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1.

Review   Open Access

The 3rd DBCLS BioHackathon: improving life science data integration with semantic Web technologies

Toshiaki Katayama, Mark D Wilkinson, Gos Micklem, Shuichi Kawashima, Atsuko Yamaguchi, Mitsuteru Nakao, Yasunori Yamamoto, Shinobu Okamoto, Kenta Oouchida, Hong-Woo Chun, Jan Aerts, Hammad Afzal, Erick Antezana, Kazuharu Arakawa, Bruno Aranda, Francois Belleau, Jerven Bolleman, Raoul Jean Bonnal, Brad Chapman, Peter Cock, Tore Eriksson, Paul Gordon, Naohisa Goto, Kazuhiro Hayashi, Heiko Horn, Ryosuke Ishiwata, Eli Kaminuma, Arek Kasprzyk, Hideya Kawaji, Nobuhiro Kido et al. Journal of Biomedical Semantics 2013, 4:6 (11 February 2013)

Abstract | Provisional PDF | PubMed

2.

Research article   Open Access

A case-control study of physical activity patterns and risk of non-fatal myocardial infarction

Jian Gong, Hannia Campos, Joseph Mark A Fiecas, Stephen T McGarvey, Robert Goldberg, Caroline Richardson, Ana Baylin BMC Public Health 2013, 13:122 (8 February 2013)

Abstract | Full text | PDF | PubMed

3.

Research   Open Access Highly Accessed

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

Kianoush Kashani, Ali Al-Khafaji, Thomas Ardiles, Antonio Artigas, Sean M Bagshaw, Max Bell, Azra Bihorac, Robert Birkhahn, Cynthia M Cely, Lakhmir S Chawla, Danielle L Davison, Thorsten Feldkamp, Lui G Forni, Michelle Gong, Kyle J Gunnerson, Michael Haase, James Hackett, Patrick M Honore, Eric AJ Hoste, Olivier Joannes-Boyau, Michael Joannidis, Patrick Kim, Jay L Koyner, Daniel T Laskowitz, Matthew E Lissauer, Gernot Marx, Peter A McCullough, Scott Mullaney, Marlies Ostermann, Thomas Rimmelé, Nathan I Shapiro, Andrew D Shaw, Jing Shi, Amy M Sprague, Jean-Louis Vincent, Christophe Vinsonneau et al. Critical Care 2013, 17:R25 (6 February 2013)

Abstract | Provisional PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Urine TIMP-2, and IGFBP7, two novel biomarkers for risk stratification of acute kidney injury, have been discovered and validated in more than 1000 critically ill patients. 

4.

Short report   Open Access

Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells

Ann B Moser, Jody Hey, Patricia K Dranchak, Mazen W Karaman, Junsong Zhao, Laura A Cox, Oliver A Ryder, Joseph G Hacia Lipids in Health and Disease 2013, 12:10 (4 February 2013)

Abstract | Full text | PDF | PubMed

5.

Research article   Open Access

Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator

Robert A Terkeltaub, H Ralph Schumacher, John D Carter, Herbert SB Baraf, Robert R Evans, Jian Wang, Shirletta King-Davis, Steven P Weinstein Arthritis Research & Therapy 2013, 15:R25 (1 February 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Treatment with indomethacin alone in patients with acute gout flare is more effective than treatment with rilonacept and no greater pain relief is provided when used in combination with rilonacept. 

6.

Research article   Open Access Highly Accessed

Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes

Natalia V Rivera, Robert Carreras-Torres, Roberta Roncarati, Chiara Viviani-Anselmi, Francesca De Micco, Alessandra Mezzelani, Werner Koch, Petra Hoppmann, Adnan Kastrati, Alexandre FR Stewart, Li Chen, Robert Roberts, Lennart C Karssen, Najaf Amin, Valentina Trimarco, Raffaele Izzo, Guido Iaccarino, Gerolama Condorelli, Annibale A Puca, Paolo Pagnotta, Flavio Airoldi, Bruno Trimarco, Cornelia M van Duijn, Gianluigi Condorelli, Carlo Briguori BMC Medical Genetics 2013, 14:11 (23 January 2013)

Abstract | Full text | PDF | PubMed

7.

