John L Rinn, Albertha J M Walhout Genome Biology 2011, 12:137 (28 December 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Several members of the Genome Biology Editorial Board give their views on the state of play in genomics

158.

Research article   Open Access

Polytomy identification in microbial phylogenetic reconstruction

Guan Lin, Chao Zhang, Dong Xu BMC Systems Biology 2011, 5(Suppl 3):S2 (23 December 2011)

Abstract | Full text | PDF

159.

Introduction   Open Access

From genes to networks: in systematic points of view

Ke Zhang, Yunlong Liu, Jack Y Yang, Hamid R Arabnia, Andrzej Niemierko, Arif Ghafoor, Weizhong Li, Youping Deng BMC Systems Biology 2011, 5(Suppl 3):I1 (23 December 2011)

Abstract | Full text | PDF

160.

Research article   Open Access

Recombinant human erythropoietin promotes the acquisition of a malignant phenotype in head and neck squamous cell carcinoma cell lines in vitro

Eric Abhold, Elham Rahimy, Jessica Wang-Rodriguez, Katherine J Blair, Michael A Yu, Kevin T Brumund, Robert A Weisman, Weg M Ongkeko BMC Research Notes 2011, 4:553 (21 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

161.

Research   Open Access

Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

Matthias Elstner, Sarina K Müller, Lars Leidolt, Christoph Laub, Lena Krieg, Falk Schlaudraff, Birgit Liss, Chris Morris, Douglass M Turnbull, Eliezer Masliah, Holger Prokisch, Thomas Klopstock, Andreas Bender Molecular Brain 2011, 4:43 (21 December 2011)

Abstract | Full text | PDF | PubMed

162.

Research article   Open Access

Individualized therapy of HHT driven by network analysis of metabolomic profiles

Neema Jamshidi, Franklin J Miller, Jess Mandel, Timothy Evans, Michael D Kuo BMC Systems Biology 2011, 5:200 (20 December 2011)

Abstract | Full text | PDF | PubMed

163.

Method   Open Access Highly Accessed

Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing

Olivier Harismendy, Richard B Schwab, Lei Bao, Jeff Olson, Sophie Rozenzhak, Steve K Kotsopoulos, Stephanie Pond, Brian Crain, Mark S Chee, Karen Messer, Darren R Link, Kelly A Frazer Genome Biology 2011, 12:R124 (20 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An ultra-deep targeted sequencing assay detects low prevalence mutations in Illumina MiSeq and GAII clinical datasets generated from heterogeneous tumor samples

164.

Research article   Open Access

Cost sensitive hierarchical document classification to triage PubMed abstracts for manual curation

Emily Seymour, Rohini Damle, Alessandro Sette, Bjoern Peters BMC Bioinformatics 2011, 12:482 (19 December 2011)

Abstract | Full text | PDF | PubMed

165.

Review   Open Access

Expression of the Epigenetic factor BORIS (CTCFL) in the Human Genome

Rosalia de Necochea-Campion, Anahit Ghochikyan, Steven F Josephs, Shelly Zacharias, Erik Woods, Feridoun Karimi-Busheri, Doru T Alexandrescu, Chien-Shing Chen, Michael G Agadjanyan, Ewa Carrier Journal of Translational Medicine 2011, 9:213 (14 December 2011)

Abstract | Full text | PDF | PubMed

166.

Proceedings   Open Access

Exploring molecular links between lymph node invasion and cancer prognosis in human breast cancer

Sangwoo Kim, Hojung Nam, Doheon Lee BMC Systems Biology 2011, 5(Suppl 2):S4 (14 December 2011)

Abstract | Full text | PDF

167.

Research article   Open Access

Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

Yofre Cabeza-Arvelaiz, Sheila M Fleming, Franziska Richter, Eliezer Masliah, Marie-Francoise Chesselet, Robert H Schiestl Molecular Neurodegeneration 2011, 6:83 (13 December 2011)

Abstract | Full text | PDF | PubMed

168.

Research article   Open Access

A diagnostic algorithm combining clinical and molecular data distinguishes Kawasaki disease from other febrile illnesses

Xuefeng B Ling, Kenneth Lau, John T Kanegaye , Zheng Pan, Sihua Peng, Jun Ji, Gigi Liu, Yuichiro Sato, Tom TS Yu, John C Whitin, James Schilling, Jane C Burns, Harvey J Cohen BMC Medicine 2011, 9:130 (6 December 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Diagnosis of Kawasaki disease, an acute vasculitis of infants and young children characterized by an array of symptoms that can mimic other benign conditions, may be easier with a new multi-step algorithm

169.

Case report   Open Access Highly Accessed

Behavioral effects of congenital ventromedial prefrontal cortex malformation

Aaron D Boes, Amanda Grafft, Charuta Joshi, Nathaniel A Chuang, Peg Nopoulos, Steven W Anderson BMC Neurology 2011, 11:151 (2 December 2011)

Abstract | Full text | PDF | PubMed

170.

Research article   Open Access

A gene-based SNP resource and linkage map for the copepod Tigriopus californicus

Brad R Foley, Colin G Rose, Daniel E Rundle, Wai Leong, Gary W Moy, Ronald S Burton, Suzanne Edmands BMC Genomics 2011, 12:568 (21 November 2011)

Abstract | Full text | PDF | PubMed

171.

Research article   Open Access

Waterpipe smoking among health sciences university students in Iran: perceptions, practices and patterns of use

Nasim Ghafouri, Jan D Hirsch, Gholamreza Heydari, Candis M Morello, Grace M Kuo, Renu F Singh BMC Research Notes 2011, 4:496 (16 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

172.

Research article   Open Access

Emergence and evolution of the glycoprotein hormone and neurotrophin gene families in vertebrates

Sandra Dos Santos, Sylvie Mazan, Byrappa Venkatesh, Joëlle Cohen-Tannoudji, Bruno Quérat BMC Evolutionary Biology 2011, 11:332 (15 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

173.

Research article   Open Access Highly Accessed

Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro

Yves Brand, Cristian Setz, Soledad Levano, Alwin Listyo, Eduardo Chavez, Kwang Pak, Michael Sung, Vesna Radojevic, Allen F Ryan, Daniel Bodmer BMC Neuroscience 2011, 12:114 (14 November 2011)

Abstract | Full text | PDF | PubMed

174.

Research article   Open Access

The emergence of complexity and restricted pleiotropy in adapting networks

Hervé Le Nagard, Lin Chao, Olivier Tenaillon BMC Evolutionary Biology 2011, 11:326 (7 November 2011)

Abstract | Full text | PDF | PubMed

175.

Review   Open Access Highly Accessed

Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae

Wei-Luen Yu, William Ansari, Nathan G Schoepp, Michael J Hannon, Stephen P Mayfield, Michael D Burkart Microbial Cell Factories 2011, 10:91 (2 November 2011)

Abstract | Full text | PDF | PubMed

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