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1.

Research article   Open Access

ClinicalTrials.gov registration can supplement information in abstracts for systematic reviews: a comparison study

Roberta W Scherer, Lynn Huynh, Ann-Margret Ervin, Jakeisha Taylor, Kay Dickersin BMC Medical Research Methodology 2013, 13:79 (18 June 2013)

Abstract | Provisional PDF

2.

Debate   Open Access Highly Accessed

A 'snip' in time: what is the best age to circumcise?

Brian J Morris, Jake H Waskett, Joya Banerjee, Richard G Wamai, Aaron AR Tobian, Ronald H Gray, Stefan A Bailis, Robert C Bailey, Jeffrey D Klausner, Robin J Willcourt, Daniel T Halperin, Thomas E Wiswell, Adrian Mindel BMC Pediatrics 2012, 12:20 (28 February 2012)

Abstract | Full text | PDF | PubMed

3.

Research article   Open Access Highly Accessed

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.

4.

Software   Open Access Highly Accessed

The Transcription Factor Encyclopedia

Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al. Genome Biology 2012, 13:R24 (29 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system

5.

Research   Open Access Highly Accessed

Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy

Savita Bisht, Georg Feldmann, Sheetal Soni, Rajani Ravi, Collins Karikar, Amarnath Maitra, Anirban Maitra Journal of Nanobiotechnology 2007, 5:3 (17 April 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

6.

Review   Open Access Highly Accessed

Systematic review of sedentary behaviour and health indicators in school-aged children and youth

Mark S Tremblay, Allana G LeBlanc, Michelle E Kho, Travis J Saunders, Richard Larouche, Rachel C Colley, Gary Goldfield, Sarah Gorber International Journal of Behavioral Nutrition and Physical Activity 2011, 8:98 (21 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research article   Open Access Highly Accessed

The Safety Attitudes Questionnaire: psychometric properties, benchmarking data, and emerging research

John B Sexton, Robert L Helmreich, Torsten B Neilands, Kathy Rowan, Keryn Vella, James Boyden, Peter R Roberts, Eric J Thomas BMC Health Services Research 2006, 6:44 (3 April 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

Research   Open Access Highly Accessed

Job satisfaction and motivation of health workers in public and private sectors: cross-sectional analysis from two Indian states

David H Peters, Subrata Chakraborty, Prasanta Mahapatra, Laura Steinhardt Human Resources for Health 2010, 8:27 (25 November 2010)

Abstract | Full text | PDF | PubMed

9.

Method   Open Access

BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions

Kasper D Hansen, Benjamin Langmead, Rafael A Irizarry Genome Biology 2012, 13:R83 (3 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An alignment, quality control and analysis pipeline for bisulfite sequencing data

10.

Research   Open Access

Vitamin A deficiency and inflammatory markers among preschool children in the Republic of the Marshall Islands

Maria Maqsood, Barbara Dancheck, Mary V Gamble, Neal A Palafox, Michelle O Ricks, Kennar Briand, Richard D Semba Nutrition Journal 2004, 3:21 (8 December 2004)

Abstract | Full text | PDF | PubMed

11.

Software   Open Access Highly Accessed

Searching for SNPs with cloud computing

Ben Langmead, Michael C Schatz, Jimmy Lin, Mihai Pop, Steven L Salzberg Genome Biology 2009, 10:R134 (20 November 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Novel software utilizing cloud computing technology to cost-effectively align and map SNPs from a human genome in three.

12.

Review   Free Highly Accessed

Bench-to-bedside review: Mobilizing patients in the intensive care unit – from pathophysiology to clinical trials

Alex D Truong, Eddy Fan, Roy G Brower, Dale M Needham Critical Care 2009, 13:216 (13 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

Research article   Open Access Highly Accessed

Determinants of use of maternal health services in Nigeria - looking beyond individual and household factors

Stella Babalola, Adesegun Fatusi BMC Pregnancy and Childbirth 2009, 9:43 (15 September 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

