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1.

Research   Open Access

The effects of pre- and post-exercise consumption of multi-ingredient performance supplements on cardiovascular health and body fat in trained men after six weeks of resistance training: a stratified, randomized, double-blind study

Michael J Ormsbee, Dennison Thomas, William Mandler, Emery G Ward, Amber W Kinsey, Lynn B Panton, Timothy P Scheett, Shirin Hooshmand, Emily Simonavice, Jeong-Su Kim Nutrition & Metabolism 2013, 10:39 (16 May 2013)

Abstract | Full text | PDF | PubMed

2.

Review   Open Access Highly Accessed

2013 WSES guidelines for management of intra-abdominal infections

Massimo Sartelli, Pierluigi Viale, Fausto Catena, Luca Ansaloni, Ernest Moore, Mark Malangoni, Frederick A Moore, George Velmahos, Raul Coimbra, Rao Ivatury, Andrew Peitzman, Kaoru Koike, Ari Leppaniemi, Walter Biffl, Clay Cothren Burlew, Zsolt J Balogh, Ken Boffard, Cino Bendinelli, Sanjay Gupta, Yoram Kluger, Ferdinando Agresta, Salomone Di Saverio, Imtiaz Wani, Alex Escalona, Carlos Ordonez, Gustavo P Fraga, Gerson Alves Pereira, Miklosh Bala, Yunfeng Cui, Sanjay Marwah et al. World Journal of Emergency Surgery 2013, 8:3 (8 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

Research   Open Access Highly Accessed

Urbanization and the global malaria recession

Andrew J Tatem, Peter W Gething, David L Smith, Simon I Hay Malaria Journal 2013, 12:133 (17 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Article that adds significant quantitative information to our understanding of the association of malaria and urbanization worldwide.

 

4.

Research   Open Access Highly Accessed

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

Kianoush Kashani, Ali Al-Khafaji, Thomas Ardiles, Antonio Artigas, Sean M Bagshaw, Max Bell, Azra Bihorac, Robert Birkhahn, Cynthia M Cely, Lakhmir S Chawla, Danielle L Davison, Thorsten Feldkamp, Lui G Forni, Michelle Gong, Kyle J Gunnerson, Michael Haase, James Hackett, Patrick M Honore, Eric AJ Hoste, Olivier Joannes-Boyau, Michael Joannidis, Patrick Kim, Jay L Koyner, Daniel T Laskowitz, Matthew E Lissauer, Gernot Marx, Peter A McCullough, Scott Mullaney, Marlies Ostermann, Thomas Rimmelé et al. Critical Care 2013, 17:R25 (6 February 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

Urine TIMP-2, and IGFBP7, two novel biomarkers for risk stratification of acute kidney injury, have been discovered and validated in more than 1000 critically ill patients. 

5.

Research article   Open Access Highly Accessed

Plant growth strategies are remodeled by spaceflight

Anna-Lisa Paul, Claire E Amalfitano, Robert J Ferl BMC Plant Biology 2012, 12:232 (7 December 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Arabidopsis plants grown in the absence of gravity exhibit the same root growth morphology as controls grown on earth, indicating that their characteristic skewing and waving patterns are a gravity independent phenomenon.

6.

Review   Open Access Highly Accessed

Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: a structured literature review

Brett F Bechtel, Timothy C Nunez, Jennifer A Lyon, Bryan A Cotton, Tyler W Barrett International Journal of Emergency Medicine 2011, 4:40 (8 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

7.

Research article   Open Access Highly Accessed

RNA-seq and microarray complement each other in transcriptome profiling

Sunitha Kogenaru, Qing Yan, Yinping Guo, Nian Wang BMC Genomics 2012, 13:629 (15 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

8.

Software   Open Access Highly Accessed

PASTA: splice junction identification from RNA-Sequencing data

Shaojun Tang, Alberto Riva BMC Bioinformatics 2013, 14:116 (4 April 2013)

Abstract | Full text | PDF | PubMed

9.

Research article   Open Access Highly Accessed

Cardiovascular fitness associated with cognitive performance in heart failure patients enrolled in cardiac rehabilitation

Sarah Garcia, Michael L Alosco, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, Morgan L Oberle, John Gunstad BMC Cardiovascular Disorders 2013, 13:29 (16 April 2013)

Abstract | Full text | PDF | PubMed

10.

