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1.

Study protocol   Open Access

A multi-level system quality improvement intervention to reduce racial disparities in hypertension care and control: study protocol

Lisa A Cooper, Jill A Marsteller, Gary J Noronha, Sarah J Flynn, Kathryn A Carson, Romsai T Boonyasai, Cheryl A Anderson, Hanan J Aboumatar, Debra L Roter, Katherine B Dietz, Edgar R Miller, Gregory P Prokopowicz, Arlene T Dalcin, Jeanne B Charleston, Michelle Simmons, Mary Huizinga Implementation Science 2013, 8:60 (4 June 2013)

Abstract | Full text | PDF | PubMed

2.

Research   Open Access

Hyperendemic malaria transmission in areas of occupation-related travel in the Peruvian Amazon

Benjamin S Parker, Maribel Paredes Olortegui, Pablo Peñataro Yori, Karin Escobedo, David Florin, Silvia Rengifo Pinedo, Roldan Cardenas Greffa, Luis Capcha Vega, Hugo Rodriguez Ferrucci, William K Pan, Cesar Banda Chavez, Joseph M Vinetz, Margaret Kosek Malaria Journal 2013, 12:178 (31 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The article identifies the primary vector and potential for transmission along a riverine system, as well as exportation of malaria to hypoendemic regions of the Iquitos area. The data confirm the focal nature of malaria transmission in the region and describe some of the factors that account for this pattern.

3.

Editorial   Free Highly Accessed

Progress in Alzheimer's disease research circa 2013: Is the glass half empty or half full?

Douglas Galasko, Todd E Golde, Philip Scheltens Alzheimer's Research & Therapy 2013, 5:26 (29 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In their editorial, Editors-in-Chief Douglas Galasko, Todd Golde and Philip Scheltens review the positive advances and challenges in Alzheimer's disease (AD) research circa 2013, and present news highlights from the journal.

4.

Research article   Open Access Highly Accessed

Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature

Suganya Viriyakosol, Akul Singhania, Joshua Fierer, Jonathan Goldberg, Theo N Kirkland, Christopher Woelk BMC Microbiology 2013, 13:121 (28 May 2013)

Abstract | Provisional PDF | PubMed |  Editor’s summary

Mycelium to spherule conversion in Coccidioides immitis strains results in widespread transcriptional modulation, however many genes important for this process in other pathogenic fungi are not differentially expressed indicating the evolution of different mechanisms for this process

5.

Research   Open Access Highly Accessed

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation

Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci, Martin Marsala Stem Cell Research & Therapy 2013, 4:57 (28 May 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Human foetal stem cell grafts improve both motor and sensory functions in rats suffering from a spinal cord injury, demonstrating potential for cell replacement therapy in human spinal cord injuries.

6.

Research   Open Access

Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia

Li Xie, Clara Ng, Thahmina Ali, Raoul Valencia, Barbara L Ferreira, Vincent Xue, Maliha Tanweer, Dan Zhou, Gabriel G Haddad, Philip E Bourne, Lei Xie BMC Genomics 2013, 14(Suppl 3):S9 (28 May 2013)

Abstract | Full text | PDF

7.

Research article   Open Access

The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition

Chris R Gissendanner, Tram Kelley BMC Developmental Biology 2013, 13:21 (17 May 2013)

Abstract | Full text | PDF | PubMed

8.

Nano Express   Open Access

Optical properties of GaP/GaNP core/shell nanowires: a temperature-dependent study

Alexander Dobrovolsky, Shula Chen, Yanjin Kuang, Supanee Sukrittanon, Charles W Tu, Weimin M Chen, Irina A Buyanova Nanoscale Research Letters 2013, 8:239 (16 May 2013)

Abstract | Full text | PDF | PubMed

9.

Research   Open Access Highly Accessed

Perceived neighborhood environment and physical activity in 11 countries: Do associations differ by country?

Ding Ding, Marc A Adams, James F Sallis, Gregory J Norman, Melbourn F Hovell, Christina D Chambers, C Hofstetter, Heather R Bowles, Maria Hagströmer, Cora L Craig, Luis Gomez, Ilse De Bourdeaudhuij, Duncan J Macfarlane, Barbara E Ainsworth, Patrick Bergman, Fiona C Bull, Harriette Carr, Lena Klasson-Heggebo, Shigeru Inoue, Norio Murase, Sandra Matsudo, Victor Matsudo, Grant McLean, Michael Sjöström, Heidi Tomten, Johan Lefevre, Vida Volbekiene, Adrian E Bauman International Journal of Behavioral Nutrition and Physical Activity 2013, 10:57 (14 May 2013)

Abstract | Full text | PDF | PubMed

10.

Research   Open Access Highly Accessed

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

Marguerite Prior, Richard Dargusch, Jennifer L Ehren, Chandramouli Chiruta, David Schubert Alzheimer's Research & Therapy 2013, 5:25 (14 May 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Novel drug candidate J147 is able to arrest and reverse memory deficits and improve several aspects of brain function in aged mice with advanced symptoms of Alzheimer's disease (AD).

11.

Research article   Open Access

The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology

Raymond C Caylor, Yishi Jin, Brian D Ackley Neural Development 2013, 8:10 (10 May 2013)

Abstract | Full text | PDF | PubMed

12.

Research   Open Access Highly Accessed

Associations of neighborhood characteristics with active park use: an observational study in two cities in the USA and Belgium

Delfien Van Dyck, James F Sallis, Greet Cardon, Benedicte Deforche, Marc A Adams, Carrie Geremia, Ilse De Bourdeaudhuij International Journal of Health Geographics 2013, 12:26 (7 May 2013)

Abstract | Full text | PDF | PubMed

13.