Commentary   Open Access Highly Accessed

Defining the critical hurdles in cancer immunotherapy

Bernard A Fox, Dolores J Schendel, Lisa H Butterfield, Steinar Aamdal, James P Allison, Paolo Ascierto, Michael B Atkins, Jirina Bartunkova, Lothar Bergmann, Neil Berinstein, Cristina C Bonorino, Ernest Borden, Jonathan L Bramson, Cedrik M Britten, Xuetao Cao, William E Carson, Alfred E Chang, Dainius Characiejus, A Raja Choudhury, George Coukos, Tanja de Gruijl, Robert O Dillman, Harry Dolstra, Glenn Dranoff, Lindy G Durrant, James H Finke, Jerome Galon, Jared A Gollob, Cécile Gouttefangeas, Fabio Grizzi et al. Journal of Translational Medicine 2011, 9:214 (14 December 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

Review   Free Highly Accessed

Clinical review: Checklists - translating evidence into practice

Bradford D Winters, Ayse P Gurses, Harold Lehmann, J Bryan Sexton, Carlyle Rampersad, Peter J Pronovost Critical Care 2009, 13:210 (31 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Review   Open Access Highly Accessed

Acute graft versus host disease

David A Jacobsohn, Georgia B Vogelsang Orphanet Journal of Rare Diseases 2007, 2:35 (4 September 2007)

Abstract | Full text | PDF | PubMed

17.

Review   Open Access Highly Accessed

Neuromyelitis optica pathogenesis and aquaporin 4

David J Graber, Michael Levy, Douglas Kerr, William F Wade Journal of Neuroinflammation 2008, 5:22 (29 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

Review   Subscription Highly Accessed

Clinical review: Neuromonitoring - an update

Nino Stocchetti, Peter Roux, Paul Vespa, Mauro Oddo, Giuseppe Citerio, Peter J Andrews, Robert D Stevens, Tarek Sharshar, Fabio S Taccone, Jean-Louis Vincent Critical Care 2013, 17:201 (15 January 2013)

Abstract | Full text | PDF | PubMed

19.

Review   Open Access Highly Accessed

Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods

Scott N Compton, John T Walkup, Anne Marie Albano, John C Piacentini, Boris Birmaher, Joel T Sherrill, Golda S Ginsburg, Moira A Rynn, James T McCracken, Bruce D Waslick, Satish Iyengar, Phillip C Kendall, John S March Child and Adolescent Psychiatry and Mental Health 2010, 4:1 (5 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

20.

Review   Open Access Highly Accessed

Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists

Virginia M Miller, Jay R Kaplan, Nicholas J Schork, Pamela Ouyang, Sarah L Berga, Nanette K Wenger, Leslee J Shaw, R Clinton Webb, Monica Mallampalli, Meir Steiner, Doris A Taylor, C Merz, Jane F Reckelhoff Biology of Sex Differences 2011, 2:14 (12 December 2011)

Abstract | Full text | PDF | PubMed

21.

Research   Open Access Highly Accessed

Traditional Indian medicine and homeopathy for HIV/AIDS: a review of the literature

M Fritts, CC Crawford, D Quibell, A Gupta, WB Jonas, I Coulter, SA Andrade AIDS Research and Therapy 2008, 5:25 (22 December 2008)

Abstract | Full text | PDF | PubMed

22.

Review   Open Access Highly Accessed

Insulin receptor signaling in the development of neuronal structure and function

Shu-Ling Chiu, Hollis T Cline Neural Development 2010, 5:7 (15 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

Review   Open Access Highly Accessed

The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance

Radwa A Noureldin, Songtao Liu, Marcelo S Nacif, Daniel P Judge, Marc K Halushka, Theodore P Abraham, Carolyn Ho, David A Bluemke Journal of Cardiovascular Magnetic Resonance 2012, 14:17 (20 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

Research   Open Access Highly Accessed

The clinical features of the overlap between COPD and asthma

Megan Hardin, Edwin K Silverman, R Graham Barr, Nadia N Hansel, Joyce D Schroeder, Barry J Make, James D Crapo, Craig P Hersh, Respiratory Research 2011, 12:127 (27 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Subjects with COPD and asthma show unique clinical features such as increased respiratory exacerbations. Improved monitoring and prevention of exacerbations in these patients may improve quality of life and potentially survival.

25.

Short report   Open Access Highly Accessed

Metabolic responses to high protein diet in Korean elite bodybuilders with high-intensity resistance exercise

Hyerang Kim, Saningun Lee, Ryowon Choue Journal of the International Society of Sports Nutrition 2011, 8:10 (4 July 2011)

Abstract | Full text | PDF | PubMed

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