Review   Open Access Highly Accessed

Review on solving the inverse problem in EEG source analysis

Roberta Grech, Tracey Cassar, Joseph Muscat, Kenneth P Camilleri, Simon G Fabri, Michalis Zervakis, Petros Xanthopoulos, Vangelis Sakkalis, Bart Vanrumste Journal of NeuroEngineering and Rehabilitation 2008, 5:25 (7 November 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

Research article   Open Access Highly Accessed

The effects of six weeks of supplementation with multi-ingredient performance supplements and resistance training on anabolic hormones, body composition, strength, and power in resistance-trained men

Michael J Ormsbee, W Kyle Mandler, D David Thomas, Emery G Ward, Amber W Kinsey, Emily Simonavice, Lynn B Panton, Jeong-Su Kim Journal of the International Society of Sports Nutrition 2012, 9:49 (15 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

Research   Open Access

The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-alpha production

Stefania Laurent, Paola Queirolo, Silvia Boero, Sandra Salvi, Patrizia Piccioli, Simona Boccardo, Simona Minghelli, Anna Morabito, Vincenzo Fontana, Gabriella Pietra, Paolo Carrega, Nicoletta Ferrari, Francesca Tosetti, Lung-Ji Chang, Maria Cristina Mingari, Guido Ferlazzo, Alessandro Poggi, Maria Pia Pistillo Journal of Translational Medicine 2013, 11:108 (1 May 2013)

Abstract | Provisional PDF | PubMed

13.

Research article   Open Access Highly Accessed

The relationship between pain and disruptive behaviors in nursing home resident with dementia

Hyochol Ahn, Ann Horgas BMC Geriatrics 2013, 13:14 (11 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Elderly people with dementia who cannot verbalize their experiences express pain through increased disruptive behaviours such as aggression and agitation, but decreased locomotive behaviours, suggesting some potential benefits of effective pain management.

14.

Short communication   Open Access

Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells

Karthik M Kodigepalli, Pavana Anur, Paul Spellman, Peter J Sims, Meera Nanjundan Molecular Cancer 2013, 12:32 (26 April 2013)

Abstract | Full text | PDF | PubMed

15.

Open letter   Free Highly Accessed

Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes

John A St John, Edward L Braun, Sally R Isberg, Lee G Miles, Amanda Y Chong, Jaime Gongora, Pauline Dalzell, Christopher Moran, Bertrand Bed'Hom, Arkhat Abzhanov, Shane C Burgess, Amanda M Cooksey, Todd A Castoe, Nicholas G Crawford, Llewellyn D Densmore, Jennifer C Drew, Scott V Edwards, Brant C Faircloth, Matthew K Fujita, Matthew J Greenwold, Federico G Hoffmann, Jonathan M Howard, Taisen Iguchi, Daniel E Janes, Shahid Khan, Satomi Kohno, AP Jason de Koning, Stacey L Lance, Fiona M McCarthy, John E McCormack et al. Genome Biology 2012, 13:415 (31 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

An Open Letter describing the project to sequence the genomes of the saltwater crocodile, the American alligator and the Indian gharial

16.

Research article   Open Access Highly Accessed

Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay

Michael Mahler, Cristina Gascon, Sima Patel, Angela Ceribelli, Marvin J Fritzler, Andreas Swart, Edward KL Chan, Minoru Satoh Arthritis Research & Therapy 2013, 15:R50 (12 April 2013)

Abstract | Full text | PDF | PubMed

17.

Research article   Open Access Highly Accessed

Phylogeographic analysis reveals significant spatial genetic structure of Incarvillea sinensis as a product of mountain building

Shaotian Chen, Yaowu Xing, Tao Su, Zhekun Zhou, Emeritus David L Dilcher, Douglas E Soltis BMC Plant Biology 2012, 12:58 (30 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

Methodology   Open Access

A diagnostic methodology for Alzheimer’s disease

Wen-Chin Hsu, Christopher Denq, Su-Shing Chen Journal of Clinical Bioinformatics 2013, 3:9 (25 April 2013)

Abstract | Full text | PDF | PubMed

19.

