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1.

Method   Open Access Highly Accessed

jMOSAiCS: joint analysis of multiple ChIP-seq datasets

Xin Zeng, Rajendran Sanalkumar, Emery H Bresnick, Hongda Li, Qiang Chang, Sunduz Keles Genome Biology 2013, 14:R38 (29 April 2013)

Abstract | Provisional PDF |  Editor’s summary

A novel probabilistic method for jointly analyzing multiple ChIP-seq datasets offers an improvement over chromHMM

2.

Research   Open Access Highly Accessed

Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study

Yaseen M Arabi, Saqib I Dara, Hani M Tamim, Asgar H Rishu, Abderrezak Bouchama, Mohammad K Khedr, Daniel Feinstein, Joseph E Parrillo, Kenneth E Wood, Sean P Keenan, Sergio Zanotti, Greg Martinka, Aseem Kumar, Anand Kumar, Critical Care 2013, 17:R72 (17 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The obesity paradox (lower mortality in the obese) is observed in patients admitted to intensive care with septic shock in a large international retrospective cohort study.

3.

Research   Open Access Highly Accessed

The role for scientists in tackling food insecurity and climate change

John R Beddington, Mohammed Asaduzzaman, Megan E Clark, Adrian Bremauntz, Marion D Guillou, Molly M Jahn, Erda Lin, Tekalign Mamo, Christine Negra, Carlos A Nobre, Robert J Scholes, Rita Sharma, Nguyen Van Bo, Judi Wakhungu Agriculture & Food Security 2012, 1:10 (20 July 2012)

Abstract | Full text | PDF | 1 comment

4.

Software   Open Access Highly Accessed

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li, Colin N Dewey BMC Bioinformatics 2011, 12:323 (4 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

RSEM is a new user-friendly software tool for quantifying transcript abundance from RNA-seq data that does not rely on a reference genome and is particularly useful for quantification with de novo transcriptome assemblies

5.

Method   Open Access Highly Accessed

Bioconductor: open software development for computational biology and bioinformatics

Robert C Gentleman, Vincent J Carey, Douglas M Bates, Ben Bolstad, Marcel Dettling, Sandrine Dudoit, Byron Ellis, Laurent Gautier, Yongchao Ge, Jeff Gentry, Kurt Hornik, Torsten Hothorn, Wolfgang Huber, Stefano Iacus, Rafael Irizarry, Friedrich Leisch, Cheng Li, Martin Maechler, Anthony J Rossini, Gunther Sawitzki, Colin Smith, Gordon Smyth, Luke Tierney, Jean YH Yang, Jianhua Zhang Genome Biology 2004, 5:R80 (15 September 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A detailed description of the aims and methods of the Bioconductor project, an initiative for the collaborative creation of extensible software for computational biology and bioinformatics.

6.

Research article   Open Access Highly Accessed

An information integration theory of consciousness

Giulio Tononi BMC Neuroscience 2004, 5:42 (2 November 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A new theory proposes that consciousness corresponds to the capacity of a system to integrate information, accounting for several neurobiological aspects of consciousness.

7.

Editorial   Open Access

Agriculture & Food Security: first anniversary

Malcolm Elliott, Molly Jahn, Magdy Madkour Agriculture & Food Security 2013, 2:7 (23 April 2013)

Abstract | Full text | PDF

8.

Research article   Open Access

Neutrophil necrosis and annexin 1 degradation associated with airway inflammation in lung transplant recipients with cystic fibrosis

Francis H C Tsao, Zhuzai Xiang, Adnan Abbasi, Keith C Meyer BMC Pulmonary Medicine 2012, 12:44 (17 August 2012)

Abstract | Full text | PDF | PubMed

9.

Forum   Open Access Highly Accessed

What does the concept of the stem cell niche really mean today?

Arthur D Lander, Judith Kimble, Hans Clevers, Elaine Fuchs, Didier Montarras, Margaret Buckingham, Anne L Calof, Andreas Trumpp, Thordur Oskarsson BMC Biology 2012, 10:19 (9 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

How do current researchers view the stem cell niche? Eight experts from different fields provide their perspective, and ask how stem cells evolve in such an environment, launching a new Forum article type within the cross-journal collection on stem cells.

10.

Research article   Open Access Highly Accessed

Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence

Benoît Remenant, Bénédicte Coupat-Goutaland, Alice Guidot, Gilles Cellier, Emmanuel Wicker, Caitilyn Allen, Mark Fegan, Olivier Pruvost, Mounira Elbaz, Alexandra Calteau, Gregory Salvignol, Damien Mornico, Sophie Mangenot, Valérie Barbe, Claudine Médigue, Philippe Prior BMC Genomics 2010, 11:379 (15 June 2010)

Abstract | Full text | PDF | PubMed

11.

Research article   Open Access Highly Accessed

Improving mammalian genome scaffolding using large insert mate-pair next-generation sequencing

Sebastiaan van Heesch, Wigard P Kloosterman, Nico Lansu, Frans-Paul Ruzius, Elizabeth Levandowsky, Clarence C Lee, Shiguo Zhou, Steve Goldstein, David C Schwartz, Timothy T Harkins, Victor Guryev, Edwin Cuppen BMC Genomics 2013, 14:257 (16 April 2013)

Abstract | Full text | PDF | PubMed

12.

Review   Open Access Highly Accessed

Needs Assessment for cancer patients and their families

Kuang-Yi Wen, David H Gustafson Health and Quality of Life Outcomes 2004, 2:11 (26 February 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

13.