Review   Open Access

A brief primer on microRNAs and their roles in angiogenesis

Sudarshan Anand Vascular Cell 2013, 5:2 (16 January 2013)

Abstract | Full text | PDF | PubMed

8.

Research   Open Access Highly Accessed

High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma

Rui Liao, Jian Sun, Han Wu, Yong Yi, Jia-Xing Wang, Hong-Wei He, Xiao-Yan Cai, Jian Zhou, Yun-Feng Cheng, Jia Fan, Shuang-Jian Qiu Journal of Experimental & Clinical Cancer Research 2013, 32:3 (11 January 2013)

Abstract | Provisional PDF | PubMed

9.

Research article   Open Access Highly Accessed

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model

David Amschl, Jörg Neddens, Daniel Havas, Stefanie Flunkert, Roland Rabl, Heinrich Römer, Edward Rockenstein, Eliezer Masliah, Manfred Windisch, Birgit Hutter-Paier BMC Neuroscience 2013, 14:6 (9 January 2013)

Abstract | Full text | PDF | PubMed

10.

Review   Open Access Highly Accessed

2013 WSES guidelines for management of intra-abdominal infections

Massimo Sartelli, Pierluigi Viale, Fausto Catena, Luca Ansaloni, Ernest Moore, Mark Malangoni, Frederick A Moore, George Velmahos, Raul Coimbra, Rao Ivatury, Andrew Peitzman, Kaoru Koike, Ari Leppaniemi, Walter Biffl, Clay Cothren Burlew, Zsolt J Balogh, Ken Boffard, Cino Bendinelli, Sanjay Gupta, Yoram Kluger, Ferdinando Agresta, Salomone Di Saverio, Imtiaz Wani, Alex Escalona, Carlos Ordonez, Gustavo P Fraga, Gerson Alves Pereira Junior, Miklosh Bala, Yunfeng Cui, Sanjay Marwah et al. World Journal of Emergency Surgery 2013, 8:3 (8 January 2013)

Abstract | Full text | PDF | PubMed

11.

Review   Open Access

Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)

Massimo Sartelli, Fausto Catena, Luca Ansaloni, Ernest Moore, Mark Malangoni, George Velmahos, Raul Coimbra, Kaoru Koike, Ari Leppaniemi, Walter Biffl, Zsolt Balogh, Cino Bendinelli, Sanjay Gupta, Yoram Kluger, Ferdinando Agresta, Salomone di Saverio, Gregorio Tugnoli, Elio Jovine, Carlos Ordonez, Carlos Augusto Gomes, Gerson Alves Pereira Junior, Kuo-Ching Yuan, Miklosh Bala, Miroslav P Peev, Yunfeng Cui, Sanjay Marwah, Sanoop Zachariah, Boris Sakakushev, Victor Kong, Adamu Ahmed et al. World Journal of Emergency Surgery 2013, 8:1 (3 January 2013)

Abstract | Full text | PDF | PubMed

12.

Editorial   Free Highly Accessed

Imaging joints for calcium pyrophosphate crystal deposition: a knock to the knees

Robert Terkeltaub Arthritis Research & Therapy 2012, 14:128 (27 December 2012)

Abstract | Full text | PDF | PubMed

13.

Method   Open Access

Differential analysis of high-throughput quantitative genetic interaction data

Gordon J Bean, Trey Ideker Genome Biology 2012, 13:R123 (26 December 2012)

Abstract | Provisional PDF | PubMed |  Editor’s summary

A new method for the differential analysis of genetic interactions

14.

Research   Open Access

Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

Zhongming Zhao, An-Yuan Guo, Edwin JCG van den Oord, Fazil Aliev, Peilin Jia, Howard J Edenberg, Brien P Riley, Danielle M Dick, Jill C Bettinger, Andrew G Davies, Michael S Grotewiel, Marc A Schuckit, Arpana Agrawal, John Kramer, John I Nurnberger, Kenneth S Kendler, Bradley T Webb, Michael F Miles BMC Genomics 2012, 13(Suppl 8):S16 (17 December 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

Research   Open Access

Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase

Daniel Elleder, Thomas J Baiga, Rebecca L Russell, John A Naughton, Stephen H Hughes, Joseph P Noel, John AT Young Virology Journal 2012, 9:305 (11 December 2012)

Abstract | Full text | PDF | PubMed

16.

