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401.

Research   Open Access

Thermal nociceptive properties of trigeminal afferent neurons in rats

Jason M Cuellar, Neil A Manering, Mikhail Klukinov, Michael I Nemenov, David C Yeomans Molecular Pain 2010, 6:39 (7 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

402.

Software   Open Access Highly Accessed

Concept-based query expansion for retrieving gene related publications from MEDLINE

Sérgio Matos, Joel P Arrais, João Maia-Rodrigues, José Oliveira BMC Bioinformatics 2010, 11:212 (28 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

403.

Brief communication   Open Access

Short-term arginine deprivation results in large-scale modulation of hepatic gene expression in both normal and tumor cells: microarray bioinformatic analysis

Hwei Leong, Carl Simkevich, Anne Lesieur-Brooks, Bonnie W Lau, Celine Fugere, Edmond Sabo, Nancy L Thompson Nutrition & Metabolism 2006, 3:37 (8 September 2006)

Abstract | Full text | PDF | PubMed

404.

Research article   Open Access Highly Accessed

Dengue-2 Structural Proteins Associate with Human Proteins to Produce a Coagulation and Innate Immune Response Biased Interactome

Brenda B Folly, Almeriane M Weffort-Santos, CG Fathman, Luis RB Soares BMC Infectious Diseases 2011, 11:34 (31 January 2011)

Abstract | Full text | PDF | PubMed

405.

Commentary   Subscription

Still a man's world, but why?

Ann Weinacker, Renee D Stapleton Critical Care 2013, 17:113 (29 January 2013)

Abstract | Full text | PDF | PubMed

406.

Review   Open Access Highly Accessed

Modelling neuroinflammatory phenotypes in vivo

Marion S Buckwalter, Tony Wyss-Coray Journal of Neuroinflammation 2004, 1:10 (1 July 2004)

Abstract | Full text | PDF | PubMed

407.

Research article   Open Access

Site-Specific Mobilization of Vinyl Chloride Respiration Islands by a Mechanism Common in Dehalococcoides

Paul J McMurdie, Laura A Hug, Elizabeth A Edwards, Susan Holmes, Alfred M Spormann BMC Genomics 2011, 12:287 (2 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

408.

Technical advance   Open Access Highly Accessed

Can modern infrared analyzers replace gas chromatography to measure anesthetic vapor concentrations?

Jan FA Hendrickx, Hendrikus JM Lemmens, Rik Carette, Andre M De Wolf, Lawrence J Saidman BMC Anesthesiology 2008, 8:2 (8 February 2008)

Abstract | Full text | PDF | PubMed

409.

Research   Open Access

Pitting of malaria parasites and spherocyte formation

Samuel B Anyona, Stanley L Schrier, Charity W Gichuki, John N Waitumbi Malaria Journal 2006, 5:64 (31 July 2006)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A tantalizing hypothesis about the relationship between the pitting of malarial parasites and spherocyte formation during malarial infection. This hypothesis, based on in vitro studies, is supported by preliminary clinical findings and is novel inasmuch as it does not recognize a role for the spleen in the process.

410.

Research article   Open Access Highly Accessed

Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

Connie Wong, Tim Stearns BMC Cell Biology 2005, 6:6 (15 February 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology

411.

Research article   Open Access

The role of economics in the QUERI program: QUERI Series

Mark W Smith, Paul G Barnett Implementation Science 2008, 3:20 (22 April 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

412.

Research article   Open Access Highly Accessed

The courage to change: Patient perceptions of 12-Step fellowships

John-Kåre Vederhus, Christine Timko, Øistein Kristensen, Thomas Clausen BMC Health Services Research 2011, 11:339 (15 December 2011)

Abstract | Full text | PDF | PubMed

413.

Research article   Open Access

Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus

Donna L Thibault, Kareem L Graham, Lowen Y Lee, Imelda Balboni, Paul J Hertzog, Paul J Utz Arthritis Research & Therapy 2009, 11:R112 (22 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

414.

Research article   Open Access

Further validation that claims data are a useful tool for epidemiologic research on hypertension

Baylah Tessier-Sherman, Deron Galusha, Oyebode A Taiwo, Linda Cantley, Martin D Slade, Sharon R Kirsche, Mark R Cullen BMC Public Health 2013, 13:51 (18 January 2013)

Abstract | Full text | PDF | PubMed

415.