Research article   Open Access Highly Accessed

RNA-seq: technical variability and sampling

Lauren M McIntyre, Kenneth K Lopiano, Alison M Morse, Victor Amin, Ann L Oberg, Linda J Young, Sergey V Nuzhdin BMC Genomics 2011, 12:293 (6 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

20.

Research   Open Access Highly Accessed

A case-referent study: light at night and breast cancer risk in Georgia

Sarah E Bauer, Sara E Wagner, Jim Burch, Rana Bayakly, John E Vena International Journal of Health Geographics 2013, 12:23 (17 April 2013)

Abstract | Full text | PDF | PubMed

21.

Review   Open Access

Congenitally corrected transposition

Gonzalo A Wallis, Diane Debich-Spicer, Robert H Anderson Orphanet Journal of Rare Diseases 2011, 6:22 (14 May 2011)

Abstract | Full text | PDF | PubMed

22.

Research article   Open Access

Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells

Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa, Kazuhito Rokutan BMC Cancer 2013, 13:229 (7 May 2013)

Abstract | Full text | PDF | PubMed

23.

Research   Open Access Highly Accessed

Exploring factors influencing asthma control and asthma-specific health-related quality of life among children

Pranav K Gandhi, Kelly M Kenzik, Lindsay A Thompson, Darren A DeWalt, Dennis A Revicki, Elizabeth A Shenkman, I-Chan Huang Respiratory Research 2013, 14:26 (23 February 2013)

Abstract | Full text | PDF | PubMed

24.

Review   Subscription

Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems

Douglas Galasko, Todd E Golde Alzheimer's Research & Therapy 2013, 5:10 (7 March 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Editors-in-Chief Douglas Galasko and Todd Golde introduce a new special series on Peripheral Biomarkers by providing an overview of key concepts relating to Alzheimer’s disease (AD) plasma, serum and blood biomarker studies.

25.

Research article   Open Access Highly Accessed

Comparative metagenomics of Daphnia symbionts

Weihong Qi, Guang Nong, James F Preston, Frida Ben-Ami, Dieter Ebert BMC Genomics 2009, 10:172 (21 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

26.

Research article   Open Access Highly Accessed

Brief psychosocial education, not core stabilization, reduced incidence of low back pain: results from the Prevention of Low Back Pain in the Military (POLM) cluster randomized trial

Steven Z George, John D Childs, Deydre S Teyhen, Samuel S Wu, Alison C Wright, Jessica L Dugan, Michael E Robinson BMC Medicine 2011, 9:128 (29 November 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

In contrast to core muscle stabilization, which is a traditional lumbar exercise, a brief psychosocial education technique can be a more effective strategy for the primary prevention of low back pain.

27.

Research article   Open Access

Normal cognition in transgenic BRI2-Aβ mice

Jungsu Kim, Paramita Chakrabarty, Amanda Hanna, Amelia March, Dennis W Dickson, David R Borchelt, Todd Golde, Christopher Janus Molecular Neurodegeneration 2013, 8:15 (12 May 2013)

Abstract | Full text | PDF | PubMed

28.

Research article   Open Access Highly Accessed

Proteomics of Streptococcus gordonii within a model developing oral microbial community

Erik L Hendrickson, Tiansong Wang, Brittany C Dickinson, Sarah E Whitmore, Christopher J Wright, Richard J Lamont, Murray Hackett BMC Microbiology 2012, 12:211 (18 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The Streptococcus gordonii proteome exhibits changes in energy metabolism and byproduct production during interactions with other dental plaque bacteria, such as Porphyromonas gingivalis, implicating nutrient transfer as an important community interaction in oral biofilms.

29.

Research   Open Access Highly Accessed

Expiratory time constant for determinations of plateau pressure, respiratory system compliance, and total resistance

Nawar Al-Rawas, Michael J Banner, Neil R Euliano, Carl G Tams, Jeff Brown, A Daniel Martin, Andrea Gabrielli Critical Care 2013, 17:R23 (5 February 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

30.