Research   Open Access

Sex differences matter in the gut: effect on mucosal immune activation and inflammation

Sumathi Sankaran-Walters, Monica Macal, Irina Grishina, Lauren Nagy, Larissa Goulart, Kathryn Coolidge, Jay Li, Anne Fenton, Theodore Williams, Mary K Miller, Jason Flamm, Thomas Prindiville, Michael George, Satya Dandekar Biology of Sex Differences 2013, 4:10 (7 May 2013)

Abstract | Full text | PDF | PubMed

14.

Research article   Open Access

Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters

Wei Hao Zheng, Åke Västermark, Maksim A Shlykov, Vamsee Reddy, Eric I Sun, Milton H Saier BMC Microbiology 2013, 13:98 (6 May 2013)

Abstract | Full text | PDF | PubMed

15.

Research article   Open Access Highly Accessed

Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors

Kirsten Ludwig, Edison S Tse, Jean YJ Wang BMC Cancer 2013, 13:221 (2 May 2013)

Abstract | Full text | PDF | PubMed

16.

Research   Open Access

Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer

Stephanie Weibel, Elisabeth Hofmann, Thomas Christian Basse-Luesebrink, Ulrike Donat, Carolin Seubert, Marion Adelfinger, Prisca Gnamlin, Christina Kober, Alexa Frentzen, Ivaylo Gentschev, Peter Michael Jakob, Aladar A Szalay Journal of Translational Medicine 2013, 11:106 (1 May 2013)

Abstract | Full text | PDF | PubMed

17.

Commentary   Open Access

World society of emergency surgery study group initiative on Timing of Acute Care Surgery classification (TACS)

Yoram Kluger, Offir Ben-Ishay, Massimo Sartelli, Luca Ansaloni, Ashraf E Abbas, Ferdinando Agresta, Walter L Biffl, Luca Baiocchi, Miklosh Bala, Fausto Catena, Raul Coimbra, Yunfeng Cui, Salomone Di Saverio, Koray Das, Tamer El Zalabany, Gustavo P Fraga, Carlos Augusto Gomes, Ricardo Alessandro Teixeira Gonsaga, Jakub Kenig, Ari Leppäniemi, Sanjay Marwah, Gerson Alves Pereira, Boris Sakakushev, Boonying Siribumrungwong, Norio Sato, Cristian Tranà, Nereo Vettoretto, Ernest E Moore World Journal of Emergency Surgery 2013, 8:17 (1 May 2013)

Abstract | Full text | PDF | PubMed

18.

Research   Open Access Highly Accessed

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

John W Whitaker, Robert Shoemaker, David L Boyle, Josh Hillman, David Anderson, Wei Wang, Gary S Firestein Genome Medicine 2013, 5:40 (30 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Key genes in cultured rheumatoid arthritis cells are stably differentially methylated compared to osteoarthritis or normal cells, and are potential therapeutic targets.

19.

Research article   Open Access

Development, scoring, and reliability of the Microscale Audit of Pedestrian Streetscapes (MAPS)

Rachel A Millstein, Kelli L Cain, James F Sallis, Terry L Conway, Carrie Geremia, Lawrence D Frank, Jim Chapman, Delfien Van Dyck, Lindsay R Dipzinski, Jacqueline Kerr, Karen Glanz, Brian E Saelens BMC Public Health 2013, 13:403 (27 April 2013)

Abstract | Provisional PDF | PubMed

20.

Short paper   Open Access

Comparison of older and newer generations of ActiGraph accelerometers with the normal filter and the low frequency extension

Kelli L Cain, Terry L Conway, Marc A Adams, Lisa E Husak, James F Sallis International Journal of Behavioral Nutrition and Physical Activity 2013, 10:51 (25 April 2013)

Abstract | Full text | PDF | PubMed

21.

Research   Open Access

ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication

Shannon Seidel, James Bruce, Mathias Leblanc, Kuo-Fen Lee, Hung Fan, Paul Ahlquist, John AT Young Virology Journal 2013, 10:130 (24 April 2013)

Abstract | Full text | PDF | PubMed

22.

Technical advance   Open Access Highly Accessed

A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants

Tanis R Fenton, Jae H Kim BMC Pediatrics 2013, 13:59 (20 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The Fenton growth chart for preterm infants has been revised to accommodate the World Health Organization Growth Standard and reflect actual age instead of completed weeks, in order to improve preterm infant growth monitoring.

23.

Debate   Open Access Highly Accessed

Fool’s gold, lost treasures, and the randomized clinical trial

David J Stewart, Razelle Kurzrock BMC Cancer 2013, 13:193 (16 April 2013)

Abstract | Full text | PDF | PubMed

24.

Methodology   Open Access

Utility of passive photography to objectively audit built environment features of active transport journeys: an observational study

Melody Oliver, Aiden R Doherty, Paul Kelly, Hannah M Badland, Suzanne Mavoa, Janine Shepherd, Jacqueline Kerr, Simon Marshall, Alexander Hamilton, Charlie Foster International Journal of Health Geographics 2013, 12:20 (10 April 2013)

Abstract | Full text | PDF | PubMed

25.

Research article   Open Access Highly Accessed

Predicting p K a values from EEM atomic charges

Radka Vařeková, Stanislav Geidl, Crina-Maria Ionescu, Ondřej Skřehota, Tomáš Bouchal, David Sehnal, Ruben Abagyan, Jaroslav Koča Journal of Cheminformatics 2013, 5:18 (10 April 2013)

Abstract | Full text | PDF | PubMed | Graphical abstract

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