Methodology article   Open Access

Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner

Xiayang Xie, Jonathan R Mathias, Marie-Ange Smith, Steven L Walker, Yong Teng, Martin Distel, Reinhard W Köster, Howard I Sirotkin, Meera T Saxena, Jeff S Mumm BMC Biology 2012, 10:93 (30 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Genetic tools that support in vivo manipulation are revolutionizing functional studies, in particular in the brain, but their precision can be spoiled by unwonted "off-site" expression. Xiayang Xie and colleagues deploy a neuron-restrictive silencer element to address this problem, demonstrating its efficacy when hitched to transgenes in zebrafish.

17.

Review   Open Access Highly Accessed

Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbes

Rama Saad, Mariam R Rizkallah, Ramy K Aziz Gut Pathogens 2012, 4:16 (30 November 2012)

Abstract | Full text | PDF | PubMed

18.

Research article   Open Access Highly Accessed

Multiple-omic data analysis of Klebsiella pneumoniae MGH 78578 reveals its transcriptional architecture and regulatory features

Joo-Hyun Seo, Jay Sung-Joong Hong, Donghyuk Kim, Byung-Kwan Cho, Tzu-Wen Huang, Shih-Feng Tsai, Bernhard O Palsson, Pep Charusanti BMC Genomics 2012, 13:679 (29 November 2012)

Abstract | Full text | PDF | PubMed

19.

Research article   Open Access Highly Accessed

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

Selena Z Kuo, Katherine J Blair, Elham Rahimy, Alan Kiang, Eric Abhold, Jian-Bing Fan, Jessica Wang-Rodriguez, Xabier Altuna, Weg M Ongkeko BMC Cancer 2012, 12:556 (24 November 2012)

Abstract | Full text | PDF | PubMed

20.

Research article   Open Access

High prevalence of lipoatrophy in pre-pubertal South African children on antiretroviral therapy: a cross-sectional study

Steve Innes, Mark F Cotton, Richard Haubrich, Maria M Conradie, Margaret van Niekerk, Clair Edson, Helena Rabie, Sonia Jain, Xiaoying Sun, Ekkehard W Zöllner, Stephen Hough, Sara H Browne BMC Pediatrics 2012, 12:183 (23 November 2012)

Abstract | Full text | PDF | PubMed

21.

Review   Open Access

Determinants of male involvement in maternal and child health services in sub-Saharan Africa: a review

John Ditekemena, Olivier Koole, Cyril Engmann, Richard Matendo, Antoinette Tshefu, Robert Ryder, Robert Colebunders Reproductive Health 2012, 9:32 (21 November 2012)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access

Correlates of STI symptoms among female sex workers with truck driver clients in two Mexican border towns

Nadine E Chen, Steffanie A Strathdee, Felipe J Uribe-Salas, Thomas L Patterson, Maria Rangel, Perth Rosen, Kimberly C Brouwer BMC Public Health 2012, 12:1000 (20 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

Keynote lecture presentation   Open Access

Translational benefits to patients in the post-genomic era

JG Gleeson Cilia 2012, 1(Suppl 1):K1 (16 November 2012)

Full text | PDF

24.

Study protocol   Open Access

The efficacy of vigorous-intensity exercise as an aid to smoking cessation in adults with elevated anxiety sensitivity: study protocol for a randomized controlled trial

Jasper A J Smits, Michael J Zvolensky, David Rosenfield, Bess H Marcus, Timothy S Church, Georita M Frierson, Mark B Powers, Michael W Otto, Michelle L Davis, Lindsey B DeBoer, Nicole F Briceno Trials 2012, 13:207 (13 November 2012)

Abstract | Full text | PDF | PubMed

25.

Career perspective   Open Access

Career perspective: John B West

John B West Extreme Physiology & Medicine 2012, 1:11 (7 November 2012)

Abstract | Full text | PDF

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