Review   Subscription

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease

Todd E Golde, Wolfgang J Streit, Paramita Chakrabarty Alzheimer's Research & Therapy 2013, 5:24 (21 May 2013)

Abstract | Full text | PDF |  Editor’s summary

Golde and colleagues review the function of innate immune signalling in Alzheimer's disease (AD) following recent studies showing variants of TREM2, a triggering receptor on myeloid cells, is significantly associated with AD risk.

31.

Research   Open Access

Synergistic use of plant-prokaryote comparative genomics for functional annotations

Svetlana Gerdes, Basma El Yacoubi, Marc Bailly, Ian K Blaby, Crysten E Blaby-Haas, Linda Jeanguenin, Aurora Lara-Núñez, Anne Pribat, Jeffrey C Waller, Andreas Wilke, Ross Overbeek, Andrew D Hanson, Valérie de Crécy-Lagard BMC Genomics 2011, 12(Suppl 1):S2 (15 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

32.

Editorial   Open Access

Second WSES convention, WJES impact factor, and emergency surgery worldwide

Fausto Catena, Massimo Sartelli, Luca Ansaloni, Frederick Moore, Ernest E Moore World Journal of Emergency Surgery 2013, 8:15 (16 April 2013)

Abstract | Full text | PDF | PubMed

33.

Research article   Open Access Highly Accessed

Identification of BACE2 as an avid ß-amyloid-degrading protease

Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A Leissring Molecular Neurodegeneration 2012, 7:46 (17 September 2012)

Abstract | Full text | PDF | PubMed

34.

Research   Open Access Highly Accessed

Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial

A Daniel Martin, Barbara K Smith, Paul D Davenport, Eloise Harman, Ricardo J Gonzalez-Rothi, Maher Baz, A Joseph Layon, Michael J Banner, Lawrence J Caruso, Harsha Deoghare, Tseng-Tien Huang, Andrea Gabrielli Critical Care 2011, 15:R84 (7 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

Methodology article   Open Access Highly Accessed

Comparison of next generation sequencing technologies for transcriptome characterization

P Kerr Wall, Jim Leebens-Mack, André S Chanderbali, Abdelali Barakat, Erik Wolcott, Haiying Liang, Lena Landherr, Lynn P Tomsho, Yi Hu, John E Carlson, Hong Ma, Stephan C Schuster, Douglas E Soltis, Pamela S Soltis, Naomi Altman, Claude W dePamphilis BMC Genomics 2009, 10:347 (1 August 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

36.

Research   Open Access Highly Accessed

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

Sandeep Singh, Jose Trevino, Namrata Bora-Singhal, Domenico Coppola, Eric Haura, Soner Altiok, Srikumar P Chellappan Molecular Cancer 2012, 11:73 (25 September 2012)

Abstract | Full text | PDF | PubMed

37.

Research article   Open Access Highly Accessed

The granulocyte colony stimulating factor pathway regulates autoantibody production in a murine induced model of systemic lupus erythematosus

Margareta Lantow, Ramya Sivakumar, Leilani Zeumer, Clive Wasserfall, Ying-Yi Zheng, Mark A Atkinson, Laurence Morel Arthritis Research & Therapy 2013, 15:R49 (8 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

B6.Sle2c2 mice are resistant to lupus due to a mutation in the granulocyte colony stimulating factor pathway, suggesting autoantibody production is inhibited by reduced neutrophil activation.

38.

Methodology   Open Access Highly Accessed

Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke

Kimberly E Hawkins, Kelly M DeMars, Changjun Yang, Gary A Rosenberg, Eduardo Candelario-Jalil Molecular Brain 2013, 6:14 (23 March 2013)

Abstract | Full text | PDF | PubMed

39.

Case report   Open Access Highly Accessed

Visual Diagnosis: Pearling: a case study

David P Nguyen, Bobby K Desai, Michael Falgiani International Journal of Emergency Medicine 2011, 4:74 (8 December 2011)

Abstract | Full text | PDF | PubMed

40.