Study protocol   Open Access

Implementation of case management to reduce cardiovascular disease risk in the Stanford and San Mateo Heart to Heart randomized controlled trial: study protocol and baseline characteristics

Jun Ma, Ky-Van Lee, Kathy Berra, Randall S Stafford Implementation Science 2006, 1:21 (27 September 2006)

Abstract | Full text | PDF | PubMed

416.

Research article   Open Access

Adherence and virologic suppression during the first 24 weeks on antiretroviral therapy among women in Johannesburg, South Africa - a prospective cohort study

Ziad El-Khatib, Anna Ekstrom, Ashraf Coovadia, Elaine J Abrams, Max Petzold, David Katzenstein, Lynn Morris, Louise Kuhn BMC Public Health 2011, 11:88 (8 February 2011)

Abstract | Full text | PDF | PubMed

417.

Research   Open Access

Improved analytical methods for microarray-based genome-composition analysis

Charles C Kim, Elizabeth A Joyce, Kaman Chan, Stanley Falkow Genome Biology 2002, 3:research0065-research0065.17 (29 October 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Genome-composition analysis using microarrays can be used to categorize genes into 'present' and 'divergent' categories. This involves selecting a signal value that is used as a cutoff to discriminate present and divergent genes, but this can result in the misclassification of many genes. A method is described that depends on the shape of the signal-ratio distribution and does not require empirical determination of a cutoff. Many genes previously classified as present using static methods are in fact divergent on the basis of microarray signal; this is corrected by our algorithm.

418.

Commentary   Free

Translational bioinformatics applications in genome medicine

Atul J Butte Genome Medicine 2009, 1:64 (29 June 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Investigators empowered by bioinformatics need to take on the role of translational scientist by building the tools to ask the questions that will yield discoveries which will improve human health.

419.

Method   Open Access

The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics

Tara A Gianoulis, Ashish Agarwal, Michael Snyder, Mark B Gerstein Genome Biology 2011, 12:R32 (31 March 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Making connections between unrelated tabulated genomics datasets

420.

Research   Open Access Highly Accessed

Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model

Hong Yang, Terry A McNearney, Rong Chu, Ying Lu, Yong Ren, David C Yeomans, Steven P Wilson, Karin N Westlund Molecular Pain 2008, 4:8 (28 February 2008)

Abstract | Full text | PDF | PubMed

421.

Research article   Open Access

ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development

Amy C Lossie, Chiao-Ling Lo, Katherine M Baumgarner, Melissa J Cramer, Joseph P Garner, Monica J Justice BMC Genetics 2012, 13:106 (12 December 2012)

Abstract | Full text | PDF | PubMed

422.

Research article   Open Access

Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae

William J Jo, Jeung Hyoun Kim, Eric Oh, Daniel Jaramillo, Patricia Holman, Alex V Loguinov, Adam P Arkin, Corey Nislow, Guri Giaever, Chris D Vulpe BMC Genomics 2009, 10:130 (25 March 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In a yeast model of growth under iron-limited conditions, the role of genes for intracellular trafficking and the peroxisome is determined by combining deletion mutants and expression profiling, which reveal separate metabolic pathway components.

423.

Research article   Open Access

Racial differences in cigarette brand recognition and impact on youth smoking

Amanda L Dauphinee, Juliana R Doxey, Nina C Schleicher, Stephen P Fortmann, Lisa Henriksen BMC Public Health 2013, 13:170 (25 February 2013)

Abstract | Full text | PDF | PubMed

424.

Research   Open Access

Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009

Olivier Humblet, Oleg Sergeyev, Larisa Altshul, Susan A Korrick, Paige L Williams, Claude Emond, Linda S Birnbaum, Jane S Burns, Mary M Lee, Boris Revich, Andrey Shelepchikov, Denis Feshin, Russ Hauser Environmental Health 2011, 10:62 (22 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

425.

Commentary   Free

Resting-state fMRI as a biomarker for Alzheimer's disease?

Jessica S Damoiseaux Alzheimer's Research & Therapy 2012, 4:8 (15 March 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Damoiseaux comments on a recent review discussing resting-state functional magnetic resonance imaging (fMRI) in the study of Alzheimer's disease, considering key aspects surrounding its biomarker potential.

426.

Research article   Open Access

Mutations of PIK3CA in gastric adenocarcinoma

Vivian Li, Chi Wong, Tsun Chan, Agnes Chan, Wei Zhao, Kent-Man Chu, Samuel So, Xin Chen, Siu Yuen, Suet Leung BMC Cancer 2005, 5:29 (23 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

427.