Research article   Open Access

Alcohol use and HIV serostatus of partner predict high-risk sexual behavior among patients receiving antiretroviral therapy in South Western Uganda

Francis Bajunirwe, David R Bangsberg, Ajay K Sethi BMC Public Health 2013, 13:430 (3 May 2013)

Abstract | Full text | PDF | PubMed

14.

Research   Open Access

Plant cell wall profiling by fast maximum likelihood reconstruction (FMLR) and region-of-interest (ROI) segmentation of solution-state 2D 1H--13C NMR spectra

Roger A Chylla, Rebecca Van Acker, Hoon Kim, Ali Azapira, Purba Mukerjee, John L Markley, Véronique Storme, Wout Boerjan, John Ralph Biotechnology for Biofuels 2013, 6:45 (26 April 2013)

Abstract | Provisional PDF | PubMed

15.

Research   Open Access

Lack of evidence of WNT3A as a candidate gene for congenital vertebral malformations

Nader Ghebranious, Cathleen L Raggio, Robert D Blank, Elizabeth McPherson, James K Burmester, Lynn Ivacic, Kristen Rasmussen, Jennifer Kislow, Ingrid Glurich, F Stig Jacobsen, Thomas Faciszewski, Richard M Pauli, Oheneba Boachie-Adjei, Philip F Giampietro Scoliosis 2007, 2:13 (23 September 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

Correspondence   Open Access Highly Accessed

Cultivation conditions and the diffusion of oxygen into culture media: The rationale for the flask-to-medium ratio in microbiology

Greg A Somerville, Richard A Proctor BMC Microbiology 2013, 13:9 (16 January 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

As laboratory technology increases in sophistication Greg Somerville and Richard Proctor highlight the importance of considering all bacterial culture conditions, such as the flask-to-medium ratio, when designing experiments, to ensure accuracy in the reporting of results.

17.

Research article   Open Access Highly Accessed

Syntenic relationships between cucumber (Cucumis sativus L.) and melon (C. melo L.) chromosomes as revealed by comparative genetic mapping

Dawei Li, Hugo E Cuevas, Luming Yang, Yuhong Li, Jordi Garcia-Mas, Juan Zalapa, Jack E Staub, Feishi Luan, Umesh Reddy, Xiaoming He, Zhenhui Gong, Yiqun Weng BMC Genomics 2011, 12:396 (5 August 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

Study protocol   Open Access

Testing use of payers to facilitate evidence-based practice adoption: protocol for a cluster-randomize d trial

Todd Molfenter, Jee-Seon Kim, Andrew Quanbeck, Terry Patel-Porter, Sandy Starr, Dennis McCarty Implementation Science 2013, 8:50 (10 May 2013)

Abstract | Provisional PDF | PubMed

19.

Research   Open Access

Improvement of the Oryza sativa Nipponbare reference genome using next generation sequence and optical map data

Yoshihiro Kawahara, Melissa de la Bastide, John P Hamilton, Hiroyuki Kanamori, W Richard McCombie, Shu Ouyang, David C Schwartz, Tsuyoshi Tanaka, Jianzhong Wu, Shiguo Zhou, Kevin L Childs, Rebecca M Davidson, Haining Lin, Lina Quesada-Ocampo, Brieanne Vaillancourt, Hiroaki Sakai, Sung Shin Lee, Jungsok Kim, Hisataka Numa, Takeshi Itoh, C Robin Buell, Takashi Matsumoto Rice 2013, 6:4 (6 February 2013)

Abstract | Full text | PDF

20.

Review   Open Access Highly Accessed

Tegument protein control of latent herpesvirus establishment and animation

Rhiannon R Penkert, Robert F Kalejta Herpesviridae 2011, 2:3 (8 February 2011)

Abstract | Full text | PDF | PubMed

21.

Research   Open Access Highly Accessed

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

Michele Carbone, Laura Ferris, Francine Baumann, Andrea Napolitano, Christopher A Lum, Erin G Flores, Giovanni Gaudino, Amy Powers, Peter Bryant-Greenwood, Thomas Krausz, Elizabeth Hyjek, Rachael Tate, Joseph Friedberg, Tracey Weigel, Harvey I Pass, Haining Yang Journal of Translational Medicine 2012, 10:179 (30 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The presence of melanocytic tumors can provide physicians with a visual marker to identify individuals who may carry germline BAP1 mutations and so are at higher risk of developing melanoma and mesothelioma.

22.

Research   Open Access Highly Accessed

Efficient isolation of live microglia with preserved phenotypes from adult mouse brain

Maria Nikodemova, Jyoti J Watters Journal of Neuroinflammation 2012, 9:147 (28 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

Review   Open Access Highly Accessed

Ryanodine receptors

E Michelle Capes, Randall Loaiza, Héctor H Valdivia Skeletal Muscle 2011, 1:18 (4 May 2011)

Abstract | Full text | PDF | PubMed

24.

Research article   Open Access Highly Accessed

Collagen density promotes mammary tumor initiation and progression

Paolo P Provenzano, David R Inman, Kevin W Eliceiri, Justin G Knittel, Long Yan, Curtis T Rueden, John G White, Patricia J Keely BMC Medicine 2008, 6:11 (28 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Increased stromal collagen density in mouse mammary tissue increases both tumor formation and tumor cell invasive and migratory properties by three fold; furthermore, a metabolic signature for flavin adenine dinucleotide is identified in invading metastatic cells.

25.

Research   Open Access

ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication

Shannon Seidel, James Bruce, Mathias Leblanc, Kuo-Fen Lee, Hung Fan, Paul Ahlquist, John AT Young Virology Journal 2013, 10:130 (24 April 2013)

Abstract | Full text | PDF | PubMed

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