Review   Open Access Highly Accessed

Mapping populations at risk: improving spatial demographic data for infectious disease modeling and metric derivation

Andrew J Tatem, Susana Adamo, Nita Bharti, Clara R Burgert, Marcia Castro, Audrey Dorelien, Gunter Fink, Catherine Linard, Mendelsohn John, Livia Montana, Mark R Montgomery, Andrew Nelson, Abdisalan M Noor, Deepa Pindolia, Greg Yetman, Deborah Balk Population Health Metrics 2012, 10:8 (16 May 2012)

Abstract | Full text | PDF | PubMed

41.

Research article   Open Access Highly Accessed

Proliferation zones in the axolotl brain and regeneration of the telencephalon

Malcolm Maden, Laurie A Manwell, Brandi K Ormerod Neural Development 2013, 8:1 (17 January 2013)

Abstract | Full text | PDF | PubMed

42.

Research article   Open Access Highly Accessed

RNA-Seq reveals genotype-specific molecular responses to water deficit in eucalyptus

Emilie Villar, Christophe Klopp, Céline Noirot, Evandro Novaes, Matias Kirst, Christophe Plomion, Jean-Marc Gion BMC Genomics 2011, 12:538 (2 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

43.

Research article   Open Access

Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer

Cydney Urbanek, Steve Goodison, Myron Chang, Stacy Porvasnik, Noburo Sakamoto, Chen-zhong Li, Susan K Boehlein, Charles J Rosser BMC Cancer 2011, 11:233 (10 June 2011)

Abstract | Full text | PDF | PubMed

44.

Research article   Open Access

Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara

Marcelo H Petri, Minoru Satoh, Beatriz T Martin-Marquez, Raul Vargas-Ramírez, Luis J Jara, Miguel A Saavedra, Claudia Cruz-Gonzalez, Lilia Andrade-Ortega, Olga Vera-Lastra, Mario Salazar-Páramo, Rosa E Prieto-Parra, Laura Gonzalez-Lopez, Jorge I Gamez-Nava, Hermes U Ramírez-Sánchez, Jason YF Chan, Steven J Ross, Edward KL Chan, Mónica Vázquez-Del Mercado Arthritis Research & Therapy 2013, 15:R48 (4 April 2013)

Abstract | Provisional PDF | PubMed

45.

Research   Open Access Highly Accessed

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

Ming Zhou, Yuhua Zhao, Yan Ding, Hao Liu, Zixing Liu, Oystein Fodstad, Adam I Riker, Sushama Kamarajugadda, Jianrong Lu, Laurie B Owen, Susan P Ledoux, Ming Tan Molecular Cancer 2010, 9:33 (9 February 2010)

Abstract | Full text | PDF | PubMed

46.

Research   Open Access Highly Accessed

100% Orange juice consumption is associated with better diet quality, improved nutrient adequacy, decreased risk for obesity, and improved biomarkers of health in adults: National Health and Nutrition Examination Survey, 2003-2006

Carol E O’Neil, Theresa A Nicklas, Gail C Rampersaud, Victor L Fulgoni III Nutrition Journal 2012, 11:107 (12 December 2012)

Abstract | Full text | PDF | PubMed

47.

Review   Open Access Highly Accessed

Gastrointestinal function development and microbiota

Antonio Di Mauro, Josef Neu, Giuseppe Riezzo, Francesco Raimondi, Domenico Martinelli, Ruggiero Francavilla, Flavia Indrio Italian Journal of Pediatrics 2013, 39:15 (24 February 2013)

Abstract | Full text | PDF | PubMed

48.

Methodology   Open Access

In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau p301l) reveals reduced neural activity in memory formation structures

Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara Molecular Neurodegeneration 2013, 8:9 (4 February 2013)

Abstract | Full text | PDF | PubMed

49.

Review   Subscription

Implantable sensor technology: measuring bone and joint biomechanics of daily life in vivo

Darryl D D'Lima, Benjamin J Fregly, Clifford W Colwell Arthritis Research & Therapy 2013, 15:203 (31 January 2013)

Abstract | Full text | PDF | PubMed

50.

Research   Open Access

Concurrent neuromechanical and functional gains following upper-extremity power training post-stroke

Carolynn Patten, Elizabeth G Condliffe, Christine A Dairaghi, Peter S Lum Journal of NeuroEngineering and Rehabilitation 2013, 10:1 (21 January 2013)

Abstract | Full text | PDF | PubMed

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