Research   Open Access Highly Accessed

Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4

William M Switzer, Marco Salemi, Shoukat H Qari, Hongwei Jia, Rebecca R Gray, Aris Katzourakis, Susan J Marriott, Kendle N Pryor, Nathan D Wolfe, Donald S Burke, Thomas M Folks, Walid Heneine Retrovirology 2009, 6:9 (2 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

428.

Research   Open Access

Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors

Glen L Kelley, Salman Azhar Nutrition & Metabolism 2005, 2:18 (9 August 2005)

Abstract | Full text | PDF | PubMed

429.

Research article   Open Access

Transcriptomic, proteomic and metabolomic analysis of UV-B signaling in maize

Paula Casati, Mabel Campi, Darren J Morrow, John F Fernandes, Virginia Walbot BMC Genomics 2011, 12:321 (16 June 2011)

Abstract | Full text | PDF | PubMed

430.

Research article   Open Access Highly Accessed

Recent breast cancer trends among Asian/Pacific Islander, Hispanic, and African-American women in the US: changes by tumor subtype

Amelia K Hausauer, Theresa HM Keegan, Ellen T Chang, Christina A Clarke Breast Cancer Research 2007, 9:R90 (27 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Multi-ethnic population-based trends provide further evidence that hormone therapy use has a major influence on rates of breast cancer subtypes and particularly on the number of estrogen-positive tumours.

431.

Database   Open Access Highly Accessed

Production of a reference transcriptome and transcriptomic database (PocilloporaBase) for the cauliflower coral, Pocillopora damicornis

Nikki Traylor-Knowles, Brian R Granger, Tristan J Lubinski, Jignesh R Parikh, Sara Garamszegi, Yu Xia, Jarrod A Marto, Les Kaufman, John R Finnerty BMC Genomics 2011, 12:585 (29 November 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

432.

Correspondence   Open Access

Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease

Kaisa Silander, Hua Tang, Sean Myles, Eveliina Jakkula, Nicholas J Timpson, Luigi Cavalli-Sforza, Leena Peltonen Genome Medicine 2009, 1:51 (12 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The protective allele for diabetes and the risk allele for coronary heart disease at the 9p21.3 locus have varying haplotype frequencies across 51 populations, implying very different population histories and highlighting the need to consider allelic background data for replication studies of genetic associations.

433.

Research   Open Access Highly Accessed

Comparative profiling of the sense and antisense transcriptome of maize lines

Jiong Ma, Darren J Morrow, John Fernandes, Virginia Walbot Genome Biology 2006, 7:R22 (13 March 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Comparative transcriptome profiling of inbred maize lines demonstrates remarkable similarities and a large number of antisense transcripts.

434.

Research   Open Access

Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months

Catherine Chiu, Miles C Miller, Ilias N Caralopoulos, Michael S Worden, Thomas Brinker, Zachary N Gordon, Conrad E Johanson, Gerald D Silverberg Fluids and Barriers of the CNS 2012, 9:3 (23 January 2012)

Abstract | Full text | PDF | PubMed

435.

Research   Open Access

BioCreative III interactive task: an overview

Cecilia N Arighi, Phoebe M Roberts, Shashank Agarwal, Sanmitra Bhattacharya, Gianni Cesareni, Andrew Chatr-aryamontri, Simon Clematide, Pascale Gaudet, Michelle Giglio, Ian Harrow, Eva Huala, Martin Krallinger, Ulf Leser, Donghui Li, Feifan Liu, Zhiyong Lu, Lois J Maltais, Naoaki Okazaki, Livia Perfetto, Fabio Rinaldi, Rune Sætre, David Salgado, Padmini Srinivasan, Philippe E Thomas, Luca Toldo, Lynette Hirschman, Cathy H Wu BMC Bioinformatics 2011, 12(Suppl 8):S4 (3 October 2011)

Abstract | Full text | PDF | PubMed

436.

Proceedings   Open Access

Ontology-driven indexing of public datasets for translational bioinformatics

Nigam H Shah, Clement Jonquet, Annie P Chiang, Atul J Butte, Rong Chen, Mark A Musen BMC Bioinformatics 2009, 10(Suppl 2):S1 (5 February 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

437.

Research highlight   Free Highly Accessed

Improving bioinformatic pipelines for exome variant calling

Hanlee P Ji Genome Medicine 2012, 4:7 (30 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Hanlee Ji discusses the Atlas2 suite, a new set of tools for calling variants in exome sequencing data that is faster and easier to use than comparable tools and could thus be useful in diagnostics.

438.

Research article   Open Access Highly Accessed

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

Katharina Faust, Stephan Gehrke, Yufeng Yang, Lichuan Yang, M Flint Beal, Bingwei Lu BMC Neuroscience 2009, 10:109 (1 September 2009)

Abstract | Full text | PDF | PubMed

439.

Research article   Open Access Highly Accessed

Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis

Gulisa Turashvili, Samuel Leung, Dmitry Turbin, Kelli Montgomery, Blake Gilks, Rob West, Melinda Carrier, David Huntsman, Samuel Aparicio BMC Cancer 2009, 9:165 (29 May 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

440.

Research   Open Access Highly Accessed

Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision

DeYong Liang, Xiaoyou Shi, Yanli Qiao, Martin S Angst, David C Yeomans, J Clark Molecular Pain 2008, 4:7 (22 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

441.

Research   Open Access

An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program

Aldi T Kraja, DC Rao, Alan B Weder, Thomas H Mosley, Stephen T Turner, Chao Hsiung, Thomas Quertermous, Richard Cooper, J David Curb, Michael A Province Nutrition & Metabolism 2005, 2:17 (2 August 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

442.

Research article   Open Access Highly Accessed

Segmental lumbar mobility in individuals with low back pain: in vivo assessment during manual and self-imposed motion using dynamic MRI

Kornelia Kulig, Christopher M Powers, Robert F Landel, Hungwen Chen, Michael Fredericson, Marc Guillet, Kim Butts BMC Musculoskeletal Disorders 2007, 8:8 (29 January 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

443.

Research article   Open Access Highly Accessed

Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patients

Gregory B Hammer, Susan T Verghese, David R Drover, Myron Yaster, Joseph R Tobin BMC Anesthesiology 2008, 8:6 (6 October 2008)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Fenoldopam mesylate is effective at lowering blood pressure in children during surgery only at higher doses than is currently licensed for in adults, and shows similar pharmacokinetics, pharmacodynamics and side effects to those seen in adults.

444.

Proceedings   Open Access

How orthogonal are the OBO Foundry ontologies?

Amir Ghazvinian, Natalya F Noy, Mark A Musen Journal of Biomedical Semantics 2011, 2(Suppl 2):S2 (17 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

445.

Research   Open Access

Characterizing multisegment foot kinematics during gait in diabetic foot patients

Zimi Sawacha, Giuseppe Cristoferi, Gabriella Guarneri, Stefano Corazza, Giulia Donà, Paolo Denti, Andrea Facchinetti, Angelo Avogaro, Claudio Cobelli Journal of NeuroEngineering and Rehabilitation 2009, 6:37 (23 October 2009)

Abstract | Full text | PDF | PubMed

446.

Research   Open Access Highly Accessed

Gene-expression patterns reveal underlying biological processes in Kawasaki disease

Stephen J Popper, Chisato Shimizu, Hiroko Shike, John T Kanegaye, Jane W Newburger, Robert P Sundel, Patrick O Brown, Jane C Burns, David A Relman Genome Biology 2007, 8:R261 (11 December 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Analysis of patterns of gene expression in peripheral blood from children with Kawasaki disease revealed dynamic and variable gene expression programs involving neutrophil activation and apoptosis.

447.

Research article   Open Access

Hearing effects from intermittent and continuous noise exposure in a study of Korean factory workers and firefighters

In-Sung Chung, Isabella M Chu, Mark R Cullen BMC Public Health 2012, 12:87 (27 January 2012)

Abstract | Full text | PDF | PubMed

448.

Research article   Open Access

Improved responsiveness and reduced sample size requirements of PROMIS physical function scales with item response theory

James F Fries, Eswar Krishnan, Matthias Rose, Bharathi Lingala, Bonnie Bruce Arthritis Research & Therapy 2011, 13:R147 (14 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

449.

Review   Open Access Highly Accessed

Homeostatic capabilities of the choroid plexus epithelium in Alzheimer's disease

Conrad Johanson, Paul McMillan, Rosemarie Tavares, Anthony Spangenberger, John Duncan, Gerald Silverberg, Edward Stopa Cerebrospinal Fluid Research 2004, 1:3 (10 December 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

450.

Method   Open Access

Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function

Weidong Tian, Lan V Zhang, Murat Taşan, Francis D Gibbons, Oliver D King, Julie Park, Zeba Wunderlich, J Michael Cherry, Frederick P Roth Genome Biology 2008, 9(Suppl 1):S7 (27 June 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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